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The map label for this gene is tcpE [H]

Identifier: 120611385

GI number: 120611385

Start: 2986774

End: 2987859

Strand: Reverse

Name: tcpE [H]

Synonym: Aave_2721

Alternate gene names: 120611385

Gene position: 2987859-2986774 (Counterclockwise)

Preceding gene: 120611386

Following gene: 120611384

Centisome position: 55.82

GC content: 63.54

Gene sequence:

>1086_bases
ATGATGCGATTCAAGGCCCTCTACAGACTGCGGCTGACGTCGGCCGTGCGTGCGGACTTCTATTCCGTTCTCGCGTCGCT
GACCGGGACAGCCGGGCGCATCCCGCTCGGCACGGCGCTGGTGAAGATGGAGTCGGAGTTGCGCAAGCAACGGCACCTGC
TGCGGCCGTTGCTTCAAGAGGTGATCCGCCGGATGCATGGAGGACGCCGTCCCATCGACGCTGCCAGCGGTCACGGTGGG
CGCACCTCGCTCAAGCTGGGGGATGCGCTGCTCACGTTCGTCCCGGCCGCCGAGGCCATGATGGTCAAGGCCGGCGAAGA
GCGCGGCGACGTATCCACCGGTCTGAAGCAAGCTGCGGTGATCGCCACCAGCCAGGCGGAGATCCAGTCCATCATCCGCG
CCGGCCTGTTCCTGGTGACGGTGTACGCCGTGGTCATGGTGGGCATCTACTACTTCTACTCCGCGGAGATCATCCCCGAG
CTCGAGCGCGCGGTACCGCGTGTGAAGTGGCCAGCGAACGCGCAGGCCTTCGCCTACGTCGCAGACCACATCTTTTTCTT
CAGCGCCGGGCTCTTCGCGCTGCTGGCCGGCGTCTGGCGAGTCTTCATCCTGCTTAACGCCAATCTCACGGGTGCCACGC
GAAATGCCCTGGACGCCTACGTCTGGCCCTTCACCATGAGCCGGCGGCTGCACTGCTTCGCGGTTCTGAGCGGCCTGAGC
GGCTTCGTCAAGACCGGCGTGCCGTTCCAGACGGCAATCGACAGCCTGTCGAGCTCGGCCAGCCGGTACATGCGGCACAA
GTTCCAGCTGGTACGCCATGAGATCAAGCTGGGCCGGCCGGACTACGTCGCGCTTCTCTCCTGCGATCTGTTCCCTGCGG
ACCGCGCATGGATCATCAATCTGTACGGCCAAACAGCCGACTTCGGTGCGTCGCTGGAACACATCGCCGATGGCTACATC
GACCACCTGATCAAGAGCGCAAAGAAGACCACCGAAATCATCAACGTCCTCGGAATCATGTGCGTCGCCGCACTGGTGAT
GTGGATCTCCAGTGCCCTGTACTCGATGCAGGGCGCCATTCGATAA

Upstream 100 bases:

>100_bases
CTCTCGCCCATGCGATCCTCAAGATGCGCCAGGGGCAGGTAGATCCCCGTGACGTCGAAACCGAACTCGGCGTTCTGCGA
GACGAGAGTACCCGCTGACC

Downstream 100 bases:

>100_bases
CCCCCCGCAAGGAGCACATCATGAACGCACACATCCCCCATTCCAATCCCCGCCGCCCGTCACACCAGCGAGGCGTGAGC
ATGATCGAGGTCGCCGTCTG

Product: type II secretion system protein

Products: NA

Alternate protein names: TCP pilus biosynthesis protein tcpE [H]

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MMRFKALYRLRLTSAVRADFYSVLASLTGTAGRIPLGTALVKMESELRKQRHLLRPLLQEVIRRMHGGRRPIDAASGHGG
RTSLKLGDALLTFVPAAEAMMVKAGEERGDVSTGLKQAAVIATSQAEIQSIIRAGLFLVTVYAVVMVGIYYFYSAEIIPE
LERAVPRVKWPANAQAFAYVADHIFFFSAGLFALLAGVWRVFILLNANLTGATRNALDAYVWPFTMSRRLHCFAVLSGLS
GFVKTGVPFQTAIDSLSSSASRYMRHKFQLVRHEIKLGRPDYVALLSCDLFPADRAWIINLYGQTADFGASLEHIADGYI
DHLIKSAKKTTEIINVLGIMCVAALVMWISSALYSMQGAIR

Sequences:

>Translated_361_residues
MMRFKALYRLRLTSAVRADFYSVLASLTGTAGRIPLGTALVKMESELRKQRHLLRPLLQEVIRRMHGGRRPIDAASGHGG
RTSLKLGDALLTFVPAAEAMMVKAGEERGDVSTGLKQAAVIATSQAEIQSIIRAGLFLVTVYAVVMVGIYYFYSAEIIPE
LERAVPRVKWPANAQAFAYVADHIFFFSAGLFALLAGVWRVFILLNANLTGATRNALDAYVWPFTMSRRLHCFAVLSGLS
GFVKTGVPFQTAIDSLSSSASRYMRHKFQLVRHEIKLGRPDYVALLSCDLFPADRAWIINLYGQTADFGASLEHIADGYI
DHLIKSAKKTTEIINVLGIMCVAALVMWISSALYSMQGAIR
>Mature_361_residues
MMRFKALYRLRLTSAVRADFYSVLASLTGTAGRIPLGTALVKMESELRKQRHLLRPLLQEVIRRMHGGRRPIDAASGHGG
RTSLKLGDALLTFVPAAEAMMVKAGEERGDVSTGLKQAAVIATSQAEIQSIIRAGLFLVTVYAVVMVGIYYFYSAEIIPE
LERAVPRVKWPANAQAFAYVADHIFFFSAGLFALLAGVWRVFILLNANLTGATRNALDAYVWPFTMSRRLHCFAVLSGLS
GFVKTGVPFQTAIDSLSSSASRYMRHKFQLVRHEIKLGRPDYVALLSCDLFPADRAWIINLYGQTADFGASLEHIADGYI
DHLIKSAKKTTEIINVLGIMCVAALVMWISSALYSMQGAIR

Specific function: Probably involved in cholera toxin receptor (GM1) interaction in order to bring the cells within close proximity of the ganglioside for efficient toxin delivery [H]

COG id: COG1459

COG function: function code NU; Type II secretory pathway, component PulF

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP F family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018076
- InterPro:   IPR001992 [H]

Pfam domain/function: PF00482 GSPII_F [H]

EC number: NA

Molecular weight: Translated: 39795; Mature: 39795

Theoretical pI: Translated: 10.21; Mature: 10.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRFKALYRLRLTSAVRADFYSVLASLTGTAGRIPLGTALVKMESELRKQRHLLRPLLQE
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VIRRMHGGRRPIDAASGHGGRTSLKLGDALLTFVPAAEAMMVKAGEERGDVSTGLKQAAV
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
IATSQAEIQSIIRAGLFLVTVYAVVMVGIYYFYSAEIIPELERAVPRVKWPANAQAFAYV
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
ADHIFFFSAGLFALLAGVWRVFILLNANLTGATRNALDAYVWPFTMSRRLHCFAVLSGLS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHH
GFVKTGVPFQTAIDSLSSSASRYMRHKFQLVRHEIKLGRPDYVALLSCDLFPADRAWIIN
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEE
LYGQTADFGASLEHIADGYIDHLIKSAKKTTEIINVLGIMCVAALVMWISSALYSMQGAI
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
R
C
>Mature Secondary Structure
MMRFKALYRLRLTSAVRADFYSVLASLTGTAGRIPLGTALVKMESELRKQRHLLRPLLQE
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VIRRMHGGRRPIDAASGHGGRTSLKLGDALLTFVPAAEAMMVKAGEERGDVSTGLKQAAV
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
IATSQAEIQSIIRAGLFLVTVYAVVMVGIYYFYSAEIIPELERAVPRVKWPANAQAFAYV
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
ADHIFFFSAGLFALLAGVWRVFILLNANLTGATRNALDAYVWPFTMSRRLHCFAVLSGLS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHH
GFVKTGVPFQTAIDSLSSSASRYMRHKFQLVRHEIKLGRPDYVALLSCDLFPADRAWIIN
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEE
LYGQTADFGASLEHIADGYIDHLIKSAKKTTEIINVLGIMCVAALVMWISSALYSMQGAI
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11179381 [H]