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The map label for this gene is fadA [H]

Identifier: 121636782

GI number: 121636782

Start: 985582

End: 986793

Strand: Direct

Name: fadA [H]

Synonym: BCG_0911

Alternate gene names: 121636782

Gene position: 985582-986793 (Clockwise)

Preceding gene: 121636780

Following gene: 121636783

Centisome position: 22.53

GC content: 67.16

Gene sequence:

>1212_bases
ATGTCCGAAGAAGCCTTCATCTACGAGGCCATCCGCACCCCGCGCGGCAAACAAAAGAACGGATCGTTGCACGAAGTCAA
GCCATTGAGCCTGGTCGTCGGCCTGATCGACGAGCTGCGCAAGCGCCATCCCGACCTCGACGAGAACCTGATCAGCGACG
TCATCTTGGGCTGCGTCTCACCGGTGGGCGACCAGGGCGGCGACATCGCCCGCGCCGCAGTGCTGGCATCGGGCATGCCG
GTCACCTCCGGCGGTGTGCAGCTCAACCGGTTCTGCGCGTCCGGCCTGGAGGCCGTCAACACCGCCGCGCAGAAGGTGCG
TTCGGGCTGGGATGACCTGGTGCTGGCCGGCGGCGTGGAGTCGATGAGCCGGGTGCCGATGGGCTCCGACGGCGGCGCTA
TGGGCCTGGACCCGGCGACCAACTACGACGTCATGTTCGTCCCGCAGGGCATCGGCGCCGACCTGATCGCCACCATCGAG
GGCTTCTCCCGCGAAGACGTCGACGCCTACGCGCTACGCAGCCAGCAAAAGGCCGCCGAGGCGTGGTCGGGCGGCTACTT
CGCCAAGTCGGTGGTGCCGGTGCGCGACCAGAACGGCCTGCTGATCCTCGATCATGACGAACACATGCGGCCGGACACCA
CCAAGGAGGGTCTGGCCAAGCTGAAGCCGGCCTTCGAAGGCCTGGCCGCGCTGGGCGGTTTCGACGACGTGGCGCTGCAG
AAGTACCACTGGGTGGAAAAGATCAACCACGTACACACCGGCGGCAACAGCTCGGGGATCGTCGACGGTGCCGCGCTGGT
GATGATCGGTTCCGCGGCCGCCGGCAAGTTGCAGGGCCTGACTCCGCGGGCGCGCATCGTCGCCACCGCCACCAGCGGCG
CCGACCCGGTGATCATGCTCACCGGCCCCACCCCGGCCACCCGCAAGGTGCTCGACCGCGCCGGGCTGACCGTCGACGAC
ATCGACCTGTTCGAGCTCAACGAGGCGTTCGCGTCGGTGGTGCTGAAGTTCCAGAAGGACCTCAACATTCCCGACGAGAA
GCTCAACGTCAACGGTGGCGCCATCGCGATGGGCCACCCGCTGGGTGCCACCGGCGCGATGATCCTGGGCACCATGGTCG
ACGAACTGGAGCGCCGCAACGCCCGACGTGCACTCATCACGCTGTGCATCGGGGGCGGCATGGGTGTCGCGACGATCATC
GAGAGGGTTTAA

Upstream 100 bases:

>100_bases
ACAGGTTGGCCGGGGGCCCTGTTAGGGTGCCGGTACGGGACCTAGTCTTGAAGAAGGATCCAAACCCCCTTTTGTGGAAT
TTGTGGAACAGGAAATCGAC

Downstream 100 bases:

>100_bases
CAGCATGCCAGACAACACAATCCAGTGGGACAAGGATGCCGACGGCATCGTCACGCTGACCATGGACGATCCCTCCGGGT
CAACCAACGTGATGAACGAG

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MSEEAFIYEAIRTPRGKQKNGSLHEVKPLSLVVGLIDELRKRHPDLDENLISDVILGCVSPVGDQGGDIARAAVLASGMP
VTSGGVQLNRFCASGLEAVNTAAQKVRSGWDDLVLAGGVESMSRVPMGSDGGAMGLDPATNYDVMFVPQGIGADLIATIE
GFSREDVDAYALRSQQKAAEAWSGGYFAKSVVPVRDQNGLLILDHDEHMRPDTTKEGLAKLKPAFEGLAALGGFDDVALQ
KYHWVEKINHVHTGGNSSGIVDGAALVMIGSAAAGKLQGLTPRARIVATATSGADPVIMLTGPTPATRKVLDRAGLTVDD
IDLFELNEAFASVVLKFQKDLNIPDEKLNVNGGAIAMGHPLGATGAMILGTMVDELERRNARRALITLCIGGGMGVATII
ERV

Sequences:

>Translated_403_residues
MSEEAFIYEAIRTPRGKQKNGSLHEVKPLSLVVGLIDELRKRHPDLDENLISDVILGCVSPVGDQGGDIARAAVLASGMP
VTSGGVQLNRFCASGLEAVNTAAQKVRSGWDDLVLAGGVESMSRVPMGSDGGAMGLDPATNYDVMFVPQGIGADLIATIE
GFSREDVDAYALRSQQKAAEAWSGGYFAKSVVPVRDQNGLLILDHDEHMRPDTTKEGLAKLKPAFEGLAALGGFDDVALQ
KYHWVEKINHVHTGGNSSGIVDGAALVMIGSAAAGKLQGLTPRARIVATATSGADPVIMLTGPTPATRKVLDRAGLTVDD
IDLFELNEAFASVVLKFQKDLNIPDEKLNVNGGAIAMGHPLGATGAMILGTMVDELERRNARRALITLCIGGGMGVATII
ERV
>Mature_402_residues
SEEAFIYEAIRTPRGKQKNGSLHEVKPLSLVVGLIDELRKRHPDLDENLISDVILGCVSPVGDQGGDIARAAVLASGMPV
TSGGVQLNRFCASGLEAVNTAAQKVRSGWDDLVLAGGVESMSRVPMGSDGGAMGLDPATNYDVMFVPQGIGADLIATIEG
FSREDVDAYALRSQQKAAEAWSGGYFAKSVVPVRDQNGLLILDHDEHMRPDTTKEGLAKLKPAFEGLAALGGFDDVALQK
YHWVEKINHVHTGGNSSGIVDGAALVMIGSAAAGKLQGLTPRARIVATATSGADPVIMLTGPTPATRKVLDRAGLTVDDI
DLFELNEAFASVVLKFQKDLNIPDEKLNVNGGAIAMGHPLGATGAMILGTMVDELERRNARRALITLCIGGGMGVATIIE
RV

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=365, Percent_Identity=37.2602739726027, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI148539872, Length=416, Percent_Identity=36.5384615384615, Blast_Score=214, Evalue=9e-56,
Organism=Homo sapiens, GI4501853, Length=400, Percent_Identity=37.25, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI4557237, Length=419, Percent_Identity=31.2649164677804, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI4504327, Length=383, Percent_Identity=30.2872062663185, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI194353979, Length=89, Percent_Identity=51.685393258427, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI1787663, Length=423, Percent_Identity=43.7352245862884, Blast_Score=308, Evalue=4e-85,
Organism=Escherichia coli, GI48994986, Length=409, Percent_Identity=38.8753056234719, Blast_Score=267, Evalue=8e-73,
Organism=Escherichia coli, GI87082165, Length=417, Percent_Identity=39.568345323741, Blast_Score=235, Evalue=4e-63,
Organism=Escherichia coli, GI1788554, Length=416, Percent_Identity=38.4615384615385, Blast_Score=226, Evalue=1e-60,
Organism=Escherichia coli, GI1788683, Length=442, Percent_Identity=28.9592760180996, Blast_Score=140, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI133906874, Length=376, Percent_Identity=38.563829787234, Blast_Score=232, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17535921, Length=414, Percent_Identity=33.0917874396135, Blast_Score=184, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI25147385, Length=417, Percent_Identity=30.6954436450839, Blast_Score=167, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI17551802, Length=417, Percent_Identity=27.8177458033573, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17535917, Length=405, Percent_Identity=26.9135802469136, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322031, Length=406, Percent_Identity=36.4532019704434, Blast_Score=203, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6325229, Length=424, Percent_Identity=31.1320754716981, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24655093, Length=415, Percent_Identity=38.0722891566265, Blast_Score=242, Evalue=3e-64,
Organism=Drosophila melanogaster, GI17648125, Length=349, Percent_Identity=36.1031518624642, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24640423, Length=367, Percent_Identity=30.7901907356948, Blast_Score=161, Evalue=7e-40,
Organism=Drosophila melanogaster, GI17137578, Length=416, Percent_Identity=30.0480769230769, Blast_Score=136, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 42385; Mature: 42254

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEEAFIYEAIRTPRGKQKNGSLHEVKPLSLVVGLIDELRKRHPDLDENLISDVILGCVS
CCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
PVGDQGGDIARAAVLASGMPVTSGGVQLNRFCASGLEAVNTAAQKVRSGWDDLVLAGGVE
CCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHH
SMSRVPMGSDGGAMGLDPATNYDVMFVPQGIGADLIATIEGFSREDVDAYALRSQQKAAE
HHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHH
AWSGGYFAKSVVPVRDQNGLLILDHDEHMRPDTTKEGLAKLKPAFEGLAALGGFDDVALQ
HHCCCCCHHEEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHH
KYHWVEKINHVHTGGNSSGIVDGAALVMIGSAAAGKLQGLTPRARIVATATSGADPVIML
HHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCEEEE
TGPTPATRKVLDRAGLTVDDIDLFELNEAFASVVLKFQKDLNIPDEKLNVNGGAIAMGHP
ECCCHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHEECCCCEEEECCC
LGATGAMILGTMVDELERRNARRALITLCIGGGMGVATIIERV
CCCHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHCC
>Mature Secondary Structure 
SEEAFIYEAIRTPRGKQKNGSLHEVKPLSLVVGLIDELRKRHPDLDENLISDVILGCVS
CCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
PVGDQGGDIARAAVLASGMPVTSGGVQLNRFCASGLEAVNTAAQKVRSGWDDLVLAGGVE
CCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHH
SMSRVPMGSDGGAMGLDPATNYDVMFVPQGIGADLIATIEGFSREDVDAYALRSQQKAAE
HHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHH
AWSGGYFAKSVVPVRDQNGLLILDHDEHMRPDTTKEGLAKLKPAFEGLAALGGFDDVALQ
HHCCCCCHHEEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHH
KYHWVEKINHVHTGGNSSGIVDGAALVMIGSAAAGKLQGLTPRARIVATATSGADPVIML
HHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCEEEE
TGPTPATRKVLDRAGLTVDDIDLFELNEAFASVVLKFQKDLNIPDEKLNVNGGAIAMGHP
ECCCHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHEECCCCEEEECCC
LGATGAMILGTMVDELERRNARRALITLCIGGGMGVATIIERV
CCCHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]