Click here to switch to the map view.

The map label for this gene is devR [H]

Identifier: 120612238

GI number: 120612238

Start: 3962443

End: 3963165

Strand: Direct

Name: devR [H]

Synonym: Aave_3591

Alternate gene names: 120612238

Gene position: 3962443-3963165 (Clockwise)

Preceding gene: 120612236

Following gene: 120612239

Centisome position: 74.03

GC content: 66.39

Gene sequence:

>723_bases
ATGACGATCCGGCCCCTACCGCCAGAACGTCATATGCCCTTGCCCGCCTCCTGCCGTCTTCCGCTGACGCGCTACGCGCT
GGTCGTGGATGACCATCCCCTCGTCGGACGCGGCATGGCCGAGTTCCTGCGCGGCCATCCCCGCCTGGCAGACGTCCGCC
ACGCCCACGAGACGTCCGAGGCCCTGCGCATCATTGCCTCGCATGGTTCCCCGGTCCTCGCCCTGGTGGATTTCTGGCTC
GCGGAGGGCGCAGCGACGTCGTTCATCGGCAATCTCTTCGCGATGTCTCCGGAAACACGCATGCTGATCATGAGCGCGGA
CCACCATCCGGCCATCGTGCTCAAGGTCCGGGCCAGTGGAGCGCACGGGTTCGTCCACAAGCGGGAATCGCCCGAGACAT
TCCATGCCGCCGTCAATGCCGTGCTCGATGGCGCCTCCTGGTTCGACCCGGGGGCAACGGCATCCCTCTCCCCCTCAGCC
CTCGGCGCCACGCCTCTGCGGGAGATCCATCTCGCTCCCGTCGATCTCGGCCTGACCCCGCGCCAGGGCCAGATCCTCGC
CTTGGTTCTGGAGGGGCTGCCCAACAAACCCATCGCGAATGCGCTGCATCTCTCGGAGCACACGGTGAAGGAACACCTGA
CGGCCATCCTGCAAAAGCTCGGGGTGAGCAATCGCGTGGAATTGATCTCCAGGCTGCGCGGTGTGCGGGTCGACGGGTCC
TGA

Upstream 100 bases:

>100_bases
CGGGGCAGTCTGTTCACCCATACGCCCCGGCAGTAGTTTGTAACTCGCCCACCTCCGCTCATGGGTTAACCTCGCGATCG
CGATCGCGGGCGCGTTGCTT

Downstream 100 bases:

>100_bases
GCCATCGGGTCACTGCGGAACCAGCCTCGAACTGCGCCAGCGATACAACGGGTTACGCAATTCCTGCCATGGCGGGGCAC
CAGACGAAGGGGCCACCACG

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MTIRPLPPERHMPLPASCRLPLTRYALVVDDHPLVGRGMAEFLRGHPRLADVRHAHETSEALRIIASHGSPVLALVDFWL
AEGAATSFIGNLFAMSPETRMLIMSADHHPAIVLKVRASGAHGFVHKRESPETFHAAVNAVLDGASWFDPGATASLSPSA
LGATPLREIHLAPVDLGLTPRQGQILALVLEGLPNKPIANALHLSEHTVKEHLTAILQKLGVSNRVELISRLRGVRVDGS

Sequences:

>Translated_240_residues
MTIRPLPPERHMPLPASCRLPLTRYALVVDDHPLVGRGMAEFLRGHPRLADVRHAHETSEALRIIASHGSPVLALVDFWL
AEGAATSFIGNLFAMSPETRMLIMSADHHPAIVLKVRASGAHGFVHKRESPETFHAAVNAVLDGASWFDPGATASLSPSA
LGATPLREIHLAPVDLGLTPRQGQILALVLEGLPNKPIANALHLSEHTVKEHLTAILQKLGVSNRVELISRLRGVRVDGS
>Mature_239_residues
TIRPLPPERHMPLPASCRLPLTRYALVVDDHPLVGRGMAEFLRGHPRLADVRHAHETSEALRIIASHGSPVLALVDFWLA
EGAATSFIGNLFAMSPETRMLIMSADHHPAIVLKVRASGAHGFVHKRESPETFHAAVNAVLDGASWFDPGATASLSPSAL
GATPLREIHLAPVDLGLTPRQGQILALVLEGLPNKPIANALHLSEHTVKEHLTAILQKLGVSNRVELISRLRGVRVDGS

Specific function: Member of the two-component regulatory system devR/devS (dosR/dosS) involved in onset of the dormancy response. When phosphorylated binds the promoter of at least its own and Acr (hspX) gene in response to hypoxia. Activates its own transcription under hy

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790102, Length=206, Percent_Identity=31.0679611650485, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788521, Length=202, Percent_Identity=28.2178217821782, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1787473, Length=204, Percent_Identity=28.921568627451, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR011990
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 25885; Mature: 25754

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIRPLPPERHMPLPASCRLPLTRYALVVDDHPLVGRGMAEFLRGHPRLADVRHAHETSE
CCCCCCCCCCCCCCCCCCCCCHHEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
ALRIIASHGSPVLALVDFWLAEGAATSFIGNLFAMSPETRMLIMSADHHPAIVLKVRASG
HHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCC
AHGFVHKRESPETFHAAVNAVLDGASWFDPGATASLSPSALGATPLREIHLAPVDLGLTP
CCCCEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCHHHEEECEECCCCCC
RQGQILALVLEGLPNKPIANALHLSEHTVKEHLTAILQKLGVSNRVELISRLRGVRVDGS
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TIRPLPPERHMPLPASCRLPLTRYALVVDDHPLVGRGMAEFLRGHPRLADVRHAHETSE
CCCCCCCCCCCCCCCCCCCCHHEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
ALRIIASHGSPVLALVDFWLAEGAATSFIGNLFAMSPETRMLIMSADHHPAIVLKVRASG
HHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCC
AHGFVHKRESPETFHAAVNAVLDGASWFDPGATASLSPSALGATPLREIHLAPVDLGLTP
CCCCEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCHHHEEECEECCCCCC
RQGQILALVLEGLPNKPIANALHLSEHTVKEHLTAILQKLGVSNRVELISRLRGVRVDGS
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]