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The map label for this gene is adhA [H]

Identifier: 120611889

GI number: 120611889

Start: 3562017

End: 3563051

Strand: Direct

Name: adhA [H]

Synonym: Aave_3231

Alternate gene names: 120611889

Gene position: 3562017-3563051 (Clockwise)

Preceding gene: 120611888

Following gene: 120611890

Centisome position: 66.55

GC content: 67.63

Gene sequence:

>1035_bases
ATGCTTCCCAAGACCATGAAAGCCGCCGTCGTCCGCGAATTCGGCAAGCCGCTGAACATCGAAGAGGCTCCGGTGCCTAC
GCCCGCCGACGACCAGATCCTCGTGAAGATCGAGGCCTCCGGCGTCTGCCACACCGACCTGCACGCCGCCGAAGGCGACT
GGCCCGTCAAGCCGAACCCGCCTTTCATCCCCGGCCACGAGGGCGTGGGTTTCGTCGCGGCCATCGGCAAGAACGTGAAG
CATGTGAAGGAAGGCGACCGCGTGGGCGTGCCCTGGCTGCATTCGGCCTGCGGCTGCTGCACCCACTGCCTGGGTGGCTG
GGAAACCCTGTGCGAATCGCAGAGCAATACCGGCTATTCGGTCAACGGCGGCTTCGCCGACTACGCGCTGGCCGACCCGG
ATTTCGTGGGCCACCTGCCCAAGGACGTCAGCTTCGTGGACATCGCCCCCGTGCTGTGCGCGGGCGTGACCGTGTACAAG
GGCCTGAAAGTGACGGATGCGAAGCCCGGCGACTGGGTGGTCATCTCCGGCATCGGCGGCCTGGGCCACATGGCCGTGCA
GTACGCCAAGGCCATGGGCCTGAACGTGGCGGCGGTGGACGTGGAGGACGACAAGCTGGAACTCGCGAAAAAGCTCGGTG
CCAGCGTGACGGTCAACGCGAAGACCGCCGACCCGGCCGCCTACCTGCAAAAGGAGGTCGGCGGCGCCCACGGTGCGCTG
GTCACGGCCGTCTCGCCCAAGGCGTTCGAGCAGGCGCTCGGCATGGTGCGGCGCGGCGGCACGGTGTCGCTCAACGGCCT
GCCGCCCGGCAATTTCCCCCTGCCCATCTTCGACATGGTGCTGCGCGGCATCACCGTGCGCGGCTCCATCGTCGGCACGC
GCCTGGACCTGCAGGAATCGCTGGACTTCGCGGCACGCGGCCAGGTCAGGGCCACCGTGGCGACCGAGAAGCTGGAGAAC
ATCAACGACGTGTTCGCGCGCATGCACAAGGGCCAGATCCAGGGCCGCATCGTGCTGGACATGGCGGCGCACTGA

Upstream 100 bases:

>100_bases
ACGTCTTGACCTGCATCAGCAGCGACCGAGGGAGGGCGGCATATGGTGGAAGCCAGCCCTCCCCGTTAACCCTTCGGATA
CAAGAAAGGATTCCCGTTCC

Downstream 100 bases:

>100_bases
CGACCGGAGGGCGAGCGCCGCCGCTGCGCTTCGGGCACACTGCAGGAAGCGCCGCCCCCATGACAGGAGACACCGCATGA
CGACGACCGCGCCCCCCGTT

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MLPKTMKAAVVREFGKPLNIEEAPVPTPADDQILVKIEASGVCHTDLHAAEGDWPVKPNPPFIPGHEGVGFVAAIGKNVK
HVKEGDRVGVPWLHSACGCCTHCLGGWETLCESQSNTGYSVNGGFADYALADPDFVGHLPKDVSFVDIAPVLCAGVTVYK
GLKVTDAKPGDWVVISGIGGLGHMAVQYAKAMGLNVAAVDVEDDKLELAKKLGASVTVNAKTADPAAYLQKEVGGAHGAL
VTAVSPKAFEQALGMVRRGGTVSLNGLPPGNFPLPIFDMVLRGITVRGSIVGTRLDLQESLDFAARGQVRATVATEKLEN
INDVFARMHKGQIQGRIVLDMAAH

Sequences:

>Translated_344_residues
MLPKTMKAAVVREFGKPLNIEEAPVPTPADDQILVKIEASGVCHTDLHAAEGDWPVKPNPPFIPGHEGVGFVAAIGKNVK
HVKEGDRVGVPWLHSACGCCTHCLGGWETLCESQSNTGYSVNGGFADYALADPDFVGHLPKDVSFVDIAPVLCAGVTVYK
GLKVTDAKPGDWVVISGIGGLGHMAVQYAKAMGLNVAAVDVEDDKLELAKKLGASVTVNAKTADPAAYLQKEVGGAHGAL
VTAVSPKAFEQALGMVRRGGTVSLNGLPPGNFPLPIFDMVLRGITVRGSIVGTRLDLQESLDFAARGQVRATVATEKLEN
INDVFARMHKGQIQGRIVLDMAAH
>Mature_344_residues
MLPKTMKAAVVREFGKPLNIEEAPVPTPADDQILVKIEASGVCHTDLHAAEGDWPVKPNPPFIPGHEGVGFVAAIGKNVK
HVKEGDRVGVPWLHSACGCCTHCLGGWETLCESQSNTGYSVNGGFADYALADPDFVGHLPKDVSFVDIAPVLCAGVTVYK
GLKVTDAKPGDWVVISGIGGLGHMAVQYAKAMGLNVAAVDVEDDKLELAKKLGASVTVNAKTADPAAYLQKEVGGAHGAL
VTAVSPKAFEQALGMVRRGGTVSLNGLPPGNFPLPIFDMVLRGITVRGSIVGTRLDLQESLDFAARGQVRATVATEKLEN
INDVFARMHKGQIQGRIVLDMAAH

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=361, Percent_Identity=29.3628808864266, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI4501933, Length=361, Percent_Identity=29.6398891966759, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI4501929, Length=361, Percent_Identity=29.3628808864266, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI71565154, Length=236, Percent_Identity=31.7796610169492, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI71565152, Length=319, Percent_Identity=28.2131661442006, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI262073058, Length=252, Percent_Identity=29.3650793650794, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI71743840, Length=252, Percent_Identity=29.3650793650794, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI194239674, Length=236, Percent_Identity=28.8135593220339, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI13236495, Length=236, Percent_Identity=28.8135593220339, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI194239676, Length=243, Percent_Identity=28.8065843621399, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI156627571, Length=287, Percent_Identity=26.8292682926829, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI156523966, Length=236, Percent_Identity=29.2372881355932, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4501939, Length=236, Percent_Identity=28.8135593220339, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI87081918, Length=337, Percent_Identity=43.9169139465875, Blast_Score=242, Evalue=2e-65,
Organism=Escherichia coli, GI1786518, Length=336, Percent_Identity=32.4404761904762, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI1788073, Length=282, Percent_Identity=33.3333333333333, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI87082401, Length=337, Percent_Identity=29.3768545994065, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1790045, Length=290, Percent_Identity=31.7241379310345, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI87082125, Length=220, Percent_Identity=35.9090909090909, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788075, Length=327, Percent_Identity=28.4403669724771, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI226510992, Length=300, Percent_Identity=29, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1787863, Length=315, Percent_Identity=27.3015873015873, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788407, Length=289, Percent_Identity=29.757785467128, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786552, Length=364, Percent_Identity=29.6703296703297, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790485, Length=314, Percent_Identity=28.6624203821656, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786825, Length=313, Percent_Identity=27.7955271565495, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1790718, Length=291, Percent_Identity=24.3986254295533, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562584, Length=346, Percent_Identity=41.907514450867, Blast_Score=246, Evalue=8e-66,
Organism=Caenorhabditis elegans, GI71988145, Length=344, Percent_Identity=37.5, Blast_Score=234, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI17562582, Length=345, Percent_Identity=41.4492753623188, Blast_Score=232, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17562876, Length=335, Percent_Identity=31.9402985074627, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17562878, Length=337, Percent_Identity=31.7507418397626, Blast_Score=110, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17507255, Length=266, Percent_Identity=28.1954887218045, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI25146526, Length=241, Percent_Identity=29.045643153527, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71997431, Length=371, Percent_Identity=25.3369272237197, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17536829, Length=277, Percent_Identity=26.3537906137184, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323961, Length=345, Percent_Identity=41.7391304347826, Blast_Score=269, Evalue=4e-73,
Organism=Saccharomyces cerevisiae, GI6324486, Length=345, Percent_Identity=41.4492753623188, Blast_Score=268, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6323729, Length=345, Percent_Identity=41.4492753623188, Blast_Score=265, Evalue=6e-72,
Organism=Saccharomyces cerevisiae, GI6319621, Length=346, Percent_Identity=39.8843930635838, Blast_Score=263, Evalue=3e-71,
Organism=Saccharomyces cerevisiae, GI6319949, Length=332, Percent_Identity=32.5301204819277, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323980, Length=340, Percent_Identity=29.1176470588235, Blast_Score=102, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6322619, Length=328, Percent_Identity=29.5731707317073, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6319955, Length=328, Percent_Identity=29.5731707317073, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6320033, Length=240, Percent_Identity=32.5, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6319258, Length=300, Percent_Identity=24.3333333333333, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17137530, Length=309, Percent_Identity=31.0679611650485, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI17737897, Length=211, Percent_Identity=32.7014218009479, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17737895, Length=365, Percent_Identity=27.1232876712329, Blast_Score=85, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36196; Mature: 36196

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPKTMKAAVVREFGKPLNIEEAPVPTPADDQILVKIEASGVCHTDLHAAEGDWPVKPNP
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCEECCCCCCCCCCCCCCCC
PFIPGHEGVGFVAAIGKNVKHVKEGDRVGVPWLHSACGCCTHCLGGWETLCESQSNTGYS
CCCCCCCCCCHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
VNGGFADYALADPDFVGHLPKDVSFVDIAPVLCAGVTVYKGLKVTDAKPGDWVVISGIGG
ECCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCCEEEEECCCC
LGHMAVQYAKAMGLNVAAVDVEDDKLELAKKLGASVTVNAKTADPAAYLQKEVGGAHGAL
HHHHHHHHHHHHCCEEEEEECCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCEE
VTAVSPKAFEQALGMVRRGGTVSLNGLPPGNFPLPIFDMVLRGITVRGSIVGTRLDLQES
EEEECHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHCCEEEECEEEEEEECHHHH
LDFAARGQVRATVATEKLENINDVFARMHKGQIQGRIVLDMAAH
CCHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECC
>Mature Secondary Structure
MLPKTMKAAVVREFGKPLNIEEAPVPTPADDQILVKIEASGVCHTDLHAAEGDWPVKPNP
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCEECCCCCCCCCCCCCCCC
PFIPGHEGVGFVAAIGKNVKHVKEGDRVGVPWLHSACGCCTHCLGGWETLCESQSNTGYS
CCCCCCCCCCHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
VNGGFADYALADPDFVGHLPKDVSFVDIAPVLCAGVTVYKGLKVTDAKPGDWVVISGIGG
ECCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCCEEEEECCCC
LGHMAVQYAKAMGLNVAAVDVEDDKLELAKKLGASVTVNAKTADPAAYLQKEVGGAHGAL
HHHHHHHHHHHHCCEEEEEECCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCEE
VTAVSPKAFEQALGMVRRGGTVSLNGLPPGNFPLPIFDMVLRGITVRGSIVGTRLDLQES
EEEECHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHCCEEEECEEEEEEECHHHH
LDFAARGQVRATVATEKLENINDVFARMHKGQIQGRIVLDMAAH
CCHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9659380; 11481432 [H]