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The map label for this gene is dpnM [H]

Identifier: 120612745

GI number: 120612745

Start: 4565768

End: 4566559

Strand: Reverse

Name: dpnM [H]

Synonym: Aave_4108

Alternate gene names: 120612745

Gene position: 4566559-4565768 (Counterclockwise)

Preceding gene: 120612746

Following gene: 120612744

Centisome position: 85.31

GC content: 64.9

Gene sequence:

>792_bases
ATGGCATTCCCTATCGTCCCGTGGATCGGCGGCAAACGCCGCCTGGTAGACCTCCTCCTGAGCCGTTTCCCGGCGCACAA
GTGCTACGTCGAAGTCTTCGCGGGCGGCGCTGCGGTGTTCTTCGCGCGCAACCCCGCAGACGTCGAGGTGCTCAACGACG
TCAACGGCGACCTAGTCAATCTCTACCGAGTGGTGACACACCACCTGGAGGAGTTCGTGCGGCAGTTCAAATGGGCCTTG
ACCTCGCGTCAGGTGTTCCGGTGGCTGCAGGAAACGCGGCCCGAGACGCTGACCGACGTGCAGCGTGCCGCGCGGTTTTT
CTACCTGCAGCAGCAGTCGTTCGGGGGCAAGGTGGCGGGCCAGACCTTCGGCACCGCCACCACGGCGCCGGCCATCAACC
TGCTGCGGATCGAGGAGTCGCTGTCTGCTGCGCATCTGCGCCTGGCGGGCGGCACCTACATCGAGCAGCTCGACTGGGCC
GAGTGCGTCGACCGCTACGACCGGCCTCACAGCCTTTTCTACTTGGACCCCCCGTACTGGGAAACGGAAGGGTATGGCGT
GCCCTTCGAGTGGGCGCAGTATGAGCTGATGGCCGCCAAGCTCAAGGCGATCCAGGGCAAGGCCATCGTCAGCATCAACG
ATCACCCGGCGATCCGCGAGTGCTTCGCGGGGTACGCGATGGAGGCGCTGACCCTCGACTACACCGTGGGAGGCGGCGCC
AACCGCGTCGAGCGCGGTGAACTTGTCATCTACAACTGGGACTACCAGGCCGAGCCTGCCGGGCTCTTTTAA

Upstream 100 bases:

>100_bases
CCCCAACCTGCAGAACACGCTGCAAGCCGGCAAGGCCCGCCACTCTCGCGAGAGCGCGCTGAGCCTACCAGACTTTTAAA
CAGCTAAAAGGCTTGCAAAC

Downstream 100 bases:

>100_bases
CCACCATGGCGACACCCGAGCAAAAGAACTTCGAGGCCGCCCTGCGCGAGCGCCTGGCCGAGCGTGCCAAGCTGCTGCTG
ACGGGGCAGGCGCAGGTGCT

Product: D12 class N6 adenine-specific DNA methyltransferase

Products: NA

Alternate protein names: M.DpnIIA; Adenine-specific methyltransferase DpnIIA; M.DpnII 1 [H]

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MAFPIVPWIGGKRRLVDLLLSRFPAHKCYVEVFAGGAAVFFARNPADVEVLNDVNGDLVNLYRVVTHHLEEFVRQFKWAL
TSRQVFRWLQETRPETLTDVQRAARFFYLQQQSFGGKVAGQTFGTATTAPAINLLRIEESLSAAHLRLAGGTYIEQLDWA
ECVDRYDRPHSLFYLDPPYWETEGYGVPFEWAQYELMAAKLKAIQGKAIVSINDHPAIRECFAGYAMEALTLDYTVGGGA
NRVERGELVIYNWDYQAEPAGLF

Sequences:

>Translated_263_residues
MAFPIVPWIGGKRRLVDLLLSRFPAHKCYVEVFAGGAAVFFARNPADVEVLNDVNGDLVNLYRVVTHHLEEFVRQFKWAL
TSRQVFRWLQETRPETLTDVQRAARFFYLQQQSFGGKVAGQTFGTATTAPAINLLRIEESLSAAHLRLAGGTYIEQLDWA
ECVDRYDRPHSLFYLDPPYWETEGYGVPFEWAQYELMAAKLKAIQGKAIVSINDHPAIRECFAGYAMEALTLDYTVGGGA
NRVERGELVIYNWDYQAEPAGLF
>Mature_262_residues
AFPIVPWIGGKRRLVDLLLSRFPAHKCYVEVFAGGAAVFFARNPADVEVLNDVNGDLVNLYRVVTHHLEEFVRQFKWALT
SRQVFRWLQETRPETLTDVQRAARFFYLQQQSFGGKVAGQTFGTATTAPAINLLRIEESLSAAHLRLAGGTYIEQLDWAE
CVDRYDRPHSLFYLDPPYWETEGYGVPFEWAQYELMAAKLKAIQGKAIVSINDHPAIRECFAGYAMEALTLDYTVGGGAN
RVERGELVIYNWDYQAEPAGLF

Specific function: This methylase recognizes the double-stranded sequence GATC, causes specific methylation on A-2 on both strands, and protects the DNA from cleavage by the DpnII endonuclease [H]

COG id: COG0338

COG function: function code L; Site-specific DNA methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N(4)/N(6)-methyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023095
- InterPro:   IPR002052
- InterPro:   IPR012327 [H]

Pfam domain/function: PF02086 MethyltransfD12 [H]

EC number: =2.1.1.72 [H]

Molecular weight: Translated: 29835; Mature: 29704

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFPIVPWIGGKRRLVDLLLSRFPAHKCYVEVFAGGAAVFFARNPADVEVLNDVNGDLVN
CCCCCCCCCCCHHHHHHHHHHHCCCHHEEEEEEECCEEEEEECCCCCEEEECCCCCHHHH
LYRVVTHHLEEFVRQFKWALTSRQVFRWLQETRPETLTDVQRAARFFYLQQQSFGGKVAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEECC
QTFGTATTAPAINLLRIEESLSAAHLRLAGGTYIEQLDWAECVDRYDRPHSLFYLDPPYW
CCCCCCCCCCCCEEEEEHHHHHHHEEEECCCHHHHHCCHHHHHHHCCCCCEEEEECCCCC
ETEGYGVPFEWAQYELMAAKLKAIQGKAIVSINDHPAIRECFAGYAMEALTLDYTVGGGA
CCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHEEEEEEECCCC
NRVERGELVIYNWDYQAEPAGLF
CCCCCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure 
AFPIVPWIGGKRRLVDLLLSRFPAHKCYVEVFAGGAAVFFARNPADVEVLNDVNGDLVN
CCCCCCCCCCHHHHHHHHHHHCCCHHEEEEEEECCEEEEEECCCCCEEEECCCCCHHHH
LYRVVTHHLEEFVRQFKWALTSRQVFRWLQETRPETLTDVQRAARFFYLQQQSFGGKVAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEECC
QTFGTATTAPAINLLRIEESLSAAHLRLAGGTYIEQLDWAECVDRYDRPHSLFYLDPPYW
CCCCCCCCCCCCEEEEEHHHHHHHEEEECCCHHHHHCCHHHHHHHCCCCCEEEEECCCCC
ETEGYGVPFEWAQYELMAAKLKAIQGKAIVSINDHPAIRECFAGYAMEALTLDYTVGGGA
CCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHEEEEEEECCCC
NRVERGELVIYNWDYQAEPAGLF
CCCCCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2989823; 3019562; 2824782; 9862809 [H]