Click here to switch to the map view.

The map label for this gene is bioF

Identifier: 120612484

GI number: 120612484

Start: 4270953

End: 4272191

Strand: Direct

Name: bioF

Synonym: Aave_3843

Alternate gene names: 120612484

Gene position: 4270953-4272191 (Clockwise)

Preceding gene: 120612483

Following gene: 120612485

Centisome position: 79.79

GC content: 74.09

Gene sequence:

>1239_bases
ATGACGACCTTTCCCTTCGCTCCCTCCTGGCTCGACGAACTGCCCGCCCGCCTGGCGGAACTCGACGCCGTCCACCTGCG
CCGCCGCCGGCGCACGGTGCGGCCGCTGCAGGGCGCGCACCTGGACGTGGACGGGCAGCCCATGCTGGCCTTCTGCAGCA
ACGACTACCTGGGGCTGGCCGGACATCCCGCGCTCGCCGATGCCGCCTGTGCGGGCGCGCGCGAATTCGGCGTGGGATCG
GGCGGCTCGCCGCTGGTGAGCGGCCACAGCCAGGCCAATGCCGCGCTGGAGGCCGACCTCGCGCGCTTCGTGCAGTTGCC
CCGGGCGCTCTACTTCTATGCCGGCTACGCGACCAACACCGGCATCGTGCCGGCGCTGGTGGGCGCGGGCGACGCGCTGT
TTTCGGATGCGCTCAACCATGCCTGCCTGATCGACGGGGCACGCCTTTCGCGCGCCACCATCCACCGCTACCCCCACGGC
GACCTCGCCGCGCTCGAAGCCCTGCTCGCTGCCAGTCCCGCGCGGCGCAAGCTCGTGGTCAGCGATGCGGTCTTCAGCAT
GGACGGCGACGTGGCCGACATCCGCACGCTGCATGCGCTCTGCGAGCGCCACGACGCGCTGCTGCTGCTCGACGATGCCC
ACGGCTTCGGCGTGCTCGGCCCGCAGGGCCGCGGCGCACTCGCCGAGGCGGGCCTGACCGGGCAGCGGGCGTCGCAGCGC
GTGCTCTACATGGCCACGCTGGGCAAGGCGGCAGGCGCCGCCGGGGCCTTCGTCGCCGGCAGCGAAGTCCTCATCGAATG
GCTGCTGCAGAAAACGCGCAGCTACATCTTCGCCACCGCCGCGCCCGCCCTGCTGGCGCGCACGCTCCAGGCCAGCCTCG
GCCTCATCGAGCGCGGGGACGCGCTGCGCGCCCACCTCGATGCCCGCATCGCGCAACTGCGCGCGGGCCTCGTTCCCGTG
CTGCAGGGCACGCACTGGGAACTGGGCACGTCGCGCACCGCCGTCCAGGCGCTCGTGATCGGCGCCAACGACGAGGCGCT
GGCCGCCATGGAAGCGCTGCGCGCGCGGGGCCTGTGGGTGCCCGCGATCCGCCCGCCGACGGTGCCGGAGGGCACGGCGC
GGCTGCGCATCGCCCTCTCGGCGGCCCACACCGAGGCGGACGTGGCCCGGCTCGTGGATGCGCTGGCCGACATCGCCCCC
ACCGCCCGATCCGCACTGCCCCAGGAGGCCGCCGCATGA

Upstream 100 bases:

>100_bases
GCCTGCGGGCGCCCCTGCTCGCAGACATCCCGCACCAGCGGCAGCCCGACCCGCGCGCCACGCCGTTCGCGCTGCCCGAC
TCCTGGACCACGCCCTCCGC

Downstream 100 bases:

>100_bases
CCTACAGCGTCAAGGAAATCTTCTACACCCTGCAGGGCGAAGGCGGCCAGGCCGGCATGCCCGCCGTGTTCTGCCGCTTC
GCCGGCTGCAACCTCTGGAG

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MTTFPFAPSWLDELPARLAELDAVHLRRRRRTVRPLQGAHLDVDGQPMLAFCSNDYLGLAGHPALADAACAGAREFGVGS
GGSPLVSGHSQANAALEADLARFVQLPRALYFYAGYATNTGIVPALVGAGDALFSDALNHACLIDGARLSRATIHRYPHG
DLAALEALLAASPARRKLVVSDAVFSMDGDVADIRTLHALCERHDALLLLDDAHGFGVLGPQGRGALAEAGLTGQRASQR
VLYMATLGKAAGAAGAFVAGSEVLIEWLLQKTRSYIFATAAPALLARTLQASLGLIERGDALRAHLDARIAQLRAGLVPV
LQGTHWELGTSRTAVQALVIGANDEALAAMEALRARGLWVPAIRPPTVPEGTARLRIALSAAHTEADVARLVDALADIAP
TARSALPQEAAA

Sequences:

>Translated_412_residues
MTTFPFAPSWLDELPARLAELDAVHLRRRRRTVRPLQGAHLDVDGQPMLAFCSNDYLGLAGHPALADAACAGAREFGVGS
GGSPLVSGHSQANAALEADLARFVQLPRALYFYAGYATNTGIVPALVGAGDALFSDALNHACLIDGARLSRATIHRYPHG
DLAALEALLAASPARRKLVVSDAVFSMDGDVADIRTLHALCERHDALLLLDDAHGFGVLGPQGRGALAEAGLTGQRASQR
VLYMATLGKAAGAAGAFVAGSEVLIEWLLQKTRSYIFATAAPALLARTLQASLGLIERGDALRAHLDARIAQLRAGLVPV
LQGTHWELGTSRTAVQALVIGANDEALAAMEALRARGLWVPAIRPPTVPEGTARLRIALSAAHTEADVARLVDALADIAP
TARSALPQEAAA
>Mature_411_residues
TTFPFAPSWLDELPARLAELDAVHLRRRRRTVRPLQGAHLDVDGQPMLAFCSNDYLGLAGHPALADAACAGAREFGVGSG
GSPLVSGHSQANAALEADLARFVQLPRALYFYAGYATNTGIVPALVGAGDALFSDALNHACLIDGARLSRATIHRYPHGD
LAALEALLAASPARRKLVVSDAVFSMDGDVADIRTLHALCERHDALLLLDDAHGFGVLGPQGRGALAEAGLTGQRASQRV
LYMATLGKAAGAAGAFVAGSEVLIEWLLQKTRSYIFATAAPALLARTLQASLGLIERGDALRAHLDARIAQLRAGLVPVL
QGTHWELGTSRTAVQALVIGANDEALAAMEALRARGLWVPAIRPPTVPEGTARLRIALSAAHTEADVARLVDALADIAPT
ARSALPQEAAA

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily

Homologues:

Organism=Homo sapiens, GI7657118, Length=375, Percent_Identity=33.6, Blast_Score=212, Evalue=6e-55,
Organism=Homo sapiens, GI284448556, Length=353, Percent_Identity=33.7110481586402, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI4758668, Length=363, Percent_Identity=29.7520661157025, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI83977442, Length=357, Percent_Identity=29.9719887955182, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI83977444, Length=357, Percent_Identity=29.9719887955182, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI83977440, Length=357, Percent_Identity=29.9719887955182, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI119220554, Length=364, Percent_Identity=29.6703296703297, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI4502025, Length=380, Percent_Identity=28.6842105263158, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI40316939, Length=380, Percent_Identity=28.6842105263158, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI5454084, Length=286, Percent_Identity=27.2727272727273, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1786993, Length=360, Percent_Identity=41.9444444444444, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI1790046, Length=399, Percent_Identity=34.8370927318296, Blast_Score=220, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI71994529, Length=402, Percent_Identity=31.8407960199005, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI32566772, Length=368, Percent_Identity=26.9021739130435, Blast_Score=131, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI17560912, Length=384, Percent_Identity=25, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17560914, Length=384, Percent_Identity=25, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71982625, Length=386, Percent_Identity=22.7979274611399, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI71982617, Length=386, Percent_Identity=22.7979274611399, Blast_Score=101, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6320438, Length=413, Percent_Identity=30.9927360774818, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6320267, Length=374, Percent_Identity=26.7379679144385, Blast_Score=129, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6323954, Length=258, Percent_Identity=25.1937984496124, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24662918, Length=372, Percent_Identity=31.7204301075269, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI17137420, Length=360, Percent_Identity=29.1666666666667, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI17136286, Length=371, Percent_Identity=27.4932614555256, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24653280, Length=303, Percent_Identity=26.4026402640264, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24653276, Length=303, Percent_Identity=26.4026402640264, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24653278, Length=303, Percent_Identity=26.4026402640264, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIOF_ACIAC (A1TTV0)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_972162.1
- ProteinModelPortal:   A1TTV0
- STRING:   A1TTV0
- GeneID:   4668027
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_3843
- NMPDR:   fig|397945.5.peg.3278
- eggNOG:   COG0156
- HOGENOM:   HBG649839
- OMA:   NISSPRI
- PhylomeDB:   A1TTV0
- ProtClustDB:   CLSK953000
- BioCyc:   AAVE397945:AAVE_3843-MONOMER
- HAMAP:   MF_01693
- InterPro:   IPR022834
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR00858

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.3.1.47

Molecular weight: Translated: 43117; Mature: 42986

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: BINDING 28-28 BINDING 140-140 BINDING 186-186 BINDING 367-367

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTFPFAPSWLDELPARLAELDAVHLRRRRRTVRPLQGAHLDVDGQPMLAFCSNDYLGLA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCEEEEECCCCCCCC
GHPALADAACAGAREFGVGSGGSPLVSGHSQANAALEADLARFVQLPRALYFYAGYATNT
CCCHHHHHHHCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GIVPALVGAGDALFSDALNHACLIDGARLSRATIHRYPHGDLAALEALLAASPARRKLVV
CCHHHHHCCCHHHHHHHCCCEEEECCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEE
SDAVFSMDGDVADIRTLHALCERHDALLLLDDAHGFGVLGPQGRGALAEAGLTGQRASQR
EHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHCCCCCCHHHCE
VLYMATLGKAAGAAGAFVAGSEVLIEWLLQKTRSYIFATAAPALLARTLQASLGLIERGD
EEEEEHHCHHCCCCCHHHCCHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHCHHHCCC
ALRAHLDARIAQLRAGLVPVLQGTHWELGTSRTAVQALVIGANDEALAAMEALRARGLWV
HHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCHHEEEEEEECCCCHHHHHHHHHHHCCCCC
PAIRPPTVPEGTARLRIALSAAHTEADVARLVDALADIAPTARSALPQEAAA
CCCCCCCCCCCCCEEEEEEEHHCCHHHHHHHHHHHHHHCHHHHHCCCHHCCC
>Mature Secondary Structure 
TTFPFAPSWLDELPARLAELDAVHLRRRRRTVRPLQGAHLDVDGQPMLAFCSNDYLGLA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCEEEEECCCCCCCC
GHPALADAACAGAREFGVGSGGSPLVSGHSQANAALEADLARFVQLPRALYFYAGYATNT
CCCHHHHHHHCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GIVPALVGAGDALFSDALNHACLIDGARLSRATIHRYPHGDLAALEALLAASPARRKLVV
CCHHHHHCCCHHHHHHHCCCEEEECCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEE
SDAVFSMDGDVADIRTLHALCERHDALLLLDDAHGFGVLGPQGRGALAEAGLTGQRASQR
EHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHCCCCCCHHHCE
VLYMATLGKAAGAAGAFVAGSEVLIEWLLQKTRSYIFATAAPALLARTLQASLGLIERGD
EEEEEHHCHHCCCCCHHHCCHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHCHHHCCC
ALRAHLDARIAQLRAGLVPVLQGTHWELGTSRTAVQALVIGANDEALAAMEALRARGLWV
HHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCHHEEEEEEECCCCHHHHHHHHHHHCCCCC
PAIRPPTVPEGTARLRIALSAAHTEADVARLVDALADIAPTARSALPQEAAA
CCCCCCCCCCCCCEEEEEEEHHCCHHHHHHHHHHHHHHCHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA