| Definition | Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome. |
|---|---|
| Accession | NC_008769 |
| Length | 4,374,522 |
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The map label for this gene is fabG [C]
Identifier: 121636689
GI number: 121636689
Start: 889819
End: 890646
Strand: Reverse
Name: fabG [C]
Synonym: BCG_0817c
Alternate gene names: 121636689
Gene position: 890646-889819 (Counterclockwise)
Preceding gene: 121636690
Following gene: 121636688
Centisome position: 20.36
GC content: 67.15
Gene sequence:
>828_bases ATGCCACGCTTCGAACCTCACCCCGCCCGGCGGACCACCGTCGTCGCCGGCGCATCGTCGGGCATCGGCGCGGCCACCGC AACCGAACTCGCCGGCCGCGGGTTTCCGGTCGCCTTGGGGGCCCGCCGCATGGACAAGTTGGCCGAGCTGGTCGACAAAA TCCGCGCCGACGGTGGCGAGGCGGTAGCCTTCCCCCTCGACGTGACCGATCCCGAGTCGGTGAAATCGTTTGTGGCGCAA ACGGTCGAGGCACTCGGCGAGGTCGAACTGCTGGTGTCCAGTGCAGGCGACATGCTCCCGGGACAGCTGCACGAGGTCAG CACCGAGGCCTTTGCAGAGCAGGTTCAGATACACCTGGTCGGTGCCAACCGGCTGGCCACGGCCGTGCTACCGGCCATGG TGGCACGCCGGCGAGGTGACCTCATCTTCGTCGGATCCGATGTGGGCCTGCGCCAACGCCCGCATATGGGTGCCTACGGC GCCGCCAAGGCCGGTCTGGCCGCTATGGTCACCAACCTGCAGATGGAGTTGGAAGGCACCGGTGTTCGCGCATCGATCGT GCATCCGGGACCCACGCTGACCGGTATGGGCTGGCAGCTGTCGGCCGAACAAGTCGGCCCAATGCTGGCGGACTGGGCAA AGTGGGGGCAGGCCCGGCACAACTACTTCTTGCGACCCAGCGACCTGGCACGCGCTATCGCGTTCGTCGCAGAAACGCCG CGCGGGTGTGTCGTGGTGAACATGGAGATTCAACCGGAGGCCCCGCTGAGGGATGCGCCCGCGCACCGTCAGAAGCTAGT ACTGGGCGAAGAGGGGATGCCGGGCTAA
Upstream 100 bases:
>100_bases GGATCCGCAACTACGAAGTCGACGACGACAACGTCGTGCGCGTCCATTCCAGCAACGTGCGCGGATTTGCCCATCTGCCG ATCAGCGTGCAGGCCAGGTA
Downstream 100 bases:
>100_bases TGAGCGCTGTTGCACTACCCCGGGTTTCGGGTGGCCACGACGAACACGGCCACCTCGAGGAGTTCCGCACCGATCCGATC GGGCTGATGCAACGGGTCCG
Product: short chain dehydrogenase
Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]
Alternate protein names: NA
Number of amino acids: Translated: 275; Mature: 274
Protein sequence:
>275_residues MPRFEPHPARRTTVVAGASSGIGAATATELAGRGFPVALGARRMDKLAELVDKIRADGGEAVAFPLDVTDPESVKSFVAQ TVEALGEVELLVSSAGDMLPGQLHEVSTEAFAEQVQIHLVGANRLATAVLPAMVARRRGDLIFVGSDVGLRQRPHMGAYG AAKAGLAAMVTNLQMELEGTGVRASIVHPGPTLTGMGWQLSAEQVGPMLADWAKWGQARHNYFLRPSDLARAIAFVAETP RGCVVVNMEIQPEAPLRDAPAHRQKLVLGEEGMPG
Sequences:
>Translated_275_residues MPRFEPHPARRTTVVAGASSGIGAATATELAGRGFPVALGARRMDKLAELVDKIRADGGEAVAFPLDVTDPESVKSFVAQ TVEALGEVELLVSSAGDMLPGQLHEVSTEAFAEQVQIHLVGANRLATAVLPAMVARRRGDLIFVGSDVGLRQRPHMGAYG AAKAGLAAMVTNLQMELEGTGVRASIVHPGPTLTGMGWQLSAEQVGPMLADWAKWGQARHNYFLRPSDLARAIAFVAETP RGCVVVNMEIQPEAPLRDAPAHRQKLVLGEEGMPG >Mature_274_residues PRFEPHPARRTTVVAGASSGIGAATATELAGRGFPVALGARRMDKLAELVDKIRADGGEAVAFPLDVTDPESVKSFVAQT VEALGEVELLVSSAGDMLPGQLHEVSTEAFAEQVQIHLVGANRLATAVLPAMVARRRGDLIFVGSDVGLRQRPHMGAYGA AKAGLAAMVTNLQMELEGTGVRASIVHPGPTLTGMGWQLSAEQVGPMLADWAKWGQARHNYFLRPSDLARAIAFVAETPR GCVVVNMEIQPEAPLRDAPAHRQKLVLGEEGMPG
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI40254992, Length=230, Percent_Identity=27.8260869565217, Blast_Score=87, Evalue=2e-17, Organism=Homo sapiens, GI7706318, Length=182, Percent_Identity=28.5714285714286, Blast_Score=86, Evalue=5e-17, Organism=Homo sapiens, GI4503817, Length=186, Percent_Identity=31.1827956989247, Blast_Score=84, Evalue=1e-16, Organism=Homo sapiens, GI7657478, Length=204, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=2e-16, Organism=Homo sapiens, GI20149619, Length=209, Percent_Identity=25.3588516746411, Blast_Score=79, Evalue=5e-15, Organism=Homo sapiens, GI19743808, Length=193, Percent_Identity=33.6787564766839, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI226371731, Length=190, Percent_Identity=30.5263157894737, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI210032110, Length=198, Percent_Identity=26.2626262626263, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI19923817, Length=215, Percent_Identity=24.1860465116279, Blast_Score=73, Evalue=3e-13, Organism=Homo sapiens, GI109715829, Length=252, Percent_Identity=25, Blast_Score=73, Evalue=3e-13, Organism=Homo sapiens, GI223718074, Length=194, Percent_Identity=31.9587628865979, Blast_Score=72, Evalue=7e-13, Organism=Homo sapiens, GI5031737, Length=187, Percent_Identity=29.4117647058824, Blast_Score=71, Evalue=1e-12, Organism=Homo sapiens, GI33667109, Length=183, Percent_Identity=29.5081967213115, Blast_Score=71, Evalue=1e-12, Organism=Homo sapiens, GI225579078, Length=222, Percent_Identity=26.1261261261261, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI146231950, Length=199, Percent_Identity=31.1557788944724, Blast_Score=67, Evalue=2e-11, Organism=Escherichia coli, GI1787335, Length=229, Percent_Identity=32.7510917030568, Blast_Score=95, Evalue=5e-21, Organism=Escherichia coli, GI1786701, Length=187, Percent_Identity=34.2245989304813, Blast_Score=91, Evalue=7e-20, Organism=Escherichia coli, GI1787820, Length=243, Percent_Identity=28.8065843621399, Blast_Score=81, Evalue=9e-17, Organism=Escherichia coli, GI87082100, Length=201, Percent_Identity=28.3582089552239, Blast_Score=76, Evalue=2e-15, Organism=Escherichia coli, GI1786812, Length=187, Percent_Identity=29.4117647058824, Blast_Score=65, Evalue=4e-12, Organism=Escherichia coli, GI1789378, Length=231, Percent_Identity=26.8398268398268, Blast_Score=63, Evalue=2e-11, Organism=Caenorhabditis elegans, GI71994604, Length=231, Percent_Identity=27.7056277056277, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17562910, Length=264, Percent_Identity=25, Blast_Score=79, Evalue=4e-15, Organism=Caenorhabditis elegans, GI25152911, Length=194, Percent_Identity=31.9587628865979, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI17551412, Length=257, Percent_Identity=24.9027237354086, Blast_Score=72, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17538486, Length=250, Percent_Identity=26.8, Blast_Score=72, Evalue=4e-13, Organism=Caenorhabditis elegans, GI17508895, Length=195, Percent_Identity=25.6410256410256, Blast_Score=71, Evalue=6e-13, Organism=Caenorhabditis elegans, GI17562904, Length=204, Percent_Identity=26.9607843137255, Blast_Score=70, Evalue=8e-13, Organism=Caenorhabditis elegans, GI17560676, Length=228, Percent_Identity=24.1228070175439, Blast_Score=70, Evalue=8e-13, Organism=Caenorhabditis elegans, GI17559104, Length=263, Percent_Identity=23.9543726235741, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI71994600, Length=187, Percent_Identity=26.2032085561497, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17567345, Length=182, Percent_Identity=24.1758241758242, Blast_Score=69, Evalue=3e-12, Organism=Caenorhabditis elegans, GI17508651, Length=249, Percent_Identity=27.710843373494, Blast_Score=67, Evalue=8e-12, Organism=Caenorhabditis elegans, GI17561402, Length=253, Percent_Identity=24.901185770751, Blast_Score=67, Evalue=9e-12, Organism=Caenorhabditis elegans, GI17564282, Length=189, Percent_Identity=24.8677248677249, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17536651, Length=238, Percent_Identity=25.6302521008403, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17538480, Length=256, Percent_Identity=22.65625, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17562906, Length=269, Percent_Identity=24.907063197026, Blast_Score=65, Evalue=3e-11, Organism=Caenorhabditis elegans, GI17536025, Length=191, Percent_Identity=27.2251308900524, Blast_Score=65, Evalue=4e-11, Organism=Caenorhabditis elegans, GI17544670, Length=262, Percent_Identity=24.8091603053435, Blast_Score=64, Evalue=6e-11, Organism=Caenorhabditis elegans, GI72000259, Length=262, Percent_Identity=25.1908396946565, Blast_Score=64, Evalue=9e-11, Organism=Saccharomyces cerevisiae, GI6323882, Length=253, Percent_Identity=27.2727272727273, Blast_Score=91, Evalue=3e-19, Organism=Saccharomyces cerevisiae, GI6322861, Length=188, Percent_Identity=28.7234042553192, Blast_Score=72, Evalue=1e-13, Organism=Saccharomyces cerevisiae, GI6324126, Length=149, Percent_Identity=29.5302013422819, Blast_Score=72, Evalue=1e-13, Organism=Saccharomyces cerevisiae, GI6322067, Length=186, Percent_Identity=26.3440860215054, Blast_Score=69, Evalue=1e-12, Organism=Drosophila melanogaster, GI21357041, Length=241, Percent_Identity=29.4605809128631, Blast_Score=91, Evalue=6e-19, Organism=Drosophila melanogaster, GI28571526, Length=234, Percent_Identity=31.1965811965812, Blast_Score=89, Evalue=2e-18, Organism=Drosophila melanogaster, GI24644339, Length=235, Percent_Identity=28.5106382978723, Blast_Score=84, Evalue=1e-16, Organism=Drosophila melanogaster, GI23397609, Length=190, Percent_Identity=33.1578947368421, Blast_Score=78, Evalue=5e-15, Organism=Drosophila melanogaster, GI21358495, Length=204, Percent_Identity=26.4705882352941, Blast_Score=78, Evalue=8e-15, Organism=Drosophila melanogaster, GI116007236, Length=250, Percent_Identity=27.2, Blast_Score=75, Evalue=4e-14, Organism=Drosophila melanogaster, GI161076933, Length=186, Percent_Identity=26.3440860215054, Blast_Score=75, Evalue=6e-14, Organism=Drosophila melanogaster, GI24641232, Length=252, Percent_Identity=25.3968253968254, Blast_Score=75, Evalue=6e-14, Organism=Drosophila melanogaster, GI24584748, Length=186, Percent_Identity=26.3440860215054, Blast_Score=74, Evalue=7e-14, Organism=Drosophila melanogaster, GI28571387, Length=245, Percent_Identity=30.2040816326531, Blast_Score=74, Evalue=8e-14, Organism=Drosophila melanogaster, GI24584744, Length=206, Percent_Identity=26.2135922330097, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI28574402, Length=206, Percent_Identity=26.2135922330097, Blast_Score=73, Evalue=2e-13, Organism=Drosophila melanogaster, GI24663911, Length=256, Percent_Identity=28.515625, Blast_Score=72, Evalue=5e-13, Organism=Drosophila melanogaster, GI116007234, Length=251, Percent_Identity=28.6852589641434, Blast_Score=71, Evalue=6e-13, Organism=Drosophila melanogaster, GI116007238, Length=138, Percent_Identity=32.6086956521739, Blast_Score=68, Evalue=9e-12, Organism=Drosophila melanogaster, GI18859837, Length=188, Percent_Identity=29.2553191489362, Blast_Score=67, Evalue=2e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.100 [C]
Molecular weight: Translated: 29065; Mature: 28934
Theoretical pI: Translated: 6.40; Mature: 6.40
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 4.0 %Met (Translated Protein) 4.4 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 3.6 %Met (Mature Protein) 4.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MPRFEPHPARRTTVVAGASSGIGAATATELAGRGFPVALGARRMDKLAELVDKIRADGGE CCCCCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCCC AVAFPLDVTDPESVKSFVAQTVEALGEVELLVSSAGDMLPGQLHEVSTEAFAEQVQIHLV EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHEEEEEEE GANRLATAVLPAMVARRRGDLIFVGSDVGLRQRPHMGAYGAAKAGLAAMVTNLQMELEGT ECHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEECC GVRASIVHPGPTLTGMGWQLSAEQVGPMLADWAKWGQARHNYFLRPSDLARAIAFVAETP CEEEEEECCCCCEECCCCEECHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC RGCVVVNMEIQPEAPLRDAPAHRQKLVLGEEGMPG CCEEEEEEEECCCCCCCCCCCHHHEEEECCCCCCC >Mature Secondary Structure PRFEPHPARRTTVVAGASSGIGAATATELAGRGFPVALGARRMDKLAELVDKIRADGGE CCCCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCCC AVAFPLDVTDPESVKSFVAQTVEALGEVELLVSSAGDMLPGQLHEVSTEAFAEQVQIHLV EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHEEEEEEE GANRLATAVLPAMVARRRGDLIFVGSDVGLRQRPHMGAYGAAKAGLAAMVTNLQMELEGT ECHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEECC GVRASIVHPGPTLTGMGWQLSAEQVGPMLADWAKWGQARHNYFLRPSDLARAIAFVAETP CEEEEEECCCCCEECCCCEECHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC RGCVVVNMEIQPEAPLRDAPAHRQKLVLGEEGMPG CCEEEEEEEECCCCCCCCCCCHHHEEEECCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NADPH [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]
Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]
General reaction: Redox reaction [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA