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The map label for this gene is adhB

Identifier: 121636685

GI number: 121636685

Start: 886481

End: 887608

Strand: Reverse

Name: adhB

Synonym: BCG_0813c

Alternate gene names: 121636685

Gene position: 887608-886481 (Counterclockwise)

Preceding gene: 121636686

Following gene: 121636684

Centisome position: 20.29

GC content: 64.01

Gene sequence:

>1128_bases
GTGAAGACCAAGGGCGCACTGATCTGGGAGTTCAACCAGCCATGGTCCGTCGAAGAGATCGAAATCGGCGACCCGCGCAA
GGACGAAGTCAAGATCCAGATGGAAGCGGCTGGGATGTGCCGCTCCGACCATCACCTGGTGACGGGCGACATCCCGATGG
CGGGCTTTCCCGTTCTGGGCGGACACGAGGGCGCGGGCATCGTCACCGAGGTCGGCCCGGGAGTCGACGACTTCGCCCCG
GGCGATCACGTGGTGTTGGCATTCATCCCATCCTGCGGCAAGTGTCCGTCCTGCCAGGCTGGAATGCGGAATCTGTGCGA
CCTGGGGGCGGGGCTGCTCGCCGGGGAATCTGTGACGGACGGCTCCTTCCGGATTCAGGCTCGCGGCCAGAACGTCTACC
CGATGACCCTGCTCGGAACGTTTTCACCGTACATGGTGGTGCACCGCAGCTCGGTGGTGAAGATCGACCCGTCGGTGCCC
TTCGAAGTCGCCTGCCTGGTTGGTTGCGGCGTCACCACCGGCTATGGTTCGGCGGTCCGCACGGCCGACGTCCGGCCGGG
CGACGACGTGGCCATCGTCGGCTTGGGTGGGGTCGGCATGGCGGCGTTGCAGGGCGCGGTCAGCGCGGGCGCCCGCTACG
TCTTCGCGGTGGAGCCGGTGGAATGGAAACGTGATCAGGCTCTGAAATTCGGTGCCACCCACGTCTACCCGGACATCAAC
GCCGCGCTGATGGGCATTGCCGAGGTCACCTACGGCCTGATGGCGCAGAAGGTGATCATCACCGTCGGCAAGCTCGATGG
CGCCGACGTCGACAGCTATCTGACCATCACGGCCAAGGGCGGCACCTGCGTGCTGACGGCCATCGGCAGCCTGGTCGACA
CCCAGGTGACGCTGAACCTCGCGATGTTGACCCTGCTGCAAAAGAACATCCAGGGCACCATCTTCGGCGGCGGCAACCCG
CACTACGACATTCCGAAGCTGTTGTCGATGTATAAGGCCGGCAAACTCAACCTCGACGACATGGTGACCACTGCGTACAA
GCTGGAGCAGATCAACGACGGATACCAGGACATGCTGAACGGCAAGAACATTCGCGGCGTGATCCGGTACACGGACGACG
ACCGCTAG

Upstream 100 bases:

>100_bases
AAACGCCCTAGCGCCGTTGACCTACACTCAGCCAGTCGGCGTTCCGGCCGAGGCTAGGGACCACTCGTAGCCGAAGTTCA
ACGATGAAAGCAGGTTTGCG

Downstream 100 bases:

>100_bases
CCGGAGATAGCCATGACCCAAACGACCCAATCCCCGGCCCTGATCGCGTCGCAGTCGTCGTGGCGGTGCGTCCAAGCCCA
CGACCGGGAGGGCTGGCTGG

Product: putative zinc-containing alcohol dehydrogenase NAD dependant adhB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MKTKGALIWEFNQPWSVEEIEIGDPRKDEVKIQMEAAGMCRSDHHLVTGDIPMAGFPVLGGHEGAGIVTEVGPGVDDFAP
GDHVVLAFIPSCGKCPSCQAGMRNLCDLGAGLLAGESVTDGSFRIQARGQNVYPMTLLGTFSPYMVVHRSSVVKIDPSVP
FEVACLVGCGVTTGYGSAVRTADVRPGDDVAIVGLGGVGMAALQGAVSAGARYVFAVEPVEWKRDQALKFGATHVYPDIN
AALMGIAEVTYGLMAQKVIITVGKLDGADVDSYLTITAKGGTCVLTAIGSLVDTQVTLNLAMLTLLQKNIQGTIFGGGNP
HYDIPKLLSMYKAGKLNLDDMVTTAYKLEQINDGYQDMLNGKNIRGVIRYTDDDR

Sequences:

>Translated_375_residues
MKTKGALIWEFNQPWSVEEIEIGDPRKDEVKIQMEAAGMCRSDHHLVTGDIPMAGFPVLGGHEGAGIVTEVGPGVDDFAP
GDHVVLAFIPSCGKCPSCQAGMRNLCDLGAGLLAGESVTDGSFRIQARGQNVYPMTLLGTFSPYMVVHRSSVVKIDPSVP
FEVACLVGCGVTTGYGSAVRTADVRPGDDVAIVGLGGVGMAALQGAVSAGARYVFAVEPVEWKRDQALKFGATHVYPDIN
AALMGIAEVTYGLMAQKVIITVGKLDGADVDSYLTITAKGGTCVLTAIGSLVDTQVTLNLAMLTLLQKNIQGTIFGGGNP
HYDIPKLLSMYKAGKLNLDDMVTTAYKLEQINDGYQDMLNGKNIRGVIRYTDDDR
>Mature_375_residues
MKTKGALIWEFNQPWSVEEIEIGDPRKDEVKIQMEAAGMCRSDHHLVTGDIPMAGFPVLGGHEGAGIVTEVGPGVDDFAP
GDHVVLAFIPSCGKCPSCQAGMRNLCDLGAGLLAGESVTDGSFRIQARGQNVYPMTLLGTFSPYMVVHRSSVVKIDPSVP
FEVACLVGCGVTTGYGSAVRTADVRPGDDVAIVGLGGVGMAALQGAVSAGARYVFAVEPVEWKRDQALKFGATHVYPDIN
AALMGIAEVTYGLMAQKVIITVGKLDGADVDSYLTITAKGGTCVLTAIGSLVDTQVTLNLAMLTLLQKNIQGTIFGGGNP
HYDIPKLLSMYKAGKLNLDDMVTTAYKLEQINDGYQDMLNGKNIRGVIRYTDDDR

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family

Homologues:

Organism=Homo sapiens, GI4501933, Length=376, Percent_Identity=38.563829787234, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI262073058, Length=377, Percent_Identity=35.5437665782493, Blast_Score=235, Evalue=6e-62,
Organism=Homo sapiens, GI71743840, Length=377, Percent_Identity=35.5437665782493, Blast_Score=234, Evalue=7e-62,
Organism=Homo sapiens, GI34577061, Length=376, Percent_Identity=37.2340425531915, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI4501929, Length=373, Percent_Identity=36.9973190348526, Blast_Score=228, Evalue=5e-60,
Organism=Homo sapiens, GI156523966, Length=373, Percent_Identity=32.7077747989276, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI71565154, Length=377, Percent_Identity=35.5437665782493, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI4501939, Length=367, Percent_Identity=32.6975476839237, Blast_Score=211, Evalue=6e-55,
Organism=Homo sapiens, GI71565152, Length=378, Percent_Identity=34.1269841269841, Blast_Score=209, Evalue=3e-54,
Organism=Escherichia coli, GI1786552, Length=375, Percent_Identity=35.7333333333333, Blast_Score=188, Evalue=4e-49,
Organism=Escherichia coli, GI1786518, Length=370, Percent_Identity=28.6486486486486, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI87082125, Length=384, Percent_Identity=27.0833333333333, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI226510992, Length=377, Percent_Identity=25.1989389920424, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788407, Length=211, Percent_Identity=29.3838862559242, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1787863, Length=210, Percent_Identity=30, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87081918, Length=205, Percent_Identity=31.7073170731707, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1786825, Length=380, Percent_Identity=23.6842105263158, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788075, Length=353, Percent_Identity=23.2294617563739, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25146526, Length=381, Percent_Identity=31.758530183727, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI71997431, Length=383, Percent_Identity=31.5926892950392, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=31.7784256559767, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI71988145, Length=375, Percent_Identity=27.7333333333333, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17562584, Length=369, Percent_Identity=27.9132791327913, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17562582, Length=377, Percent_Identity=26.525198938992, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17562876, Length=359, Percent_Identity=24.5125348189415, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=380, Percent_Identity=33.1578947368421, Blast_Score=204, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6319621, Length=217, Percent_Identity=29.0322580645161, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323729, Length=232, Percent_Identity=28.448275862069, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=366, Percent_Identity=25.1366120218579, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=212, Percent_Identity=29.2452830188679, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324486, Length=212, Percent_Identity=28.3018867924528, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6319258, Length=236, Percent_Identity=28.3898305084746, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17737895, Length=378, Percent_Identity=35.1851851851852, Blast_Score=211, Evalue=5e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADHB_MYCBO (Q7U1B9)

Other databases:

- EMBL:   BX248336
- RefSeq:   NP_854442.1
- ProteinModelPortal:   Q7U1B9
- SMR:   Q7U1B9
- EnsemblBacteria:   EBMYCT00000016596
- GeneID:   1092459
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb0784c
- GeneTree:   EBGT00050000015148
- HOGENOM:   HBG753318
- OMA:   LMGRTIN
- ProtClustDB:   CLSK799741
- BioCyc:   MBOV233413:MB0784C-MONOMER
- BRENDA:   1.1.1.1
- GO:   GO:0005737
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11695

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N; SSF50129 GroES_like

EC number: =1.1.1.1

Molecular weight: Translated: 39748; Mature: 39748

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKGALIWEFNQPWSVEEIEIGDPRKDEVKIQMEAAGMCRSDHHLVTGDIPMAGFPVLG
CCCCCCEEEECCCCCCCEEEECCCCCCCCEEEEEEECCCCCCCCEEEECCCCCCCCCEEC
GHEGAGIVTEVGPGVDDFAPGDHVVLAFIPSCGKCPSCQAGMRNLCDLGAGLLAGESVTD
CCCCCCEEEECCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
GSFRIQARGQNVYPMTLLGTFSPYMVVHRSSVVKIDPSVPFEVACLVGCGVTTGYGSAVR
CEEEEEECCCEECEEEEECCCCCEEEEECCEEEEECCCCCEEEEEEEECCCCCCCCCCEE
TADVRPGDDVAIVGLGGVGMAALQGAVSAGARYVFAVEPVEWKRDQALKFGATHVYPDIN
ECCCCCCCCEEEEEECCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEECCEEECCCCH
AALMGIAEVTYGLMAQKVIITVGKLDGADVDSYLTITAKGGTCVLTAIGSLVDTQVTLNL
HHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCEEEEEECCCEEEEEEHHHHHHHHHHHHH
AMLTLLQKNIQGTIFGGGNPHYDIPKLLSMYKAGKLNLDDMVTTAYKLEQINDGYQDMLN
HHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHC
GKNIRGVIRYTDDDR
CCCEEEEEEECCCCC
>Mature Secondary Structure
MKTKGALIWEFNQPWSVEEIEIGDPRKDEVKIQMEAAGMCRSDHHLVTGDIPMAGFPVLG
CCCCCCEEEECCCCCCCEEEECCCCCCCCEEEEEEECCCCCCCCEEEECCCCCCCCCEEC
GHEGAGIVTEVGPGVDDFAPGDHVVLAFIPSCGKCPSCQAGMRNLCDLGAGLLAGESVTD
CCCCCCEEEECCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
GSFRIQARGQNVYPMTLLGTFSPYMVVHRSSVVKIDPSVPFEVACLVGCGVTTGYGSAVR
CEEEEEECCCEECEEEEECCCCCEEEEECCEEEEECCCCCEEEEEEEECCCCCCCCCCEE
TADVRPGDDVAIVGLGGVGMAALQGAVSAGARYVFAVEPVEWKRDQALKFGATHVYPDIN
ECCCCCCCCEEEEEECCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEECCEEECCCCH
AALMGIAEVTYGLMAQKVIITVGKLDGADVDSYLTITAKGGTCVLTAIGSLVDTQVTLNL
HHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCEEEEEECCCEEEEEEHHHHHHHHHHHHH
AMLTLLQKNIQGTIFGGGNPHYDIPKLLSMYKAGKLNLDDMVTTAYKLEQINDGYQDMLN
HHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHC
GKNIRGVIRYTDDDR
CCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972