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The map label for this gene is fadN [H]

Identifier: 120612724

GI number: 120612724

Start: 4538768

End: 4541170

Strand: Reverse

Name: fadN [H]

Synonym: Aave_4087

Alternate gene names: 120612724

Gene position: 4541170-4538768 (Counterclockwise)

Preceding gene: 120612725

Following gene: 120612723

Centisome position: 84.84

GC content: 67.0

Gene sequence:

>2403_bases
ATGTCCCGATTCCAAGTGAAGAAAGTCGCCGTGCTCGGCGCGGGCGTGATGGGCGCGCAGATCGCCGCCCACCTCGCCAA
CGTGAAGGTGCCCGTGGTGCTGTTCGACCTGCCTGCCAAGGAAGGCCCGCAGAACGGCATCGTCACCAAGGCCGTCGAGG
GCCTGAAAAAGCTCAAGCCCTCGCCGCTGGGCGTGGCGGACGATGTCGCGCTGATCGGCCAGGCCAACTACGAAGAACAC
CTGGAGCAGCTGCGCGGCTGCGACCTCATCATCGAGGCGATCGCCGAGCGCATGGACTGGAAGCTCGACCTCTACAGGAA
GATCGCGCCCTTCGTCGCGCCGAACGCCATCGTGGCGTCCAATACCTCGGGCCTGTCGATCACGAAGCTCTCCGAGGCGC
TGCCCGATGCGATCAAGCCGCGCTTCTGCGGCATCCACTTCTTCAACCCGCCGCGCTACATGACGCTGGTGGAGTTGATC
GACACGCCCACCACCAAGGCGGAAGTGCTGGACCAGCTCGAAGCCTTCGTCACGAGCGGCCTGGGCAAGGGCGTGGTGCG
CGCGCACGACACGCCCAACTTCATCGCCAACCGCGTCGGCATCGCCGGCATGCTGGCGACGATGAAGGAGGTGGAGAATT
TCGGCCTCACCTACGACGTGGTGGACGACCTCACGGGCAAGAAGCTGGGGCGCGCTTCCAGCGGCACCTTCCGCACGGCC
GACGTGGTGGGGCTGGATACGATGGCGCACGTCATCAAGACGCTGCAGGACAACCTGTCCGAAGAGACCGACCCGTTCTA
CGGCAGCTTCGGCACGCCCGAGGTGCTGAACAAACTCATCGAGATGAAGCACCTGGGCCAGAAGTCCAAGGCCGGCTTCT
ACAAGAAGGTGGGCCGGGATATCCTGCGTTTCGACCTGGCCGAAGGCGACTACGTGCCCGGCGGCCAGAAGGCCGACGAG
GTCTATGGCCGCATGCTGAAGAAGCCCGCCGCGGAGCGCTTGAAGCTGCTGCGCAATGCCGAGGGTGCGCAGGGCCGTTT
CCTGTGGGCGATCCTGCGCAACAGCTTCCACTACGCCGCCGTGCATCTGGCAACGATTGCCGACAACGCGCGTGACGTGG
ACCAGGCGATGCGCTGGGGCTTCGGCATGAAGCAGGGCCCGTTCGAGCTGTGGCAGGAGGCCGGCTGGCTCGAGGTGGCG
AAGATGATCCAGGAGGACATCGACGCGGGCAAGGCACTCAGCAAGGCGCCGCTGCCCGAGTGGGTGTTCAAGGGGCCGGT
GGCCGAGGCCGGCGGCGTGCACACCGCCGAAGGCTCCTGGAGCGCCTCGAAGCAGAAGTTCGTGCCGCGCCGCCAGCTGC
CGGTCTACGAGCGCCAGCACTTCCCTGAGAAACTGCTGGGCGAAAGCAACCTGCCCGACTGGCGCACGGCCGGCACCACG
GTGGCTGAATCCGACGCGCTGCGCACCTGGACGCTGGATGGCAAGGTGCTCATCGCCAGCATCCAGAGCAAGATGCACGC
GATCAGCCCCGACGTGATGGAAGGGCTGATGGAGGCCATCGACACCGCCGAGCGCGACTACGACGGCCTGGTGATCTGGT
CCGGCGACGCGCCCTTCAGCGTGGGCGCCGACCTGCAGGCCACCATGCCGGCCTTCGTCGTGGCCGGCGTCTCGGCGATC
GAAGGCGTCGAGCAGGAGCTGCAGAACCTGATGCTGCGCCTGCGCTATGCCCAGGTGCCGGTGGTGTCTGCCATCCACGG
CATGGCGCTGGGCGGCGGCTGCGAGCTGGCCGTCTATTCGTCGCGCCGCGTGGCCCACATGGAAAGCTATATCGGCCTGG
TCGAGGTGGGCGTGGGCCTGGTGCCGGGCGCTGGCGGGCTGACCTACATCGCCCGCCGCGCGGCGGAGAATGCCGCGGCC
TCCACGGGCAAGGACCTGCTGCCCTTCCTCACGGAGGGTTTCACCGCCGCCGCGATGGCCAAGGTGGGAACCAGCGCGCT
GGAATCGCGCAAGCTCGGCTACCTGCTGGAGAGCGACATCGTCGTGCCGCACAAGGACGAGGTGCTGTTCGTGGCGCTGA
ACGAGGCGAAGGCCATGGCCGCCAGCGGCTGGCGCGCGCCGAACAGGCGCCTCTTCCCGGTCGCCGGGCGCAGCGGCATC
GCCACCATCCGCGGCTCGCTGGTGAACATGCGCGACGGTGGCTTCATCAGCGACCACGACCAGCACATCGCCACGCTGAT
CGCCGAAATTGTCTGCGGCGGCGATGTGGATGCCGGCACGCTGGTGAGCGAGGAGTACCTGATGGCGCTGGAGCGCAAGG
CGTTCTGCGCGCTCATCCAGCATCCCAAGACGCAGGAGCGCATCCTGGGCATGCTGAACACCGGCAAGCCGGTACGCAAT
TGA

Upstream 100 bases:

>100_bases
TCGACGGCGGCGCCAGGCTGGAAGTGCGCGGCTACCTGGGGCCCTTCTGGCGCACGCAGGTCTGGCAGCGCGTGCAGTAA
CCCATTCACGAGAAACCACC

Downstream 100 bases:

>100_bases
CCTCCCGCATGACCGCCGTCCCCGCCGCCTCTTTCGCGCCGAACCGCCTGCAACTGCAGCTGGAACAGGTGGACGAGTTC
CCGGAGTTCCTGCGCCCCTG

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 800; Mature: 799

Protein sequence:

>800_residues
MSRFQVKKVAVLGAGVMGAQIAAHLANVKVPVVLFDLPAKEGPQNGIVTKAVEGLKKLKPSPLGVADDVALIGQANYEEH
LEQLRGCDLIIEAIAERMDWKLDLYRKIAPFVAPNAIVASNTSGLSITKLSEALPDAIKPRFCGIHFFNPPRYMTLVELI
DTPTTKAEVLDQLEAFVTSGLGKGVVRAHDTPNFIANRVGIAGMLATMKEVENFGLTYDVVDDLTGKKLGRASSGTFRTA
DVVGLDTMAHVIKTLQDNLSEETDPFYGSFGTPEVLNKLIEMKHLGQKSKAGFYKKVGRDILRFDLAEGDYVPGGQKADE
VYGRMLKKPAAERLKLLRNAEGAQGRFLWAILRNSFHYAAVHLATIADNARDVDQAMRWGFGMKQGPFELWQEAGWLEVA
KMIQEDIDAGKALSKAPLPEWVFKGPVAEAGGVHTAEGSWSASKQKFVPRRQLPVYERQHFPEKLLGESNLPDWRTAGTT
VAESDALRTWTLDGKVLIASIQSKMHAISPDVMEGLMEAIDTAERDYDGLVIWSGDAPFSVGADLQATMPAFVVAGVSAI
EGVEQELQNLMLRLRYAQVPVVSAIHGMALGGGCELAVYSSRRVAHMESYIGLVEVGVGLVPGAGGLTYIARRAAENAAA
STGKDLLPFLTEGFTAAAMAKVGTSALESRKLGYLLESDIVVPHKDEVLFVALNEAKAMAASGWRAPNRRLFPVAGRSGI
ATIRGSLVNMRDGGFISDHDQHIATLIAEIVCGGDVDAGTLVSEEYLMALERKAFCALIQHPKTQERILGMLNTGKPVRN

Sequences:

>Translated_800_residues
MSRFQVKKVAVLGAGVMGAQIAAHLANVKVPVVLFDLPAKEGPQNGIVTKAVEGLKKLKPSPLGVADDVALIGQANYEEH
LEQLRGCDLIIEAIAERMDWKLDLYRKIAPFVAPNAIVASNTSGLSITKLSEALPDAIKPRFCGIHFFNPPRYMTLVELI
DTPTTKAEVLDQLEAFVTSGLGKGVVRAHDTPNFIANRVGIAGMLATMKEVENFGLTYDVVDDLTGKKLGRASSGTFRTA
DVVGLDTMAHVIKTLQDNLSEETDPFYGSFGTPEVLNKLIEMKHLGQKSKAGFYKKVGRDILRFDLAEGDYVPGGQKADE
VYGRMLKKPAAERLKLLRNAEGAQGRFLWAILRNSFHYAAVHLATIADNARDVDQAMRWGFGMKQGPFELWQEAGWLEVA
KMIQEDIDAGKALSKAPLPEWVFKGPVAEAGGVHTAEGSWSASKQKFVPRRQLPVYERQHFPEKLLGESNLPDWRTAGTT
VAESDALRTWTLDGKVLIASIQSKMHAISPDVMEGLMEAIDTAERDYDGLVIWSGDAPFSVGADLQATMPAFVVAGVSAI
EGVEQELQNLMLRLRYAQVPVVSAIHGMALGGGCELAVYSSRRVAHMESYIGLVEVGVGLVPGAGGLTYIARRAAENAAA
STGKDLLPFLTEGFTAAAMAKVGTSALESRKLGYLLESDIVVPHKDEVLFVALNEAKAMAASGWRAPNRRLFPVAGRSGI
ATIRGSLVNMRDGGFISDHDQHIATLIAEIVCGGDVDAGTLVSEEYLMALERKAFCALIQHPKTQERILGMLNTGKPVRN
>Mature_799_residues
SRFQVKKVAVLGAGVMGAQIAAHLANVKVPVVLFDLPAKEGPQNGIVTKAVEGLKKLKPSPLGVADDVALIGQANYEEHL
EQLRGCDLIIEAIAERMDWKLDLYRKIAPFVAPNAIVASNTSGLSITKLSEALPDAIKPRFCGIHFFNPPRYMTLVELID
TPTTKAEVLDQLEAFVTSGLGKGVVRAHDTPNFIANRVGIAGMLATMKEVENFGLTYDVVDDLTGKKLGRASSGTFRTAD
VVGLDTMAHVIKTLQDNLSEETDPFYGSFGTPEVLNKLIEMKHLGQKSKAGFYKKVGRDILRFDLAEGDYVPGGQKADEV
YGRMLKKPAAERLKLLRNAEGAQGRFLWAILRNSFHYAAVHLATIADNARDVDQAMRWGFGMKQGPFELWQEAGWLEVAK
MIQEDIDAGKALSKAPLPEWVFKGPVAEAGGVHTAEGSWSASKQKFVPRRQLPVYERQHFPEKLLGESNLPDWRTAGTTV
AESDALRTWTLDGKVLIASIQSKMHAISPDVMEGLMEAIDTAERDYDGLVIWSGDAPFSVGADLQATMPAFVVAGVSAIE
GVEQELQNLMLRLRYAQVPVVSAIHGMALGGGCELAVYSSRRVAHMESYIGLVEVGVGLVPGAGGLTYIARRAAENAAAS
TGKDLLPFLTEGFTAAAMAKVGTSALESRKLGYLLESDIVVPHKDEVLFVALNEAKAMAASGWRAPNRRLFPVAGRSGIA
TIRGSLVNMRDGGFISDHDQHIATLIAEIVCGGDVDAGTLVSEEYLMALERKAFCALIQHPKTQERILGMLNTGKPVRN

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=302, Percent_Identity=33.4437086092715, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI296179427, Length=317, Percent_Identity=32.807570977918, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI20127408, Length=299, Percent_Identity=29.7658862876254, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI68989263, Length=140, Percent_Identity=35, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI261878539, Length=253, Percent_Identity=26.0869565217391, Blast_Score=70, Evalue=1e-11,
Organism=Escherichia coli, GI1787661, Length=296, Percent_Identity=29.7297297297297, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1790281, Length=210, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17549919, Length=297, Percent_Identity=30.6397306397306, Blast_Score=117, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17563036, Length=297, Percent_Identity=31.3131313131313, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17553560, Length=303, Percent_Identity=29.7029702970297, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17558304, Length=346, Percent_Identity=28.6127167630058, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17508953, Length=328, Percent_Identity=30.4878048780488, Blast_Score=95, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25144276, Length=328, Percent_Identity=30.4878048780488, Blast_Score=95, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17508951, Length=328, Percent_Identity=30.4878048780488, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71985923, Length=295, Percent_Identity=27.1186440677966, Blast_Score=86, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71985930, Length=294, Percent_Identity=24.8299319727891, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI19921000, Length=296, Percent_Identity=31.4189189189189, Blast_Score=88, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24583077, Length=296, Percent_Identity=31.4189189189189, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24583079, Length=296, Percent_Identity=31.4189189189189, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI45549573, Length=227, Percent_Identity=29.9559471365639, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =1.1.1.35 [H]

Molecular weight: Translated: 86580; Mature: 86449

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRFQVKKVAVLGAGVMGAQIAAHLANVKVPVVLFDLPAKEGPQNGIVTKAVEGLKKLKP
CCCHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCC
SPLGVADDVALIGQANYEEHLEQLRGCDLIIEAIAERMDWKLDLYRKIAPFVAPNAIVAS
CCCCCCCCHHHHCCCCHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEC
NTSGLSITKLSEALPDAIKPRFCGIHFFNPPRYMTLVELIDTPTTKAEVLDQLEAFVTSG
CCCCCCHHHHHHHCHHHCCCCEEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
LGKGVVRAHDTPNFIANRVGIAGMLATMKEVENFGLTYDVVDDLTGKKLGRASSGTFRTA
CCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHCCCCCCCCEEEH
DVVGLDTMAHVIKTLQDNLSEETDPFYGSFGTPEVLNKLIEMKHLGQKSKAGFYKKVGRD
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHCCHHHHHHHHH
ILRFDLAEGDYVPGGQKADEVYGRMLKKPAAERLKLLRNAEGAQGRFLWAILRNSFHYAA
HHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHH
VHLATIADNARDVDQAMRWGFGMKQGPFELWQEAGWLEVAKMIQEDIDAGKALSKAPLPE
HHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCH
WVFKGPVAEAGGVHTAEGSWSASKQKFVPRRQLPVYERQHFPEKLLGESNLPDWRTAGTT
HHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHCCCHHHCCCCCCCCCCCCCCC
VAESDALRTWTLDGKVLIASIQSKMHAISPDVMEGLMEAIDTAERDYDGLVIWSGDAPFS
EECCCCEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCC
VGADLQATMPAFVVAGVSAIEGVEQELQNLMLRLRYAQVPVVSAIHGMALGGGCELAVYS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHEECCCCEEEEEC
SRRVAHMESYIGLVEVGVGLVPGAGGLTYIARRAAENAAASTGKDLLPFLTEGFTAAAMA
CCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHH
KVGTSALESRKLGYLLESDIVVPHKDEVLFVALNEAKAMAASGWRAPNRRLFPVAGRSGI
HHHHHHHHHHHCCHHHHCCEECCCCCCEEEEEECCHHHHHHCCCCCCCCCEEEECCCCCH
ATIRGSLVNMRDGGFISDHDQHIATLIAEIVCGGDVDAGTLVSEEYLMALERKAFCALIQ
HHHHCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
HPKTQERILGMLNTGKPVRN
CCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SRFQVKKVAVLGAGVMGAQIAAHLANVKVPVVLFDLPAKEGPQNGIVTKAVEGLKKLKP
CCHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCC
SPLGVADDVALIGQANYEEHLEQLRGCDLIIEAIAERMDWKLDLYRKIAPFVAPNAIVAS
CCCCCCCCHHHHCCCCHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEC
NTSGLSITKLSEALPDAIKPRFCGIHFFNPPRYMTLVELIDTPTTKAEVLDQLEAFVTSG
CCCCCCHHHHHHHCHHHCCCCEEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
LGKGVVRAHDTPNFIANRVGIAGMLATMKEVENFGLTYDVVDDLTGKKLGRASSGTFRTA
CCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHCCCCCCCCEEEH
DVVGLDTMAHVIKTLQDNLSEETDPFYGSFGTPEVLNKLIEMKHLGQKSKAGFYKKVGRD
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHCCHHHHHHHHH
ILRFDLAEGDYVPGGQKADEVYGRMLKKPAAERLKLLRNAEGAQGRFLWAILRNSFHYAA
HHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHH
VHLATIADNARDVDQAMRWGFGMKQGPFELWQEAGWLEVAKMIQEDIDAGKALSKAPLPE
HHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCH
WVFKGPVAEAGGVHTAEGSWSASKQKFVPRRQLPVYERQHFPEKLLGESNLPDWRTAGTT
HHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHCCCHHHCCCCCCCCCCCCCCC
VAESDALRTWTLDGKVLIASIQSKMHAISPDVMEGLMEAIDTAERDYDGLVIWSGDAPFS
EECCCCEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCC
VGADLQATMPAFVVAGVSAIEGVEQELQNLMLRLRYAQVPVVSAIHGMALGGGCELAVYS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHEECCCCEEEEEC
SRRVAHMESYIGLVEVGVGLVPGAGGLTYIARRAAENAAASTGKDLLPFLTEGFTAAAMA
CCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHH
KVGTSALESRKLGYLLESDIVVPHKDEVLFVALNEAKAMAASGWRAPNRRLFPVAGRSGI
HHHHHHHHHHHCCHHHHCCEECCCCCCEEEEEECCHHHHHHCCCCCCCCCEEEECCCCCH
ATIRGSLVNMRDGGFISDHDQHIATLIAEIVCGGDVDAGTLVSEEYLMALERKAFCALIQ
HHHHCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
HPKTQERILGMLNTGKPVRN
CCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]