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The map label for this gene is kefC [H]

Identifier: 120612555

GI number: 120612555

Start: 4337973

End: 4339844

Strand: Direct

Name: kefC [H]

Synonym: Aave_3916

Alternate gene names: 120612555

Gene position: 4337973-4339844 (Clockwise)

Preceding gene: 120612551

Following gene: 120612556

Centisome position: 81.04

GC content: 71.9

Gene sequence:

>1872_bases
ATGGCCCACGCACCCACCTGGCTCACCTACGGATTCCTCTACCTCGGCGCCGCCGTACTGGCAGTGCCCATCGCGCGCGC
ACTCGGGCTCGGCGCCATCATCGGCTATCTCGCGGCCGGCATTGCCATCGGCCCGTGGGGCCTGGGCCTGGTGAGCAATG
TGCAGGACATCCTGCATTTCGCCGAGTTCGGCGTGGTGCTGATGCTGTTCCTCGTGGGGCTGGAGCTGCAGCCGAGCCGC
CTCTGGAGCCTGCGGCGGCCGATCTTCGGGCTCGGCAGCGCGCAGGTGCTGGGCTGCGCGGCCCTGCTGTGGGCGGTGGC
CTGGGCCTGCGGGCTGCCGTGGCGCGTGGCGCTGGTCGGGGCGCTGGGGCTGGCGCTGTCGTCCACCGCGATCGCGCTGC
AGGTGCTGGCCGAGCGCAACCTGATGCGCACGGACAGCGGGCAGAAGGCGTTCTCGATCCTGCTCTTCCAGGACGTGGCG
GCCATCCCCATCCTCGCGCTGCTGCCGCTGCTGGCCGCCGGCGCGGAGGGCGCGGGCGGCGCGGCGCAGCCCCACACGGC
CAGCGGCCTGGCGCTGGAGGCCGCGAAGATCGTCGGCGTGGTGGGCGGGATCGTGCTGGGCGGGCGCCTGCTGCTGCGCC
CGCTGCTGCGCTGGATCGCGCGCAGCCGCACGCCGGAGATCTTCACGGCCGCGGCGCTGCTGCTGGTGGTCGCCACGGCC
ATGCTGATGCTGGCCGTGGGCCTGTCGATGGCGCTGGGCGCCTTCCTCGCCGGCGTGCTGCTGGCCGAGAGCGAATACCG
CCGCGAGCTGGAAACCGACCTGGAGCCGTTCAAGGGCCTGCTGCTGGGCCTGTTCTTCATGGCCGTGGGCATGACCATCG
ACTTCGGCGTGCTGATGCGCTCGCCCTGGACCATGCTGGCGCTGCTGTTCGGCTTCCTTGCCGTGAAGGCGGTGGTGATC
CACACGCTCGCGCGCGCCACGGGCATGGCCTACCAGGAGCGGCCGGTGTTCACGCTGCTGCTGGCGCAGGGGGGCGAGTT
CGCGTTCGTGGTGTTCCAGACGGCCGCGGGCGCGGGGGCCATCCCGGCCGAGACGTCCTCGCTGCTCATCGGCGCGGTGG
CGCTGTCGATGCTGCTCAGCCCGCTGCTGCTCACCGCGCTCGACCGCGTGCTGCTGCGGCGCCATGCGCGCCTGGGCACC
GAGCCACCGCCGGACGTGGAGGAGATCTCCGAGCCGCAGGAAGCGCCGGTGATCATCGCGGGCTTCGGCCGGTACGGGCA
GATCGTGGCGCGCATGATGCTGGCGCAGGGCGTGCCGGCCACGGTGCTGGACCACAGCGTGGACATGCTGGAGGTGGCGC
ACACCTTCGGCTACCGCGTGTTCTACGGCGACGCCACGCGGCTGGACCTGCTGCGCATCGCGGGCGCGGCGCAGGCGCGC
GTGCTGGTGGTGGCGGTGGACGACACCGAGCAGTCGCTCAAGATCGTGAAGATCGCGCGCAAGCATTTTCCGCAGCTGCA
GATCGTGGCCCGCGCGCGCGACGTGACGCACTGGAACGCGCTGCGCGACCTGGGCGTGACGCGGGTCGAGCGCGAGGTGT
TCGAGTCCAGCCTGAAGACCGCGCGCACCGTGCTGGAGGTGATGGGCATGCCCGCCGCGCAGGCCGAGGCGCTGGCGAAC
CGCTTCCGCCACCACAACATCGCCCTGGCCGACCGCATGTACCCCCACCACAAGGACCGCGCGAAAATGATCGCCGTGGC
CCAGCAGGGCCGCCAGCAACTGGTGGAACAGATGGCCAAGGAGCGGCAGGAAATCGCCGCTGCCGCGGCGCAATCGGAGC
AAGGTGGGGGCCTGCCGCCGGGCAGGCACTGA

Upstream 100 bases:

>100_bases
TGGCCGCCGACACGGTGGAGCATGTTAACGGGCACAATGCGCCGGCGCCCCCCTCTTCCGCCTCCCCCTCCTCGTCCCTG
CCGCTGCCGACACCGCGTCC

Downstream 100 bases:

>100_bases
AGTCCCCTGAAAGGCCCGGGCTGGAACCGCAGGCCGCGGCTCGGCCTGCCCAGCGCATGGAAAAAAGGCCACGGCCCAGC
CCCGCAGGCTGCGAAAAATC

Product: glutathione-regulated potassium-efflux system protein KefC

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 623; Mature: 622

Protein sequence:

>623_residues
MAHAPTWLTYGFLYLGAAVLAVPIARALGLGAIIGYLAAGIAIGPWGLGLVSNVQDILHFAEFGVVLMLFLVGLELQPSR
LWSLRRPIFGLGSAQVLGCAALLWAVAWACGLPWRVALVGALGLALSSTAIALQVLAERNLMRTDSGQKAFSILLFQDVA
AIPILALLPLLAAGAEGAGGAAQPHTASGLALEAAKIVGVVGGIVLGGRLLLRPLLRWIARSRTPEIFTAAALLLVVATA
MLMLAVGLSMALGAFLAGVLLAESEYRRELETDLEPFKGLLLGLFFMAVGMTIDFGVLMRSPWTMLALLFGFLAVKAVVI
HTLARATGMAYQERPVFTLLLAQGGEFAFVVFQTAAGAGAIPAETSSLLIGAVALSMLLSPLLLTALDRVLLRRHARLGT
EPPPDVEEISEPQEAPVIIAGFGRYGQIVARMMLAQGVPATVLDHSVDMLEVAHTFGYRVFYGDATRLDLLRIAGAAQAR
VLVVAVDDTEQSLKIVKIARKHFPQLQIVARARDVTHWNALRDLGVTRVEREVFESSLKTARTVLEVMGMPAAQAEALAN
RFRHHNIALADRMYPHHKDRAKMIAVAQQGRQQLVEQMAKERQEIAAAAAQSEQGGGLPPGRH

Sequences:

>Translated_623_residues
MAHAPTWLTYGFLYLGAAVLAVPIARALGLGAIIGYLAAGIAIGPWGLGLVSNVQDILHFAEFGVVLMLFLVGLELQPSR
LWSLRRPIFGLGSAQVLGCAALLWAVAWACGLPWRVALVGALGLALSSTAIALQVLAERNLMRTDSGQKAFSILLFQDVA
AIPILALLPLLAAGAEGAGGAAQPHTASGLALEAAKIVGVVGGIVLGGRLLLRPLLRWIARSRTPEIFTAAALLLVVATA
MLMLAVGLSMALGAFLAGVLLAESEYRRELETDLEPFKGLLLGLFFMAVGMTIDFGVLMRSPWTMLALLFGFLAVKAVVI
HTLARATGMAYQERPVFTLLLAQGGEFAFVVFQTAAGAGAIPAETSSLLIGAVALSMLLSPLLLTALDRVLLRRHARLGT
EPPPDVEEISEPQEAPVIIAGFGRYGQIVARMMLAQGVPATVLDHSVDMLEVAHTFGYRVFYGDATRLDLLRIAGAAQAR
VLVVAVDDTEQSLKIVKIARKHFPQLQIVARARDVTHWNALRDLGVTRVEREVFESSLKTARTVLEVMGMPAAQAEALAN
RFRHHNIALADRMYPHHKDRAKMIAVAQQGRQQLVEQMAKERQEIAAAAAQSEQGGGLPPGRH
>Mature_622_residues
AHAPTWLTYGFLYLGAAVLAVPIARALGLGAIIGYLAAGIAIGPWGLGLVSNVQDILHFAEFGVVLMLFLVGLELQPSRL
WSLRRPIFGLGSAQVLGCAALLWAVAWACGLPWRVALVGALGLALSSTAIALQVLAERNLMRTDSGQKAFSILLFQDVAA
IPILALLPLLAAGAEGAGGAAQPHTASGLALEAAKIVGVVGGIVLGGRLLLRPLLRWIARSRTPEIFTAAALLLVVATAM
LMLAVGLSMALGAFLAGVLLAESEYRRELETDLEPFKGLLLGLFFMAVGMTIDFGVLMRSPWTMLALLFGFLAVKAVVIH
TLARATGMAYQERPVFTLLLAQGGEFAFVVFQTAAGAGAIPAETSSLLIGAVALSMLLSPLLLTALDRVLLRRHARLGTE
PPPDVEEISEPQEAPVIIAGFGRYGQIVARMMLAQGVPATVLDHSVDMLEVAHTFGYRVFYGDATRLDLLRIAGAAQARV
LVVAVDDTEQSLKIVKIARKHFPQLQIVARARDVTHWNALRDLGVTRVEREVFESSLKTARTVLEVMGMPAAQAEALANR
FRHHNIALADRMYPHHKDRAKMIAVAQQGRQQLVEQMAKERQEIAAAAAQSEQGGGLPPGRH

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=408, Percent_Identity=28.6764705882353, Blast_Score=83, Evalue=6e-16,
Organism=Escherichia coli, GI1786232, Length=616, Percent_Identity=48.3766233766234, Blast_Score=537, Evalue=1e-154,
Organism=Escherichia coli, GI1789749, Length=602, Percent_Identity=45.8471760797342, Blast_Score=481, Evalue=1e-137,
Organism=Escherichia coli, GI1786685, Length=544, Percent_Identity=28.3088235294118, Blast_Score=164, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 66491; Mature: 66359

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHAPTWLTYGFLYLGAAVLAVPIARALGLGAIIGYLAAGIAIGPWGLGLVSNVQDILHF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AEFGVVLMLFLVGLELQPSRLWSLRRPIFGLGSAQVLGCAALLWAVAWACGLPWRVALVG
HHHHHHHHHHHHCCCCCHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHH
ALGLALSSTAIALQVLAERNLMRTDSGQKAFSILLFQDVAAIPILALLPLLAAGAEGAGG
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
AAQPHTASGLALEAAKIVGVVGGIVLGGRLLLRPLLRWIARSRTPEIFTAAALLLVVATA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
MLMLAVGLSMALGAFLAGVLLAESEYRRELETDLEPFKGLLLGLFFMAVGMTIDFGVLMR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SPWTMLALLFGFLAVKAVVIHTLARATGMAYQERPVFTLLLAQGGEFAFVVFQTAAGAGA
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCC
IPAETSSLLIGAVALSMLLSPLLLTALDRVLLRRHARLGTEPPPDVEEISEPQEAPVIIA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCEEEE
GFGRYGQIVARMMLAQGVPATVLDHSVDMLEVAHTFGYRVFYGDATRLDLLRIAGAAQAR
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHCCCCCE
VLVVAVDDTEQSLKIVKIARKHFPQLQIVARARDVTHWNALRDLGVTRVEREVFESSLKT
EEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARTVLEVMGMPAAQAEALANRFRHHNIALADRMYPHHKDRAKMIAVAQQGRQQLVEQMAK
HHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ERQEIAAAAAQSEQGGGLPPGRH
HHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
AHAPTWLTYGFLYLGAAVLAVPIARALGLGAIIGYLAAGIAIGPWGLGLVSNVQDILHF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AEFGVVLMLFLVGLELQPSRLWSLRRPIFGLGSAQVLGCAALLWAVAWACGLPWRVALVG
HHHHHHHHHHHHCCCCCHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHH
ALGLALSSTAIALQVLAERNLMRTDSGQKAFSILLFQDVAAIPILALLPLLAAGAEGAGG
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
AAQPHTASGLALEAAKIVGVVGGIVLGGRLLLRPLLRWIARSRTPEIFTAAALLLVVATA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
MLMLAVGLSMALGAFLAGVLLAESEYRRELETDLEPFKGLLLGLFFMAVGMTIDFGVLMR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SPWTMLALLFGFLAVKAVVIHTLARATGMAYQERPVFTLLLAQGGEFAFVVFQTAAGAGA
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCC
IPAETSSLLIGAVALSMLLSPLLLTALDRVLLRRHARLGTEPPPDVEEISEPQEAPVIIA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCEEEE
GFGRYGQIVARMMLAQGVPATVLDHSVDMLEVAHTFGYRVFYGDATRLDLLRIAGAAQAR
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHCCCCCE
VLVVAVDDTEQSLKIVKIARKHFPQLQIVARARDVTHWNALRDLGVTRVEREVFESSLKT
EEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARTVLEVMGMPAAQAEALANRFRHHNIALADRMYPHHKDRAKMIAVAQQGRQQLVEQMAK
HHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ERQEIAAAAAQSEQGGGLPPGRH
HHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA