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The map label for this gene is rmlA1 [H]

Identifier: 120612801

GI number: 120612801

Start: 4617215

End: 4618090

Strand: Reverse

Name: rmlA1 [H]

Synonym: Aave_4164

Alternate gene names: 120612801

Gene position: 4618090-4617215 (Counterclockwise)

Preceding gene: 120612802

Following gene: 120612800

Centisome position: 86.27

GC content: 66.67

Gene sequence:

>876_bases
ATGACCGCACGCAAGGGCATCATCCTCGCCGGGGGATCGGGCACACGCCTGCACCCCGCCACGCTCGCCATCAGCAAGCA
ACTGCTTCCGGTGTACGACAAGCCGATGATCTACTACCCGCTCAGCACCCTGATGCTGGCGGGCATCCGCGACATCCTCA
TCATCAGCACGCCGCAGGACACGCCACGGTTCGAGCAACTGCTGGGCGATGGCAGCCAGTGGGGCATCCGCCTGAGCTAT
GCCGTGCAGCCCAGCCCCGACGGCCTGGCGCAGGCCTTCCTCATCGGGGAGAAATTCCTGGATGGCCAGCCCAGTGCGCT
CGTGCTGGGCGACAACATCTTCCACGGCCACGATTTCGAGGATCTCCTGCGCAGCGCCATGGGGCGCCAGGAGGGGGCCA
GCGTGTTCGCCTACCACGTGCAGGATCCTGAACGCTACGGTGTGGCCGAGTTCGACGCCACCGGCAAGGTCCTGTCGATC
GAGGAAAAGCCCAAGGTCCCGAAGTCCAGCTACGCCGTCACGGGCCTCTACTTCTACGACCAGCACGTGGTCGAGCGCGC
CGCCGGCCTGAAGCCCTCCGCGCGCGGCGAGCTGGAAATCACCGACCTCAACCGCGTCTACCTCGAGCGCGAGTCCCTGC
ACGTCGAGATCATGGGCCGCGGCTACGCCTGGCTCGATACCGGGACGCACGAAAGCCTGCTCGAAGCCGGGCAGTTCATC
GCGACCCTGGAGCACCGGCAGGGGCTCAAGATCGCCTGTCCGGAGGAGATCGCCTGGCGGCATCGCCTCATCGACGACGA
CCAGCTCGAGCGCCTCGCCAGGCCGCTCGCCAAGAGCGGCTACGGTGCCTACCTCCTCAGGTTGCTGGCCGGTTGA

Upstream 100 bases:

>100_bases
TCCAGTCCACCTTCGGCCTGGCCCTGCCGCACTGGCAGGCGGGCATCGCTCGGATGCTCGCGGAAATCCTCTGAAACCCC
AAAAACTTCCTGCATACAGC

Downstream 100 bases:

>100_bases
TCGTCACCCATATCGCTTCCTGACCGCGCCATCGATCCAACGCTTTCCCATGAACGTCCTCCCCACGAGCATCCCCGATG
TCGTCGTTCTCGAACCCAAA

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MTARKGIILAGGSGTRLHPATLAISKQLLPVYDKPMIYYPLSTLMLAGIRDILIISTPQDTPRFEQLLGDGSQWGIRLSY
AVQPSPDGLAQAFLIGEKFLDGQPSALVLGDNIFHGHDFEDLLRSAMGRQEGASVFAYHVQDPERYGVAEFDATGKVLSI
EEKPKVPKSSYAVTGLYFYDQHVVERAAGLKPSARGELEITDLNRVYLERESLHVEIMGRGYAWLDTGTHESLLEAGQFI
ATLEHRQGLKIACPEEIAWRHRLIDDDQLERLARPLAKSGYGAYLLRLLAG

Sequences:

>Translated_291_residues
MTARKGIILAGGSGTRLHPATLAISKQLLPVYDKPMIYYPLSTLMLAGIRDILIISTPQDTPRFEQLLGDGSQWGIRLSY
AVQPSPDGLAQAFLIGEKFLDGQPSALVLGDNIFHGHDFEDLLRSAMGRQEGASVFAYHVQDPERYGVAEFDATGKVLSI
EEKPKVPKSSYAVTGLYFYDQHVVERAAGLKPSARGELEITDLNRVYLERESLHVEIMGRGYAWLDTGTHESLLEAGQFI
ATLEHRQGLKIACPEEIAWRHRLIDDDQLERLARPLAKSGYGAYLLRLLAG
>Mature_290_residues
TARKGIILAGGSGTRLHPATLAISKQLLPVYDKPMIYYPLSTLMLAGIRDILIISTPQDTPRFEQLLGDGSQWGIRLSYA
VQPSPDGLAQAFLIGEKFLDGQPSALVLGDNIFHGHDFEDLLRSAMGRQEGASVFAYHVQDPERYGVAEFDATGKVLSIE
EKPKVPKSSYAVTGLYFYDQHVVERAAGLKPSARGELEITDLNRVYLERESLHVEIMGRGYAWLDTGTHESLLEAGQFIA
TLEHRQGLKIACPEEIAWRHRLIDDDQLERLARPLAKSGYGAYLLRLLAG

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=246, Percent_Identity=24.7967479674797, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI11761621, Length=246, Percent_Identity=24.7967479674797, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI1788351, Length=288, Percent_Identity=71.5277777777778, Blast_Score=445, Evalue=1e-126,
Organism=Escherichia coli, GI1790224, Length=285, Percent_Identity=67.3684210526316, Blast_Score=400, Evalue=1e-113,
Organism=Escherichia coli, GI1787488, Length=296, Percent_Identity=25.6756756756757, Blast_Score=72, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI133931050, Length=192, Percent_Identity=27.0833333333333, Blast_Score=81, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6320148, Length=265, Percent_Identity=27.1698113207547, Blast_Score=82, Evalue=7e-17,
Organism=Drosophila melanogaster, GI21355443, Length=249, Percent_Identity=23.2931726907631, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24644084, Length=249, Percent_Identity=23.2931726907631, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32232; Mature: 32101

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARKGIILAGGSGTRLHPATLAISKQLLPVYDKPMIYYPLSTLMLAGIRDILIISTPQD
CCCCCCEEEECCCCCEECHHHHHHHHHHCCCCCCCEEEECHHHHHHHCCCEEEEEECCCC
TPRFEQLLGDGSQWGIRLSYAVQPSPDGLAQAFLIGEKFLDGQPSALVLGDNIFHGHDFE
CHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHH
DLLRSAMGRQEGASVFAYHVQDPERYGVAEFDATGKVLSIEEKPKVPKSSYAVTGLYFYD
HHHHHHCCCCCCCEEEEEEECCCHHCCCEEECCCCCEEEECCCCCCCCCCEEEEEEEEHH
QHVVERAAGLKPSARGELEITDLNRVYLERESLHVEIMGRGYAWLDTGTHESLLEAGQFI
HHHHHHHHCCCCCCCCCEEEEECCEEEEECCCEEEEEEECCEEEEECCCHHHHHHHHHHH
ATLEHRQGLKIACPEEIAWRHRLIDDDQLERLARPLAKSGYGAYLLRLLAG
HHHHHCCCCEEECCHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure 
TARKGIILAGGSGTRLHPATLAISKQLLPVYDKPMIYYPLSTLMLAGIRDILIISTPQD
CCCCCEEEECCCCCEECHHHHHHHHHHCCCCCCCEEEECHHHHHHHCCCEEEEEECCCC
TPRFEQLLGDGSQWGIRLSYAVQPSPDGLAQAFLIGEKFLDGQPSALVLGDNIFHGHDFE
CHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHH
DLLRSAMGRQEGASVFAYHVQDPERYGVAEFDATGKVLSIEEKPKVPKSSYAVTGLYFYD
HHHHHHCCCCCCCEEEEEEECCCHHCCCEEECCCCCEEEECCCCCCCCCCEEEEEEEEHH
QHVVERAAGLKPSARGELEITDLNRVYLERESLHVEIMGRGYAWLDTGTHESLLEAGQFI
HHHHHHHHCCCCCCCCCEEEEECCEEEEECCCEEEEEEECCEEEEECCCHHHHHHHHHHH
ATLEHRQGLKIACPEEIAWRHRLIDDDQLERLARPLAKSGYGAYLLRLLAG
HHHHHCCCCEEECCHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]