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The map label for this gene is degS [H]

Identifier: 120612504

GI number: 120612504

Start: 4289070

End: 4290410

Strand: Direct

Name: degS [H]

Synonym: Aave_3863

Alternate gene names: 120612504

Gene position: 4289070-4290410 (Clockwise)

Preceding gene: 120612502

Following gene: 120612505

Centisome position: 80.13

GC content: 66.22

Gene sequence:

>1341_bases
ATGCGCTGGTCCAATTTTCGCAAGATGGCCGTCAGCCTGCCCCTGGCGCTGCTGGCAGCCGCTGCGTTGGTTGGCATCAA
TGAAGCCGGATACGCACGGTCCAACGAGGCCGTGCGCGCACTGTCGAGCACCTACACGACCCGGGCCGCGCTCAACCGCA
TGATGCAGAACATGCTGGACGCGGAAACGGGCCTGCGCGGCTACCTGCTCACGGGCGACGACCGCTATCTCCAGCCCTAC
CAGAAGGCGGCAGCCACCATCGATGCCAATCTCGAGGAGCTGCGGAGCATCTACCGGGACTCCCCCGAAGACCAGGAAGA
CTTCACGCAGCTCTCCCGGCAGATCTCCCGCAAGATGTCCGAACTGGACCTGAGCCTGCGCCTGCGCCGCCAGAACAACG
ACGACGCATGGAAGTTCGTCCTCTCCACCGATGTCGGCAAGGAGAACATGGATGCCATCCGCACGCTGTCCGGCCGCCTC
GCGCAGCGCAGCGCGGACCGCTCCACGCACCACACCGACGAGATCCTCCACTCGCTCACGCTTTCGCGCATCGGCATCGC
TACCGTCGTGGTGATCGGCCTGCTCGCGTTCTACATGTACCTGCGCCAGGCCAGCGCCCTGCAAACCGCCCAGGAACGGG
AGCAGCAGGCCCTGCAGCGCGAGCGCGACCGGCTGGAACTGCTGGTGCGCGAACGCACCGCGTCGCTGACCGAACTGGCG
AACCACCTGCAGCAGGTGCGCGAGGACGAGCGGGGCCACCTGGCCCGGGAACTGCACGACGAGCTGGGAGCGCTGCTCAC
CGCGGCCAAGCTCGACGTCGCGCGGCTGAAGTCGAAGATCGATGCCCAGTCGCCCGAGATCGCCGAGCGGCTCAAGCACC
TCACCGAAACCCTGAACAGCGGCATCGCCCTCAAGCGCAGGATCATCGAAGACCTCCGGCCTTCGTCCCTTTTCAACCTG
GGGCTCACCGCATCGCTGGAGATCCTGGCGCGCGAATTCGAGCAGCGCAGCAGCGTGGAGGTGGAACTCAACCTCGAGCC
GGTGGAACTGCCGGAGGCTGTGCAGCTCACGATCTACCGGATGGTGCAGGAGTCGCTGACCAACATCGGCAAGTACGCCA
ATGCCACCAAGGTGCTGGTGGCCGTGCACAACTATCCCACCCATGTGGCGGTACAGATCCGCGACAACGGCTCCGGCTTC
GACACCAGCAAGGTGCACGCCTCCGCCCACGGGCTCATGGGTATGCGCCACCGCGTCGAGGCCGCCGGCGGGCGCCTGAC
GGTGACCTCCGAGGCCAACGAAGGCACGCTCGTTTCCGCGGTGCTGCCCGTCGTGCACTGA

Upstream 100 bases:

>100_bases
GGTGGCCCATCCACCGTTGCGGGAGCGTGCCTGCAGCGATCGCCGCAGGCTGGTGACATTATCCAGAATTCACCCCCATC
TCTTTCGGAGAAACATACAT

Downstream 100 bases:

>100_bases
ATGCTGGGGCGCGCCAGCGCGCGTCCCTTCACCGCCGGCTCCGTGCCGGTGTCCAGCGCTTCTCCTACCGTTTCCCCCGG
CTTCTTCCTCCCGTCTCCTG

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MRWSNFRKMAVSLPLALLAAAALVGINEAGYARSNEAVRALSSTYTTRAALNRMMQNMLDAETGLRGYLLTGDDRYLQPY
QKAAATIDANLEELRSIYRDSPEDQEDFTQLSRQISRKMSELDLSLRLRRQNNDDAWKFVLSTDVGKENMDAIRTLSGRL
AQRSADRSTHHTDEILHSLTLSRIGIATVVVIGLLAFYMYLRQASALQTAQEREQQALQRERDRLELLVRERTASLTELA
NHLQQVREDERGHLARELHDELGALLTAAKLDVARLKSKIDAQSPEIAERLKHLTETLNSGIALKRRIIEDLRPSSLFNL
GLTASLEILAREFEQRSSVEVELNLEPVELPEAVQLTIYRMVQESLTNIGKYANATKVLVAVHNYPTHVAVQIRDNGSGF
DTSKVHASAHGLMGMRHRVEAAGGRLTVTSEANEGTLVSAVLPVVH

Sequences:

>Translated_446_residues
MRWSNFRKMAVSLPLALLAAAALVGINEAGYARSNEAVRALSSTYTTRAALNRMMQNMLDAETGLRGYLLTGDDRYLQPY
QKAAATIDANLEELRSIYRDSPEDQEDFTQLSRQISRKMSELDLSLRLRRQNNDDAWKFVLSTDVGKENMDAIRTLSGRL
AQRSADRSTHHTDEILHSLTLSRIGIATVVVIGLLAFYMYLRQASALQTAQEREQQALQRERDRLELLVRERTASLTELA
NHLQQVREDERGHLARELHDELGALLTAAKLDVARLKSKIDAQSPEIAERLKHLTETLNSGIALKRRIIEDLRPSSLFNL
GLTASLEILAREFEQRSSVEVELNLEPVELPEAVQLTIYRMVQESLTNIGKYANATKVLVAVHNYPTHVAVQIRDNGSGF
DTSKVHASAHGLMGMRHRVEAAGGRLTVTSEANEGTLVSAVLPVVH
>Mature_446_residues
MRWSNFRKMAVSLPLALLAAAALVGINEAGYARSNEAVRALSSTYTTRAALNRMMQNMLDAETGLRGYLLTGDDRYLQPY
QKAAATIDANLEELRSIYRDSPEDQEDFTQLSRQISRKMSELDLSLRLRRQNNDDAWKFVLSTDVGKENMDAIRTLSGRL
AQRSADRSTHHTDEILHSLTLSRIGIATVVVIGLLAFYMYLRQASALQTAQEREQQALQRERDRLELLVRERTASLTELA
NHLQQVREDERGHLARELHDELGALLTAAKLDVARLKSKIDAQSPEIAERLKHLTETLNSGIALKRRIIEDLRPSSLFNL
GLTASLEILAREFEQRSSVEVELNLEPVELPEAVQLTIYRMVQESLTNIGKYANATKVLVAVHNYPTHVAVQIRDNGSGF
DTSKVHASAHGLMGMRHRVEAAGGRLTVTSEANEGTLVSAVLPVVH

Specific function: Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=198, Percent_Identity=27.7777777777778, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788812, Length=202, Percent_Identity=29.2079207920792, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI87082311, Length=209, Percent_Identity=31.1004784688995, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49865; Mature: 49865

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRWSNFRKMAVSLPLALLAAAALVGINEAGYARSNEAVRALSSTYTTRAALNRMMQNMLD
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AETGLRGYLLTGDDRYLQPYQKAAATIDANLEELRSIYRDSPEDQEDFTQLSRQISRKMS
HHCCCCEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
ELDLSLRLRRQNNDDAWKFVLSTDVGKENMDAIRTLSGRLAQRSADRSTHHTDEILHSLT
HHHHHHHEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
LSRIGIATVVVIGLLAFYMYLRQASALQTAQEREQQALQRERDRLELLVRERTASLTELA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NHLQQVREDERGHLARELHDELGALLTAAKLDVARLKSKIDAQSPEIAERLKHLTETLNS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
GIALKRRIIEDLRPSSLFNLGLTASLEILAREFEQRSSVEVELNLEPVELPEAVQLTIYR
CHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHH
MVQESLTNIGKYANATKVLVAVHNYPTHVAVQIRDNGSGFDTSKVHASAHGLMGMRHRVE
HHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
AAGGRLTVTSEANEGTLVSAVLPVVH
HCCCEEEEECCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MRWSNFRKMAVSLPLALLAAAALVGINEAGYARSNEAVRALSSTYTTRAALNRMMQNMLD
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AETGLRGYLLTGDDRYLQPYQKAAATIDANLEELRSIYRDSPEDQEDFTQLSRQISRKMS
HHCCCCEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
ELDLSLRLRRQNNDDAWKFVLSTDVGKENMDAIRTLSGRLAQRSADRSTHHTDEILHSLT
HHHHHHHEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
LSRIGIATVVVIGLLAFYMYLRQASALQTAQEREQQALQRERDRLELLVRERTASLTELA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NHLQQVREDERGHLARELHDELGALLTAAKLDVARLKSKIDAQSPEIAERLKHLTETLNS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
GIALKRRIIEDLRPSSLFNLGLTASLEILAREFEQRSSVEVELNLEPVELPEAVQLTIYR
CHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHH
MVQESLTNIGKYANATKVLVAVHNYPTHVAVQIRDNGSGFDTSKVHASAHGLMGMRHRVE
HHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
AAGGRLTVTSEANEGTLVSAVLPVVH
HCCCEEEEECCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7765823 [H]