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The map label for this gene is moaE2

Identifier: 121636789

GI number: 121636789

Start: 994320

End: 994745

Strand: Direct

Name: moaE2

Synonym: BCG_0918

Alternate gene names: 121636789

Gene position: 994320-994745 (Clockwise)

Preceding gene: 121636788

Following gene: 121636794

Centisome position: 22.73

GC content: 67.14

Gene sequence:

>426_bases
ATGACGCAGGTCCTGCGCGCCGCGCTGACAGATCAACCGATCTTTCTGGCCGAGCACGAGGAGCTGGTGAGCCATCGGTC
GGCTGGCGCCATTGTCGGGTTCGTCGGAATGATCCGCGACCGTGACGGTGGACGGGGGGTGTTGCGGCTGGAGTACTCCG
CGCACCCGTCGGCCGCACAGGTCCTTGCGGATTTGGTGGCGGAGGTAGCTGAAGAGTCCAGTGGCGTGCGTGCGGTGGCG
GCCAGCCACCGGATCGGCGTCTTGCAGGTCGGGGAGGCCGCCCTGGTGGCGGCGGTTGCCGCCGATCACCGGCGGGCGGC
GTTTGGCACCTGTGCGCACCTGGTGGAGACCATCAAGGCGCGGCTTCCCGTGTGGAAGCACCAGTTCTTCGAGGACGGTA
CCGACGAATGGGTGGGTTCGGTTTAA

Upstream 100 bases:

>100_bases
ATCTGCCGGGATCGCCTGGAGGTGTACGTGACGGCCTCGGGGTGCTCGCCGATGTGCTGGACCATGCTCTCGAGCAGATC
GCCGGTGGAGATCACCCGCG

Downstream 100 bases:

>100_bases
AGTCCGGCCTCAGCCCGTCAGCCGATGACGTACGGCTGTGCGAGCGAGTCCAGCGCATCGTTGCCGCAGACGTCCTGGGC
CCGAATCGCCTGCCACAGCT

Product: putative molybdenum cofactor biosynthesis protein e2 moaE2

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E 2; Molybdopterin-converting factor large subunit 2; Molybdopterin-converting factor subunit 2

Number of amino acids: Translated: 141; Mature: 140

Protein sequence:

>141_residues
MTQVLRAALTDQPIFLAEHEELVSHRSAGAIVGFVGMIRDRDGGRGVLRLEYSAHPSAAQVLADLVAEVAEESSGVRAVA
ASHRIGVLQVGEAALVAAVAADHRRAAFGTCAHLVETIKARLPVWKHQFFEDGTDEWVGSV

Sequences:

>Translated_141_residues
MTQVLRAALTDQPIFLAEHEELVSHRSAGAIVGFVGMIRDRDGGRGVLRLEYSAHPSAAQVLADLVAEVAEESSGVRAVA
ASHRIGVLQVGEAALVAAVAADHRRAAFGTCAHLVETIKARLPVWKHQFFEDGTDEWVGSV
>Mature_140_residues
TQVLRAALTDQPIFLAEHEELVSHRSAGAIVGFVGMIRDRDGGRGVLRLEYSAHPSAAQVLADLVAEVAEESSGVRAVAA
SHRIGVLQVGEAALVAAVAADHRRAAFGTCAHLVETIKARLPVWKHQFFEDGTDEWVGSV

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family

Homologues:

Organism=Homo sapiens, GI4758732, Length=133, Percent_Identity=30.8270676691729, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17509279, Length=126, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21356259, Length=131, Percent_Identity=29.7709923664122, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOAE2_MYCTU (O53878)

Other databases:

- EMBL:   BX842574
- EMBL:   AE000516
- PIR:   B70816
- RefSeq:   NP_215381.1
- RefSeq:   NP_335316.1
- ProteinModelPortal:   O53878
- SMR:   O53878
- EnsemblBacteria:   EBMYCT00000002954
- EnsemblBacteria:   EBMYCT00000071922
- GeneID:   885431
- GeneID:   926198
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT0889
- KEGG:   mtu:Rv0866
- TIGR:   MT0889
- TubercuList:   Rv0866
- GeneTree:   EBGT00050000017227
- HOGENOM:   HBG460564
- OMA:   PHRSEAF
- ProtClustDB:   CLSK871864
- InterPro:   IPR003448
- Gene3D:   G3DSA:3.90.1170.40

Pfam domain/function: PF02391 MoaE; SSF54690 Mb_biosynth_MoaE

EC number: NA

Molecular weight: Translated: 15048; Mature: 14917

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: BINDING 119-119

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQVLRAALTDQPIFLAEHEELVSHRSAGAIVGFVGMIRDRDGGRGVLRLEYSAHPSAAQ
CHHHHHHHHCCCCEEEECHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHH
VLADLVAEVAEESSGVRAVAASHRIGVLQVGEAALVAAVAADHRRAAFGTCAHLVETIKA
HHHHHHHHHHHCCCCCEEEHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLPVWKHQFFEDGTDEWVGSV
HCCHHHHHHHCCCCHHHCCCC
>Mature Secondary Structure 
TQVLRAALTDQPIFLAEHEELVSHRSAGAIVGFVGMIRDRDGGRGVLRLEYSAHPSAAQ
HHHHHHHHCCCCEEEECHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHH
VLADLVAEVAEESSGVRAVAASHRIGVLQVGEAALVAAVAADHRRAAFGTCAHLVETIKA
HHHHHHHHHHHCCCCCEEEHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLPVWKHQFFEDGTDEWVGSV
HCCHHHHHHHCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036