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The map label for this gene is ubiB

Identifier: 120612286

GI number: 120612286

Start: 4014542

End: 4016110

Strand: Reverse

Name: ubiB

Synonym: Aave_3641

Alternate gene names: 120612286

Gene position: 4016110-4014542 (Counterclockwise)

Preceding gene: 120612287

Following gene: 120612285

Centisome position: 75.03

GC content: 67.18

Gene sequence:

>1569_bases
ATGAGCCGCCTTTTCCGCGGCGCCACCATCGTCTGGGTGGTGCTGCGCTATGGACTGGATGAGCTGGTACTGACGAGCTT
CCAGAAGCCGTGGCTGCGGCTGCTGGCACGCATCGTCTCCTTCGGCCGCAAGCTGGACGCGCCGCGCGGACAGCGCCTGC
GCGAGGCCCTGGAGCGGCTGGGGCCCATCTTCGTGAAGTTCGGGCAGGTGCTGTCCACGCGGCGCGACCTGCTGCCGCCG
GACATCGCCAACGAACTGGCGCTGCTGCAGGACCGCGTTCCGCCCTTCGACCCGGACGTGGCCGTGGCCACCATCGAACG
CGCCTTCCGCCGGCCGGTGGGCGAGGTGTTCGTCTCGTTCGAGCGCGTGCCGGTGGCGAGCGCATCCATCGCGCAGGTGC
ATTTCGCCATCGTGCGCGACCGCCACGGCGTGGAGCGCGAGGTGGCCGTGAAGGTGCTGCGGCCCGGCATGCTGCCCGTG
ATCGACAACGACCTGGGCCTCATGCGCGCCATGGCCGGCTGGGTGGAGAGCCTGTCGGCCGACGGCAAGCGCCTGAAGCC
GCGGCAGGTGGTGGCGGAGTTCGACAACTACCTGCACGACGAGCTGGACCTGATCCGCGAGGCCGCCAATGCCGCGCAGC
TGCGCCGCAACATGGAGAGACTGGGCCTGGTGCGCATCCCGGAGATCCTCTGGGACTTCTGCCACCCGGAAGTGCTGGTG
ATGGAGCGCATGAAGGGCGTGCCGATCAGCCAGATCGAGCGGCTGCGCGCGGCCGGGGTGGACATCCGCCAGCTGGCGCG
CGACGGCGTCACCATCTTCTTCACCCAGGTCTTCCGCGACGGCTTCTTCCACGCGGACATGCACCCGGGCAACATCCAGG
TGAGCCTGGAGCCGGGTTCGTTCGGCCGCTACATCTCGCTGGATTTCGGCATCGTCGGCTCGCTCACCGAGTTCGACAAG
GAATACCTCGCCCAGAACTTCACCGCCTTCTTCCGCCGCGACTACAAGCGCGTGGCGGAGCTGCACGTGGAGAGCGGCTG
GGTGCCGGCCGACACGCGCATCAACGAACTGGAGTCGGCCATCCGCGCCGTCTGCGAGCCGTACTTCGACCGCCCGCTCA
AGGAGATCTCGCTCGGCATGGTGCTGATGCGGCTGTTCCAGACCTCGCGGCGCTTCCACGTGGAGATCCAGCCGCAGCTC
GTGCTGCTGCAGAAGACGCTGCTCAACATCGAAGGCCTGGGCCGCCAGCTCGACCCGGAACTGGACCTCTGGAGCACAGC
CAAGCCGTTCCTGGAAAAGTGGATGCTCGACCAGATGGGGCCGCAGCGGCTCTGGCGCGAAGTGAAGGCCGAGTCGCCGC
ATTTCGCGAAGATGCTGCCTGAGCTGCCGCGCCTGCTGCACGACTACCTGCACCACAAGCCGCACGATCACCGGCGCGAG
ATGCAGGAACTGCTCGCCGAGCAGCGCCGCACCAACCGGCTCCTGCAGAGCATCATCTACGGTGGCATGGGTTTTGTATT
GGGACTGCTGGCGCTGCAGTTCCTGATCCGCATCCGGTTCTTCCACTAA

Upstream 100 bases:

>100_bases
CGCAGGCGCTCAGGCAGTTCGTCGGCATGCGCATGGGAGGACGCCCCGCAGCGGGCGGCACCGCCCAGGCGGCCGCTCCC
GCTTCCGATCGCGGCGTTCC

Downstream 100 bases:

>100_bases
AGCCCCCCGCAGCGCCGCCTGCGCATTCCCTTTCCCGACAACCCTCACTTCGCGACATCGAGGAGCATGCCGTGCTGCTG
ACCCTGGTCATCGTCTATCT

Product: putative ubiquinone biosynthesis protein UbiB

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 522; Mature: 521

Protein sequence:

>522_residues
MSRLFRGATIVWVVLRYGLDELVLTSFQKPWLRLLARIVSFGRKLDAPRGQRLREALERLGPIFVKFGQVLSTRRDLLPP
DIANELALLQDRVPPFDPDVAVATIERAFRRPVGEVFVSFERVPVASASIAQVHFAIVRDRHGVEREVAVKVLRPGMLPV
IDNDLGLMRAMAGWVESLSADGKRLKPRQVVAEFDNYLHDELDLIREAANAAQLRRNMERLGLVRIPEILWDFCHPEVLV
MERMKGVPISQIERLRAAGVDIRQLARDGVTIFFTQVFRDGFFHADMHPGNIQVSLEPGSFGRYISLDFGIVGSLTEFDK
EYLAQNFTAFFRRDYKRVAELHVESGWVPADTRINELESAIRAVCEPYFDRPLKEISLGMVLMRLFQTSRRFHVEIQPQL
VLLQKTLLNIEGLGRQLDPELDLWSTAKPFLEKWMLDQMGPQRLWREVKAESPHFAKMLPELPRLLHDYLHHKPHDHRRE
MQELLAEQRRTNRLLQSIIYGGMGFVLGLLALQFLIRIRFFH

Sequences:

>Translated_522_residues
MSRLFRGATIVWVVLRYGLDELVLTSFQKPWLRLLARIVSFGRKLDAPRGQRLREALERLGPIFVKFGQVLSTRRDLLPP
DIANELALLQDRVPPFDPDVAVATIERAFRRPVGEVFVSFERVPVASASIAQVHFAIVRDRHGVEREVAVKVLRPGMLPV
IDNDLGLMRAMAGWVESLSADGKRLKPRQVVAEFDNYLHDELDLIREAANAAQLRRNMERLGLVRIPEILWDFCHPEVLV
MERMKGVPISQIERLRAAGVDIRQLARDGVTIFFTQVFRDGFFHADMHPGNIQVSLEPGSFGRYISLDFGIVGSLTEFDK
EYLAQNFTAFFRRDYKRVAELHVESGWVPADTRINELESAIRAVCEPYFDRPLKEISLGMVLMRLFQTSRRFHVEIQPQL
VLLQKTLLNIEGLGRQLDPELDLWSTAKPFLEKWMLDQMGPQRLWREVKAESPHFAKMLPELPRLLHDYLHHKPHDHRRE
MQELLAEQRRTNRLLQSIIYGGMGFVLGLLALQFLIRIRFFH
>Mature_521_residues
SRLFRGATIVWVVLRYGLDELVLTSFQKPWLRLLARIVSFGRKLDAPRGQRLREALERLGPIFVKFGQVLSTRRDLLPPD
IANELALLQDRVPPFDPDVAVATIERAFRRPVGEVFVSFERVPVASASIAQVHFAIVRDRHGVEREVAVKVLRPGMLPVI
DNDLGLMRAMAGWVESLSADGKRLKPRQVVAEFDNYLHDELDLIREAANAAQLRRNMERLGLVRIPEILWDFCHPEVLVM
ERMKGVPISQIERLRAAGVDIRQLARDGVTIFFTQVFRDGFFHADMHPGNIQVSLEPGSFGRYISLDFGIVGSLTEFDKE
YLAQNFTAFFRRDYKRVAELHVESGWVPADTRINELESAIRAVCEPYFDRPLKEISLGMVLMRLFQTSRRFHVEIQPQLV
LLQKTLLNIEGLGRQLDPELDLWSTAKPFLEKWMLDQMGPQRLWREVKAESPHFAKMLPELPRLLHDYLHHKPHDHRREM
QELLAEQRRTNRLLQSIIYGGMGFVLGLLALQFLIRIRFFH

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily

Homologues:

Organism=Homo sapiens, GI40254938, Length=278, Percent_Identity=28.4172661870504, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI41393593, Length=274, Percent_Identity=29.5620437956204, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI32261307, Length=316, Percent_Identity=30.0632911392405, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI217035081, Length=233, Percent_Identity=29.1845493562232, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI217416386, Length=208, Percent_Identity=31.7307692307692, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI27363457, Length=208, Percent_Identity=31.7307692307692, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI34147522, Length=215, Percent_Identity=28.3720930232558, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI2367309, Length=525, Percent_Identity=51.2380952380952, Blast_Score=482, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17559152, Length=287, Percent_Identity=25.7839721254355, Blast_Score=114, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6325148, Length=472, Percent_Identity=24.7881355932203, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323282, Length=259, Percent_Identity=25.8687258687259, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24662575, Length=254, Percent_Identity=30.3149606299213, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI22024280, Length=255, Percent_Identity=30.1960784313725, Blast_Score=112, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIB_ACIAC (A1TTA2)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_971964.1
- ProteinModelPortal:   A1TTA2
- STRING:   A1TTA2
- GeneID:   4668941
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_3641
- NMPDR:   fig|397945.5.peg.3108
- eggNOG:   COG0661
- HOGENOM:   HBG593509
- OMA:   LERFWAD
- PhylomeDB:   A1TTA2
- ProtClustDB:   PRK04750
- BioCyc:   AAVE397945:AAVE_3641-MONOMER
- HAMAP:   MF_00414
- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232
- TIGRFAMs:   TIGR01982

Pfam domain/function: PF03109 ABC1; SSF56112 Kinase_like

EC number: NA

Molecular weight: Translated: 60352; Mature: 60221

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x15ae9298)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRLFRGATIVWVVLRYGLDELVLTSFQKPWLRLLARIVSFGRKLDAPRGQRLREALERL
CCCHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
GPIFVKFGQVLSTRRDLLPPDIANELALLQDRVPPFDPDVAVATIERAFRRPVGEVFVSF
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHH
ERVPVASASIAQVHFAIVRDRHGVEREVAVKVLRPGMLPVIDNDLGLMRAMAGWVESLSA
HHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHCC
DGKRLKPRQVVAEFDNYLHDELDLIREAANAAQLRRNMERLGLVRIPEILWDFCHPEVLV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCHHHHH
MERMKGVPISQIERLRAAGVDIRQLARDGVTIFFTQVFRDGFFHADMHPGNIQVSLEPGS
HHHHCCCCHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCC
FGRYISLDFGIVGSLTEFDKEYLAQNFTAFFRRDYKRVAELHVESGWVPADTRINELESA
CCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
IRAVCEPYFDRPLKEISLGMVLMRLFQTSRRFHVEIQPQLVLLQKTLLNIEGLGRQLDPE
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCC
LDLWSTAKPFLEKWMLDQMGPQRLWREVKAESPHFAKMLPELPRLLHDYLHHKPHDHRRE
CCCHHCHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
MQELLAEQRRTNRLLQSIIYGGMGFVLGLLALQFLIRIRFFH
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure 
SRLFRGATIVWVVLRYGLDELVLTSFQKPWLRLLARIVSFGRKLDAPRGQRLREALERL
CCHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
GPIFVKFGQVLSTRRDLLPPDIANELALLQDRVPPFDPDVAVATIERAFRRPVGEVFVSF
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHH
ERVPVASASIAQVHFAIVRDRHGVEREVAVKVLRPGMLPVIDNDLGLMRAMAGWVESLSA
HHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHCC
DGKRLKPRQVVAEFDNYLHDELDLIREAANAAQLRRNMERLGLVRIPEILWDFCHPEVLV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCHHHHH
MERMKGVPISQIERLRAAGVDIRQLARDGVTIFFTQVFRDGFFHADMHPGNIQVSLEPGS
HHHHCCCCHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCC
FGRYISLDFGIVGSLTEFDKEYLAQNFTAFFRRDYKRVAELHVESGWVPADTRINELESA
CCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
IRAVCEPYFDRPLKEISLGMVLMRLFQTSRRFHVEIQPQLVLLQKTLLNIEGLGRQLDPE
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCC
LDLWSTAKPFLEKWMLDQMGPQRLWREVKAESPHFAKMLPELPRLLHDYLHHKPHDHRRE
CCCHHCHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
MQELLAEQRRTNRLLQSIIYGGMGFVLGLLALQFLIRIRFFH
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA