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The map label for this gene is ggt [H]

Identifier: 120611963

GI number: 120611963

Start: 3659118

End: 3661127

Strand: Direct

Name: ggt [H]

Synonym: Aave_3307

Alternate gene names: 120611963

Gene position: 3659118-3661127 (Clockwise)

Preceding gene: 120611958

Following gene: 120611965

Centisome position: 68.36

GC content: 71.54

Gene sequence:

>2010_bases
ATGCATAGCCTCGGCAAGCCTCACTCACCATCTTCCCTGCCCCCCGCATGGGGCCTTCCCGCAGCGCTGGCTGCCGCGCT
GCTGGCCCTCTCGGGCTGCGGCGGCAGCGGCAGCGGCGGAACGGCCCTCGTGCCAGGCCAGGACAACGCCTGCGCCGTGA
CGAGCGACAACGGACTGGTCACGGTCGGCTCCGGCCTGCCGGGCGACCCGGCCGCGCCCGAGCCGGCTTCGGGCTACCGC
GTCGGCAAGACCGCGGTCCATGCGAAACAGTACATGGTGACCACGGCCAATCCGTACGCATCGCGTGCCGGCTGCGAGGT
GCTGAAGAAAGGCGGTTCGGCCGTGGACGCGGCCGTCGCCGTGCAGATGGTGCTCGGGCTCGTGGAGCCGCAATCCTCCG
GTCTCGGAGGCGGCGCCTTCATGCTGCATTACGACGCCGTCCAGAAGAAGGTCCAGGCCTACGACGGCCGAGAGACCGCC
CCGGCGGCCGCGACCGCCAACTACCTGCGCTGGGTCAGCGACACCGACCGCACCGCGCCGCAGCCGGGCGGCGCGCGCGC
CAGCGGGCGCTCCATCGGCACGCCGGGCGCGGTCCGCATGCTCGAGCTGGCCCACCGCGACCACGGGCGTCTGGCCTGGG
GCGACCTGTTCCAGCCGGCCGAGCAACTGGCGCGCGACGGCTTCCCCATCGGCGGCCGCATGGCCGCGGCGATTTCCGGC
TCCGCCTCCGGCCTGGCCCGCGACGCGGAAGCCGTGGCCTACTTCTTCAATGCCGATGGAACACCCAAGGCCCTGGGCAC
GGTGCTGAAGAACACCGCCTACGCCGACACGCTGTCCGCCATCGCCCGCAACGGCGCCGATGCCTTCTACACGGGCCCGA
TCGCCCAGGGCATCGTCGCGAAGATCCAGGCCACCAGCGGCGGCTCGCCGGCCGTCGCCATCACGCCGGGCCTGACGCAG
CTGAGCGACCTGGCGGACTACCGCGCCAAGCGCCGCGATCCGGTCTGCACCACCTACCGCGACTACTGGGTGTGCGGCAT
GTCGCCCCCCTCCTCCGGCGGCATCGCCGTGGCCTCCGCGCTCGGCATCCTGGAGAACTTCGATCTTTCGCGACACAAGC
CCACGGCCATCGACATCGAGGGAGGCAAGCCCACGGTGATGGGAGTGCATCTCGTGAGCGAGGCGGAGCGCCTGGCCTAC
GCCGACCGCGACAAGTACGTGGCCGATACCGACTTCGTCCCCCTGCCCGGCGGCTCCCCCGCGCGCATGCTCGACAAGTC
GTACCTGCGCGCGCGCGCCGGCCTGATCAGCACCACCCGCAGCATGGGCACCGCCACGGCGGGCGATTTCGGCACCGCCG
CCGCCGGGGTCGTGCCGCTCGAGGAACGCGGCACCACGCACTTCACCATCGTGGACAAGGAGGGCAACGCCGTGGTCATG
ACCACGACGGTGGAAGCCAGCATGGGCTCCTTCCACATGACCCGGGGCTTCCTGCTGAACAACCAGCTCACCGACTTCGC
CTCCACGCCCACGGATGCCTCGGGCGCGCCGGTCGCCAACCGCGTGGAGCCCGGCAAGCGCCCCCGCAGCTCCATGGCCC
CGACCCTGGTGTTCCGCAAGGCTGCCGACGGCGGCATCGGCGAGTTCGTGATGGGCACCGGCTCGCCCGGCGGCGGCACC
ATCATCCAGTACGTGGTGAAGACCGTGGTCGGCGCGCTCGACTGGGGCCTGGATGCGCAGCAGGCCACGTCGCTCGTGGA
CTTCGGCGCCAGCAACAGCGCCACCACCTCGGTCGGCGGCGAGCATCCGAACGTCAACACGGCGAACAACGGCAACGATG
ATCCCCTGATCACCGGCCTGCGCGCGCTGGGCCATACGGTCTCGACCTCCGCCCAGTCCAGCGGCACGGCCACGATCCTG
CGGGTGAACCGCAACGGCGCCAGCGTGCTGCAGGGCGGCGCCGATCCGCGGCGCGAAGGCGTGGTCCTGGGCGACACCTT
CAAGCCCTGA

Upstream 100 bases:

>100_bases
CCCGGCGAACCACCTATGCTTGCGGGGCGCCCCGGGAAGGGAGCCTCCCGGAGACCGCGCACCCCTCAACCATCCTCCAC
CAACAAGAAAGCGATTCCGG

Downstream 100 bases:

>100_bases
CGCACCGGCATCCGGTGCCGGCTGTGGTCGGCGCCGGATGCGGCAGCCGCCGGATGGCCCGCCTCAGCGGGCCGCGGCGT
TGGCCGGGCCGAGCGGCTCC

Product: gamma-glutamyltransferase 1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 669; Mature: 669

Protein sequence:

>669_residues
MHSLGKPHSPSSLPPAWGLPAALAAALLALSGCGGSGSGGTALVPGQDNACAVTSDNGLVTVGSGLPGDPAAPEPASGYR
VGKTAVHAKQYMVTTANPYASRAGCEVLKKGGSAVDAAVAVQMVLGLVEPQSSGLGGGAFMLHYDAVQKKVQAYDGRETA
PAAATANYLRWVSDTDRTAPQPGGARASGRSIGTPGAVRMLELAHRDHGRLAWGDLFQPAEQLARDGFPIGGRMAAAISG
SASGLARDAEAVAYFFNADGTPKALGTVLKNTAYADTLSAIARNGADAFYTGPIAQGIVAKIQATSGGSPAVAITPGLTQ
LSDLADYRAKRRDPVCTTYRDYWVCGMSPPSSGGIAVASALGILENFDLSRHKPTAIDIEGGKPTVMGVHLVSEAERLAY
ADRDKYVADTDFVPLPGGSPARMLDKSYLRARAGLISTTRSMGTATAGDFGTAAAGVVPLEERGTTHFTIVDKEGNAVVM
TTTVEASMGSFHMTRGFLLNNQLTDFASTPTDASGAPVANRVEPGKRPRSSMAPTLVFRKAADGGIGEFVMGTGSPGGGT
IIQYVVKTVVGALDWGLDAQQATSLVDFGASNSATTSVGGEHPNVNTANNGNDDPLITGLRALGHTVSTSAQSSGTATIL
RVNRNGASVLQGGADPRREGVVLGDTFKP

Sequences:

>Translated_669_residues
MHSLGKPHSPSSLPPAWGLPAALAAALLALSGCGGSGSGGTALVPGQDNACAVTSDNGLVTVGSGLPGDPAAPEPASGYR
VGKTAVHAKQYMVTTANPYASRAGCEVLKKGGSAVDAAVAVQMVLGLVEPQSSGLGGGAFMLHYDAVQKKVQAYDGRETA
PAAATANYLRWVSDTDRTAPQPGGARASGRSIGTPGAVRMLELAHRDHGRLAWGDLFQPAEQLARDGFPIGGRMAAAISG
SASGLARDAEAVAYFFNADGTPKALGTVLKNTAYADTLSAIARNGADAFYTGPIAQGIVAKIQATSGGSPAVAITPGLTQ
LSDLADYRAKRRDPVCTTYRDYWVCGMSPPSSGGIAVASALGILENFDLSRHKPTAIDIEGGKPTVMGVHLVSEAERLAY
ADRDKYVADTDFVPLPGGSPARMLDKSYLRARAGLISTTRSMGTATAGDFGTAAAGVVPLEERGTTHFTIVDKEGNAVVM
TTTVEASMGSFHMTRGFLLNNQLTDFASTPTDASGAPVANRVEPGKRPRSSMAPTLVFRKAADGGIGEFVMGTGSPGGGT
IIQYVVKTVVGALDWGLDAQQATSLVDFGASNSATTSVGGEHPNVNTANNGNDDPLITGLRALGHTVSTSAQSSGTATIL
RVNRNGASVLQGGADPRREGVVLGDTFKP
>Mature_669_residues
MHSLGKPHSPSSLPPAWGLPAALAAALLALSGCGGSGSGGTALVPGQDNACAVTSDNGLVTVGSGLPGDPAAPEPASGYR
VGKTAVHAKQYMVTTANPYASRAGCEVLKKGGSAVDAAVAVQMVLGLVEPQSSGLGGGAFMLHYDAVQKKVQAYDGRETA
PAAATANYLRWVSDTDRTAPQPGGARASGRSIGTPGAVRMLELAHRDHGRLAWGDLFQPAEQLARDGFPIGGRMAAAISG
SASGLARDAEAVAYFFNADGTPKALGTVLKNTAYADTLSAIARNGADAFYTGPIAQGIVAKIQATSGGSPAVAITPGLTQ
LSDLADYRAKRRDPVCTTYRDYWVCGMSPPSSGGIAVASALGILENFDLSRHKPTAIDIEGGKPTVMGVHLVSEAERLAY
ADRDKYVADTDFVPLPGGSPARMLDKSYLRARAGLISTTRSMGTATAGDFGTAAAGVVPLEERGTTHFTIVDKEGNAVVM
TTTVEASMGSFHMTRGFLLNNQLTDFASTPTDASGAPVANRVEPGKRPRSSMAPTLVFRKAADGGIGEFVMGTGSPGGGT
IIQYVVKTVVGALDWGLDAQQATSLVDFGASNSATTSVGGEHPNVNTANNGNDDPLITGLRALGHTVSTSAQSSGTATIL
RVNRNGASVLQGGADPRREGVVLGDTFKP

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=493, Percent_Identity=31.8458417849899, Blast_Score=199, Evalue=7e-51,
Organism=Homo sapiens, GI73915090, Length=493, Percent_Identity=31.8458417849899, Blast_Score=199, Evalue=7e-51,
Organism=Homo sapiens, GI73915096, Length=493, Percent_Identity=31.8458417849899, Blast_Score=199, Evalue=7e-51,
Organism=Homo sapiens, GI73915094, Length=493, Percent_Identity=31.8458417849899, Blast_Score=199, Evalue=7e-51,
Organism=Homo sapiens, GI113429324, Length=489, Percent_Identity=30.879345603272, Blast_Score=175, Evalue=2e-43,
Organism=Homo sapiens, GI113429326, Length=493, Percent_Identity=30.2231237322515, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI153266885, Length=510, Percent_Identity=28.6274509803922, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI153266901, Length=511, Percent_Identity=28.3757338551859, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI109148539, Length=475, Percent_Identity=30.7368421052632, Blast_Score=132, Evalue=9e-31,
Organism=Homo sapiens, GI153266907, Length=510, Percent_Identity=26.6666666666667, Blast_Score=110, Evalue=4e-24,
Organism=Escherichia coli, GI1789856, Length=509, Percent_Identity=36.1493123772102, Blast_Score=278, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI193208245, Length=517, Percent_Identity=33.0754352030948, Blast_Score=188, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI193208247, Length=517, Percent_Identity=33.0754352030948, Blast_Score=188, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17542894, Length=573, Percent_Identity=28.9703315881326, Blast_Score=181, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI72000294, Length=500, Percent_Identity=31.2, Blast_Score=171, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI212646519, Length=504, Percent_Identity=30.7539682539683, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17506189, Length=508, Percent_Identity=27.755905511811, Blast_Score=160, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17564448, Length=468, Percent_Identity=25.6410256410256, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323330, Length=492, Percent_Identity=26.6260162601626, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI45551474, Length=578, Percent_Identity=28.2006920415225, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI161077878, Length=578, Percent_Identity=28.3737024221453, Blast_Score=163, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24642670, Length=578, Percent_Identity=28.2006920415225, Blast_Score=163, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24642666, Length=578, Percent_Identity=28.2006920415225, Blast_Score=163, Evalue=4e-40,
Organism=Drosophila melanogaster, GI161077880, Length=579, Percent_Identity=28.1519861830743, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI18859893, Length=487, Percent_Identity=30.5954825462012, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI161077496, Length=481, Percent_Identity=26.6112266112266, Blast_Score=128, Evalue=2e-29,
Organism=Drosophila melanogaster, GI18859741, Length=495, Percent_Identity=28.0808080808081, Blast_Score=122, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 68265; Mature: 68265

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSLGKPHSPSSLPPAWGLPAALAAALLALSGCGGSGSGGTALVPGQDNACAVTSDNGLV
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEEEEECCCCEE
TVGSGLPGDPAAPEPASGYRVGKTAVHAKQYMVTTANPYASRAGCEVLKKGGSAVDAAVA
EECCCCCCCCCCCCCCCCCCCCHHHHHHEEEEEEECCCHHHHHHHHHHHCCCCHHHHHHH
VQMVLGLVEPQSSGLGGGAFMLHYDAVQKKVQAYDGRETAPAAATANYLRWVSDTDRTAP
HHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCC
QPGGARASGRSIGTPGAVRMLELAHRDHGRLAWGDLFQPAEQLARDGFPIGGRMAAAISG
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCCCCEEEEEECC
SASGLARDAEAVAYFFNADGTPKALGTVLKNTAYADTLSAIARNGADAFYTGPIAQGIVA
CCCCHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHCCEE
KIQATSGGSPAVAITPGLTQLSDLADYRAKRRDPVCTTYRDYWVCGMSPPSSGGIAVASA
EEEECCCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEEECCEEEEECCCCCCCCHHHHHH
LGILENFDLSRHKPTAIDIEGGKPTVMGVHLVSEAERLAYADRDKYVADTDFVPLPGGSP
HHHHHCCCCCCCCCCEEEECCCCCEEEEEEEHHHHHHHHHCCCCCEEECCCCEECCCCCH
ARMLDKSYLRARAGLISTTRSMGTATAGDFGTAAAGVVPLEERGTTHFTIVDKEGNAVVM
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCEEHHCCCCEEEEEEECCCCEEEE
TTTVEASMGSFHMTRGFLLNNQLTDFASTPTDASGAPVANRVEPGKRPRSSMAPTLVFRK
EEEECCCCCCEEHHHCEEECCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHCCCEEEEEE
AADGGIGEFVMGTGSPGGGTIIQYVVKTVVGALDWGLDAQQATSLVDFGASNSATTSVGG
CCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCC
EHPNVNTANNGNDDPLITGLRALGHTVSTSAQSSGTATILRVNRNGASVLQGGADPRREG
CCCCCCCCCCCCCCHHHHHHHHHCCHHCCCCCCCCCEEEEEECCCCHHHHCCCCCCCCCC
VVLGDTFKP
EEECCCCCC
>Mature Secondary Structure
MHSLGKPHSPSSLPPAWGLPAALAAALLALSGCGGSGSGGTALVPGQDNACAVTSDNGLV
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEEEEECCCCEE
TVGSGLPGDPAAPEPASGYRVGKTAVHAKQYMVTTANPYASRAGCEVLKKGGSAVDAAVA
EECCCCCCCCCCCCCCCCCCCCHHHHHHEEEEEEECCCHHHHHHHHHHHCCCCHHHHHHH
VQMVLGLVEPQSSGLGGGAFMLHYDAVQKKVQAYDGRETAPAAATANYLRWVSDTDRTAP
HHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCC
QPGGARASGRSIGTPGAVRMLELAHRDHGRLAWGDLFQPAEQLARDGFPIGGRMAAAISG
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCCCCEEEEEECC
SASGLARDAEAVAYFFNADGTPKALGTVLKNTAYADTLSAIARNGADAFYTGPIAQGIVA
CCCCHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHCCEE
KIQATSGGSPAVAITPGLTQLSDLADYRAKRRDPVCTTYRDYWVCGMSPPSSGGIAVASA
EEEECCCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEEECCEEEEECCCCCCCCHHHHHH
LGILENFDLSRHKPTAIDIEGGKPTVMGVHLVSEAERLAYADRDKYVADTDFVPLPGGSP
HHHHHCCCCCCCCCCEEEECCCCCEEEEEEEHHHHHHHHHCCCCCEEECCCCEECCCCCH
ARMLDKSYLRARAGLISTTRSMGTATAGDFGTAAAGVVPLEERGTTHFTIVDKEGNAVVM
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCEEHHCCCCEEEEEEECCCCEEEE
TTTVEASMGSFHMTRGFLLNNQLTDFASTPTDASGAPVANRVEPGKRPRSSMAPTLVFRK
EEEECCCCCCEEHHHCEEECCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHCCCEEEEEE
AADGGIGEFVMGTGSPGGGTIIQYVVKTVVGALDWGLDAQQATSLVDFGASNSATTSVGG
CCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCC
EHPNVNTANNGNDDPLITGLRALGHTVSTSAQSSGTATILRVNRNGASVLQGGADPRREG
CCCCCCCCCCCCCCHHHHHHHHHCCHHCCCCCCCCCEEEEEECCCCHHHHCCCCCCCCCC
VVLGDTFKP
EEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]