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The map label for this gene is lolC [H]

Identifier: 120612344

GI number: 120612344

Start: 4076605

End: 4077858

Strand: Reverse

Name: lolC [H]

Synonym: Aave_3700

Alternate gene names: 120612344

Gene position: 4077858-4076605 (Counterclockwise)

Preceding gene: 120612357

Following gene: 120612343

Centisome position: 76.18

GC content: 68.82

Gene sequence:

>1254_bases
ATGCAACTTCCCTACGAACTGGCCCTGGGCTGGCGCTACACCCGGGCCGGACGCGCCACGCGGCGCAACGGCTTCATCTC
GTTCATCTCCGGCGTCTCCATGCTGGGCATCGCCCTCGGGGTGGCCGCCCTCATCATCGTGCTCAGCGTGATGAACGGCT
TCCAGAAGGAAGTGCGCGACCGCATGCTCAGCGTGGTGTCCCACATCGAGATCTTCGCGCCCCAGGGCGCCGCGCTGCCC
GATCCCGCGCTCACCATGGCTGAGACCCGCAAGAACCCCGAGGTGGTGGGCGCCGCGCCTTTCGTCGGCTCGCAGGCGCT
GATCGCCCGGGGCGAGGACATGAAGGGCGCCCTGGTGCGCGGCATCGATCCGGACCGCGAAGGCGAGGTGACCGACCTGG
CGGCCCGCAATGCCGATGCCGTGCGCACCCTCACCCCCGGCAGCTTCCATGTGGTGCTGGGCGTGGAGCTGGCGCGGGCG
CTCGGCGTGCGCGTGGGCGATCCCGTCACCCTCATCGCGCCGGGCGGGCAGGTCACGCCGGCCGGCGTGGTGCCGCGCCT
CAAGCAGATGACCGTCTCGGGCATCTTCGAATCCGGCCACTACGAATACGACTCCGCCCTGGTGCTGCTGCACCATGCCG
ACGCCGAGCGCATCTTCCGCCTGGAAGGCCCCACCGGCATCCGCCTCAAGCTGCGCGACCTGCACCAGGCGCCGGAGGTG
ACGCAGGAACTCGCCCGGTCCCTCTCCGGCGACCTGCTGATCCGCGACTGGACGCAGCAGAACCGCACCTGGTTCGCCGC
CGTCCAGCTCGAAAAGCGCATGATGTTCATCATCCTCACGCTCATCGTGGCGGTGGCGGCCTTCAACCTGGTCTCCACCC
TGGTGATGACCGTGACCGACAAGCGCGCCGACATCGCCATCCTGCGCACCCTCGGCGCCAGCCCGCGCAGCATCATGGCC
GTGTTCGTGGTGCAGGGCGCGCTGGTGGGCGTGATCGGCACGGCCTGCGGGCTGGCCCTCGGCCTGCTCGTGGCCTTCAA
CATCGACGTCATCGTGCCGGCCATCGAGCATGCGCTGCACGCCAGTTTCCTGCCCAAAGACATCTACCTGATCAGCAAGA
TGCCCAGCGACCCCCAGAGCAGCGACATCACCCCCATCGCGGTCATCTCCCTCGTGCTGGCCTTCGCGGCCACCCTGTAC
CCGAGCTGGCGCGCCAGCCGCGTGAATCCCGCGGAGGCATTGCGTTATGAGTAG

Upstream 100 bases:

>100_bases
GGTGGATCTCCGACATGGCGGGTATTGTCCGGGATGCCACAATCGGCGCCGTCCCGGTGCCGCCAATCCCGTCGCGGCGC
GGGGCCGCTTTTTCCCCACC

Downstream 100 bases:

>100_bases
TCAGGAACACCCCCCTGAGCCGCTTCGCGGCTTCCCCCCGCTCTCGCCGTGCTGCGCACGTCGGGCGGGTGGACGCAGCC
CTCGCTGCGGGGCGGCCCTT

Product: LolC/E family lipoprotein releasing system, transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MQLPYELALGWRYTRAGRATRRNGFISFISGVSMLGIALGVAALIIVLSVMNGFQKEVRDRMLSVVSHIEIFAPQGAALP
DPALTMAETRKNPEVVGAAPFVGSQALIARGEDMKGALVRGIDPDREGEVTDLAARNADAVRTLTPGSFHVVLGVELARA
LGVRVGDPVTLIAPGGQVTPAGVVPRLKQMTVSGIFESGHYEYDSALVLLHHADAERIFRLEGPTGIRLKLRDLHQAPEV
TQELARSLSGDLLIRDWTQQNRTWFAAVQLEKRMMFIILTLIVAVAAFNLVSTLVMTVTDKRADIAILRTLGASPRSIMA
VFVVQGALVGVIGTACGLALGLLVAFNIDVIVPAIEHALHASFLPKDIYLISKMPSDPQSSDITPIAVISLVLAFAATLY
PSWRASRVNPAEALRYE

Sequences:

>Translated_417_residues
MQLPYELALGWRYTRAGRATRRNGFISFISGVSMLGIALGVAALIIVLSVMNGFQKEVRDRMLSVVSHIEIFAPQGAALP
DPALTMAETRKNPEVVGAAPFVGSQALIARGEDMKGALVRGIDPDREGEVTDLAARNADAVRTLTPGSFHVVLGVELARA
LGVRVGDPVTLIAPGGQVTPAGVVPRLKQMTVSGIFESGHYEYDSALVLLHHADAERIFRLEGPTGIRLKLRDLHQAPEV
TQELARSLSGDLLIRDWTQQNRTWFAAVQLEKRMMFIILTLIVAVAAFNLVSTLVMTVTDKRADIAILRTLGASPRSIMA
VFVVQGALVGVIGTACGLALGLLVAFNIDVIVPAIEHALHASFLPKDIYLISKMPSDPQSSDITPIAVISLVLAFAATLY
PSWRASRVNPAEALRYE
>Mature_417_residues
MQLPYELALGWRYTRAGRATRRNGFISFISGVSMLGIALGVAALIIVLSVMNGFQKEVRDRMLSVVSHIEIFAPQGAALP
DPALTMAETRKNPEVVGAAPFVGSQALIARGEDMKGALVRGIDPDREGEVTDLAARNADAVRTLTPGSFHVVLGVELARA
LGVRVGDPVTLIAPGGQVTPAGVVPRLKQMTVSGIFESGHYEYDSALVLLHHADAERIFRLEGPTGIRLKLRDLHQAPEV
TQELARSLSGDLLIRDWTQQNRTWFAAVQLEKRMMFIILTLIVAVAAFNLVSTLVMTVTDKRADIAILRTLGASPRSIMA
VFVVQGALVGVIGTACGLALGLLVAFNIDVIVPAIEHALHASFLPKDIYLISKMPSDPQSSDITPIAVISLVLAFAATLY
PSWRASRVNPAEALRYE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=421, Percent_Identity=33.729216152019, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI1787360, Length=426, Percent_Identity=35.4460093896714, Blast_Score=201, Evalue=7e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 44908; Mature: 44908

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLPYELALGWRYTRAGRATRRNGFISFISGVSMLGIALGVAALIIVLSVMNGFQKEVRD
CCCCHHHHCCEEEHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMLSVVSHIEIFAPQGAALPDPALTMAETRKNPEVVGAAPFVGSQALIARGEDMKGALVR
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCEEECCCCCCCCHHEECCCCCCCHHEE
GIDPDREGEVTDLAARNADAVRTLTPGSFHVVLGVELARALGVRVGDPVTLIAPGGQVTP
CCCCCCCCCCHHHHHCCCCCEEEECCCCEEEEEHHHHHHHHCCCCCCCEEEEECCCCCCC
AGVVPRLKQMTVSGIFESGHYEYDSALVLLHHADAERIFRLEGPTGIRLKLRDLHQAPEV
CHHHHHHHHHHHHHHHHCCCEECCCEEEEEEECCHHHEEEECCCCCCEEEHHHHHCCHHH
TQELARSLSGDLLIRDWTQQNRTWFAAVQLEKRMMFIILTLIVAVAAFNLVSTLVMTVTD
HHHHHHHCCCCEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KRADIAILRTLGASPRSIMAVFVVQGALVGVIGTACGLALGLLVAFNIDVIVPAIEHALH
CCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASFLPKDIYLISKMPSDPQSSDITPIAVISLVLAFAATLYPSWRASRVNPAEALRYE
HHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCC
>Mature Secondary Structure
MQLPYELALGWRYTRAGRATRRNGFISFISGVSMLGIALGVAALIIVLSVMNGFQKEVRD
CCCCHHHHCCEEEHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMLSVVSHIEIFAPQGAALPDPALTMAETRKNPEVVGAAPFVGSQALIARGEDMKGALVR
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCEEECCCCCCCCHHEECCCCCCCHHEE
GIDPDREGEVTDLAARNADAVRTLTPGSFHVVLGVELARALGVRVGDPVTLIAPGGQVTP
CCCCCCCCCCHHHHHCCCCCEEEECCCCEEEEEHHHHHHHHCCCCCCCEEEEECCCCCCC
AGVVPRLKQMTVSGIFESGHYEYDSALVLLHHADAERIFRLEGPTGIRLKLRDLHQAPEV
CHHHHHHHHHHHHHHHHCCCEECCCEEEEEEECCHHHEEEECCCCCCEEEHHHHHCCHHH
TQELARSLSGDLLIRDWTQQNRTWFAAVQLEKRMMFIILTLIVAVAAFNLVSTLVMTVTD
HHHHHHHCCCCEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KRADIAILRTLGASPRSIMAVFVVQGALVGVIGTACGLALGLLVAFNIDVIVPAIEHALH
CCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASFLPKDIYLISKMPSDPQSSDITPIAVISLVLAFAATLYPSWRASRVNPAEALRYE
HHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]