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The map label for this gene is guaA [H]

Identifier: 120612021

GI number: 120612021

Start: 3723054

End: 3724679

Strand: Reverse

Name: guaA [H]

Synonym: Aave_3367

Alternate gene names: 120612021

Gene position: 3724679-3723054 (Counterclockwise)

Preceding gene: 120612022

Following gene: 120612020

Centisome position: 69.58

GC content: 66.91

Gene sequence:

>1626_bases
ATGCAACACCAGAAGATCCTCATCCTCGACTTCGGCTCCCAGGTCACCCAGCTCATCGCGCGCCGCGTGCGCGAGGCCCA
TGTGTACTGCGAGGTGCATCCCTGCGACGTGAGCGACGCCTGGGTGCGCGAATACGCCGCCGACGGCTCGCTCAAGGGCG
TGATCCTCTCGGGCAGCCACGCCAGCGTGTACGAGGAGACCACCGACCGCGCGCCGCAGGCCGTGTTCGAACTGGGCGTG
CCCGTGCTGGGCATCTGCTATGGCATGCAGACCATGGCGCAGCAGCTCGGCGGCAAGGTCGAGGGCGGCCACAAGCGCGA
ATTCGGTTACGCCGAAGTGCGTGCCCACGGCCACACGGCGCTGCTGAAAGACATCGCCGACTTCACCACCGCCGAAGGCC
ACGGCATGCTCAAGGTCTGGATGAGCCATGGCGACAAGGTCGCCGAGATGCCGCCCGGCTTCAAACTCATGGCCTCCACG
CCCAGCTGCCCGATCGCCGGCATGGCCGACGAGGCGCGCCGCTTCTACGCCGTGCAGTTCCACCCGGAGGTGACGCACAC
CGTGCAGGGCCGCGCGCTGCTCGACCGCTTCGTGCTCGGCATCTGCGGCGTGCAGCCGGACTGGGTCATGAAGGACCACA
TCGCCGAGGCCGTGGAATCCATCCGCGCCCAGGTGGGCGACGAGGAAGTCATCCTCGGCCTCTCGGGTGGCGTGGATTCC
AGCGTGGCCGCCGCGCTCATCCACCGCGCCATCGGCGACCAGCTCACCTGCGTGTTCGTCGATCACGGCCTGCTGCGCCT
GAACGAGGGCGACATGGTGATGGACATGTTCGTGGGCAAGCTGCACGCCAAGGTCGTGCGGGTGGATGCGAGCGAGCTCT
TCCTGCGCGAACTGGCCGGCGTGAGCGACCCCGAGCAGAAGCGCAAGATCATCGGCCGCCTGTTCGTGGACGTCTTCAAG
GCCGAGGCCGCCAAGCTCACCGCCTCGGGCGCATCGAGGAAGGAGAAGGGCGCCACCTTCCTGGCCCAGGGCACCATCTA
CCCGGACGTGATCGAATCCGGCGGCGCCAAGAGCAAGAAGGCCGTCACCATCAAGAGCCACCACAACGTCGGCGGCCTGC
CGGAACAGCTCGGTCTCAAGCTGCTGGAGCCCCTGCGCGACCTGTTCAAGGACGAAGTGCGCGAACTGGGCGTGGCCCTC
GGCCTGCCGCACGACATGGTCTATCGCCATCCCTTCCCCGGCCCCGGCCTGGGCGTGCGCATCCTGGGTGAGGTGAAGAA
GGAATACGCCGACCTGCTGCGCCGCGCCGACGCGATCTTCATCGAGGAACTGCGCAACCACGTGGACGCCGAAACCGGCA
AGACCTGGTATGACCTCACCAGCCAGGCCTTCACCGTCTTCCTGCCCGTGAAGAGCGTCGGCGTGATGGGCGACGGCCGC
ACCTACGACTACGTCGTCGCCCTGCGCGCCGTGCAGACCAGCGATTTCATGACCGCCGACTGGGCCGAGCTGCCATACGC
GCTGCTCAAGAAGGTGTCGGGAAGGATCATCAATGAAGTCCGCGGGATCAACCGGGTGACGTACGACGTGTCGAGCAAGC
CGCCGGCGACGATCGAGTGGGAGTGA

Upstream 100 bases:

>100_bases
GCCGCGCGGACCGGCGTGGCGCTGCTCGACCTGTCCACGTTCTGATCCCTCGCGATTTCCCACCCTTTCTCTTTCCGCTC
ACCGTTCTCTCCCGACCACC

Downstream 100 bases:

>100_bases
AATCGGGTCCTTCGGGGACTATCGCCAGTTATCGAAAAGCCGACGTAACGTGTTGATTTAAAAGAAAATACGTCACGACA
GCTATCGGTGGCTATCGACG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MQHQKILILDFGSQVTQLIARRVREAHVYCEVHPCDVSDAWVREYAADGSLKGVILSGSHASVYEETTDRAPQAVFELGV
PVLGICYGMQTMAQQLGGKVEGGHKREFGYAEVRAHGHTALLKDIADFTTAEGHGMLKVWMSHGDKVAEMPPGFKLMAST
PSCPIAGMADEARRFYAVQFHPEVTHTVQGRALLDRFVLGICGVQPDWVMKDHIAEAVESIRAQVGDEEVILGLSGGVDS
SVAAALIHRAIGDQLTCVFVDHGLLRLNEGDMVMDMFVGKLHAKVVRVDASELFLRELAGVSDPEQKRKIIGRLFVDVFK
AEAAKLTASGASRKEKGATFLAQGTIYPDVIESGGAKSKKAVTIKSHHNVGGLPEQLGLKLLEPLRDLFKDEVRELGVAL
GLPHDMVYRHPFPGPGLGVRILGEVKKEYADLLRRADAIFIEELRNHVDAETGKTWYDLTSQAFTVFLPVKSVGVMGDGR
TYDYVVALRAVQTSDFMTADWAELPYALLKKVSGRIINEVRGINRVTYDVSSKPPATIEWE

Sequences:

>Translated_541_residues
MQHQKILILDFGSQVTQLIARRVREAHVYCEVHPCDVSDAWVREYAADGSLKGVILSGSHASVYEETTDRAPQAVFELGV
PVLGICYGMQTMAQQLGGKVEGGHKREFGYAEVRAHGHTALLKDIADFTTAEGHGMLKVWMSHGDKVAEMPPGFKLMAST
PSCPIAGMADEARRFYAVQFHPEVTHTVQGRALLDRFVLGICGVQPDWVMKDHIAEAVESIRAQVGDEEVILGLSGGVDS
SVAAALIHRAIGDQLTCVFVDHGLLRLNEGDMVMDMFVGKLHAKVVRVDASELFLRELAGVSDPEQKRKIIGRLFVDVFK
AEAAKLTASGASRKEKGATFLAQGTIYPDVIESGGAKSKKAVTIKSHHNVGGLPEQLGLKLLEPLRDLFKDEVRELGVAL
GLPHDMVYRHPFPGPGLGVRILGEVKKEYADLLRRADAIFIEELRNHVDAETGKTWYDLTSQAFTVFLPVKSVGVMGDGR
TYDYVVALRAVQTSDFMTADWAELPYALLKKVSGRIINEVRGINRVTYDVSSKPPATIEWE
>Mature_541_residues
MQHQKILILDFGSQVTQLIARRVREAHVYCEVHPCDVSDAWVREYAADGSLKGVILSGSHASVYEETTDRAPQAVFELGV
PVLGICYGMQTMAQQLGGKVEGGHKREFGYAEVRAHGHTALLKDIADFTTAEGHGMLKVWMSHGDKVAEMPPGFKLMAST
PSCPIAGMADEARRFYAVQFHPEVTHTVQGRALLDRFVLGICGVQPDWVMKDHIAEAVESIRAQVGDEEVILGLSGGVDS
SVAAALIHRAIGDQLTCVFVDHGLLRLNEGDMVMDMFVGKLHAKVVRVDASELFLRELAGVSDPEQKRKIIGRLFVDVFK
AEAAKLTASGASRKEKGATFLAQGTIYPDVIESGGAKSKKAVTIKSHHNVGGLPEQLGLKLLEPLRDLFKDEVRELGVAL
GLPHDMVYRHPFPGPGLGVRILGEVKKEYADLLRRADAIFIEELRNHVDAETGKTWYDLTSQAFTVFLPVKSVGVMGDGR
TYDYVVALRAVQTSDFMTADWAELPYALLKKVSGRIINEVRGINRVTYDVSSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=576, Percent_Identity=34.5486111111111, Blast_Score=273, Evalue=4e-73,
Organism=Escherichia coli, GI1788854, Length=541, Percent_Identity=62.1072088724584, Blast_Score=665, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992717, Length=585, Percent_Identity=35.2136752136752, Blast_Score=297, Evalue=8e-81,
Organism=Caenorhabditis elegans, GI71992710, Length=585, Percent_Identity=35.2136752136752, Blast_Score=297, Evalue=8e-81,
Organism=Caenorhabditis elegans, GI133901714, Length=585, Percent_Identity=35.3846153846154, Blast_Score=297, Evalue=8e-81,
Organism=Saccharomyces cerevisiae, GI6323873, Length=541, Percent_Identity=50.2772643253235, Blast_Score=521, Evalue=1e-149,
Organism=Drosophila melanogaster, GI281365319, Length=566, Percent_Identity=34.982332155477, Blast_Score=289, Evalue=3e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 59322; Mature: 59322

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHQKILILDFGSQVTQLIARRVREAHVYCEVHPCDVSDAWVREYAADGSLKGVILSGSH
CCCCEEEEEECCHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHCCCCCCEEEEECCC
ASVYEETTDRAPQAVFELGVPVLGICYGMQTMAQQLGGKVEGGHKREFGYAEVRAHGHTA
CHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCHHH
LLKDIADFTTAEGHGMLKVWMSHGDKVAEMPPGFKLMASTPSCPIAGMADEARRFYAVQF
HHHHHHHHHCCCCCCEEEEEECCCCEECCCCCCCEEEECCCCCCCCCCCHHCCEEEEEEE
HPEVTHTVQGRALLDRFVLGICGVQPDWVMKDHIAEAVESIRAQVGDEEVILGLSGGVDS
CCCHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
SVAAALIHRAIGDQLTCVFVDHGLLRLNEGDMVMDMFVGKLHAKVVRVDASELFLRELAG
HHHHHHHHHHHCCCEEEEEEECCEEEECCCCEEHHHHHHHHHHHHEEECHHHHHHHHHCC
VSDPEQKRKIIGRLFVDVFKAEAAKLTASGASRKEKGATFLAQGTIYPDVIESGGAKSKK
CCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHCCCEEEEECCCCHHHHHCCCCCCCE
AVTIKSHHNVGGLPEQLGLKLLEPLRDLFKDEVRELGVALGLPHDMVYRHPFPGPGLGVR
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHH
ILGEVKKEYADLLRRADAIFIEELRNHVDAETGKTWYDLTSQAFTVFLPVKSVGVMGDGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCEEEEEEEHHHEEECCCCC
TYDYVVALRAVQTSDFMTADWAELPYALLKKVSGRIINEVRGINRVTYDVSSKPPATIEW
CEEEEEEEEHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEC
E
C
>Mature Secondary Structure
MQHQKILILDFGSQVTQLIARRVREAHVYCEVHPCDVSDAWVREYAADGSLKGVILSGSH
CCCCEEEEEECCHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHCCCCCCEEEEECCC
ASVYEETTDRAPQAVFELGVPVLGICYGMQTMAQQLGGKVEGGHKREFGYAEVRAHGHTA
CHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCHHH
LLKDIADFTTAEGHGMLKVWMSHGDKVAEMPPGFKLMASTPSCPIAGMADEARRFYAVQF
HHHHHHHHHCCCCCCEEEEEECCCCEECCCCCCCEEEECCCCCCCCCCCHHCCEEEEEEE
HPEVTHTVQGRALLDRFVLGICGVQPDWVMKDHIAEAVESIRAQVGDEEVILGLSGGVDS
CCCHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
SVAAALIHRAIGDQLTCVFVDHGLLRLNEGDMVMDMFVGKLHAKVVRVDASELFLRELAG
HHHHHHHHHHHCCCEEEEEEECCEEEECCCCEEHHHHHHHHHHHHEEECHHHHHHHHHCC
VSDPEQKRKIIGRLFVDVFKAEAAKLTASGASRKEKGATFLAQGTIYPDVIESGGAKSKK
CCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHCCCEEEEECCCCHHHHHCCCCCCCE
AVTIKSHHNVGGLPEQLGLKLLEPLRDLFKDEVRELGVALGLPHDMVYRHPFPGPGLGVR
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHH
ILGEVKKEYADLLRRADAIFIEELRNHVDAETGKTWYDLTSQAFTVFLPVKSVGVMGDGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCEEEEEEEHHHEEECCCCC
TYDYVVALRAVQTSDFMTADWAELPYALLKKVSGRIINEVRGINRVTYDVSSKPPATIEW
CEEEEEEEEHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA