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The map label for this gene is dnaX [H]

Identifier: 120611312

GI number: 120611312

Start: 2906537

End: 2908642

Strand: Direct

Name: dnaX [H]

Synonym: Aave_2644

Alternate gene names: 120611312

Gene position: 2906537-2908642 (Clockwise)

Preceding gene: 120611310

Following gene: 120611313

Centisome position: 54.3

GC content: 71.84

Gene sequence:

>2106_bases
ATGCCCGGCAGTTCCCTGTCACCAAATGTTAGTGGCGCCGCGCGCCCAGCAGGGGCTGGCGACCCCCGTAGAATCCCGCG
GATGTCCTATCTCGTGCTCGCCCGCAAATACCGCCCCAAGACCTTCTCGGAGATGGTCGGGCAGGAACATGTGGTGCAGG
CGCTCTCGAATGCGCTGGTCCAGCAGCGCCTGCACCATGCGTACCTGTTCACGGGCACGCGCGGGGTGGGCAAGACCACG
GTGTCGCGCATCCTGGCCAAGTCGCTCAACTGCCAGGGCGAGGACGGGCAGGGCGGCATCACCGCCACGCCCTGCGGCGT
ATGCCAGGCCTGCCGGGACATCGATGCCGGCCGCTTCGTGGATTACACCGAGCTCGATGCCGCCTCCAACCGCGGCGTGG
ACGAAGTGCAGGGCCTGCTGGAGCAGGCCGTGTACAAGCCGGTGCAGGGCCGCTTCAAGGTCTTCATGATCGACGAGGTC
CACATGCTCACGAACACCGCGTTCAACGCGATGCTCAAGACGCTGGAGGAGCCGCCCGAATACCTGAAGTTCGTGCTGGC
CACGACCGACCCGCAGAAGGTGCCGGTCACCGTGCTCAGCCGCTGCCTGCAGTTCAACCTGCGGCCCATGGCGCCGGAAA
CCGTGCTGGAGCACCTCACCCGGGTACTCGCCCGGGAAAGCGTGCCGGCCGAGCCGCAGGCGCTGCGGCTGCTGGCGCGC
GCGGCCCGCGGTTCCATGCGCGATGCGCTGTCGCTCACCGACCAGGCCATCGCCTTCGGCAGCGGCCAGCTCCAGGAAGC
CGGCGTGCGGCAGATGCTGGGCAGCGTGGACCGCAGCTACGTGTTCCGCCTCATCGATGCGCTGGCGCGCGGCGACGGCC
GCACGGTGGTGGAGACTTCCGAATCCCTGCGCATGCACGGGCTTTCCGCCGCCTCCACGCTCGAGGAAATGAGCGCCGTG
CTGCAGCGCATGGCCGTGTTCCAGGCCGTGCCCCAGATGGCAGACGTCGTGGACCCGGCCGATCCGGAGGCCTCCGAAAT
CGCGCGGCTGGCCGGCACGCTGCCCGCCGACGAGACGCAACTGCTCTACAGCATCTGCCTGCACGGACGCACGGAACTCG
GCCTCGCGCCCGACGAGTATGCGGCCCTCACCATGGCGTTGCTGCGGCTGCTGGCCTTCAAGCCTGCCGCGGAGGGCGGA
ACGCCCCCGGCGGAAAAAAAAACACTGAAACCGCCCCAGGCGCAGCCTCCGGCGCCTGAGCCGGAGCCGGCATCCGCCGC
GGAACCTGTACCTTCCATCGCCGCATCCGGGGCGGTCTCCGCGCCTGTGGAGCCCGCCACCGCGGCACCGCCCGGGCCGG
AGCCCCGGCCTGCCGAAGCGCACGCGCCCGAGCCCGAGCCGCATTCCCCCGCGCCGCTGGAGCCCCCCTCCGGCGAGGCC
CCCTGGGCGGACGATGCCCCCCCCCCGGCCGCGGTCGCCGCCACGGCGGCACCGGCCCCCGTGCAGGAGCCGTCGTCCAG
CGCCGCCGTGGCGGCGGCCGTGCGCCTGCCGGTCAGGACGCCGGCCGACCTGCAGGCGCACCGGCCTGCCGAGGTCGCGC
TACCTGCCGCCAGCACCCCCGATTTCGTGGCCATTCCCGTGCGGGTCGCGCCGGAGCCTGGCATGCGGCTGCAGCCAGCG
GCCGCGCCCGGCGCCCTGCCGGCCTCGGCCCGCTACACGCCGACGGAAGAGGGCGATGTCTGGCATGCCACCGTGATGCA
GCTCGTCGCGGCCGAGGCCATCAATGCCCTGGTGCGCGAACTCGCGCTGCAGTCCCAGCTGGTGGCCCGCGACGCCGACC
ACTGGCTGCTGCGCGTGGAGCGCGAGTCGCTCAACCAGCCCACGGCCCGCGAGCGCCTGCGCGCCGCGCTGGAGGCGGCC
GGCTTCGCCCGCCAGATCAGCGTGGAGGTGGGCACGGTCATCGACAGCCCCGCGCGGCGCAATGCCCATGCGGCCGCGGA
GCGCCAGCGGCGCGCGCAGGAGATCGTGGAAAACGATCCCTACGTGCAGGCGCTGGTGCGGGACTTCGGGGCGAGAATCG
TTCCTGGCAGCATCAAACCCGCATGA

Upstream 100 bases:

>100_bases
CGATCAGCAGGCCCAGGCGGCGTGCGATGCCCATGCGGGCGAACCAAGGCGTGTTTGTCTCCATGATCCCCTCTTTTCGG
TGCGGGTGGCCGGTGCGGGA

Downstream 100 bases:

>100_bases
AGGCCCGCATGACGTGCCGCGCGGTCCGCGCTCGCCGCCCGACGCACCGTCCCGCCGGCCCCACCTGATTTTTCGCTTTC
GATTTCGACCCTCAGAGAAA

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 701; Mature: 700

Protein sequence:

>701_residues
MPGSSLSPNVSGAARPAGAGDPRRIPRMSYLVLARKYRPKTFSEMVGQEHVVQALSNALVQQRLHHAYLFTGTRGVGKTT
VSRILAKSLNCQGEDGQGGITATPCGVCQACRDIDAGRFVDYTELDAASNRGVDEVQGLLEQAVYKPVQGRFKVFMIDEV
HMLTNTAFNAMLKTLEEPPEYLKFVLATTDPQKVPVTVLSRCLQFNLRPMAPETVLEHLTRVLARESVPAEPQALRLLAR
AARGSMRDALSLTDQAIAFGSGQLQEAGVRQMLGSVDRSYVFRLIDALARGDGRTVVETSESLRMHGLSAASTLEEMSAV
LQRMAVFQAVPQMADVVDPADPEASEIARLAGTLPADETQLLYSICLHGRTELGLAPDEYAALTMALLRLLAFKPAAEGG
TPPAEKKTLKPPQAQPPAPEPEPASAAEPVPSIAASGAVSAPVEPATAAPPGPEPRPAEAHAPEPEPHSPAPLEPPSGEA
PWADDAPPPAAVAATAAPAPVQEPSSSAAVAAAVRLPVRTPADLQAHRPAEVALPAASTPDFVAIPVRVAPEPGMRLQPA
AAPGALPASARYTPTEEGDVWHATVMQLVAAEAINALVRELALQSQLVARDADHWLLRVERESLNQPTARERLRAALEAA
GFARQISVEVGTVIDSPARRNAHAAAERQRRAQEIVENDPYVQALVRDFGARIVPGSIKPA

Sequences:

>Translated_701_residues
MPGSSLSPNVSGAARPAGAGDPRRIPRMSYLVLARKYRPKTFSEMVGQEHVVQALSNALVQQRLHHAYLFTGTRGVGKTT
VSRILAKSLNCQGEDGQGGITATPCGVCQACRDIDAGRFVDYTELDAASNRGVDEVQGLLEQAVYKPVQGRFKVFMIDEV
HMLTNTAFNAMLKTLEEPPEYLKFVLATTDPQKVPVTVLSRCLQFNLRPMAPETVLEHLTRVLARESVPAEPQALRLLAR
AARGSMRDALSLTDQAIAFGSGQLQEAGVRQMLGSVDRSYVFRLIDALARGDGRTVVETSESLRMHGLSAASTLEEMSAV
LQRMAVFQAVPQMADVVDPADPEASEIARLAGTLPADETQLLYSICLHGRTELGLAPDEYAALTMALLRLLAFKPAAEGG
TPPAEKKTLKPPQAQPPAPEPEPASAAEPVPSIAASGAVSAPVEPATAAPPGPEPRPAEAHAPEPEPHSPAPLEPPSGEA
PWADDAPPPAAVAATAAPAPVQEPSSSAAVAAAVRLPVRTPADLQAHRPAEVALPAASTPDFVAIPVRVAPEPGMRLQPA
AAPGALPASARYTPTEEGDVWHATVMQLVAAEAINALVRELALQSQLVARDADHWLLRVERESLNQPTARERLRAALEAA
GFARQISVEVGTVIDSPARRNAHAAAERQRRAQEIVENDPYVQALVRDFGARIVPGSIKPA
>Mature_700_residues
PGSSLSPNVSGAARPAGAGDPRRIPRMSYLVLARKYRPKTFSEMVGQEHVVQALSNALVQQRLHHAYLFTGTRGVGKTTV
SRILAKSLNCQGEDGQGGITATPCGVCQACRDIDAGRFVDYTELDAASNRGVDEVQGLLEQAVYKPVQGRFKVFMIDEVH
MLTNTAFNAMLKTLEEPPEYLKFVLATTDPQKVPVTVLSRCLQFNLRPMAPETVLEHLTRVLARESVPAEPQALRLLARA
ARGSMRDALSLTDQAIAFGSGQLQEAGVRQMLGSVDRSYVFRLIDALARGDGRTVVETSESLRMHGLSAASTLEEMSAVL
QRMAVFQAVPQMADVVDPADPEASEIARLAGTLPADETQLLYSICLHGRTELGLAPDEYAALTMALLRLLAFKPAAEGGT
PPAEKKTLKPPQAQPPAPEPEPASAAEPVPSIAASGAVSAPVEPATAAPPGPEPRPAEAHAPEPEPHSPAPLEPPSGEAP
WADDAPPPAAVAATAAPAPVQEPSSSAAVAAAVRLPVRTPADLQAHRPAEVALPAASTPDFVAIPVRVAPEPGMRLQPAA
APGALPASARYTPTEEGDVWHATVMQLVAAEAINALVRELALQSQLVARDADHWLLRVERESLNQPTARERLRAALEAAG
FARQISVEVGTVIDSPARRNAHAAAERQRRAQEIVENDPYVQALVRDFGARIVPGSIKPA

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=309, Percent_Identity=25.8899676375405, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI194306571, Length=312, Percent_Identity=25.6410256410256, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI194306567, Length=312, Percent_Identity=25.6410256410256, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI194306569, Length=221, Percent_Identity=25.7918552036199, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1786676, Length=369, Percent_Identity=51.4905149051491, Blast_Score=380, Evalue=1e-106,
Organism=Escherichia coli, GI1787341, Length=150, Percent_Identity=35.3333333333333, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17541988, Length=224, Percent_Identity=25.8928571428571, Blast_Score=66, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71986063, Length=250, Percent_Identity=24, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6324039, Length=219, Percent_Identity=26.027397260274, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324478, Length=255, Percent_Identity=24.3137254901961, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322528, Length=299, Percent_Identity=23.0769230769231, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19921076, Length=343, Percent_Identity=23.6151603498542, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17647857, Length=250, Percent_Identity=27.6, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI18859927, Length=318, Percent_Identity=22.9559748427673, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 74415; Mature: 74284

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00018 EF_HAND_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGSSLSPNVSGAARPAGAGDPRRIPRMSYLVLARKYRPKTFSEMVGQEHVVQALSNALV
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHCHHHHHHHHHHHHH
QQRLHHAYLFTGTRGVGKTTVSRILAKSLNCQGEDGQGGITATPCGVCQACRDIDAGRFV
HHHHHHHHHEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCC
DYTELDAASNRGVDEVQGLLEQAVYKPVQGRFKVFMIDEVHMLTNTAFNAMLKTLEEPPE
CHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCHH
YLKFVLATTDPQKVPVTVLSRCLQFNLRPMAPETVLEHLTRVLARESVPAEPQALRLLAR
HHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
AARGSMRDALSLTDQAIAFGSGQLQEAGVRQMLGSVDRSYVFRLIDALARGDGRTVVETS
HHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECH
ESLRMHGLSAASTLEEMSAVLQRMAVFQAVPQMADVVDPADPEASEIARLAGTLPADETQ
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHH
LLYSICLHGRTELGLAPDEYAALTMALLRLLAFKPAAEGGTPPAEKKTLKPPQAQPPAPE
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
PEPASAAEPVPSIAASGAVSAPVEPATAAPPGPEPRPAEAHAPEPEPHSPAPLEPPSGEA
CCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PWADDAPPPAAVAATAAPAPVQEPSSSAAVAAAVRLPVRTPADLQAHRPAEVALPAASTP
CCCCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCC
DFVAIPVRVAPEPGMRLQPAAAPGALPASARYTPTEEGDVWHATVMQLVAAEAINALVRE
CEEEEEEEECCCCCCEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LALQSQLVARDADHWLLRVERESLNQPTARERLRAALEAAGFARQISVEVGTVIDSPARR
HHHHHHHHHHCCCHHHEEEEHHHCCCCHHHHHHHHHHHHHHHHHHEEEHHHHHHCCCHHC
NAHAAAERQRRAQEIVENDPYVQALVRDFGARIVPGSIKPA
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEECCCCCCCC
>Mature Secondary Structure 
PGSSLSPNVSGAARPAGAGDPRRIPRMSYLVLARKYRPKTFSEMVGQEHVVQALSNALV
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHCHHHHHHHHHHHHH
QQRLHHAYLFTGTRGVGKTTVSRILAKSLNCQGEDGQGGITATPCGVCQACRDIDAGRFV
HHHHHHHHHEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCC
DYTELDAASNRGVDEVQGLLEQAVYKPVQGRFKVFMIDEVHMLTNTAFNAMLKTLEEPPE
CHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCHH
YLKFVLATTDPQKVPVTVLSRCLQFNLRPMAPETVLEHLTRVLARESVPAEPQALRLLAR
HHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
AARGSMRDALSLTDQAIAFGSGQLQEAGVRQMLGSVDRSYVFRLIDALARGDGRTVVETS
HHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECH
ESLRMHGLSAASTLEEMSAVLQRMAVFQAVPQMADVVDPADPEASEIARLAGTLPADETQ
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHH
LLYSICLHGRTELGLAPDEYAALTMALLRLLAFKPAAEGGTPPAEKKTLKPPQAQPPAPE
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
PEPASAAEPVPSIAASGAVSAPVEPATAAPPGPEPRPAEAHAPEPEPHSPAPLEPPSGEA
CCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PWADDAPPPAAVAATAAPAPVQEPSSSAAVAAAVRLPVRTPADLQAHRPAEVALPAASTP
CCCCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCC
DFVAIPVRVAPEPGMRLQPAAAPGALPASARYTPTEEGDVWHATVMQLVAAEAINALVRE
CEEEEEEEECCCCCCEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LALQSQLVARDADHWLLRVERESLNQPTARERLRAALEAAGFARQISVEVGTVIDSPARR
HHHHHHHHHHCCCHHHEEEEHHHCCCCHHHHHHHHHHHHHHHHHHEEEHHHHHHCCCHHC
NAHAAAERQRRAQEIVENDPYVQALVRDFGARIVPGSIKPA
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]