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The map label for this gene is hbd [H]

Identifier: 120612897

GI number: 120612897

Start: 4724647

End: 4725495

Strand: Direct

Name: hbd [H]

Synonym: Aave_4261

Alternate gene names: 120612897

Gene position: 4724647-4725495 (Clockwise)

Preceding gene: 120612896

Following gene: 120612901

Centisome position: 88.27

GC content: 66.2

Gene sequence:

>849_bases
ATGACGATCAACACCGTCGGCATCATCGGCGCGGGCACCATGGGCAACGGCATCGCGCAGGCCTGCGCGGTCGCCGGCAT
CGACGCGGTGATGGTGGACATTTCCGACGCGGCCGTGAAAAAGGGCCTCGCCACCGTGTCCGGCAGCCTGGACCGGCTCA
TCAAGAAGGAAAAGATCACCGCGGCCGACAAGGACGCGGCGCTGGCGCGCATCAGGACCTCGACGAACTACGACGACCTG
AAGGCCGCGCAGCTCATCATCGAGGCCGCCACCGAGAACCACGAACTCAAGGTGAAGATCCTCGAGCAGGTGGACGCGAT
CGCCGCGCCCGATGTGATCGTGGCCTCCAACACCTCGTCGATCTCGATCACGCAACTGGCCGCCGCCACCTCGCGGCCCG
ACCGCTTCATCGGCATGCACTTCTTCAACCCGGTGCCGATGATGGCGCTGGTGGAGATCATCCGCGGCCTGCAGACCAGC
GACGCCACGCACGACGCCGTGAAGGCGCTGGCCGAGCGCCTGGGCAAGAGCCCCATCACGGTGAAGAACGCGCCGGGCTT
CGTCGTGAACCGCATCCTGGTGCCGATGATCAACGAGGCCTTCTTCGTGCTGGCCGAGGGCCTGGCCACGCCGGAAGACA
TCGACGCCGGCATGAAGCTCGGCTGCAACCAGCCGATCGGCCCGCTGGCGCTGGCCGACATGATCGGCCTGGACGTGTGC
CTGGCGGTGATGAATGTCTATCTGGAAGAGTTCGGCGACAGCAAGTACCGGCCCTGCCCGCTGCTCAAGGAAATGGTGGC
CGCGGGGCGCCTGGGCCGCAAGACGGGCCAGGGGGTGTACAGCTATTGA

Upstream 100 bases:

>100_bases
TCTGGATCGCGCTCGCGCTCACGCGGCGGCGCTTCGCGAAATAGGTTTTTCCGCTGTCCTTTCTTTTGTCTTTTCCACTC
GTTCTTCAGGAGGATTCCCA

Downstream 100 bases:

>100_bases
GGGGTGCCGCCGAGGCCGCGCGCCTGTGCCTCGCGGCCGATGTCTCCGGCCTGCGCCTGCATGGCCTGCACCACCTGCGG
CAGGCGCGCCTCGGTCAGGC

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MTINTVGIIGAGTMGNGIAQACAVAGIDAVMVDISDAAVKKGLATVSGSLDRLIKKEKITAADKDAALARIRTSTNYDDL
KAAQLIIEAATENHELKVKILEQVDAIAAPDVIVASNTSSISITQLAAATSRPDRFIGMHFFNPVPMMALVEIIRGLQTS
DATHDAVKALAERLGKSPITVKNAPGFVVNRILVPMINEAFFVLAEGLATPEDIDAGMKLGCNQPIGPLALADMIGLDVC
LAVMNVYLEEFGDSKYRPCPLLKEMVAAGRLGRKTGQGVYSY

Sequences:

>Translated_282_residues
MTINTVGIIGAGTMGNGIAQACAVAGIDAVMVDISDAAVKKGLATVSGSLDRLIKKEKITAADKDAALARIRTSTNYDDL
KAAQLIIEAATENHELKVKILEQVDAIAAPDVIVASNTSSISITQLAAATSRPDRFIGMHFFNPVPMMALVEIIRGLQTS
DATHDAVKALAERLGKSPITVKNAPGFVVNRILVPMINEAFFVLAEGLATPEDIDAGMKLGCNQPIGPLALADMIGLDVC
LAVMNVYLEEFGDSKYRPCPLLKEMVAAGRLGRKTGQGVYSY
>Mature_281_residues
TINTVGIIGAGTMGNGIAQACAVAGIDAVMVDISDAAVKKGLATVSGSLDRLIKKEKITAADKDAALARIRTSTNYDDLK
AAQLIIEAATENHELKVKILEQVDAIAAPDVIVASNTSSISITQLAAATSRPDRFIGMHFFNPVPMMALVEIIRGLQTSD
ATHDAVKALAERLGKSPITVKNAPGFVVNRILVPMINEAFFVLAEGLATPEDIDAGMKLGCNQPIGPLALADMIGLDVCL
AVMNVYLEEFGDSKYRPCPLLKEMVAAGRLGRKTGQGVYSY

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=287, Percent_Identity=40.418118466899, Blast_Score=218, Evalue=7e-57,
Organism=Homo sapiens, GI296179427, Length=305, Percent_Identity=38.6885245901639, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI20127408, Length=284, Percent_Identity=35.5633802816901, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI261878539, Length=295, Percent_Identity=32.2033898305085, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI68989263, Length=295, Percent_Identity=32.2033898305085, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI115430219, Length=230, Percent_Identity=30, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI1787661, Length=283, Percent_Identity=38.86925795053, Blast_Score=213, Evalue=1e-56,
Organism=Escherichia coli, GI1788682, Length=263, Percent_Identity=38.4030418250951, Blast_Score=167, Evalue=8e-43,
Organism=Escherichia coli, GI1790281, Length=264, Percent_Identity=35.2272727272727, Blast_Score=159, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17549919, Length=287, Percent_Identity=41.1149825783972, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17553560, Length=286, Percent_Identity=40.5594405594406, Blast_Score=216, Evalue=9e-57,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=36.5853658536585, Blast_Score=199, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI25144276, Length=283, Percent_Identity=37.4558303886926, Blast_Score=184, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17508951, Length=283, Percent_Identity=37.4558303886926, Blast_Score=184, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17508953, Length=283, Percent_Identity=37.4558303886926, Blast_Score=184, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17558304, Length=283, Percent_Identity=37.1024734982332, Blast_Score=180, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI71985923, Length=287, Percent_Identity=31.3588850174216, Blast_Score=146, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71985930, Length=287, Percent_Identity=32.0557491289199, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI115533614, Length=204, Percent_Identity=28.4313725490196, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI193203623, Length=204, Percent_Identity=28.4313725490196, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24583077, Length=284, Percent_Identity=36.9718309859155, Blast_Score=190, Evalue=9e-49,
Organism=Drosophila melanogaster, GI24583079, Length=284, Percent_Identity=36.9718309859155, Blast_Score=190, Evalue=9e-49,
Organism=Drosophila melanogaster, GI19921000, Length=284, Percent_Identity=36.9718309859155, Blast_Score=190, Evalue=9e-49,
Organism=Drosophila melanogaster, GI45549573, Length=259, Percent_Identity=27.4131274131274, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI20129993, Length=255, Percent_Identity=25.4901960784314, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 29754; Mature: 29623

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTINTVGIIGAGTMGNGIAQACAVAGIDAVMVDISDAAVKKGLATVSGSLDRLIKKEKIT
CCEEEEEEEECCCCCHHHHHHHHHHCCHHEEEECHHHHHHHHHHHHHHHHHHHHHHHHCC
AADKDAALARIRTSTNYDDLKAAQLIIEAATENHELKVKILEQVDAIAAPDVIVASNTSS
CCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCEEEECCCCC
ISITQLAAATSRPDRFIGMHFFNPVPMMALVEIIRGLQTSDATHDAVKALAERLGKSPIT
EEHHHHHHHCCCCCCEEEHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEE
VKNAPGFVVNRILVPMINEAFFVLAEGLATPEDIDAGMKLGCNQPIGPLALADMIGLDVC
EECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
LAVMNVYLEEFGDSKYRPCPLLKEMVAAGRLGRKTGQGVYSY
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TINTVGIIGAGTMGNGIAQACAVAGIDAVMVDISDAAVKKGLATVSGSLDRLIKKEKIT
CEEEEEEEECCCCCHHHHHHHHHHCCHHEEEECHHHHHHHHHHHHHHHHHHHHHHHHCC
AADKDAALARIRTSTNYDDLKAAQLIIEAATENHELKVKILEQVDAIAAPDVIVASNTSS
CCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCEEEECCCCC
ISITQLAAATSRPDRFIGMHFFNPVPMMALVEIIRGLQTSDATHDAVKALAERLGKSPIT
EEHHHHHHHCCCCCCEEEHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEE
VKNAPGFVVNRILVPMINEAFFVLAEGLATPEDIDAGMKLGCNQPIGPLALADMIGLDVC
EECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
LAVMNVYLEEFGDSKYRPCPLLKEMVAAGRLGRKTGQGVYSY
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA