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The map label for this gene is rskA

Identifier: 121636358

GI number: 121636358

Start: 563906

End: 564604

Strand: Reverse

Name: rskA

Synonym: BCG_0483c

Alternate gene names: 121636358

Gene position: 564604-563906 (Counterclockwise)

Preceding gene: 121636359

Following gene: 121636356

Centisome position: 12.91

GC content: 68.24

Gene sequence:

>699_bases
ATGACTGAACATACCGATTTTGAGCTGCTCGAGCTGGCTACCCCGTATGCCCTGAACGCTGTGTCCGACGATGAACGAGC
CGACATCGACCGACGGGTGGCCGCCGCGCCCTCGCCGGTAGCCGCGGCTTTCAACGACGAAGTTCGAGCCGTCCGCGAGA
CGATGGCCGTCGTCTCGGCGGCCACCACCGCCGAGCCGCCAGCACATCTGCGGACGGCCATCCTGGATGCGACCAAGCCC
GAGGTTAGGCGCCAATCACGCTGGCGTACGGCAGCCTTTGCGTCCGCAGCGGCGATCGCTGTGGGGCTGGGGGCGTTCGA
CCTGGGGGTGCTGACCCGGCCATCGCCACCCCCCACCGTGGCCGAGCAAGTTCTGACGGCGCCGGACGTACGGACGGTCT
CTCGCCCACTGGGCGCCGGGACGGCCACGGTGGTGTTCTCCCGCGACCGCAACACAGGTCTGCTGGTGATGAACAATGTG
GCGCCACCATCCCGGGGAACCGTGTATCAGATGTGGCTGCTGGGAGGGGCCAAAGGGCCGAGGTCGGCGGAGACGATGGG
CACCGCGGCGGTGACGCCCTCGACGACGGCGACGCTGACCGATCTCGGAGCCTCGACCGCACTGGCATTCACCGTCGAAC
CCGGCACCGGATCACCACAGCCCACCGGTACCATCTTGGCCGAGCTGCCGCTCGGGTGA

Upstream 100 bases:

>100_bases
AAATCCCGCATGCGCGACGCCCTGCGCAGCCTGCGCAACTGCCTGGACGTGTCATGACTGCGCCGGCCGAGCGAAGCGAT
GCGTTGGGAGAGCGGCGCTC

Downstream 100 bases:

>100_bases
GCCGAGGACGCACACCCCGGCCCCTCACCGCAGTCTCGGCGCGACAATGGTGCCCAGCATCGCGACGAACACGCCGGGTA
CCACTAGGGCGGCGCTGCCG

Product: hypothetical protein

Products: NA

Alternate protein names: Regulator of sigK

Number of amino acids: Translated: 232; Mature: 231

Protein sequence:

>232_residues
MTEHTDFELLELATPYALNAVSDDERADIDRRVAAAPSPVAAAFNDEVRAVRETMAVVSAATTAEPPAHLRTAILDATKP
EVRRQSRWRTAAFASAAAIAVGLGAFDLGVLTRPSPPPTVAEQVLTAPDVRTVSRPLGAGTATVVFSRDRNTGLLVMNNV
APPSRGTVYQMWLLGGAKGPRSAETMGTAAVTPSTTATLTDLGASTALAFTVEPGTGSPQPTGTILAELPLG

Sequences:

>Translated_232_residues
MTEHTDFELLELATPYALNAVSDDERADIDRRVAAAPSPVAAAFNDEVRAVRETMAVVSAATTAEPPAHLRTAILDATKP
EVRRQSRWRTAAFASAAAIAVGLGAFDLGVLTRPSPPPTVAEQVLTAPDVRTVSRPLGAGTATVVFSRDRNTGLLVMNNV
APPSRGTVYQMWLLGGAKGPRSAETMGTAAVTPSTTATLTDLGASTALAFTVEPGTGSPQPTGTILAELPLG
>Mature_231_residues
TEHTDFELLELATPYALNAVSDDERADIDRRVAAAPSPVAAAFNDEVRAVRETMAVVSAATTAEPPAHLRTAILDATKPE
VRRQSRWRTAAFASAAAIAVGLGAFDLGVLTRPSPPPTVAEQVLTAPDVRTVSRPLGAGTATVVFSRDRNTGLLVMNNVA
PPSRGTVYQMWLLGGAKGPRSAETMGTAAVTPSTTATLTDLGASTALAFTVEPGTGSPQPTGTILAELPLG

Specific function: Represses sigK, the extracytoplasmic function (ECF) sigma factor K, by binding to it and inhibiting its activity. However, in M.bovis it is probably dysfunctional, due to at least one of the two natural occurring polymorphisms in its encoding gene, when c

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anti-sigma-K factor family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RSKA_MYCBO (Q7U1Z7)

Other databases:

- EMBL:   BX248335
- RefSeq:   NP_854115.1
- EnsemblBacteria:   EBMYCT00000017513
- GeneID:   1091471
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb0452c
- GeneTree:   EBGT00050000018535
- HOGENOM:   HBG700106
- OMA:   VYQMWLI
- ProtClustDB:   CLSK790524
- BioCyc:   MBOV233413:MB0452C-MONOMER
- InterPro:   IPR018764

Pfam domain/function: PF10099 DUF2337

EC number: NA

Molecular weight: Translated: 24013; Mature: 23882

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x13416f70)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEHTDFELLELATPYALNAVSDDERADIDRRVAAAPSPVAAAFNDEVRAVRETMAVVSA
CCCCCCCHHEECCCCEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
ATTAEPPAHLRTAILDATKPEVRRQSRWRTAAFASAAAIAVGLGAFDLGVLTRPSPPPTV
HCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCEECCCCCCHHH
AEQVLTAPDVRTVSRPLGAGTATVVFSRDRNTGLLVMNNVAPPSRGTVYQMWLLGGAKGP
HHHHHCCCCHHHHHCCCCCCEEEEEEECCCCCCEEEECCCCCCCCCCEEEEEEECCCCCC
RSAETMGTAAVTPSTTATLTDLGASTALAFTVEPGTGSPQPTGTILAELPLG
CCHHHCCCEEECCCCCCHHHHCCCCEEEEEEEECCCCCCCCCCEEEEECCCH
>Mature Secondary Structure 
TEHTDFELLELATPYALNAVSDDERADIDRRVAAAPSPVAAAFNDEVRAVRETMAVVSA
CCCCCCHHEECCCCEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
ATTAEPPAHLRTAILDATKPEVRRQSRWRTAAFASAAAIAVGLGAFDLGVLTRPSPPPTV
HCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCEECCCCCCHHH
AEQVLTAPDVRTVSRPLGAGTATVVFSRDRNTGLLVMNNVAPPSRGTVYQMWLLGGAKGP
HHHHHCCCCHHHHHCCCCCCEEEEEEECCCCCCEEEECCCCCCCCCCEEEEEEECCCCCC
RSAETMGTAAVTPSTTATLTDLGASTALAFTVEPGTGSPQPTGTILAELPLG
CCHHHCCCEEECCCCCCHHHHCCCCEEEEEEEECCCCCCCCCCEEEEECCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12788972