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The map label for this gene is cycA [H]

Identifier: 120611276

GI number: 120611276

Start: 2856755

End: 2858218

Strand: Direct

Name: cycA [H]

Synonym: Aave_2608

Alternate gene names: 120611276

Gene position: 2856755-2858218 (Clockwise)

Preceding gene: 120611275

Following gene: 120611277

Centisome position: 53.37

GC content: 67.14

Gene sequence:

>1464_bases
ATGACACCTCAGGCCACGCCCGCGACACCCGATCCCGCGGGGCACGACCATCTGCAGCGCAACCTCACCAACCGGCACAT
CCAGCTCATCGCCATCGGGGGCGCGATCGGCACCGGCCTTTTCATGGGCTCGGGCAAGACGATCAGCCTCGCGGGCCCGT
CCATCGTGTTCGTGTACATGGTGATCGGCTTCATGCTGTTCTTCGTGATGCGCGCCATGGGCGAGCTGCTGCTCTCCGAC
CTGCGCTACAAGTCCTTCATCGATTTTTCCGCCGACCTGCTCGGGCCCTGGGCCGGGTTCTTCACCGGCTGGACCTACTG
GTTCTGCTGGATCGTCACGGGCATCGCCGACGTGATCGCGATATCGGCATACACCCAGTTCTGGTTTCCGCACATCCCGC
AGTGGGCGCCGGCCCTGGGCTGCGTGGGGCTGCTGCTCTCGCTCAACCTCCTCACTGTCAAGCTCTTCGGCGAGATCGAA
TTCTGGTTCGCCATGGTCAAGATCGTCGCCATCGTGGCGCTGGTGGCCACCGGCCTCTACATGGTGGGCACGGACTTCGT
CGCCCCGGCGGGGCACGAGGCCAGCCTGAGCAACCTCTGGAACGACGGCGGCATGTTTCCCCACGGGCTGATGGGCTTCT
TCGCGGGCTTCCAGATCGCGGTGTTCGCCTTCTCGGGCATCGAGCTGGTCGGCACCACCGCGGCGGAGGCGCAGGACCCG
GAGCGCAGCCTGCCGCGGGCCATCAACTCCATTCCCTTGCGCATCATCGTCTTCTACGTGCTGGCGCTGGTCGCCATCAT
GGCGGTCACGCCATGGCGCGAGGTCGTGCCCGGCAGGAGCCCGTTCGTGGAGCTGTTCGTGCTCGCAGGGCTGCCGGCCG
CTGCAGGCGTCATCAACTTCGTCGTGCTGACCTCGGCGGCCTCGTCCGCCAACAGTGGCGTGTTCTCCACCAGCCGCATG
CTCTACGGACTGGCGCTCAAGGAGGACGCACCCCGGGCCTTCCGCCACCTGTCGAAGCAGAGCGTGCCCTCGCGCGGCCT
GCTGTTCTCGTGCACCTGCCTGCTGGCGGGTGCCCTGCTGATGTGGGTGATTCCCGACCTCGTGGAAGCGTTCACCCTGG
TCACCACCGTGTCGGCCATCCTGTTCATGTTCACCTGGTCGCTGATCCTGCTGTCCTATATCGCCTACCGGCGCAACCAT
CCGGAACGGCACGCCGCGTCCATCTACAAGATGCCCGGCGGCGCGGCGATGTGCGCGGTCTGCCTGGCGTTCTTCGTGTT
CATCCTGGGGCTGCTGGCGCTGGAATCGGACACGCGCAAGGCGCTCATCGCGACCCCGCTCTGGTTCGTGCTGCTGGGGG
CGGCCTACAGCCTGCTGCGCCCCGGTTCCCGCCGGGCGGCCGTGCTGGACGCCGAGGCGGGGATGGCCCCGGGCTCGGTG
CCCGGACCGGCTTCCAGCCGCTGA

Upstream 100 bases:

>100_bases
TGCCGGGCGGCTTCTTTCGGCCGTTGCCCGGCTTTCGTTCCGCCTTCCGCGGCGATGCGCGCGGGCCGGTTTCCCTCTCT
CTTTCTTTGGAGTTCCCTGA

Downstream 100 bases:

>100_bases
CCGGGCGGGGCGTTCCAGGGGACGGCGGCACCAGGTCCATGCGGGGCGCGGCTTCGTGCCGCGCGGCCCGAAAAGCCGGG
CGCTTTCCGCCTTCTTCCAG

Product: D-alanine/D-serine/glycine permease

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MTPQATPATPDPAGHDHLQRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIVFVYMVIGFMLFFVMRAMGELLLSD
LRYKSFIDFSADLLGPWAGFFTGWTYWFCWIVTGIADVIAISAYTQFWFPHIPQWAPALGCVGLLLSLNLLTVKLFGEIE
FWFAMVKIVAIVALVATGLYMVGTDFVAPAGHEASLSNLWNDGGMFPHGLMGFFAGFQIAVFAFSGIELVGTTAAEAQDP
ERSLPRAINSIPLRIIVFYVLALVAIMAVTPWREVVPGRSPFVELFVLAGLPAAAGVINFVVLTSAASSANSGVFSTSRM
LYGLALKEDAPRAFRHLSKQSVPSRGLLFSCTCLLAGALLMWVIPDLVEAFTLVTTVSAILFMFTWSLILLSYIAYRRNH
PERHAASIYKMPGGAAMCAVCLAFFVFILGLLALESDTRKALIATPLWFVLLGAAYSLLRPGSRRAAVLDAEAGMAPGSV
PGPASSR

Sequences:

>Translated_487_residues
MTPQATPATPDPAGHDHLQRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIVFVYMVIGFMLFFVMRAMGELLLSD
LRYKSFIDFSADLLGPWAGFFTGWTYWFCWIVTGIADVIAISAYTQFWFPHIPQWAPALGCVGLLLSLNLLTVKLFGEIE
FWFAMVKIVAIVALVATGLYMVGTDFVAPAGHEASLSNLWNDGGMFPHGLMGFFAGFQIAVFAFSGIELVGTTAAEAQDP
ERSLPRAINSIPLRIIVFYVLALVAIMAVTPWREVVPGRSPFVELFVLAGLPAAAGVINFVVLTSAASSANSGVFSTSRM
LYGLALKEDAPRAFRHLSKQSVPSRGLLFSCTCLLAGALLMWVIPDLVEAFTLVTTVSAILFMFTWSLILLSYIAYRRNH
PERHAASIYKMPGGAAMCAVCLAFFVFILGLLALESDTRKALIATPLWFVLLGAAYSLLRPGSRRAAVLDAEAGMAPGSV
PGPASSR
>Mature_486_residues
TPQATPATPDPAGHDHLQRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIVFVYMVIGFMLFFVMRAMGELLLSDL
RYKSFIDFSADLLGPWAGFFTGWTYWFCWIVTGIADVIAISAYTQFWFPHIPQWAPALGCVGLLLSLNLLTVKLFGEIEF
WFAMVKIVAIVALVATGLYMVGTDFVAPAGHEASLSNLWNDGGMFPHGLMGFFAGFQIAVFAFSGIELVGTTAAEAQDPE
RSLPRAINSIPLRIIVFYVLALVAIMAVTPWREVVPGRSPFVELFVLAGLPAAAGVINFVVLTSAASSANSGVFSTSRML
YGLALKEDAPRAFRHLSKQSVPSRGLLFSCTCLLAGALLMWVIPDLVEAFTLVTTVSAILFMFTWSLILLSYIAYRRNHP
ERHAASIYKMPGGAAMCAVCLAFFVFILGLLALESDTRKALIATPLWFVLLGAAYSLLRPGSRRAAVLDAEAGMAPGSVP
GPASSR

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=359, Percent_Identity=23.6768802228412, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI181337167, Length=337, Percent_Identity=24.6290801186944, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1790653, Length=470, Percent_Identity=69.5744680851064, Blast_Score=670, Evalue=0.0,
Organism=Escherichia coli, GI1786602, Length=454, Percent_Identity=39.647577092511, Blast_Score=332, Evalue=4e-92,
Organism=Escherichia coli, GI1786789, Length=463, Percent_Identity=37.5809935205184, Blast_Score=329, Evalue=2e-91,
Organism=Escherichia coli, GI1786302, Length=456, Percent_Identity=37.5, Blast_Score=323, Evalue=2e-89,
Organism=Escherichia coli, GI48994972, Length=443, Percent_Identity=39.7291196388262, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI87081915, Length=405, Percent_Identity=37.5308641975309, Blast_Score=291, Evalue=7e-80,
Organism=Escherichia coli, GI1788480, Length=405, Percent_Identity=34.8148148148148, Blast_Score=225, Evalue=5e-60,
Organism=Escherichia coli, GI87081708, Length=394, Percent_Identity=32.994923857868, Blast_Score=218, Evalue=5e-58,
Organism=Escherichia coli, GI1789017, Length=338, Percent_Identity=31.9526627218935, Blast_Score=199, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17532491, Length=374, Percent_Identity=23.5294117647059, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17540018, Length=353, Percent_Identity=25.2124645892351, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324061, Length=445, Percent_Identity=32.1348314606742, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6324924, Length=426, Percent_Identity=30.5164319248826, Blast_Score=184, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6320772, Length=445, Percent_Identity=28.9887640449438, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6324990, Length=416, Percent_Identity=28.3653846153846, Blast_Score=160, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6322892, Length=401, Percent_Identity=28.6783042394015, Blast_Score=150, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6324059, Length=452, Percent_Identity=28.5398230088496, Blast_Score=146, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6321629, Length=404, Percent_Identity=27.7227722772277, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6320251, Length=407, Percent_Identity=26.5356265356265, Blast_Score=139, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6324553, Length=395, Percent_Identity=28.1012658227848, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6319824, Length=407, Percent_Identity=26.5356265356265, Blast_Score=133, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6320717, Length=413, Percent_Identity=25.6658595641646, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6319542, Length=420, Percent_Identity=25, Blast_Score=129, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6319543, Length=408, Percent_Identity=25.2450980392157, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6321053, Length=402, Percent_Identity=26.1194029850746, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6322967, Length=394, Percent_Identity=26.3959390862944, Blast_Score=116, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6319608, Length=400, Percent_Identity=25, Blast_Score=114, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6324981, Length=421, Percent_Identity=26.603325415677, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320364, Length=477, Percent_Identity=24.7379454926625, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI45550968, Length=404, Percent_Identity=27.2277227722772, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19921172, Length=404, Percent_Identity=27.2277227722772, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52463; Mature: 52332

Theoretical pI: Translated: 8.14; Mature: 8.14

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPQATPATPDPAGHDHLQRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIVFVYM
CCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCHHHHHEEECCCCEEEECCCHHHHHHH
VIGFMLFFVMRAMGELLLSDLRYKSFIDFSADLLGPWAGFFTGWTYWFCWIVTGIADVIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISAYTQFWFPHIPQWAPALGCVGLLLSLNLLTVKLFGEIEFWFAMVKIVAIVALVATGLY
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MVGTDFVAPAGHEASLSNLWNDGGMFPHGLMGFFAGFQIAVFAFSGIELVGTTAAEAQDP
HHCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHEECCHHHCCCC
ERSLPRAINSIPLRIIVFYVLALVAIMAVTPWREVVPGRSPFVELFVLAGLPAAAGVINF
HHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHCCCHHHHHHHH
VVLTSAASSANSGVFSTSRMLYGLALKEDAPRAFRHLSKQSVPSRGLLFSCTCLLAGALL
HHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
MWVIPDLVEAFTLVTTVSAILFMFTWSLILLSYIAYRRNHPERHAASIYKMPGGAAMCAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHH
CLAFFVFILGLLALESDTRKALIATPLWFVLLGAAYSLLRPGSRRAAVLDAEAGMAPGSV
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCC
PGPASSR
CCCCCCC
>Mature Secondary Structure 
TPQATPATPDPAGHDHLQRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIVFVYM
CCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCHHHHHEEECCCCEEEECCCHHHHHHH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CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]