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The map label for this gene is tycC [H]

Identifier: 120612372

GI number: 120612372

Start: 4118230

End: 4122336

Strand: Reverse

Name: tycC [H]

Synonym: Aave_3729

Alternate gene names: 120612372

Gene position: 4122336-4118230 (Counterclockwise)

Preceding gene: 120612373

Following gene: 120612367

Centisome position: 77.01

GC content: 75.48

Gene sequence:

>4107_bases
ATGACCACCGAAATGCACGAGCTCTCGCGCCGCTTCGCGGCCCTCACCCCTGACAAGCGCCAGGTGTTCCTGGAGCGGCT
GCGTGCCAGCGGCATCGGCTTCGAGGCGCTGCCCGTGGTGCCCAGGGCCGCCGCCGGCGAAGCCCCCATGGCCTATGCCC
AGCGGCCCCTGTGGCTCGCCTGGCAGCGCGATCCCGCCTCGCCCGCCTACAACCTCGCCGGCCGCATGGCGCTGCCCGGC
TCGCCGGATGCCGCCGCGGTGCACCGCGCCCTGGCCACGCTGGTGGCGCGCCACGCCGCGCTGCACACCTGCTTCGGCTG
CGACGCGCAGGACCAGCCGGTGCAGCGGGAAGACCCGCAGCAGCGCTTCGGCTGGTCGGTGCGCGAATGGAGCATGCCGC
GCGACCAGGCGCAGGAGGCCCTGGCCGCGCAGGCGCAGGCCTTCGCCATGGAACCCTTCGACCTGGAGCGCGGCCCCGTC
TTTCGCGCCTGCCTGCACGTCTTCCCCGAAGGCGCGCCCGAGCTGGTGCTCTGCGTGCACCACATCGCGGCCGACGGGCA
GTCCATCGGGCTGCTGCTGTCCGAATTGCGCGCGCTGCTCGCCGCACCGGGCGAAGCGGCGCCAGCCCCGGCGGCGCCGG
GCGCGGCAGCGCTGGGCTATGCGGATTACGCCGCCTGGCAGCGCCACTGGATGGAAGCCGGGGAGCTGCAGCGCCAGATC
GGCCACTGGCGCGAACGCCTGCGCGACGCGCCGCTGGCGACCGCGCTGCCGCTGGACCGGCCGCGCACCGCCCGGCGCGG
CACGCAGGGCGGCATGGTCCATGCGGTGCTGGACGAGTCCGTGTCCGCCTCGCTGCGCGCGCTGGGCCGCGCGCATGCGG
CCTCGCCCTACCTGGTGTGCCTGTCCCTGCTCGGGCTGCTGCTGCACCGCCTGGACGGCCAGGACGACCTGTGCATCGGC
GTGCCCACCACCACGCGCGACCGGCCCGAACTGGCCGGCGTGGTGGGGCATTTCACCAACGTGCTGGTGCTGCGGCTGCA
GGCCGACCGGGACTGGTCCTTCGCGCGGTGGCTGGAGCACGTGCGCGACCGCTTCGTCGAGGCCAAGGCGCACCAGGAAG
TGCCGCTGGACATGCTGGTGGATGCGCTCCCGGTGCCGCGCGTACCCGGCCTGCATCCGCTGTTCCAGGTCAAGTCCACC
CAGCAGCAGGCCGCCCCGCGCGGGGCGCGGCAGCCGGCCGCGGCGGCCGGAAGCATCCCGGTGGACGAGGTGCATTTCGA
CCTGAGCGTGGACGTGCTGGACGATGGCGACACCCTCTCGTTCGGCATCGCCTACGCGGCCGACCTGTTCGACCGCGGCA
CCATCCTGCGCCTGGCCGACGGGCTGCGCCTGCTGGCGCGGCAGGCGGCCGACGGCGGCATCCCGGCCATCGGGAACGCG
GCGCTGCCGCCCGTGCCGCAGCTGCGCGGCGAGGAGACGGCATGGCCTTTCGCGAACGTGCCGGACGCCTTCGCCGCCGC
CGCGCGGCGCGATCCCGCGGCCCCGGCCATCGCCGCGGGCGGCCGCACGATCGCCTACGCGGAACTCGACCGCGCGAGCG
CCGCATGGGCGCAGCGCCTGCAGGCCCACGGCATCCGCGCGGAAGACCGCGTGGCCGTGTGCCTGGAGCGCGGCCCCGAA
TTCGTGCTGGCCTGGCTCGCGGCGATGCGGGCAGGGGCCGTCTGCGTGCCGCTGGACCCGGCGCTGCCGCGCACCCGGCG
CGACGAGCTGCTGCGCGATTGCGGCGCCGTCCTGCTGATCGGCGATCTCCCGCAGCCCCCGGAAGGCGTGCCGCGGTGGC
GCGTGGATTTCGGTGCGTCCGGCACGGCGGACACCGAGCCGCCACCTTCGATCCGGCCGCTGCACCCCTCGCAGGGCGCC
TACATGATCTACACCTCCGGCTCCACCGGGCGGCCCAAGGGCGTGGTCGTGCCCCACGGCGCGCTGGCGAACTACGCCCA
GGGCGTGCTCCAGCGCCTGGATGCGGGCCCGGGCCGCTGCTTCGCGATGGTCTCCACCGTGGGCGCGGACCTGGGGCATA
CCGCGCTGTTCGGCGCGCTGTGCTCGGGCGGCTGCCTCTACCTGCCTTCCCCGGCCGAGGCGTTCGATCCGGATGCGTTC
GCGGCCGGCATGGAGCGCTGCGGCGCCGACGTGCTGAAGATCGTCCCCAGCCACCTGCGCGGCCTGCTGAATGCGCGCCA
CCCCGCCGCGGCGCTGCCGCGCCATACCCTGGTGCTGGGCGGCGAGACGGCCGACGATGAACTGCTGCGCACCGTGCGCG
CGCTGCGCCCGGGCCTGCGCATCCTCAACCACTACGGCCCCACCGAAACCACGGTGGGCGTGCTCACCCATGCCGCCGCG
CCGCCGGACGAGGGCCCGCGCGGGTTCACCGCGCTGCCGCTGGGCCGGCCCCTGCCGGGCATCCGGGTCCACGTGCTGGA
CGCCCGCCTGGAGCCCGTGCAGCCCGGCATGCCCGGCGAGCTGTACCTGGCCGGGCGCGGGCTCGCGCGCGGCTATGCCG
GCCGGCCCGGCACCACGGCGGAACGGTTCGTCGCCTCGCCCTTCGAGGCCGGCGCGCGCCTCTACCGCACGGGCGACCGC
GTGCGGCTGCGCGGCGACGGGGTGCTGGAATTCCTCGGTCGCGCGGACGACCAGGTCAAGATCCGCGGATGGCGCGTGGA
GCCCGCGGAGGTCGCCCAGCGCCTGCGCGAGTGCGCCGGCGTGGCCCATGCGGTGGTGGTCGCGCGGGCCCGCGAAACCG
ATGGCGCCATGGCGCTGCATGCCTATGTGGTGCCCGCCGATGCCCATGTGCTGGCCGATCCCGGCGCGCTGGCGGCGCAA
CTGCTCGCGCAGTTGCAGGCGCAGTTGCAGGCGGCGCTGCCGGCCTGGATGGTGCCGGACCACATCCTGCCCATCGCCGC
GCTGCCGCTCACGCCCAACGGCAAGCTCGACCGCCGTGCCCTGCCGCTGCCCGCCGCCGCGCCCGAAGAGGCCGCCCGCG
GAGAGCCCCCGCGCGGCCCCCTGGAAGAAGCGATCGCGAAGGTGTGGAGCGAGGTGCTGCGCGTCGATCACGTCGGCCGC
GACGACAGCTTCCACGCGCTCGGCGGCGATTCCATCCTGTGCCTGAAGCTGGTCGCCCGCCTGCGCAGGCAGGTGCCGGG
CGGCGCGCAGGCGAGCCTGGCCGATGTCATGCAGTCGCCCACGCTCGCGCACCTGGCGCAGCGGCTGCGCGAACGATTCG
AGGGCGCGCACGACGCGGTCTGCCTGCAGGACGAAGGCAGCGGCGTGCCGCTCTACTGCCTGCCCGGCATGGTCGTGAAC
ACGCGCGAGTTCCTGCCGCTGGCCGAGGCGCTGCGTGGGGAGCGCGCCGTGCACGCCTTCGTGAGCCACGTGTACACGCG
GCAGCGCTGGCGCGGGTTCGCGGTGGAGGCCCTCGCGGCCGAGTACGCGGACTTCATCGCGGCCACCGCCGCGGGCGGGC
GGTGCGCCCTGCTGGGCTGGTCCTCCGGCGGCGACCTGGCCGTCGAGACCGCACGGCGCCTGCAGGGCCGCGTGGAGGTC
GCCTTCACCGCGCTGGTGGACGTGCACCGCACGGAGCCCCTGCGCGCCGGCCGGCCGCTATCCGTGGCCGAGCGCGCGCA
GGCGCAGGCCCGGCTGGACGCCTGGCTGGCCGCCTCCACCATGGCCGACCGCTGGCGCGGGCTGCTGGAGCGCATGCATG
CCGACGAACGCGACGGCGTGCTGCAGCAACTGCTCGATGCCCCGCAGCCCCTGCCGCTGGACGGCGAAGGCGAGGACCGC
CACGAATACCTGCTCTGGACCACGCTCGACAAGCGCGTGCAGGCCTGCCGGCACGTGCCCGCCTGCGACGGCCTGCCGGT
CCACCTCTTCCAGGCGGGCCGCTCGGTGGAAGAGGGCGGGGCGCTGCGCGACTGGTCCGCGATCGCGGACGTGCGCGGCG
TGCAGGTCGTGGAAGGCGCGGGCCACCTGGACATCATCCGCCAGCCCGCCTTCATCGGGGCCCTGCGCGAGGCACTGCGC
GCGGCCGACCGCGCCCCGCGCGCATGA

Upstream 100 bases:

>100_bases
GGCGGATGGCGCCGCCGCGGCCGACGACCCGGCCCGGCGCATCGACGCCCTGCTGGGCGAGCTGGAACTCTGAATCACGA
ACGGGAAAGACGACCATCGC

Downstream 100 bases:

>100_bases
AACAAAAGCAGGCGCCCGAAAGCGCCTGCCGGCCTTACCAGCGGTACGTGGCCGTCGCCACCACCCGGCGCGGATCGCCG
TAGTAGCAGTTGCCGTACTG

Product: amino acid adenylation domain-containing protein

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: Tyrocidine synthase III; ATP-dependent asparagine adenylase; AsnA; Asparagine activase; ATP-dependent glutamine adenylase; GlnA; Glutamine activase; ATP-dependent tyrosine adenylase; TyrA; Tyrosine activase; ATP-dependent valine adenylase; ValA; Valine activase; ATP-dependent ornithine adenylase; OrnA; Ornithine activase; ATP-dependent leucine adenylase; LeuA; Leucine activase [H]

Number of amino acids: Translated: 1368; Mature: 1367

Protein sequence:

>1368_residues
MTTEMHELSRRFAALTPDKRQVFLERLRASGIGFEALPVVPRAAAGEAPMAYAQRPLWLAWQRDPASPAYNLAGRMALPG
SPDAAAVHRALATLVARHAALHTCFGCDAQDQPVQREDPQQRFGWSVREWSMPRDQAQEALAAQAQAFAMEPFDLERGPV
FRACLHVFPEGAPELVLCVHHIAADGQSIGLLLSELRALLAAPGEAAPAPAAPGAAALGYADYAAWQRHWMEAGELQRQI
GHWRERLRDAPLATALPLDRPRTARRGTQGGMVHAVLDESVSASLRALGRAHAASPYLVCLSLLGLLLHRLDGQDDLCIG
VPTTTRDRPELAGVVGHFTNVLVLRLQADRDWSFARWLEHVRDRFVEAKAHQEVPLDMLVDALPVPRVPGLHPLFQVKST
QQQAAPRGARQPAAAAGSIPVDEVHFDLSVDVLDDGDTLSFGIAYAADLFDRGTILRLADGLRLLARQAADGGIPAIGNA
ALPPVPQLRGEETAWPFANVPDAFAAAARRDPAAPAIAAGGRTIAYAELDRASAAWAQRLQAHGIRAEDRVAVCLERGPE
FVLAWLAAMRAGAVCVPLDPALPRTRRDELLRDCGAVLLIGDLPQPPEGVPRWRVDFGASGTADTEPPPSIRPLHPSQGA
YMIYTSGSTGRPKGVVVPHGALANYAQGVLQRLDAGPGRCFAMVSTVGADLGHTALFGALCSGGCLYLPSPAEAFDPDAF
AAGMERCGADVLKIVPSHLRGLLNARHPAAALPRHTLVLGGETADDELLRTVRALRPGLRILNHYGPTETTVGVLTHAAA
PPDEGPRGFTALPLGRPLPGIRVHVLDARLEPVQPGMPGELYLAGRGLARGYAGRPGTTAERFVASPFEAGARLYRTGDR
VRLRGDGVLEFLGRADDQVKIRGWRVEPAEVAQRLRECAGVAHAVVVARARETDGAMALHAYVVPADAHVLADPGALAAQ
LLAQLQAQLQAALPAWMVPDHILPIAALPLTPNGKLDRRALPLPAAAPEEAARGEPPRGPLEEAIAKVWSEVLRVDHVGR
DDSFHALGGDSILCLKLVARLRRQVPGGAQASLADVMQSPTLAHLAQRLRERFEGAHDAVCLQDEGSGVPLYCLPGMVVN
TREFLPLAEALRGERAVHAFVSHVYTRQRWRGFAVEALAAEYADFIAATAAGGRCALLGWSSGGDLAVETARRLQGRVEV
AFTALVDVHRTEPLRAGRPLSVAERAQAQARLDAWLAASTMADRWRGLLERMHADERDGVLQQLLDAPQPLPLDGEGEDR
HEYLLWTTLDKRVQACRHVPACDGLPVHLFQAGRSVEEGGALRDWSAIADVRGVQVVEGAGHLDIIRQPAFIGALREALR
AADRAPRA

Sequences:

>Translated_1368_residues
MTTEMHELSRRFAALTPDKRQVFLERLRASGIGFEALPVVPRAAAGEAPMAYAQRPLWLAWQRDPASPAYNLAGRMALPG
SPDAAAVHRALATLVARHAALHTCFGCDAQDQPVQREDPQQRFGWSVREWSMPRDQAQEALAAQAQAFAMEPFDLERGPV
FRACLHVFPEGAPELVLCVHHIAADGQSIGLLLSELRALLAAPGEAAPAPAAPGAAALGYADYAAWQRHWMEAGELQRQI
GHWRERLRDAPLATALPLDRPRTARRGTQGGMVHAVLDESVSASLRALGRAHAASPYLVCLSLLGLLLHRLDGQDDLCIG
VPTTTRDRPELAGVVGHFTNVLVLRLQADRDWSFARWLEHVRDRFVEAKAHQEVPLDMLVDALPVPRVPGLHPLFQVKST
QQQAAPRGARQPAAAAGSIPVDEVHFDLSVDVLDDGDTLSFGIAYAADLFDRGTILRLADGLRLLARQAADGGIPAIGNA
ALPPVPQLRGEETAWPFANVPDAFAAAARRDPAAPAIAAGGRTIAYAELDRASAAWAQRLQAHGIRAEDRVAVCLERGPE
FVLAWLAAMRAGAVCVPLDPALPRTRRDELLRDCGAVLLIGDLPQPPEGVPRWRVDFGASGTADTEPPPSIRPLHPSQGA
YMIYTSGSTGRPKGVVVPHGALANYAQGVLQRLDAGPGRCFAMVSTVGADLGHTALFGALCSGGCLYLPSPAEAFDPDAF
AAGMERCGADVLKIVPSHLRGLLNARHPAAALPRHTLVLGGETADDELLRTVRALRPGLRILNHYGPTETTVGVLTHAAA
PPDEGPRGFTALPLGRPLPGIRVHVLDARLEPVQPGMPGELYLAGRGLARGYAGRPGTTAERFVASPFEAGARLYRTGDR
VRLRGDGVLEFLGRADDQVKIRGWRVEPAEVAQRLRECAGVAHAVVVARARETDGAMALHAYVVPADAHVLADPGALAAQ
LLAQLQAQLQAALPAWMVPDHILPIAALPLTPNGKLDRRALPLPAAAPEEAARGEPPRGPLEEAIAKVWSEVLRVDHVGR
DDSFHALGGDSILCLKLVARLRRQVPGGAQASLADVMQSPTLAHLAQRLRERFEGAHDAVCLQDEGSGVPLYCLPGMVVN
TREFLPLAEALRGERAVHAFVSHVYTRQRWRGFAVEALAAEYADFIAATAAGGRCALLGWSSGGDLAVETARRLQGRVEV
AFTALVDVHRTEPLRAGRPLSVAERAQAQARLDAWLAASTMADRWRGLLERMHADERDGVLQQLLDAPQPLPLDGEGEDR
HEYLLWTTLDKRVQACRHVPACDGLPVHLFQAGRSVEEGGALRDWSAIADVRGVQVVEGAGHLDIIRQPAFIGALREALR
AADRAPRA
>Mature_1367_residues
TTEMHELSRRFAALTPDKRQVFLERLRASGIGFEALPVVPRAAAGEAPMAYAQRPLWLAWQRDPASPAYNLAGRMALPGS
PDAAAVHRALATLVARHAALHTCFGCDAQDQPVQREDPQQRFGWSVREWSMPRDQAQEALAAQAQAFAMEPFDLERGPVF
RACLHVFPEGAPELVLCVHHIAADGQSIGLLLSELRALLAAPGEAAPAPAAPGAAALGYADYAAWQRHWMEAGELQRQIG
HWRERLRDAPLATALPLDRPRTARRGTQGGMVHAVLDESVSASLRALGRAHAASPYLVCLSLLGLLLHRLDGQDDLCIGV
PTTTRDRPELAGVVGHFTNVLVLRLQADRDWSFARWLEHVRDRFVEAKAHQEVPLDMLVDALPVPRVPGLHPLFQVKSTQ
QQAAPRGARQPAAAAGSIPVDEVHFDLSVDVLDDGDTLSFGIAYAADLFDRGTILRLADGLRLLARQAADGGIPAIGNAA
LPPVPQLRGEETAWPFANVPDAFAAAARRDPAAPAIAAGGRTIAYAELDRASAAWAQRLQAHGIRAEDRVAVCLERGPEF
VLAWLAAMRAGAVCVPLDPALPRTRRDELLRDCGAVLLIGDLPQPPEGVPRWRVDFGASGTADTEPPPSIRPLHPSQGAY
MIYTSGSTGRPKGVVVPHGALANYAQGVLQRLDAGPGRCFAMVSTVGADLGHTALFGALCSGGCLYLPSPAEAFDPDAFA
AGMERCGADVLKIVPSHLRGLLNARHPAAALPRHTLVLGGETADDELLRTVRALRPGLRILNHYGPTETTVGVLTHAAAP
PDEGPRGFTALPLGRPLPGIRVHVLDARLEPVQPGMPGELYLAGRGLARGYAGRPGTTAERFVASPFEAGARLYRTGDRV
RLRGDGVLEFLGRADDQVKIRGWRVEPAEVAQRLRECAGVAHAVVVARARETDGAMALHAYVVPADAHVLADPGALAAQL
LAQLQAQLQAALPAWMVPDHILPIAALPLTPNGKLDRRALPLPAAAPEEAARGEPPRGPLEEAIAKVWSEVLRVDHVGRD
DSFHALGGDSILCLKLVARLRRQVPGGAQASLADVMQSPTLAHLAQRLRERFEGAHDAVCLQDEGSGVPLYCLPGMVVNT
REFLPLAEALRGERAVHAFVSHVYTRQRWRGFAVEALAAEYADFIAATAAGGRCALLGWSSGGDLAVETARRLQGRVEVA
FTALVDVHRTEPLRAGRPLSVAERAQAQARLDAWLAASTMADRWRGLLERMHADERDGVLQQLLDAPQPLPLDGEGEDRH
EYLLWTTLDKRVQACRHVPACDGLPVHLFQAGRSVEEGGALRDWSAIADVRGVQVVEGAGHLDIIRQPAFIGALREALRA
ADRAPRA

Specific function: Incorporates six amino acids (for tyrocidine A, Asn, Gln, Tyr, Val, Orn, and Leu) in their L-configuration into the peptide product [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 6 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI28416953, Length=539, Percent_Identity=26.7161410018553, Blast_Score=107, Evalue=1e-22,
Organism=Homo sapiens, GI42544132, Length=579, Percent_Identity=24.5250431778929, Blast_Score=100, Evalue=9e-21,
Organism=Homo sapiens, GI58082049, Length=530, Percent_Identity=26.2264150943396, Blast_Score=98, Evalue=5e-20,
Organism=Homo sapiens, GI157311624, Length=528, Percent_Identity=25.7575757575758, Blast_Score=96, Evalue=2e-19,
Organism=Homo sapiens, GI157311622, Length=528, Percent_Identity=25.7575757575758, Blast_Score=96, Evalue=2e-19,
Organism=Homo sapiens, GI13375727, Length=537, Percent_Identity=23.463687150838, Blast_Score=91, Evalue=6e-18,
Organism=Homo sapiens, GI38505220, Length=531, Percent_Identity=24.6704331450094, Blast_Score=91, Evalue=6e-18,
Organism=Homo sapiens, GI115511026, Length=490, Percent_Identity=24.4897959183673, Blast_Score=86, Evalue=2e-16,
Organism=Homo sapiens, GI122937307, Length=500, Percent_Identity=26, Blast_Score=86, Evalue=3e-16,
Organism=Homo sapiens, GI8923896, Length=378, Percent_Identity=27.5132275132275, Blast_Score=84, Evalue=1e-15,
Organism=Homo sapiens, GI253970489, Length=378, Percent_Identity=27.5132275132275, Blast_Score=83, Evalue=1e-15,
Organism=Escherichia coli, GI1786801, Length=1202, Percent_Identity=28.369384359401, Blast_Score=285, Evalue=2e-77,
Organism=Escherichia coli, GI145693145, Length=536, Percent_Identity=24.8134328358209, Blast_Score=109, Evalue=2e-24,
Organism=Escherichia coli, GI1790505, Length=536, Percent_Identity=25, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1786529, Length=382, Percent_Identity=25.3926701570681, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17556356, Length=1186, Percent_Identity=21.8381112984823, Blast_Score=151, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17550940, Length=596, Percent_Identity=23.993288590604, Blast_Score=114, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71982997, Length=389, Percent_Identity=26.9922879177378, Blast_Score=67, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71983001, Length=387, Percent_Identity=26.6149870801034, Blast_Score=67, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6319591, Length=963, Percent_Identity=24.2990654205607, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24648676, Length=601, Percent_Identity=28.6189683860233, Blast_Score=161, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24667955, Length=542, Percent_Identity=25.830258302583, Blast_Score=107, Evalue=9e-23,
Organism=Drosophila melanogaster, GI62472339, Length=542, Percent_Identity=25.830258302583, Blast_Score=105, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24667959, Length=374, Percent_Identity=27.2727272727273, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24581924, Length=389, Percent_Identity=26.2210796915167, Blast_Score=86, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24582852, Length=452, Percent_Identity=24.7787610619469, Blast_Score=76, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR006163
- InterPro:   IPR020806
- InterPro:   IPR006162
- InterPro:   IPR001031 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding; PF00975 Thioesterase [H]

EC number: 2.7.7.- [C]

Molecular weight: Translated: 146837; Mature: 146706

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTEMHELSRRFAALTPDKRQVFLERLRASGIGFEALPVVPRAAAGEAPMAYAQRPLWLA
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCCCEEEE
WQRDPASPAYNLAGRMALPGSPDAAAVHRALATLVARHAALHTCFGCDAQDQPVQREDPQ
ECCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
QRFGWSVREWSMPRDQAQEALAAQAQAFAMEPFDLERGPVFRACLHVFPEGAPELVLCVH
HHHCCCHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHH
HIAADGQSIGLLLSELRALLAAPGEAAPAPAAPGAAALGYADYAAWQRHWMEAGELQRQI
HHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GHWRERLRDAPLATALPLDRPRTARRGTQGGMVHAVLDESVSASLRALGRAHAASPYLVC
HHHHHHHHCCCCHHCCCCCCCHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCHHHHH
LSLLGLLLHRLDGQDDLCIGVPTTTRDRPELAGVVGHFTNVLVLRLQADRDWSFARWLEH
HHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHCEEEEEEECCCCCCHHHHHHH
VRDRFVEAKAHQEVPLDMLVDALPVPRVPGLHPLFQVKSTQQQAAPRGARQPAAAAGSIP
HHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCHHHHHHCHHHHHCCCCCCCCCCCCCCCC
VDEVHFDLSVDVLDDGDTLSFGIAYAADLFDRGTILRLADGLRLLARQAADGGIPAIGNA
HHHEEEEEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
ALPPVPQLRGEETAWPFANVPDAFAAAARRDPAAPAIAAGGRTIAYAELDRASAAWAQRL
CCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHH
QAHGIRAEDRVAVCLERGPEFVLAWLAAMRAGAVCVPLDPALPRTRRDELLRDCGAVLLI
HHCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHCCCEEEE
GDLPQPPEGVPRWRVDFGASGTADTEPPPSIRPLHPSQGAYMIYTSGSTGRPKGVVVPHG
CCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEECCH
ALANYAQGVLQRLDAGPGRCFAMVSTVGADLGHTALFGALCSGGCLYLPSPAEAFDPDAF
HHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCEEECCCCCCCCCCHHH
AAGMERCGADVLKIVPSHLRGLLNARHPAAALPRHTLVLGGETADDELLRTVRALRPGLR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHH
ILNHYGPTETTVGVLTHAAAPPDEGPRGFTALPLGRPLPGIRVHVLDARLEPVQPGMPGE
HHHHCCCCHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCCEEEEEECCCCCCCCCCCCE
LYLAGRGLARGYAGRPGTTAERFVASPFEAGARLYRTGDRVRLRGDGVLEFLGRADDQVK
EEEECCCHHCCCCCCCCCHHHHHHCCCHHHHHHHEECCCEEEECCCHHHHHHCCCCCEEE
IRGWRVEPAEVAQRLRECAGVAHAVVVARARETDGAMALHAYVVPADAHVLADPGALAAQ
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEECCCHHHHHH
LLAQLQAQLQAALPAWMVPDHILPIAALPLTPNGKLDRRALPLPAAAPEEAARGEPPRGP
HHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCC
LEEAIAKVWSEVLRVDHVGRDDSFHALGGDSILCLKLVARLRRQVPGGAQASLADVMQSP
HHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
TLAHLAQRLRERFEGAHDAVCLQDEGSGVPLYCLPGMVVNTREFLPLAEALRGERAVHAF
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEECCCEEECCHHHHHHHHHHCCHHHHHHH
VSHVYTRQRWRGFAVEALAAEYADFIAATAAGGRCALLGWSSGGDLAVETARRLQGRVEV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHCCHHHH
AFTALVDVHRTEPLRAGRPLSVAERAQAQARLDAWLAASTMADRWRGLLERMHADERDGV
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LQQLLDAPQPLPLDGEGEDRHEYLLWTTLDKRVQACRHVPACDGLPVHLFQAGRSVEEGG
HHHHHCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHCCCCCCCCCHHHHHCCCCHHCCC
ALRDWSAIADVRGVQVVEGAGHLDIIRQPAFIGALREALRAADRAPRA
CCCHHHHHHHCCCCEEECCCCCHHHHHCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TTEMHELSRRFAALTPDKRQVFLERLRASGIGFEALPVVPRAAAGEAPMAYAQRPLWLA
CCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCCCEEEE
WQRDPASPAYNLAGRMALPGSPDAAAVHRALATLVARHAALHTCFGCDAQDQPVQREDPQ
ECCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
QRFGWSVREWSMPRDQAQEALAAQAQAFAMEPFDLERGPVFRACLHVFPEGAPELVLCVH
HHHCCCHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHH
HIAADGQSIGLLLSELRALLAAPGEAAPAPAAPGAAALGYADYAAWQRHWMEAGELQRQI
HHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GHWRERLRDAPLATALPLDRPRTARRGTQGGMVHAVLDESVSASLRALGRAHAASPYLVC
HHHHHHHHCCCCHHCCCCCCCHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCHHHHH
LSLLGLLLHRLDGQDDLCIGVPTTTRDRPELAGVVGHFTNVLVLRLQADRDWSFARWLEH
HHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHCEEEEEEECCCCCCHHHHHHH
VRDRFVEAKAHQEVPLDMLVDALPVPRVPGLHPLFQVKSTQQQAAPRGARQPAAAAGSIP
HHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCHHHHHHCHHHHHCCCCCCCCCCCCCCCC
VDEVHFDLSVDVLDDGDTLSFGIAYAADLFDRGTILRLADGLRLLARQAADGGIPAIGNA
HHHEEEEEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
ALPPVPQLRGEETAWPFANVPDAFAAAARRDPAAPAIAAGGRTIAYAELDRASAAWAQRL
CCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHH
QAHGIRAEDRVAVCLERGPEFVLAWLAAMRAGAVCVPLDPALPRTRRDELLRDCGAVLLI
HHCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHCCCEEEE
GDLPQPPEGVPRWRVDFGASGTADTEPPPSIRPLHPSQGAYMIYTSGSTGRPKGVVVPHG
CCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEECCH
ALANYAQGVLQRLDAGPGRCFAMVSTVGADLGHTALFGALCSGGCLYLPSPAEAFDPDAF
HHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCEEECCCCCCCCCCHHH
AAGMERCGADVLKIVPSHLRGLLNARHPAAALPRHTLVLGGETADDELLRTVRALRPGLR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHH
ILNHYGPTETTVGVLTHAAAPPDEGPRGFTALPLGRPLPGIRVHVLDARLEPVQPGMPGE
HHHHCCCCHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCCEEEEEECCCCCCCCCCCCE
LYLAGRGLARGYAGRPGTTAERFVASPFEAGARLYRTGDRVRLRGDGVLEFLGRADDQVK
EEEECCCHHCCCCCCCCCHHHHHHCCCHHHHHHHEECCCEEEECCCHHHHHHCCCCCEEE
IRGWRVEPAEVAQRLRECAGVAHAVVVARARETDGAMALHAYVVPADAHVLADPGALAAQ
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEECCCHHHHHH
LLAQLQAQLQAALPAWMVPDHILPIAALPLTPNGKLDRRALPLPAAAPEEAARGEPPRGP
HHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCC
LEEAIAKVWSEVLRVDHVGRDDSFHALGGDSILCLKLVARLRRQVPGGAQASLADVMQSP
HHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
TLAHLAQRLRERFEGAHDAVCLQDEGSGVPLYCLPGMVVNTREFLPLAEALRGERAVHAF
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEECCCEEECCHHHHHHHHHHCCHHHHHHH
VSHVYTRQRWRGFAVEALAAEYADFIAATAAGGRCALLGWSSGGDLAVETARRLQGRVEV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHCCHHHH
AFTALVDVHRTEPLRAGRPLSVAERAQAQARLDAWLAASTMADRWRGLLERMHADERDGV
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LQQLLDAPQPLPLDGEGEDRHEYLLWTTLDKRVQACRHVPACDGLPVHLFQAGRSVEEGG
HHHHHCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHCCCCCCCCCHHHHHCCCCHHCCC
ALRDWSAIADVRGVQVVEGAGHLDIIRQPAFIGALREALRAADRAPRA
CCCHHHHHHHCCCCEEECCCCCHHHHHCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9352938; 10801488 [H]