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The map label for this gene is ggtA [H]

Identifier: 121636697

GI number: 121636697

Start: 897632

End: 899170

Strand: Reverse

Name: ggtA [H]

Synonym: BCG_0825c

Alternate gene names: 121636697

Gene position: 899170-897632 (Counterclockwise)

Preceding gene: 121636698

Following gene: 121636691

Centisome position: 20.55

GC content: 64.91

Gene sequence:

>1539_bases
ATGCCCATCCTGGCGACAAACGTCGTGTGCACGTCACAACCGCTGGCCGCGCAAGCGGGTCTTCGGATGCTGGCCGACGG
CGGCAACGCGGTCGACGCCGCCGTCGCCACAGCCATCACCCTCACCGTGGTGGAACCGGTGTCCAATGGCATCGGCTCGG
ACGCCTTCAGCATCGTCTGGGACGGGCAAAAACTGCACGGCCTGAACGCGTCCGGCCGCTCACCCTCGGCGTGGACGCCA
GAGTACTTCGGCGGCAACGCCGTTCCCGTGCTCGGCTGGAACTCCGTGACGGTGCCCGGTGCGGTGTCGGCCTGGGTGGA
ACTGCACGCCAGGTTCGGCAGGCTACCATTCGAAACACTCTTCGAGCCCGCCATCTCGTACGGCCGCAACGGCTTTCTGG
TCTCACCGACCGTCGCGGCACAATGGGCGGCACAGGTGCCGTTGTTCGCATCCCAGCCCGGATTCGCCGATGCGTTCATG
CCCGGCGGACGAGCGCCGAAACCCGGTGAGCTGTTTACCTTTCCTGACCACGCGGCGACGCTAGAGAAGATCGCGGCGAC
CAACGGTGAGGAGTTCTACCGGGGAGAGCTGGCCGCCAAACTCGAGGCGCACTCGGCGGCAAACGGCGGGGTGATGCGTG
CCGACGACCTCGCCGCCCATCGCGTGGACTGGGTCGACACGATCACGGGAACCTACCGCGGGTACACCATCCACCAGATA
CCGCCCAACGGCCAGGGCATCGTGGCCTTGATCGCCCTCGGAATCCTCGAGCATTTCGATATGTCATCGTGGTCAGTGGA
TTCCGCTGAAAGTGTGCACGTGCAGATCGAAGCACTGAAGCTTGCCTTCGCCGACGCGCAAGCGTGTGTCGCCGACATCG
ACTACATGCCGGTGCACCCGAAGCGCCTGCTCGACAAGGAGTATCTGCGGCAGCGCGCCACGCTGATCGATCCAAAGAGG
GCAATGCCGGCGGCCACCGGCATCCCGCGAGGCGGCACCGTCTATCTGGCCGCCGCCGATGCTGCGGGAATGATGGTGTC
CATGATTCAGTCGAACTACCTTGGGTTCGGCTCCGGTGTGGTGGTGCCCGGCACCGGCATTTCGCTGCACAATCGCGGCT
CGGATTTCACTGTGGTGCCGAGACATCCGAACCGGGTTGGGCCACGGAAGCGCCCCTATCACACGATCATCCCAGGTTTT
GTGACCCGCGACGGTGCGCCGGTGATGAGCTTCGGGGTGATGGGCGGCATGATGCAACCCCAGGGTCACGTGCAGGTGCT
GGTGCGCATCGCCGACTACGGCCAGAACCCCCAGGCGGCCTGTGACGGCCCTCGGTTCCGCTGGGTGAACGGTATGCGGG
TCAGTTTCGAAAACGGCTTCCCGGATTCAACTCTCGATGAACTGCGGCAGCGTGGGCATGACTTGGTCGCAGTAGCGGAC
TACAGCCAGTTCGGGAGTTGTCAGGCAATCTGGCGGCTCGACGATGGGTACCTCGCGGCCAGCGATCCCCGCCGTGATGG
CCAAGCCGCAGCCTGCTAG

Upstream 100 bases:

>100_bases
CACAGCTACCCGCCGAGCTGACCTGGTTCGCGCCGCTGCTCACAGGTTAAGCGGCGTGAGCACGCCGTTTGGTTGGACCT
TCCCCTACGCTTGGCCGCGC

Downstream 100 bases:

>100_bases
ACGCTGATCTTCCCCTCGGCCGCCCGTAAACCGATATCGCTGCGGAAATGACCTCCTGGCAACCGAATTGAACTGAGGAT
TTCATACGCGTGTGCGCGTG

Product: putative bifunctional acylase ggtA: cephalosporin acylase + gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 512; Mature: 511

Protein sequence:

>512_residues
MPILATNVVCTSQPLAAQAGLRMLADGGNAVDAAVATAITLTVVEPVSNGIGSDAFSIVWDGQKLHGLNASGRSPSAWTP
EYFGGNAVPVLGWNSVTVPGAVSAWVELHARFGRLPFETLFEPAISYGRNGFLVSPTVAAQWAAQVPLFASQPGFADAFM
PGGRAPKPGELFTFPDHAATLEKIAATNGEEFYRGELAAKLEAHSAANGGVMRADDLAAHRVDWVDTITGTYRGYTIHQI
PPNGQGIVALIALGILEHFDMSSWSVDSAESVHVQIEALKLAFADAQACVADIDYMPVHPKRLLDKEYLRQRATLIDPKR
AMPAATGIPRGGTVYLAAADAAGMMVSMIQSNYLGFGSGVVVPGTGISLHNRGSDFTVVPRHPNRVGPRKRPYHTIIPGF
VTRDGAPVMSFGVMGGMMQPQGHVQVLVRIADYGQNPQAACDGPRFRWVNGMRVSFENGFPDSTLDELRQRGHDLVAVAD
YSQFGSCQAIWRLDDGYLAASDPRRDGQAAAC

Sequences:

>Translated_512_residues
MPILATNVVCTSQPLAAQAGLRMLADGGNAVDAAVATAITLTVVEPVSNGIGSDAFSIVWDGQKLHGLNASGRSPSAWTP
EYFGGNAVPVLGWNSVTVPGAVSAWVELHARFGRLPFETLFEPAISYGRNGFLVSPTVAAQWAAQVPLFASQPGFADAFM
PGGRAPKPGELFTFPDHAATLEKIAATNGEEFYRGELAAKLEAHSAANGGVMRADDLAAHRVDWVDTITGTYRGYTIHQI
PPNGQGIVALIALGILEHFDMSSWSVDSAESVHVQIEALKLAFADAQACVADIDYMPVHPKRLLDKEYLRQRATLIDPKR
AMPAATGIPRGGTVYLAAADAAGMMVSMIQSNYLGFGSGVVVPGTGISLHNRGSDFTVVPRHPNRVGPRKRPYHTIIPGF
VTRDGAPVMSFGVMGGMMQPQGHVQVLVRIADYGQNPQAACDGPRFRWVNGMRVSFENGFPDSTLDELRQRGHDLVAVAD
YSQFGSCQAIWRLDDGYLAASDPRRDGQAAAC
>Mature_511_residues
PILATNVVCTSQPLAAQAGLRMLADGGNAVDAAVATAITLTVVEPVSNGIGSDAFSIVWDGQKLHGLNASGRSPSAWTPE
YFGGNAVPVLGWNSVTVPGAVSAWVELHARFGRLPFETLFEPAISYGRNGFLVSPTVAAQWAAQVPLFASQPGFADAFMP
GGRAPKPGELFTFPDHAATLEKIAATNGEEFYRGELAAKLEAHSAANGGVMRADDLAAHRVDWVDTITGTYRGYTIHQIP
PNGQGIVALIALGILEHFDMSSWSVDSAESVHVQIEALKLAFADAQACVADIDYMPVHPKRLLDKEYLRQRATLIDPKRA
MPAATGIPRGGTVYLAAADAAGMMVSMIQSNYLGFGSGVVVPGTGISLHNRGSDFTVVPRHPNRVGPRKRPYHTIIPGFV
TRDGAPVMSFGVMGGMMQPQGHVQVLVRIADYGQNPQAACDGPRFRWVNGMRVSFENGFPDSTLDELRQRGHDLVAVADY
SQFGSCQAIWRLDDGYLAASDPRRDGQAAAC

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=524, Percent_Identity=27.4809160305344, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI73915090, Length=524, Percent_Identity=27.4809160305344, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI73915096, Length=524, Percent_Identity=27.4809160305344, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI73915094, Length=524, Percent_Identity=27.4809160305344, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI113429324, Length=538, Percent_Identity=26.7657992565056, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI113429326, Length=543, Percent_Identity=26.3351749539595, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI109148539, Length=541, Percent_Identity=27.9112754158965, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI153266885, Length=547, Percent_Identity=25.9597806215722, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI153266901, Length=548, Percent_Identity=25.9124087591241, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI153266907, Length=542, Percent_Identity=24.9077490774908, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1789856, Length=529, Percent_Identity=30.0567107750473, Blast_Score=212, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI17506189, Length=551, Percent_Identity=25.5898366606171, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI193208247, Length=480, Percent_Identity=24.375, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI193208245, Length=480, Percent_Identity=24.375, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI72000294, Length=550, Percent_Identity=24.3636363636364, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI212646519, Length=539, Percent_Identity=24.860853432282, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI18859893, Length=516, Percent_Identity=27.906976744186, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI45551474, Length=525, Percent_Identity=26.0952380952381, Blast_Score=132, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24642670, Length=525, Percent_Identity=26.0952380952381, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24642666, Length=525, Percent_Identity=26.0952380952381, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI161077880, Length=525, Percent_Identity=26.0952380952381, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI161077878, Length=532, Percent_Identity=25.9398496240602, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI161077496, Length=521, Percent_Identity=24.9520153550864, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI18859741, Length=542, Percent_Identity=25.830258302583, Blast_Score=103, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 54593; Mature: 54462

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPILATNVVCTSQPLAAQAGLRMLADGGNAVDAAVATAITLTVVEPVSNGIGSDAFSIVW
CCEEEEEEEECCCCHHHHHCCEEEECCCCHHHHHHHHHEEEEEEHHHHCCCCCCCEEEEE
DGQKLHGLNASGRSPSAWTPEYFGGNAVPVLGWNSVTVPGAVSAWVELHARFGRLPFETL
CCCEEECCCCCCCCCCCCCCHHCCCCEEEEECCCCEECCHHHHHHHHHHHHHCCCCHHHH
FEPAISYGRNGFLVSPTVAAQWAAQVPLFASQPGFADAFMPGGRAPKPGELFTFPDHAAT
HHHHHHHCCCCEEECCHHHHHHHHCCCEEECCCCCCHHCCCCCCCCCCCCEEECCCHHHH
LEKIAATNGEEFYRGELAAKLEAHSAANGGVMRADDLAAHRVDWVDTITGTYRGYTIHQI
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHCCHHHHHCCCCCCEEEEEC
PPNGQGIVALIALGILEHFDMSSWSVDSAESVHVQIEALKLAFADAQACVADIDYMPVHP
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEEEHHHHHHHHHCCCCCCCCH
KRLLDKEYLRQRATLIDPKRAMPAATGIPRGGTVYLAAADAAGMMVSMIQSNYLGFGSGV
HHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCE
VVPGTGISLHNRGSDFTVVPRHPNRVGPRKRPYHTIIPGFVTRDGAPVMSFGVMGGMMQP
EECCCCEEEECCCCCEEEECCCCCCCCCCCCCCEEECCCEEECCCCCHHHHHHHCCCCCC
QGHVQVLVRIADYGQNPQAACDGPRFRWVNGMRVSFENGFPDSTLDELRQRGHDLVAVAD
CCCEEEEEEEECCCCCCCCCCCCCCEEEECCEEEEECCCCCCHHHHHHHHCCCCEEEEEC
YSQFGSCQAIWRLDDGYLAASDPRRDGQAAAC
CCCCCCEEEEEEECCCEEECCCCCCCCCCCCC
>Mature Secondary Structure 
PILATNVVCTSQPLAAQAGLRMLADGGNAVDAAVATAITLTVVEPVSNGIGSDAFSIVW
CEEEEEEEECCCCHHHHHCCEEEECCCCHHHHHHHHHEEEEEEHHHHCCCCCCCEEEEE
DGQKLHGLNASGRSPSAWTPEYFGGNAVPVLGWNSVTVPGAVSAWVELHARFGRLPFETL
CCCEEECCCCCCCCCCCCCCHHCCCCEEEEECCCCEECCHHHHHHHHHHHHHCCCCHHHH
FEPAISYGRNGFLVSPTVAAQWAAQVPLFASQPGFADAFMPGGRAPKPGELFTFPDHAAT
HHHHHHHCCCCEEECCHHHHHHHHCCCEEECCCCCCHHCCCCCCCCCCCCEEECCCHHHH
LEKIAATNGEEFYRGELAAKLEAHSAANGGVMRADDLAAHRVDWVDTITGTYRGYTIHQI
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHCCHHHHHCCCCCCEEEEEC
PPNGQGIVALIALGILEHFDMSSWSVDSAESVHVQIEALKLAFADAQACVADIDYMPVHP
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEEEHHHHHHHHHCCCCCCCCH
KRLLDKEYLRQRATLIDPKRAMPAATGIPRGGTVYLAAADAAGMMVSMIQSNYLGFGSGV
HHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCE
VVPGTGISLHNRGSDFTVVPRHPNRVGPRKRPYHTIIPGFVTRDGAPVMSFGVMGGMMQP
EECCCCEEEECCCCCEEEECCCCCCCCCCCCCCEEECCCEEECCCCCHHHHHHHCCCCCC
QGHVQVLVRIADYGQNPQAACDGPRFRWVNGMRVSFENGFPDSTLDELRQRGHDLVAVAD
CCCEEEEEEEECCCCCCCCCCCCCCEEEECCEEEEECCCCCCHHHHHHHHCCCCEEEEEC
YSQFGSCQAIWRLDDGYLAASDPRRDGQAAAC
CCCCCCEEEEEEECCCEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]