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The map label for this gene is aroA [H]

Identifier: 120611940

GI number: 120611940

Start: 3630269

End: 3632308

Strand: Direct

Name: aroA [H]

Synonym: Aave_3284

Alternate gene names: 120611940

Gene position: 3630269-3632308 (Clockwise)

Preceding gene: 120611939

Following gene: 120611941

Centisome position: 67.82

GC content: 70.39

Gene sequence:

>2040_bases
ATGTACAGCACCGCGTTTCTCGACCTCCCTCCCCTGGATACCGCCGGAGGAGCCGTGCGGCTGCCGGGCTCCAAGAGCAT
TTCCAACCGCGTCCTGCTGCTGGCCGCACTGAGCGAGGGGACGACGGAAGTCCATGACCTGCTGGCTTCCGACGACACGC
GCGTGATGCTGGATGCGCTGCGGGAAATCGGCTGCGGCGTCGATGAAGGCGCGGCCGCGCAGGGCACGGTGCGCATCACC
GGCCTGGGGACGTCCCCCGCGCGTTCCCCGTCGAAGCTCTTCCTGGGCAACGCGGGCACGGCCATGCGGCCGCTGACGGC
GGCGCTGGCCCTGCTGGGCGGCGAGTTCGAGCTCTCCGGCGTTCCGCGCATGCACGAGCGCCCGATAGGCGACCTGGTGG
AGGCCCTGCTGCAGCTCGGCTGCCACATCAGCTACCTGGGCAATCCTGGCTTCCCGCCGCTGCGCATCGCGCATGCGGGC
GGCGTCCCGCCGCTGGCGCTGGATGCGCCCGTGCGCGTGCGCGGCGACGTATCCAGCCAGTTCCTCACCGCCCTGCTGAT
GGCCCTGCCGCTGGTGGCACGCGAGAAGGACGTGGTGATCGAGGTGGTGGGCGAGCTGATTTCGCGCCCCTATATCCACA
TCACGCTGCAGTTGCTGGAGCGCTTCGGCATCCGGGTGCGGCACGACGAATGGCAGCGCTTCACCATCCCGGCCGGCAGC
CGCTACCGCTCCCCGGGCACCATCCACGTCGAGGCCGACGCCTCCTCGGCCAGCTATTTCATCGCCCTGGGTGCCCTGGC
GGCCCCGGCGCCCGGCCAGGAGCCGCTGCGCATCCTCGGCGTGGGCCTGGACTCGATCCAGGGCGACATCCGCTTCGCCG
AGGCGGCCCGCGCCATGGGCGCGGAGGTCACCGGCGGCCCGAACTGGCTGGTGGTGCGCCGCGGCGCCTGGCCGCTGAGG
GCGGTCGATCTCGACTGCAACCACATTCCCGATGCCGCCATGACGCTGGCGGTGATGGCGCTGTACGCGCAGGGCACGAC
CACGCTGCGCAACATCGCGAGCTGGCGCGTCAAGGAAACGGACCGCATCGCCGCGATGGCGCAGGGATGCCGGCGCCTGG
GCGCCACCGTCGAGGAAGGGTCGGACTTCCTGCGCGTCACCCCGCCCGCCTCGCCGGCTGATTGGCGCGCGGCGAGCATC
CACACCTACGACGATCACCGCATCGCGATGTGCTTTTCGCTGGCGGCGTTCAATCCGGCGAAGCTCCCGGTGCGCATCGA
GGATCCGAAGTGCGTGGCCAAGACCTTCCCGGACTATTTCGAGGCCCTCTTCTCGGTCGCTGGAACACCCGTGGAGCACG
TTCCCGTGATCTGCATCGACGGCCCGACGGCATCGGGCAAGGGCACGGTGGCGGCAGCGGTGGCGCAGCGGCTGGGCTAC
CGCTTCCTGGACTCGGGCGCGATGTACCGCATCACCGCGCTGGCGGCGCTGCGTGCCGGGCTGTCCATCGACGCGGCCCA
CCAGGACCGGATCGCGGCCCTGGCGCGCACCCTGCCGGTACGGTTCGAGTCCGGCCGCATCTGGCTGGGCGAGGACGACG
TGACGGATGCCATCCGCACCGAGGAGGCCGGCATGAACGCCTCCCGCGTCTCGGCCCTGCCGTCGGTGCGCGAGGCCCTG
GTGGCGCTGCAGCACGGCTTCCGGCGCCTGCCGGGACTGGTTGCGGACGGCCGCGACATGGGCACGGTGATCTTCCCGGG
CGCCGCATTGAAGGTCTATCTCACGGCGAGCGCGGCCTGCCGGGCGGAGCGGCGCCATAAACAGTTGATTTCAAAGGGAA
TTTCCGCTAATATCGACGATCTTCGCGCAGATCTGGAGGCGCGCGACGTCCGGGACAGCACCCGGCCGGTCGCGCCCCTG
AAGCCTGCGCAGGATGCACTGGTGCTGGACAACTCCCTGCTGTCGGTCGAAGAAGCCGTCGAGCAGGTGCTTGCCTGGTG
GCAGCAGCGACAGCCCTTCGCGCACCCCGCGCAGGACTGA

Upstream 100 bases:

>100_bases
GGCGACGGACAAGGGCTCGAAGACCTCATCACCCTCGCCAGCGAAACCCGCGCCCATTGGCGCATGGGCGCCCGCCGCGC
CTCCTAGATTCCCGCAGCCG

Downstream 100 bases:

>100_bases
ACCGGGCCCGCAAGGCCTCCTACCGCACCTGCAGCGCACGGCCTTGCGATGTGTTCAACCCCAACCGTGGCCACCGGCCA
CACAACCTTCCGCAGGCAAC

Product: bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidine monophosphate kinase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS [H]

Number of amino acids: Translated: 679; Mature: 679

Protein sequence:

>679_residues
MYSTAFLDLPPLDTAGGAVRLPGSKSISNRVLLLAALSEGTTEVHDLLASDDTRVMLDALREIGCGVDEGAAAQGTVRIT
GLGTSPARSPSKLFLGNAGTAMRPLTAALALLGGEFELSGVPRMHERPIGDLVEALLQLGCHISYLGNPGFPPLRIAHAG
GVPPLALDAPVRVRGDVSSQFLTALLMALPLVAREKDVVIEVVGELISRPYIHITLQLLERFGIRVRHDEWQRFTIPAGS
RYRSPGTIHVEADASSASYFIALGALAAPAPGQEPLRILGVGLDSIQGDIRFAEAARAMGAEVTGGPNWLVVRRGAWPLR
AVDLDCNHIPDAAMTLAVMALYAQGTTTLRNIASWRVKETDRIAAMAQGCRRLGATVEEGSDFLRVTPPASPADWRAASI
HTYDDHRIAMCFSLAAFNPAKLPVRIEDPKCVAKTFPDYFEALFSVAGTPVEHVPVICIDGPTASGKGTVAAAVAQRLGY
RFLDSGAMYRITALAALRAGLSIDAAHQDRIAALARTLPVRFESGRIWLGEDDVTDAIRTEEAGMNASRVSALPSVREAL
VALQHGFRRLPGLVADGRDMGTVIFPGAALKVYLTASAACRAERRHKQLISKGISANIDDLRADLEARDVRDSTRPVAPL
KPAQDALVLDNSLLSVEEAVEQVLAWWQQRQPFAHPAQD

Sequences:

>Translated_679_residues
MYSTAFLDLPPLDTAGGAVRLPGSKSISNRVLLLAALSEGTTEVHDLLASDDTRVMLDALREIGCGVDEGAAAQGTVRIT
GLGTSPARSPSKLFLGNAGTAMRPLTAALALLGGEFELSGVPRMHERPIGDLVEALLQLGCHISYLGNPGFPPLRIAHAG
GVPPLALDAPVRVRGDVSSQFLTALLMALPLVAREKDVVIEVVGELISRPYIHITLQLLERFGIRVRHDEWQRFTIPAGS
RYRSPGTIHVEADASSASYFIALGALAAPAPGQEPLRILGVGLDSIQGDIRFAEAARAMGAEVTGGPNWLVVRRGAWPLR
AVDLDCNHIPDAAMTLAVMALYAQGTTTLRNIASWRVKETDRIAAMAQGCRRLGATVEEGSDFLRVTPPASPADWRAASI
HTYDDHRIAMCFSLAAFNPAKLPVRIEDPKCVAKTFPDYFEALFSVAGTPVEHVPVICIDGPTASGKGTVAAAVAQRLGY
RFLDSGAMYRITALAALRAGLSIDAAHQDRIAALARTLPVRFESGRIWLGEDDVTDAIRTEEAGMNASRVSALPSVREAL
VALQHGFRRLPGLVADGRDMGTVIFPGAALKVYLTASAACRAERRHKQLISKGISANIDDLRADLEARDVRDSTRPVAPL
KPAQDALVLDNSLLSVEEAVEQVLAWWQQRQPFAHPAQD
>Mature_679_residues
MYSTAFLDLPPLDTAGGAVRLPGSKSISNRVLLLAALSEGTTEVHDLLASDDTRVMLDALREIGCGVDEGAAAQGTVRIT
GLGTSPARSPSKLFLGNAGTAMRPLTAALALLGGEFELSGVPRMHERPIGDLVEALLQLGCHISYLGNPGFPPLRIAHAG
GVPPLALDAPVRVRGDVSSQFLTALLMALPLVAREKDVVIEVVGELISRPYIHITLQLLERFGIRVRHDEWQRFTIPAGS
RYRSPGTIHVEADASSASYFIALGALAAPAPGQEPLRILGVGLDSIQGDIRFAEAARAMGAEVTGGPNWLVVRRGAWPLR
AVDLDCNHIPDAAMTLAVMALYAQGTTTLRNIASWRVKETDRIAAMAQGCRRLGATVEEGSDFLRVTPPASPADWRAASI
HTYDDHRIAMCFSLAAFNPAKLPVRIEDPKCVAKTFPDYFEALFSVAGTPVEHVPVICIDGPTASGKGTVAAAVAQRLGY
RFLDSGAMYRITALAALRAGLSIDAAHQDRIAALARTLPVRFESGRIWLGEDDVTDAIRTEEAGMNASRVSALPSVREAL
VALQHGFRRLPGLVADGRDMGTVIFPGAALKVYLTASAACRAERRHKQLISKGISANIDDLRADLEARDVRDSTRPVAPL
KPAQDALVLDNSLLSVEEAVEQVLAWWQQRQPFAHPAQD

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1787137, Length=437, Percent_Identity=51.0297482837529, Blast_Score=394, Evalue=1e-110,
Organism=Escherichia coli, GI1787139, Length=224, Percent_Identity=50, Blast_Score=203, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6320332, Length=524, Percent_Identity=34.1603053435114, Blast_Score=227, Evalue=5e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792 [H]

Pfam domain/function: PF00275 EPSP_synthase [H]

EC number: =2.5.1.19 [H]

Molecular weight: Translated: 72647; Mature: 72647

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00104 EPSP_SYNTHASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSTAFLDLPPLDTAGGAVRLPGSKSISNRVLLLAALSEGTTEVHDLLASDDTRVMLDAL
CCCCEEEECCCCCCCCCEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCHHHHHHHH
REIGCGVDEGAAAQGTVRITGLGTSPARSPSKLFLGNAGTAMRPLTAALALLGGEFELSG
HHHCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCEEECC
VPRMHERPIGDLVEALLQLGCHISYLGNPGFPPLRIAHAGGVPPLALDAPVRVRGDVSSQ
CCCHHCCCHHHHHHHHHHHCCEEEECCCCCCCCEEEECCCCCCCEEECCCEEEECCCHHH
FLTALLMALPLVAREKDVVIEVVGELISRPYIHITLQLLERFGIRVRHDEWQRFTIPAGS
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHCCEEEECCCEEEECCCCC
RYRSPGTIHVEADASSASYFIALGALAAPAPGQEPLRILGVGLDSIQGDIRFAEAARAMG
CCCCCCEEEEEECCCCCEEEEEEHHHCCCCCCCCCEEEEECCHHHHCCCHHHHHHHHHCC
AEVTGGPNWLVVRRGAWPLRAVDLDCNHIPDAAMTLAVMALYAQGTTTLRNIASWRVKET
CCCCCCCCEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCHH
DRIAAMAQGCRRLGATVEEGSDFLRVTPPASPADWRAASIHTYDDHRIAMCFSLAAFNPA
HHHHHHHHHHHHHCCCHHCCCCEEEECCCCCCCCCCEEEEEECCCCCEEEEEHHHCCCCC
KLPVRIEDPKCVAKTFPDYFEALFSVAGTPVEHVPVICIDGPTASGKGTVAAAVAQRLGY
CCCEEECCCHHHHHCCHHHHHHHHHHCCCCHHHCCEEEECCCCCCCCCHHHHHHHHHHCC
RFLDSGAMYRITALAALRAGLSIDAAHQDRIAALARTLPVRFESGRIWLGEDDVTDAIRT
EECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEECCEEEECCCCHHHHHHH
EEAGMNASRVSALPSVREALVALQHGFRRLPGLVADGRDMGTVIFPGAALKVYLTASAAC
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCEEEECCCEEEEEEECHHHH
RAERRHKQLISKGISANIDDLRADLEARDVRDSTRPVAPLKPAQDALVLDNSLLSVEEAV
HHHHHHHHHHHCCCCCCHHHHHHCCHHHHCCCCCCCCCCCCCCCCCEEECCHHHHHHHHH
EQVLAWWQQRQPFAHPAQD
HHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MYSTAFLDLPPLDTAGGAVRLPGSKSISNRVLLLAALSEGTTEVHDLLASDDTRVMLDAL
CCCCEEEECCCCCCCCCEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCHHHHHHHH
REIGCGVDEGAAAQGTVRITGLGTSPARSPSKLFLGNAGTAMRPLTAALALLGGEFELSG
HHHCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCEEECC
VPRMHERPIGDLVEALLQLGCHISYLGNPGFPPLRIAHAGGVPPLALDAPVRVRGDVSSQ
CCCHHCCCHHHHHHHHHHHCCEEEECCCCCCCCEEEECCCCCCCEEECCCEEEECCCHHH
FLTALLMALPLVAREKDVVIEVVGELISRPYIHITLQLLERFGIRVRHDEWQRFTIPAGS
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHCCEEEECCCEEEECCCCC
RYRSPGTIHVEADASSASYFIALGALAAPAPGQEPLRILGVGLDSIQGDIRFAEAARAMG
CCCCCCEEEEEECCCCCEEEEEEHHHCCCCCCCCCEEEEECCHHHHCCCHHHHHHHHHCC
AEVTGGPNWLVVRRGAWPLRAVDLDCNHIPDAAMTLAVMALYAQGTTTLRNIASWRVKET
CCCCCCCCEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCHH
DRIAAMAQGCRRLGATVEEGSDFLRVTPPASPADWRAASIHTYDDHRIAMCFSLAAFNPA
HHHHHHHHHHHHHCCCHHCCCCEEEECCCCCCCCCCEEEEEECCCCCEEEEEHHHCCCCC
KLPVRIEDPKCVAKTFPDYFEALFSVAGTPVEHVPVICIDGPTASGKGTVAAAVAQRLGY
CCCEEECCCHHHHHCCHHHHHHHHHHCCCCHHHCCEEEECCCCCCCCCHHHHHHHHHHCC
RFLDSGAMYRITALAALRAGLSIDAAHQDRIAALARTLPVRFESGRIWLGEDDVTDAIRT
EECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEECCEEEECCCCHHHHHHH
EEAGMNASRVSALPSVREALVALQHGFRRLPGLVADGRDMGTVIFPGAALKVYLTASAAC
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCEEEECCCEEEEEEECHHHH
RAERRHKQLISKGISANIDDLRADLEARDVRDSTRPVAPLKPAQDALVLDNSLLSVEEAV
HHHHHHHHHHHCCCCCCHHHHHHCCHHHHCCCCCCCCCCCCCCCCCEEECCHHHHHHHHH
EQVLAWWQQRQPFAHPAQD
HHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA