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The map label for this gene is paaF [H]

Identifier: 120612720

GI number: 120612720

Start: 4535173

End: 4535946

Strand: Reverse

Name: paaF [H]

Synonym: Aave_4083

Alternate gene names: 120612720

Gene position: 4535946-4535173 (Counterclockwise)

Preceding gene: 120612721

Following gene: 120612719

Centisome position: 84.74

GC content: 67.44

Gene sequence:

>774_bases
ATGACCGCATCCCAGGACATCCTCACGCACGTCGAATCCGGCGTGACCACCATCACGTTCAACCGGGTGGACAAGAAGAA
CTCCATCACGCGCGCCATGTATGCCGCGCTGGCGGACGCCTTCGAGGCCGCGGCGCAGGATGTCGCCGTGCGCGTGGTGG
TGCTCCAGGGCGATGTGGCCATCTTCAGCGCCGGCAACGACATCGGGGATTTCCTCGACAATCCGCCTTCCACGCAGGAG
TCGCCGGTGTTCCGGTTCCTGCGGGCGATCGCCACGTTCCCGAAACCGGTGGTGGCGGCCGTGTGCGGCCCGGCGGTGGG
GATCGGCACGACCATGCTGCTGCACTGCGATCTCGTCTATGCTGGCGACAATGCGGCGTTCTCGATGCCGTTCGTGAACC
TGGGCCTGTGCCCCGAAGCCGGCTCCAGCCTGCTGGTGCCACGCATGATGGGCTACCACCGCGCCGCCGAGGCCCTGCTG
CTGGGCGAGCCGTTCATGGCCGAAGCCGCGCTCGAAGTGGGCCTCGTGAACCGCGTCGTGCCCCCGACGGAATGCAACAT
GGTGGCCCAGACGCAGGCGCGCAAGCTCGCGGCCAAGCCATTGTCGTCCCTCATCGAGACCAAGCGCCTCATGAAGAAAG
ACCAGACCGCGCCCCTGCTCGAGCGCATCGCCGAGGAAGGCGCCGTCTTCGGGCGGATGCTCCAGGAGCCGGCCGCCCGC
GAAGCCTTCACGGCGTTCATGCAAAAGCGCCGGCCCGACTTCAGCGCCAGCTGA

Upstream 100 bases:

>100_bases
AGTGCAGCTCTGGAACCAGGGCGGCACCATGCTCGCGAGCAGCCACCAGATCGTCTACTACAAAGAATGAATGAATAAAG
AAAGCGCAGGAGCATCGCCC

Downstream 100 bases:

>100_bases
ACGCGTTTCGCCCATCCCGGCGGGCGGCGTATCTCCGGGGTAACGATACGTGCCGAAAACGGCTGGTCGGCGCTACATTC
GGCGACATAGCCATCAACGG

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MTASQDILTHVESGVTTITFNRVDKKNSITRAMYAALADAFEAAAQDVAVRVVVLQGDVAIFSAGNDIGDFLDNPPSTQE
SPVFRFLRAIATFPKPVVAAVCGPAVGIGTTMLLHCDLVYAGDNAAFSMPFVNLGLCPEAGSSLLVPRMMGYHRAAEALL
LGEPFMAEAALEVGLVNRVVPPTECNMVAQTQARKLAAKPLSSLIETKRLMKKDQTAPLLERIAEEGAVFGRMLQEPAAR
EAFTAFMQKRRPDFSAS

Sequences:

>Translated_257_residues
MTASQDILTHVESGVTTITFNRVDKKNSITRAMYAALADAFEAAAQDVAVRVVVLQGDVAIFSAGNDIGDFLDNPPSTQE
SPVFRFLRAIATFPKPVVAAVCGPAVGIGTTMLLHCDLVYAGDNAAFSMPFVNLGLCPEAGSSLLVPRMMGYHRAAEALL
LGEPFMAEAALEVGLVNRVVPPTECNMVAQTQARKLAAKPLSSLIETKRLMKKDQTAPLLERIAEEGAVFGRMLQEPAAR
EAFTAFMQKRRPDFSAS
>Mature_256_residues
TASQDILTHVESGVTTITFNRVDKKNSITRAMYAALADAFEAAAQDVAVRVVVLQGDVAIFSAGNDIGDFLDNPPSTQES
PVFRFLRAIATFPKPVVAAVCGPAVGIGTTMLLHCDLVYAGDNAAFSMPFVNLGLCPEAGSSLLVPRMMGYHRAAEALLL
GEPFMAEAALEVGLVNRVVPPTECNMVAQTQARKLAAKPLSSLIETKRLMKKDQTAPLLERIAEEGAVFGRMLQEPAARE
AFTAFMQKRRPDFSAS

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI45643119, Length=243, Percent_Identity=35.8024691358025, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI260275230, Length=243, Percent_Identity=35.8024691358025, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI260274832, Length=243, Percent_Identity=35.8024691358025, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI4757968, Length=258, Percent_Identity=27.906976744186, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI49355787, Length=258, Percent_Identity=27.906976744186, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI25453481, Length=258, Percent_Identity=26.7441860465116, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI51538573, Length=258, Percent_Identity=26.7441860465116, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4757966, Length=183, Percent_Identity=31.1475409836066, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI51538581, Length=183, Percent_Identity=31.1475409836066, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI31542718, Length=251, Percent_Identity=29.4820717131474, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI221136756, Length=258, Percent_Identity=26.3565891472868, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI221136753, Length=258, Percent_Identity=26.3565891472868, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI221307494, Length=258, Percent_Identity=26.3565891472868, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI194097323, Length=244, Percent_Identity=29.5081967213115, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI116235487, Length=254, Percent_Identity=25.1968503937008, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI70995211, Length=192, Percent_Identity=28.6458333333333, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI68989263, Length=187, Percent_Identity=31.5508021390374, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI4502327, Length=259, Percent_Identity=26.6409266409266, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787659, Length=250, Percent_Identity=31.2, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1787660, Length=261, Percent_Identity=36.7816091954023, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788597, Length=253, Percent_Identity=30.8300395256917, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI87082183, Length=250, Percent_Identity=28.4, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI221142681, Length=245, Percent_Identity=29.7959183673469, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790281, Length=179, Percent_Identity=30.7262569832402, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1788682, Length=127, Percent_Identity=33.0708661417323, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17535521, Length=248, Percent_Identity=32.6612903225806, Blast_Score=121, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17549921, Length=177, Percent_Identity=38.9830508474576, Blast_Score=113, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17554946, Length=251, Percent_Identity=31.8725099601594, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI25145438, Length=254, Percent_Identity=30.7086614173228, Blast_Score=107, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17560910, Length=187, Percent_Identity=31.0160427807487, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17540714, Length=181, Percent_Identity=29.8342541436464, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17540306, Length=249, Percent_Identity=28.1124497991968, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17534483, Length=184, Percent_Identity=26.0869565217391, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17536985, Length=183, Percent_Identity=24.5901639344262, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17558304, Length=164, Percent_Identity=27.4390243902439, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323314, Length=233, Percent_Identity=24.0343347639485, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24654903, Length=257, Percent_Identity=30.7392996108949, Blast_Score=127, Evalue=5e-30,
Organism=Drosophila melanogaster, GI20129971, Length=247, Percent_Identity=29.9595141700405, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24653477, Length=247, Percent_Identity=29.9595141700405, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24653139, Length=257, Percent_Identity=30.7392996108949, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI19922422, Length=253, Percent_Identity=28.0632411067194, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21357171, Length=191, Percent_Identity=28.7958115183246, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI19920382, Length=183, Percent_Identity=25.1366120218579, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 27560; Mature: 27429

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASQDILTHVESGVTTITFNRVDKKNSITRAMYAALADAFEAAAQDVAVRVVVLQGDVA
CCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCEE
IFSAGNDIGDFLDNPPSTQESPVFRFLRAIATFPKPVVAAVCGPAVGIGTTMLLHCDLVY
EEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHEEEEE
AGDNAAFSMPFVNLGLCPEAGSSLLVPRMMGYHRAAEALLLGEPFMAEAALEVGLVNRVV
ECCCCEEECCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
PPTECNMVAQTQARKLAAKPLSSLIETKRLMKKDQTAPLLERIAEEGAVFGRMLQEPAAR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCHHHH
EAFTAFMQKRRPDFSAS
HHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TASQDILTHVESGVTTITFNRVDKKNSITRAMYAALADAFEAAAQDVAVRVVVLQGDVA
CCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCEE
IFSAGNDIGDFLDNPPSTQESPVFRFLRAIATFPKPVVAAVCGPAVGIGTTMLLHCDLVY
EEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHEEEEE
AGDNAAFSMPFVNLGLCPEAGSSLLVPRMMGYHRAAEALLLGEPFMAEAALEVGLVNRVV
ECCCCEEECCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
PPTECNMVAQTQARKLAAKPLSSLIETKRLMKKDQTAPLLERIAEEGAVFGRMLQEPAAR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCHHHH
EAFTAFMQKRRPDFSAS
HHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]