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The map label for this gene is pheS

Identifier: 121610037

GI number: 121610037

Start: 3443090

End: 3444142

Strand: Direct

Name: pheS

Synonym: Veis_3093

Alternate gene names: 121610037

Gene position: 3443090-3444142 (Clockwise)

Preceding gene: 121610036

Following gene: 121610038

Centisome position: 61.85

GC content: 63.34

Gene sequence:

>1053_bases
ATGAACGAGTTGGATTCCCTGGTTGAGAGCGCGCGGCAACGCTTTGCCCAAAGCACCAGTCCTGCTGATCTGGAGAATGC
CAAAGCGCAGTTTCTGGGCAAGTCGGGCCGCGTAACCGAGTTGATGAAGGGCATGGCGCAACTGTGTGTCGCGGAAAAGA
AAACCCGTGGCGCCGCCATCAACTTGGCCAAACAGGCCATCGAGGCCGCCCTCAACGCACGCCGCCAGGCCCTGGCCGAT
GCACAGTTGCAGCAGCAATTGACAGCCGATGCGCTCGACGTGAGCCTGCCGGGCCGCCAGCGCGGGCAGGGCGGCCTGCA
CCCTGTGTCACTGACGCTGGAGCGCATCGAGGGCCTGTTCGGCTCCATGGGTTTTGACGTGGCCGATGGCCCCGAGATCG
AGACCGACTGGTTCAACTTCACCGCCCTGAACACACCCGAGGACCACCCGGCGCGTTCCATGCACGACACCTTCTATGTA
GAAGGCGGCACTGCCGGCGCCCCCAACCTGCTGCGCACGCACACCAGCCCGATGCAAATACGCCACGCGGTGCAGCATGT
CAAAGCGCATCGCGCGGCGTTGGATGCGGGCCAGCCCATGCCCGAGATCCGCGTGATCGCCCCTGGCCGCGCCTACCGCA
TCGACAGCGACGCCACGCACTCGCCGATGTTCCACCAGTGCGAGGGCCTGTGGATCGGCGAGAACGTGGGCTTCAAGGAC
CTGAAGGTCATCTTCACGGGCTTTTGCCGCAGGTTTTTTGAAAGCGATGATTTGGTGCTGCGCTTTCGTCCCAGTTTTTT
CCCCTTTACGGAGCCCAGCGCCGAGATCGACATCCGGTTTCAGACCGGCCCGCTGGCTGGCCGCTGGCTGGAAGTGGCCG
GCTCGGGCCAGGTGCACCCGAACGTGGTGCGCAACATGGGACTGGATCCCGAAAAGTACATCGGCTTTGCCTTCGGCATG
GGGCTGGACCGACTGACCATGCTGCGCTACGGCGTCAGCGACCTGCGCCTGTTCTTTGACGGCGACATCCGTTTTCTGTC
GCAGTTCCGGTAA

Upstream 100 bases:

>100_bases
GGTTTCATGCGCAGTCGTTTGCGGGACGGCGCACTAGTGTCGTGTCACCAGGGCTTTGCTTTGGACAGCGCCAGTCCTTG
TGCATTTTCAATGAGTCGCC

Downstream 100 bases:

>100_bases
CGCCGATCCGTACAAGAGTCTGACCATGCAATTTCCCGAATCCTGGTTGCGCGAGTTCTGTAACCCGCCGCTGACCACGG
TCGAACTGGCGCAAACGCTG

Product: phenylalanyl-tRNA synthetase subunit alpha

Products: NA

Alternate protein names: Phenylalanine--tRNA ligase alpha chain; PheRS

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MNELDSLVESARQRFAQSTSPADLENAKAQFLGKSGRVTELMKGMAQLCVAEKKTRGAAINLAKQAIEAALNARRQALAD
AQLQQQLTADALDVSLPGRQRGQGGLHPVSLTLERIEGLFGSMGFDVADGPEIETDWFNFTALNTPEDHPARSMHDTFYV
EGGTAGAPNLLRTHTSPMQIRHAVQHVKAHRAALDAGQPMPEIRVIAPGRAYRIDSDATHSPMFHQCEGLWIGENVGFKD
LKVIFTGFCRRFFESDDLVLRFRPSFFPFTEPSAEIDIRFQTGPLAGRWLEVAGSGQVHPNVVRNMGLDPEKYIGFAFGM
GLDRLTMLRYGVSDLRLFFDGDIRFLSQFR

Sequences:

>Translated_350_residues
MNELDSLVESARQRFAQSTSPADLENAKAQFLGKSGRVTELMKGMAQLCVAEKKTRGAAINLAKQAIEAALNARRQALAD
AQLQQQLTADALDVSLPGRQRGQGGLHPVSLTLERIEGLFGSMGFDVADGPEIETDWFNFTALNTPEDHPARSMHDTFYV
EGGTAGAPNLLRTHTSPMQIRHAVQHVKAHRAALDAGQPMPEIRVIAPGRAYRIDSDATHSPMFHQCEGLWIGENVGFKD
LKVIFTGFCRRFFESDDLVLRFRPSFFPFTEPSAEIDIRFQTGPLAGRWLEVAGSGQVHPNVVRNMGLDPEKYIGFAFGM
GLDRLTMLRYGVSDLRLFFDGDIRFLSQFR
>Mature_350_residues
MNELDSLVESARQRFAQSTSPADLENAKAQFLGKSGRVTELMKGMAQLCVAEKKTRGAAINLAKQAIEAALNARRQALAD
AQLQQQLTADALDVSLPGRQRGQGGLHPVSLTLERIEGLFGSMGFDVADGPEIETDWFNFTALNTPEDHPARSMHDTFYV
EGGTAGAPNLLRTHTSPMQIRHAVQHVKAHRAALDAGQPMPEIRVIAPGRAYRIDSDATHSPMFHQCEGLWIGENVGFKD
LKVIFTGFCRRFFESDDLVLRFRPSFFPFTEPSAEIDIRFQTGPLAGRWLEVAGSGQVHPNVVRNMGLDPEKYIGFAFGM
GLDRLTMLRYGVSDLRLFFDGDIRFLSQFR

Specific function: Unknown

COG id: COG0016

COG function: function code J; Phenylalanyl-tRNA synthetase alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha chain type 1 subfamily

Homologues:

Organism=Homo sapiens, GI5729820, Length=297, Percent_Identity=32.3232323232323, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI4758340, Length=270, Percent_Identity=30.3703703703704, Blast_Score=111, Evalue=9e-25,
Organism=Escherichia coli, GI1788007, Length=350, Percent_Identity=52, Blast_Score=354, Evalue=5e-99,
Organism=Caenorhabditis elegans, GI32563657, Length=276, Percent_Identity=30.7971014492754, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17508957, Length=276, Percent_Identity=30.7971014492754, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI32566635, Length=367, Percent_Identity=28.6103542234332, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6321087, Length=366, Percent_Identity=27.8688524590164, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6325304, Length=93, Percent_Identity=40.8602150537634, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI18858079, Length=290, Percent_Identity=28.6206896551724, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI17137424, Length=301, Percent_Identity=28.2392026578073, Blast_Score=95, Evalue=7e-20,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYFA_VEREI (A1WMG9)

Other databases:

- EMBL:   CP000542
- RefSeq:   YP_997844.1
- STRING:   A1WMG9
- GeneID:   4692190
- GenomeReviews:   CP000542_GR
- KEGG:   vei:Veis_3093
- NMPDR:   fig|391735.5.peg.2870
- eggNOG:   COG0016
- HOGENOM:   HBG284353
- OMA:   FRASYFP
- PhylomeDB:   A1WMG9
- ProtClustDB:   PRK00488
- BioCyc:   VEIS391735:VEIS_3093-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00281
- InterPro:   IPR006195
- InterPro:   IPR004529
- InterPro:   IPR004188
- InterPro:   IPR022911
- InterPro:   IPR002319
- InterPro:   IPR010978
- PANTHER:   PTHR11538
- TIGRFAMs:   TIGR00468

Pfam domain/function: PF02912 Phe_tRNA-synt_N; PF01409 tRNA-synt_2d; SSF46589 tRNA_binding_arm

EC number: =6.1.1.20

Molecular weight: Translated: 38809; Mature: 38809

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNELDSLVESARQRFAQSTSPADLENAKAQFLGKSGRVTELMKGMAQLCVAEKKTRGAAI
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHH
NLAKQAIEAALNARRQALADAQLQQQLTADALDVSLPGRQRGQGGLHPVSLTLERIEGLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHH
GSMGFDVADGPEIETDWFNFTALNTPEDHPARSMHDTFYVEGGTAGAPNLLRTHTSPMQI
HHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEECCCCCCCCHHHHCCCCHHHH
RHAVQHVKAHRAALDAGQPMPEIRVIAPGRAYRIDSDATHSPMFHQCEGLWIGENVGFKD
HHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEECCCCCCCCHHHHCCCEEEECCCCHHH
LKVIFTGFCRRFFESDDLVLRFRPSFFPFTEPSAEIDIRFQTGPLAGRWLEVAGSGQVHP
HHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCCEEEECCCCCCCH
NVVRNMGLDPEKYIGFAFGMGLDRLTMLRYGVSDLRLFFDGDIRFLSQFR
HHHHHCCCCHHHHHHHHHHCCHHHHHHHHHCHHHEEEEECCCHHHHHHCC
>Mature Secondary Structure
MNELDSLVESARQRFAQSTSPADLENAKAQFLGKSGRVTELMKGMAQLCVAEKKTRGAAI
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHH
NLAKQAIEAALNARRQALADAQLQQQLTADALDVSLPGRQRGQGGLHPVSLTLERIEGLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHH
GSMGFDVADGPEIETDWFNFTALNTPEDHPARSMHDTFYVEGGTAGAPNLLRTHTSPMQI
HHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEECCCCCCCCHHHHCCCCHHHH
RHAVQHVKAHRAALDAGQPMPEIRVIAPGRAYRIDSDATHSPMFHQCEGLWIGENVGFKD
HHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEECCCCCCCCHHHHCCCEEEECCCCHHH
LKVIFTGFCRRFFESDDLVLRFRPSFFPFTEPSAEIDIRFQTGPLAGRWLEVAGSGQVHP
HHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCCEEEECCCCCCCH
NVVRNMGLDPEKYIGFAFGMGLDRLTMLRYGVSDLRLFFDGDIRFLSQFR
HHHHHCCCCHHHHHHHHHHCCHHHHHHHHHCHHHEEEEECCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA