Click here to switch to the map view.

The map label for this gene is uvrY [H]

Identifier: 120612503

GI number: 120612503

Start: 4288292

End: 4288924

Strand: Reverse

Name: uvrY [H]

Synonym: Aave_3862

Alternate gene names: 120612503

Gene position: 4288924-4288292 (Counterclockwise)

Preceding gene: 120612510

Following gene: 120612498

Centisome position: 80.13

GC content: 62.24

Gene sequence:

>633_bases
ATGATCAAGATCGGCATTGTGGATGACCATGCGATTGTCCGCTCGGGATTGCGACAATTTCTGTCAGAACATGTAGACCT
TCGCGTAGTCGGCGAGGCCGCGAACGGCCGCGAAGCCATCGACCTCGTGCGCAACCACGAGATCGACGTGCTGCTGATGG
ACCTGTCGATGCCCGGCCAGAGCGGCCTCGATGCGCTGGCCATGCTGCGTGCGAAAGCGCCGGACATGGGCATCCTCATC
CTGAGCGGGTACCCCGAGGAACACTACGCGATCAACCTCATTCGCCAGGGCGCCAGCGGCTACCTGAACAAGGAATGCGA
CCCCAAGGAGATCGTGGAGGCCATCCGCACCATCTCGCTGGGCCGCCGCTACCTCACGCCGGCCGTCGCGGACCTGCTCG
CGCAACAGCTCAATCGCAAGGACGACGCGCCTCCGCACGAGCAGTTGTCCGAGCGTGAATTCCAGGTCTTCCTGAAGCTG
GCCAAGGGCGAGACAGCGGGCGACATCGCCAAGTCGCTGTCCCTCAGCGTCAAGACCGTGAGCACGTACCGCACGCGCCT
GATGGAGAAGATGGCGCTGTCGTCCAACAGCGACCTGACCTACTACGCGCTGAAGAACAAGCTGATCGATTGA

Upstream 100 bases:

>100_bases
CACCAGCCTGCGGCGATCGCTGCAGGCACGCTCCCGCAACGGTGGATGGGCCACCTGACCAACGATGGGCAGCCCAGCTG
CCTCTTGAAAGAAACTCTCA

Downstream 100 bases:

>100_bases
TCGCCGGCTGTGGAAAGCGTCCCGGCGTAACCGATTCGCGAGGCCCCGGGCGCTTCCCTTCCGGCCATTGGCGCGGCCCG
CCTGGCGGGCGGCGGCATGG

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MIKIGIVDDHAIVRSGLRQFLSEHVDLRVVGEAANGREAIDLVRNHEIDVLLMDLSMPGQSGLDALAMLRAKAPDMGILI
LSGYPEEHYAINLIRQGASGYLNKECDPKEIVEAIRTISLGRRYLTPAVADLLAQQLNRKDDAPPHEQLSEREFQVFLKL
AKGETAGDIAKSLSLSVKTVSTYRTRLMEKMALSSNSDLTYYALKNKLID

Sequences:

>Translated_210_residues
MIKIGIVDDHAIVRSGLRQFLSEHVDLRVVGEAANGREAIDLVRNHEIDVLLMDLSMPGQSGLDALAMLRAKAPDMGILI
LSGYPEEHYAINLIRQGASGYLNKECDPKEIVEAIRTISLGRRYLTPAVADLLAQQLNRKDDAPPHEQLSEREFQVFLKL
AKGETAGDIAKSLSLSVKTVSTYRTRLMEKMALSSNSDLTYYALKNKLID
>Mature_210_residues
MIKIGIVDDHAIVRSGLRQFLSEHVDLRVVGEAANGREAIDLVRNHEIDVLLMDLSMPGQSGLDALAMLRAKAPDMGILI
LSGYPEEHYAINLIRQGASGYLNKECDPKEIVEAIRTISLGRRYLTPAVADLLAQQLNRKDDAPPHEQLSEREFQVFLKL
AKGETAGDIAKSLSLSVKTVSTYRTRLMEKMALSSNSDLTYYALKNKLID

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=211, Percent_Identity=36.9668246445498, Blast_Score=158, Evalue=2e-40,
Organism=Escherichia coli, GI1790102, Length=199, Percent_Identity=39.1959798994975, Blast_Score=127, Evalue=4e-31,
Organism=Escherichia coli, GI1788521, Length=206, Percent_Identity=35.9223300970874, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1788712, Length=203, Percent_Identity=30.0492610837438, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787473, Length=182, Percent_Identity=33.5164835164835, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1786747, Length=198, Percent_Identity=28.2828282828283, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI87082052, Length=107, Percent_Identity=40.1869158878505, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788546, Length=202, Percent_Identity=26.7326732673267, Blast_Score=68, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23289; Mature: 23289

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKIGIVDDHAIVRSGLRQFLSEHVDLRVVGEAANGREAIDLVRNHEIDVLLMDLSMPGQ
CEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCEEEEEEECCCCC
SGLDALAMLRAKAPDMGILILSGYPEEHYAINLIRQGASGYLNKECDPKEIVEAIRTISL
CCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
GRRYLTPAVADLLAQQLNRKDDAPPHEQLSEREFQVFLKLAKGETAGDIAKSLSLSVKTV
CHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
STYRTRLMEKMALSSNSDLTYYALKNKLID
HHHHHHHHHHHHHCCCCCEEEEEEHHHCCC
>Mature Secondary Structure
MIKIGIVDDHAIVRSGLRQFLSEHVDLRVVGEAANGREAIDLVRNHEIDVLLMDLSMPGQ
CEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCEEEEEEECCCCC
SGLDALAMLRAKAPDMGILILSGYPEEHYAINLIRQGASGYLNKECDPKEIVEAIRTISL
CCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
GRRYLTPAVADLLAQQLNRKDDAPPHEQLSEREFQVFLKLAKGETAGDIAKSLSLSVKTV
CHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
STYRTRLMEKMALSSNSDLTYYALKNKLID
HHHHHHHHHHHHHCCCCCEEEEEEHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]