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The map label for this gene is corC [H]

Identifier: 120612822

GI number: 120612822

Start: 4637889

End: 4638773

Strand: Reverse

Name: corC [H]

Synonym: Aave_4185

Alternate gene names: 120612822

Gene position: 4638773-4637889 (Counterclockwise)

Preceding gene: 120612823

Following gene: 120612821

Centisome position: 86.66

GC content: 68.36

Gene sequence:

>885_bases
GTGTCCGACCCCCACCCTGCGCGCCCCTCCGACCGCGAAGACAAGCGCACGTTCCTGCAGCGCCTCATCGAATTCATCCA
TCCCGGCCCCGATTCCAAGGATGAACTGATCGCCACCCTGGCCGAGGCGGAGGACAACGACGTCATCAATGCCGATGCGC
GCGTGATGCTCGAACGCGTCCTGCGCATGGCCGAGATGACGGCCAGCGACGTGATGGTGCCTGCGCCGCGCATGGACCTG
ATCGACATCGACCAGCCGTTCGAGGCGCTGCTGCACCAGGTGATCGATACCGCCCATTCGCGGTTCCCGGTGTACCAGGG
GGAGCGCGAGAACATCATCGGCATCCTCATGGCGAAGGACCTGCTCAAGCTGCAGCGGGCGCCCGAGCTGAACCTCCGGG
CGTTGCTGCGCTCCGTGGTGTACGTGCCCGAGAGCAAGGGGCTGAACGACCTGCTGCGCGAGTTCCGCGCCAACCGCATC
CACATGGCGGTGGTGATCGACGAGTTCGGCCGGGTGGCCGGGCTGGTCACCATCGAGGACGTGCTCGAGCAGATCGTGGG
CGAGATCGAGGACGAATTCGACATCCCCGAGGACGAGGGCGACATCTTCGCCCTGGCGGACCGGACCTACCGCGTGAGCG
GCGACACGCCCGTGGAGCGCGTGGCCGAGGCCTTCGACCTGCCCGCCCTCGAAGGCTCCGACAAGGACGAGGAGTTCGAG
ACCATCGGCGGCCTGATCGCGCACGAGCTGGGCCATGCGCCGCGCCGCGGGGAATCGCTGGACCTCGGCGGCCTGCGCTT
CGTCGTGCTGCACACCAAGGGCGGCGCGGTGCGCTGGTTCAAGGTGTCGCCGCAGCCCCCGGGCGCCGAACCGGACGCCG
GCTGA

Upstream 100 bases:

>100_bases
GGGTATGAGGGCCGGTCCGCGGCACGCCAGCGGGGAGTGTCGCGGGCATCCGCTATCCTTGGAGGCCTGACAACCACCGC
ACGTCCTGCACACCGAGACC

Downstream 100 bases:

>100_bases
CCATGCTCCTGCAAGCCTATGGCAACGGGCGCCCGCGCGCGCCCGCGGCGCTCCTGTTGACGGCAGCCGTGCTGGCCGGG
CTGGCGCAGGCGGCTTCCAT

Product: CBS domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MSDPHPARPSDREDKRTFLQRLIEFIHPGPDSKDELIATLAEAEDNDVINADARVMLERVLRMAEMTASDVMVPAPRMDL
IDIDQPFEALLHQVIDTAHSRFPVYQGERENIIGILMAKDLLKLQRAPELNLRALLRSVVYVPESKGLNDLLREFRANRI
HMAVVIDEFGRVAGLVTIEDVLEQIVGEIEDEFDIPEDEGDIFALADRTYRVSGDTPVERVAEAFDLPALEGSDKDEEFE
TIGGLIAHELGHAPRRGESLDLGGLRFVVLHTKGGAVRWFKVSPQPPGAEPDAG

Sequences:

>Translated_294_residues
MSDPHPARPSDREDKRTFLQRLIEFIHPGPDSKDELIATLAEAEDNDVINADARVMLERVLRMAEMTASDVMVPAPRMDL
IDIDQPFEALLHQVIDTAHSRFPVYQGERENIIGILMAKDLLKLQRAPELNLRALLRSVVYVPESKGLNDLLREFRANRI
HMAVVIDEFGRVAGLVTIEDVLEQIVGEIEDEFDIPEDEGDIFALADRTYRVSGDTPVERVAEAFDLPALEGSDKDEEFE
TIGGLIAHELGHAPRRGESLDLGGLRFVVLHTKGGAVRWFKVSPQPPGAEPDAG
>Mature_293_residues
SDPHPARPSDREDKRTFLQRLIEFIHPGPDSKDELIATLAEAEDNDVINADARVMLERVLRMAEMTASDVMVPAPRMDLI
DIDQPFEALLHQVIDTAHSRFPVYQGERENIIGILMAKDLLKLQRAPELNLRALLRSVVYVPESKGLNDLLREFRANRIH
MAVVIDEFGRVAGLVTIEDVLEQIVGEIEDEFDIPEDEGDIFALADRTYRVSGDTPVERVAEAFDLPALEGSDKDEEFET
IGGLIAHELGHAPRRGESLDLGGLRFVVLHTKGGAVRWFKVSPQPPGAEPDAG

Specific function: Plays a role in the transport of magnesium and cobalt ions [H]

COG id: COG4535

COG function: function code P; Putative Mg2+ and Co2+ transporter CorC

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=206, Percent_Identity=29.6116504854369, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI40068053, Length=177, Percent_Identity=27.683615819209, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI40068055, Length=177, Percent_Identity=27.683615819209, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1786879, Length=294, Percent_Identity=41.156462585034, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI87082033, Length=252, Percent_Identity=31.3492063492063, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1788119, Length=242, Percent_Identity=30.9917355371901, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI145693175, Length=276, Percent_Identity=26.8115942028986, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1790664, Length=242, Percent_Identity=25.2066115702479, Blast_Score=86, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC [H]

EC number: NA

Molecular weight: Translated: 32770; Mature: 32638

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPHPARPSDREDKRTFLQRLIEFIHPGPDSKDELIATLAEAEDNDVINADARVMLERV
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEECHHHHHHHHHH
LRMAEMTASDVMVPAPRMDLIDIDQPFEALLHQVIDTAHSRFPVYQGERENIIGILMAKD
HHHHHHHHCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
LLKLQRAPELNLRALLRSVVYVPESKGLNDLLREFRANRIHMAVVIDEFGRVAGLVTIED
HHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHH
VLEQIVGEIEDEFDIPEDEGDIFALADRTYRVSGDTPVERVAEAFDLPALEGSDKDEEFE
HHHHHHHHHHHHCCCCCCCCCEEEEECCEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHH
TIGGLIAHELGHAPRRGESLDLGGLRFVVLHTKGGAVRWFKVSPQPPGAEPDAG
HHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
SDPHPARPSDREDKRTFLQRLIEFIHPGPDSKDELIATLAEAEDNDVINADARVMLERV
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEECHHHHHHHHHH
LRMAEMTASDVMVPAPRMDLIDIDQPFEALLHQVIDTAHSRFPVYQGERENIIGILMAKD
HHHHHHHHCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
LLKLQRAPELNLRALLRSVVYVPESKGLNDLLREFRANRIHMAVVIDEFGRVAGLVTIED
HHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHH
VLEQIVGEIEDEFDIPEDEGDIFALADRTYRVSGDTPVERVAEAFDLPALEGSDKDEEFE
HHHHHHHHHHHHCCCCCCCCCEEEEECCEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHH
TIGGLIAHELGHAPRRGESLDLGGLRFVVLHTKGGAVRWFKVSPQPPGAEPDAG
HHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]