Click here to switch to the map view.

The map label for this gene is moeA [H]

Identifier: 120611324

GI number: 120611324

Start: 2916858

End: 2918204

Strand: Reverse

Name: moeA [H]

Synonym: Aave_2656

Alternate gene names: 120611324

Gene position: 2918204-2916858 (Counterclockwise)

Preceding gene: 120611325

Following gene: 120611323

Centisome position: 54.52

GC content: 74.54

Gene sequence:

>1347_bases
ATGACCTTTCGCCCAGGCCACCCGCCGCCCCCATCGACGCCGCCCGCCACGGCCCCCGCAGCCACCGTGGCGCACGACCT
GCCCGTGGACGCCGTGCATGAGCGGCTCGCCGCACTCGCCGAACCGGTGCGCGGCATCGAACAGGTGGGCATCTTCGCCG
CGCTCGACCGCATTCTGGCCGAGGATGTCGTCTCGCCCATGGACGTACCGCCGCACGACAACTCCGCCATGGACGGCTTC
GCTTTCGACGGCGCGGCCCTGGTGGACGGGCAGCCGCTGACCCTGCAGGTGGCCGGCACCGTGCTCGCCGGCCACCGCTG
GCAGGGGTGCCTCGGGCCGGGCCAGTGCCTGCGCATCATGACCGGCGCGGTGATGCCGCACGGAGCGGACACCGTGATTC
CCCAGGAAGCCGCCCTCACCGCGTCCCCCGCGGGCGGGATGGAGCACATCACCATCCCCCCGGGCGCGGTCCGCCGGGGC
GACCACCGCCGGTGCGCGGGCGAGGACCTTGCACGCGGCCGGACCGCCCTCGCCAGGGGAACCCGGCTCGCGCCGGCCGC
GCTCGGGCTGCTGGCGAGCCTCGGGCAGGCCACGGTGCCCGTCGTCCGCCGCCTGCGGGTGGCGTTCTTCTCCACGGGGG
ACGAGATCCTCAGCCTGGGAACGCCCTGGCGCGAGGGGGCCGTGTACGACAGCAACCGCTACACCCTGTTCGGGCTGCTG
GCACGCATGGGCGTGGAGCCCATCGACCTGGGCGCCGTCCCGGACGAGCCGCAGGCCCTGGAATCCACGCTGCGCGCGGC
GGCGGCGCGTGCCGACGCCATCGTCACCAGCGGCGGCGTCAGCACGGGTGTCGCCGACCACACGCGCACGCTGCTCGACC
ACCTCGGCCAGGTGGAGTTCTGGCGCATCGCCATGCGGCCGGGCCGCCCGATGGCCGCGGGCCGCATCCCGCGCCCGGAG
GGGGCCGCCAGCAGCGAAGCCGGAGCGGACGGAGCCGCCGTGCTGTTCGCGCTGCCCGGCAATCCCGTGGCGGCGATGGT
GGCTTTTCTCGTCTTCGTGCGGCCGGCGCTGTGGCGGATGATGGGCTGCGAGCCCATGGCACCGCCCGCGTTGCGCGCCC
TCGCGGCCGAACCGCTGCACAAGCGCCCCGGACGTACCGAATACCAGCGCGGCATCGTCTTCCAGGATGCGGACGGCGCC
CTGCGCGTGCGCACCACCGGGCCACAGGGCTCCGGACTGCTGAGCTCCATGGTGCAGGCCCACGGGCTCATCCTGCTGCC
GCACGCCCGTGGCCCCGTCGCCGTGGGCGAGCCGGTGGACGTGCTGTTGTTTGACGGCATGCTCTGA

Upstream 100 bases:

>100_bases
TCCGCCCCTGGGGCCTGCTGCCGGGCGCCATCCGGGTGGCCGGCATCCCTTACGACAAGCTTCACATGTACCGCATGCTG
CCCCGAGCCACATGAGCCCC

Downstream 100 bases:

>100_bases
CACGGGAATGCCCTGGCCGGGCGTACCCTTGCAACCATCCCCCACCGACCGGAAAGCCCATGCCCTATACCGCCCAGCAC
CTCGCCGAAGCCCCTGCACG

Product: molybdopterin molybdochelatase

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MTFRPGHPPPPSTPPATAPAATVAHDLPVDAVHERLAALAEPVRGIEQVGIFAALDRILAEDVVSPMDVPPHDNSAMDGF
AFDGAALVDGQPLTLQVAGTVLAGHRWQGCLGPGQCLRIMTGAVMPHGADTVIPQEAALTASPAGGMEHITIPPGAVRRG
DHRRCAGEDLARGRTALARGTRLAPAALGLLASLGQATVPVVRRLRVAFFSTGDEILSLGTPWREGAVYDSNRYTLFGLL
ARMGVEPIDLGAVPDEPQALESTLRAAAARADAIVTSGGVSTGVADHTRTLLDHLGQVEFWRIAMRPGRPMAAGRIPRPE
GAASSEAGADGAAVLFALPGNPVAAMVAFLVFVRPALWRMMGCEPMAPPALRALAAEPLHKRPGRTEYQRGIVFQDADGA
LRVRTTGPQGSGLLSSMVQAHGLILLPHARGPVAVGEPVDVLLFDGML

Sequences:

>Translated_448_residues
MTFRPGHPPPPSTPPATAPAATVAHDLPVDAVHERLAALAEPVRGIEQVGIFAALDRILAEDVVSPMDVPPHDNSAMDGF
AFDGAALVDGQPLTLQVAGTVLAGHRWQGCLGPGQCLRIMTGAVMPHGADTVIPQEAALTASPAGGMEHITIPPGAVRRG
DHRRCAGEDLARGRTALARGTRLAPAALGLLASLGQATVPVVRRLRVAFFSTGDEILSLGTPWREGAVYDSNRYTLFGLL
ARMGVEPIDLGAVPDEPQALESTLRAAAARADAIVTSGGVSTGVADHTRTLLDHLGQVEFWRIAMRPGRPMAAGRIPRPE
GAASSEAGADGAAVLFALPGNPVAAMVAFLVFVRPALWRMMGCEPMAPPALRALAAEPLHKRPGRTEYQRGIVFQDADGA
LRVRTTGPQGSGLLSSMVQAHGLILLPHARGPVAVGEPVDVLLFDGML
>Mature_447_residues
TFRPGHPPPPSTPPATAPAATVAHDLPVDAVHERLAALAEPVRGIEQVGIFAALDRILAEDVVSPMDVPPHDNSAMDGFA
FDGAALVDGQPLTLQVAGTVLAGHRWQGCLGPGQCLRIMTGAVMPHGADTVIPQEAALTASPAGGMEHITIPPGAVRRGD
HRRCAGEDLARGRTALARGTRLAPAALGLLASLGQATVPVVRRLRVAFFSTGDEILSLGTPWREGAVYDSNRYTLFGLLA
RMGVEPIDLGAVPDEPQALESTLRAAAARADAIVTSGGVSTGVADHTRTLLDHLGQVEFWRIAMRPGRPMAAGRIPRPEG
AASSEAGADGAAVLFALPGNPVAAMVAFLVFVRPALWRMMGCEPMAPPALRALAAEPLHKRPGRTEYQRGIVFQDADGAL
RVRTTGPQGSGLLSSMVQAHGLILLPHARGPVAVGEPVDVLLFDGML

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=413, Percent_Identity=35.3510895883777, Blast_Score=192, Evalue=7e-49,
Organism=Homo sapiens, GI66932975, Length=413, Percent_Identity=35.3510895883777, Blast_Score=192, Evalue=8e-49,
Organism=Escherichia coli, GI1787049, Length=406, Percent_Identity=39.9014778325123, Blast_Score=281, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI25147659, Length=399, Percent_Identity=32.0802005012531, Blast_Score=161, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17562606, Length=343, Percent_Identity=26.8221574344023, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17136978, Length=417, Percent_Identity=30.2158273381295, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24638841, Length=417, Percent_Identity=30.2158273381295, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 46700; Mature: 46569

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFRPGHPPPPSTPPATAPAATVAHDLPVDAVHERLAALAEPVRGIEQVGIFAALDRILA
CCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDVVSPMDVPPHDNSAMDGFAFDGAALVDGQPLTLQVAGTVLAGHRWQGCLGPGQCLRIM
HHHCCCCCCCCCCCCCCCCEECCCEEEECCCCEEEEEECHHHCCCCCCCCCCHHHHHHHH
TGAVMPHGADTVIPQEAALTASPAGGMEHITIPPGAVRRGDHRRCAGEDLARGRTALARG
HHHCCCCCCCCCCCCHHHEECCCCCCCEEEECCCHHHCCCCCCCCCHHHHHHHHHHHHCC
TRLAPAALGLLASLGQATVPVVRRLRVAFFSTGDEILSLGTPWREGAVYDSNRYTLFGLL
CCCHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCEECCCCHHHHHHH
ARMGVEPIDLGAVPDEPQALESTLRAAAARADAIVTSGGVSTGVADHTRTLLDHLGQVEF
HHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHCCCCEE
WRIAMRPGRPMAAGRIPRPEGAASSEAGADGAAVLFALPGNPVAAMVAFLVFVRPALWRM
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
MGCEPMAPPALRALAAEPLHKRPGRTEYQRGIVFQDADGALRVRTTGPQGSGLLSSMVQA
HCCCCCCCHHHHHHHHCHHHCCCCCCHHHCCCEEECCCCEEEEEECCCCCCHHHHHHHHH
HGLILLPHARGPVAVGEPVDVLLFDGML
CCEEEEECCCCCEECCCCCEEEEECCCC
>Mature Secondary Structure 
TFRPGHPPPPSTPPATAPAATVAHDLPVDAVHERLAALAEPVRGIEQVGIFAALDRILA
CCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDVVSPMDVPPHDNSAMDGFAFDGAALVDGQPLTLQVAGTVLAGHRWQGCLGPGQCLRIM
HHHCCCCCCCCCCCCCCCCEECCCEEEECCCCEEEEEECHHHCCCCCCCCCCHHHHHHHH
TGAVMPHGADTVIPQEAALTASPAGGMEHITIPPGAVRRGDHRRCAGEDLARGRTALARG
HHHCCCCCCCCCCCCHHHEECCCCCCCEEEECCCHHHCCCCCCCCCHHHHHHHHHHHHCC
TRLAPAALGLLASLGQATVPVVRRLRVAFFSTGDEILSLGTPWREGAVYDSNRYTLFGLL
CCCHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCEECCCCHHHHHHH
ARMGVEPIDLGAVPDEPQALESTLRAAAARADAIVTSGGVSTGVADHTRTLLDHLGQVEF
HHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHCCCCEE
WRIAMRPGRPMAAGRIPRPEGAASSEAGADGAAVLFALPGNPVAAMVAFLVFVRPALWRM
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
MGCEPMAPPALRALAAEPLHKRPGRTEYQRGIVFQDADGALRVRTTGPQGSGLLSSMVQA
HCCCCCCCHHHHHHHHCHHHCCCCCCHHHCCCEEECCCCEEEEEECCCCCCHHHHHHHHH
HGLILLPHARGPVAVGEPVDVLLFDGML
CCEEEEECCCCCEECCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]