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The map label for this gene is mutB [H]

Identifier: 121610330

GI number: 121610330

Start: 3767172

End: 3769367

Strand: Direct

Name: mutB [H]

Synonym: Veis_3398

Alternate gene names: 121610330

Gene position: 3767172-3769367 (Clockwise)

Preceding gene: 121610324

Following gene: 121610331

Centisome position: 67.67

GC content: 64.89

Gene sequence:

>2196_bases
ATGAGTGACAAGCCCCACAGCACCGCCCCCGAGTTCGCCGCTGCTTCGCTCGAAGCCTGGGCCAAAGCCGCTGCCAAGTC
GGCGCCTGGTGGCGCTGTCGGCGCTCTGAACTGGGTCACGCCCGATGGCATTACCGTCAAGCCGCTGTACACCGCTGCGG
ACACGGCCGGGCTGCGCTACGCCGACACGCTGCCCGGCTTTGAGCCTTATCTGCGCGGCCCGCAGGCCACGATGTATGCG
GTGCGCCCCTGGACCATCCGCCAGTACGCAGGGTTCTCGACCGCCGAGGAGTCCAACGCCTTCTACCGCAAGGCGCTGGC
GGCGGGAGGGCAGGGGGTGTCGGTGGCGTTCGACCTGGCCACGCACCGTGGCTATGACAGCGACCATCCCCGGGTGACGG
GGGATGTGGGCAAGGCCGGTGTGGCGATCGACTCGGTCGAGGACATGAAGATTTTGTTCGACCAGATTCCGCTGGACCAG
GTGTCGGTCTCGATGACCATGAACGGCGCGGTGCTGCCCGTGCTGGCCGGCTATGTGGTGGCGGCCGAGGAGCAGGGCGT
GCGCCAGGAGCAGCTCTCCGGGACGATTCAGAACGATATCCTGAAAGAGTTCATGGTGCGCAATACCTATATCTATCCGC
CCAAGCCGTCGATGCGGATCATTGGCGACATCATCGGCTACACGGCCAGCCACATGCCCCGGTTCAACTCGATCTCGATC
TCGGGCTACCACATGCAAGAGGCCGGAGCCAACCAGGCGCTGGAGTTGGCCTTCACGCTGGCCGATGGCAAGGAGTATGT
GAAGACTGCGCTGGCCCGGGGCATGGATGTCGATGAGTTCGCCGGGCGCCTGTCGTTCTTCTGGGCCGTAGGCATGAATT
TCTATCTGGAGGTGGCCAAGATGCGCGCGGCACGCCTGCTGTGGTGCCGCATCATGAAGCAGACCGGGGCCAGAAATCCC
AAGAGCCTGATGCTGCGCACGCATTGCCAGACCTCGGGCTGGTCGCTGACCGAGCAGGACCCTTACAACAACGTGGTGCG
CACCACCATCGAGGCCATGGCGGCGGTGTTTGGCGGCACGCAGAGCTTGCACACCAACGCATTCGATGAAGCCATCGCGC
TGCCCACCGAGTTCAGCGCCCGCATTGCGCGCAATACGCAGCTCATCCTCCAGGAGGAGACCCACATCGCCAAGGTGATC
GACCCCTGGGCCGGCTCGTACATGATGGAAAAACTCACGCAGGATATGGCCGATGCGGCGTGGGCCATCATCGAAGAAGT
CGAGGCCATGGGCGGCATGACCCGGGCGGTGGACAGCGGCTGGGCCAAGCTGAAGATCGAAGCCGCTGCCGCGCAAAAAC
AGGCCCGCATCGATAGCGGCCAGGACGTGATCGTGGGCGTGAACAAATACCAGCCCGGGACCGAGGATGTCATCGAGGTG
CGCGACATCGACAACGTGGCGGTGCGCCACGGGCAAATTGCCCGTCTGCAAAAAATGAAAGCGGGGCGCGACACCGCCGG
CGTGCACGCGGCACTGGACGCCATCACGCTTGCGGCGCAGAACGGCTCGGGGAACCTGCTGGAACTGAGCATTCAGGCGA
TGCGCTTGCGGGCCACCGTGGGGGAAGTGAGCGACGCGCTGGAAAAAGCCTTTGGCCGGCACCGCGCAGACAGCAACAAG
GTCTCGGGCGTATACGCGGCGGCCTACGACAGCGCGCAGGCGGACACCATGGAATACTGGAATGCGCTGAAGGCCGACAT
TGCCGCCTTTGCCGACAAACAGGGGCGCCGCCCGCGCGTCATGGTCAGCAAACTGGGCCAGGATGGCCACGACCGTGGCG
CCAAGGTCGTGGCCACGGCCTTTGCCGACCTGGGCTTTGACGTGGACATCGGCCCGCTGTTCCAGACGCCCGAGGAATGC
GCACGCCAGGCGATCGAAAACGACGTGCACGCCGTGGGCGTGTCCACACTGGCCGCCGGCCACAAAACGCTGGTGCCGGC
CATCATTGCCGCGCTCAAGGCGCAGGGGGCCGACGACATCATCGTGTTCGTCGGCGGGGTGATTCCGCGCCAGGACTACG
ATTTTCTGTACGCCGCCGGTGTGCATGGCATCTACGGCCCGGGCACGCCGATTCCGGTCAGCGCACGCGACGTACTGCGC
CAGATCGAAAAGACGCTCGCGGCGACGGGCAAGTAA

Upstream 100 bases:

>100_bases
GTTGTTCCATGCCCCTGTACGCCGTTGCACGCCGCGGCCCCATGCCCGAATGCCATCGCGGGCCTGGACGCCACCCGCCT
TCTTCGGAGAAGCCTTCACC

Downstream 100 bases:

>100_bases
AAAGCACCTGCCCATGAAAACGCAAATCATCCTGGTGTCGCGTCACCGATCAGATGTCGTAGGCTGCGCGCAGCCATCGG
AGCGCAGCGCAAGGCGCAGC

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-alpha [H]

Number of amino acids: Translated: 731; Mature: 730

Protein sequence:

>731_residues
MSDKPHSTAPEFAAASLEAWAKAAAKSAPGGAVGALNWVTPDGITVKPLYTAADTAGLRYADTLPGFEPYLRGPQATMYA
VRPWTIRQYAGFSTAEESNAFYRKALAAGGQGVSVAFDLATHRGYDSDHPRVTGDVGKAGVAIDSVEDMKILFDQIPLDQ
VSVSMTMNGAVLPVLAGYVVAAEEQGVRQEQLSGTIQNDILKEFMVRNTYIYPPKPSMRIIGDIIGYTASHMPRFNSISI
SGYHMQEAGANQALELAFTLADGKEYVKTALARGMDVDEFAGRLSFFWAVGMNFYLEVAKMRAARLLWCRIMKQTGARNP
KSLMLRTHCQTSGWSLTEQDPYNNVVRTTIEAMAAVFGGTQSLHTNAFDEAIALPTEFSARIARNTQLILQEETHIAKVI
DPWAGSYMMEKLTQDMADAAWAIIEEVEAMGGMTRAVDSGWAKLKIEAAAAQKQARIDSGQDVIVGVNKYQPGTEDVIEV
RDIDNVAVRHGQIARLQKMKAGRDTAGVHAALDAITLAAQNGSGNLLELSIQAMRLRATVGEVSDALEKAFGRHRADSNK
VSGVYAAAYDSAQADTMEYWNALKADIAAFADKQGRRPRVMVSKLGQDGHDRGAKVVATAFADLGFDVDIGPLFQTPEEC
ARQAIENDVHAVGVSTLAAGHKTLVPAIIAALKAQGADDIIVFVGGVIPRQDYDFLYAAGVHGIYGPGTPIPVSARDVLR
QIEKTLAATGK

Sequences:

>Translated_731_residues
MSDKPHSTAPEFAAASLEAWAKAAAKSAPGGAVGALNWVTPDGITVKPLYTAADTAGLRYADTLPGFEPYLRGPQATMYA
VRPWTIRQYAGFSTAEESNAFYRKALAAGGQGVSVAFDLATHRGYDSDHPRVTGDVGKAGVAIDSVEDMKILFDQIPLDQ
VSVSMTMNGAVLPVLAGYVVAAEEQGVRQEQLSGTIQNDILKEFMVRNTYIYPPKPSMRIIGDIIGYTASHMPRFNSISI
SGYHMQEAGANQALELAFTLADGKEYVKTALARGMDVDEFAGRLSFFWAVGMNFYLEVAKMRAARLLWCRIMKQTGARNP
KSLMLRTHCQTSGWSLTEQDPYNNVVRTTIEAMAAVFGGTQSLHTNAFDEAIALPTEFSARIARNTQLILQEETHIAKVI
DPWAGSYMMEKLTQDMADAAWAIIEEVEAMGGMTRAVDSGWAKLKIEAAAAQKQARIDSGQDVIVGVNKYQPGTEDVIEV
RDIDNVAVRHGQIARLQKMKAGRDTAGVHAALDAITLAAQNGSGNLLELSIQAMRLRATVGEVSDALEKAFGRHRADSNK
VSGVYAAAYDSAQADTMEYWNALKADIAAFADKQGRRPRVMVSKLGQDGHDRGAKVVATAFADLGFDVDIGPLFQTPEEC
ARQAIENDVHAVGVSTLAAGHKTLVPAIIAALKAQGADDIIVFVGGVIPRQDYDFLYAAGVHGIYGPGTPIPVSARDVLR
QIEKTLAATGK
>Mature_730_residues
SDKPHSTAPEFAAASLEAWAKAAAKSAPGGAVGALNWVTPDGITVKPLYTAADTAGLRYADTLPGFEPYLRGPQATMYAV
RPWTIRQYAGFSTAEESNAFYRKALAAGGQGVSVAFDLATHRGYDSDHPRVTGDVGKAGVAIDSVEDMKILFDQIPLDQV
SVSMTMNGAVLPVLAGYVVAAEEQGVRQEQLSGTIQNDILKEFMVRNTYIYPPKPSMRIIGDIIGYTASHMPRFNSISIS
GYHMQEAGANQALELAFTLADGKEYVKTALARGMDVDEFAGRLSFFWAVGMNFYLEVAKMRAARLLWCRIMKQTGARNPK
SLMLRTHCQTSGWSLTEQDPYNNVVRTTIEAMAAVFGGTQSLHTNAFDEAIALPTEFSARIARNTQLILQEETHIAKVID
PWAGSYMMEKLTQDMADAAWAIIEEVEAMGGMTRAVDSGWAKLKIEAAAAQKQARIDSGQDVIVGVNKYQPGTEDVIEVR
DIDNVAVRHGQIARLQKMKAGRDTAGVHAALDAITLAAQNGSGNLLELSIQAMRLRATVGEVSDALEKAFGRHRADSNKV
SGVYAAAYDSAQADTMEYWNALKADIAAFADKQGRRPRVMVSKLGQDGHDRGAKVVATAFADLGFDVDIGPLFQTPEECA
RQAIENDVHAVGVSTLAAGHKTLVPAIIAALKAQGADDIIVFVGGVIPRQDYDFLYAAGVHGIYGPGTPIPVSARDVLRQ
IEKTLAATGK

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=708, Percent_Identity=63.8418079096045, Blast_Score=938, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=712, Percent_Identity=61.376404494382, Blast_Score=884, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=733, Percent_Identity=61.3915416098226, Blast_Score=911, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 78710; Mature: 78579

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00544 METMALONYL_COA_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKPHSTAPEFAAASLEAWAKAAAKSAPGGAVGALNWVTPDGITVKPLYTAADTAGLRY
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEEEECCCCCCCEE
ADTLPGFEPYLRGPQATMYAVRPWTIRQYAGFSTAEESNAFYRKALAAGGQGVSVAFDLA
CCCCCCCHHHHCCCCCEEEEECCEEEHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEH
THRGYDSDHPRVTGDVGKAGVAIDSVEDMKILFDQIPLDQVSVSMTMNGAVLPVLAGYVV
HCCCCCCCCCEEECCCCCCCEEECCHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHE
AAEEQGVRQEQLSGTIQNDILKEFMVRNTYIYPPKPSMRIIGDIIGYTASHMPRFNSISI
EECCCCCHHHHHCCHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHCCCCCCEEEE
SGYHMQEAGANQALELAFTLADGKEYVKTALARGMDVDEFAGRLSFFWAVGMNFYLEVAK
ECEEHHHCCCCCEEEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
MRAARLLWCRIMKQTGARNPKSLMLRTHCQTSGWSLTEQDPYNNVVRTTIEAMAAVFGGT
HHHHHHHHHHHHHHHCCCCCHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
QSLHTNAFDEAIALPTEFSARIARNTQLILQEETHIAKVIDPWAGSYMMEKLTQDMADAA
CHHCCCHHHHHHCCCCHHHHHHHCCCEEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHH
WAIIEEVEAMGGMTRAVDSGWAKLKIEAAAAQKQARIDSGQDVIVGVNKYQPGTEDVIEV
HHHHHHHHHHCCHHHHHCCCCEEEEEEHHHHHHHHHCCCCCEEEEEECCCCCCCHHHEEE
RDIDNVAVRHGQIARLQKMKAGRDTAGVHAALDAITLAAQNGSGNLLELSIQAMRLRATV
CCCCHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHEEEEECCCCCEEEEEHHHHHHHHHH
GEVSDALEKAFGRHRADSNKVSGVYAAAYDSAQADTMEYWNALKADIAAFADKQGRRPRV
HHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHH
MVSKLGQDGHDRGAKVVATAFADLGFDVDIGPLFQTPEECARQAIENDVHAVGVSTLAAG
HHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCC
HKTLVPAIIAALKAQGADDIIVFVGGVIPRQDYDFLYAAGVHGIYGPGTPIPVSARDVLR
HHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHH
QIEKTLAATGK
HHHHHHHCCCC
>Mature Secondary Structure 
SDKPHSTAPEFAAASLEAWAKAAAKSAPGGAVGALNWVTPDGITVKPLYTAADTAGLRY
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEEEECCCCCCCEE
ADTLPGFEPYLRGPQATMYAVRPWTIRQYAGFSTAEESNAFYRKALAAGGQGVSVAFDLA
CCCCCCCHHHHCCCCCEEEEECCEEEHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEH
THRGYDSDHPRVTGDVGKAGVAIDSVEDMKILFDQIPLDQVSVSMTMNGAVLPVLAGYVV
HCCCCCCCCCEEECCCCCCCEEECCHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHE
AAEEQGVRQEQLSGTIQNDILKEFMVRNTYIYPPKPSMRIIGDIIGYTASHMPRFNSISI
EECCCCCHHHHHCCHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHCCCCCCEEEE
SGYHMQEAGANQALELAFTLADGKEYVKTALARGMDVDEFAGRLSFFWAVGMNFYLEVAK
ECEEHHHCCCCCEEEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
MRAARLLWCRIMKQTGARNPKSLMLRTHCQTSGWSLTEQDPYNNVVRTTIEAMAAVFGGT
HHHHHHHHHHHHHHHCCCCCHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
QSLHTNAFDEAIALPTEFSARIARNTQLILQEETHIAKVIDPWAGSYMMEKLTQDMADAA
CHHCCCHHHHHHCCCCHHHHHHHCCCEEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHH
WAIIEEVEAMGGMTRAVDSGWAKLKIEAAAAQKQARIDSGQDVIVGVNKYQPGTEDVIEV
HHHHHHHHHHCCHHHHHCCCCEEEEEEHHHHHHHHHCCCCCEEEEEECCCCCCCHHHEEE
RDIDNVAVRHGQIARLQKMKAGRDTAGVHAALDAITLAAQNGSGNLLELSIQAMRLRATV
CCCCHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHEEEEECCCCCEEEEEHHHHHHHHHH
GEVSDALEKAFGRHRADSNKVSGVYAAAYDSAQADTMEYWNALKADIAAFADKQGRRPRV
HHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHH
MVSKLGQDGHDRGAKVVATAFADLGFDVDIGPLFQTPEECARQAIENDVHAVGVSTLAAG
HHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCC
HKTLVPAIIAALKAQGADDIIVFVGGVIPRQDYDFLYAAGVHGIYGPGTPIPVSARDVLR
HHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHH
QIEKTLAATGK
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8566763; 12949112 [H]