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The map label for this gene is acdA [H]

Identifier: 120611270

GI number: 120611270

Start: 2849243

End: 2850409

Strand: Reverse

Name: acdA [H]

Synonym: Aave_2602

Alternate gene names: 120611270

Gene position: 2850409-2849243 (Counterclockwise)

Preceding gene: 120611271

Following gene: 120611269

Centisome position: 53.25

GC content: 67.78

Gene sequence:

>1167_bases
ATGGATTTCGAACTGACCGAAGAACAACGCGCCTTCGCCGACACCGCCCGCGAGTTCGCCCGGGCCGAACTGGCACCCCA
TGCAGCGCAATGGGACGCGGAAGGCATCTTCCCGCGCGAGGCGATCGCGAAAGCCGGCGCCCTGGGCTTCTGCGGCCTCT
ACGCGCCCGAGAACGCCGGCGGCCTCGCCCTGCCCCGGCTGGACGCCACGCTGGTGTTCGAGGAAATGGCGGCCATCGAT
CCCTCGACCACCGCCTTCATCACCATCCACAACATGGCGACCTGGATGCTGGGTACCTGGGCCACCGATGCGGTGCGGAA
CCATTGGGGCCCACTGCTCACGAGTGGGCAGAAGCTCGCCAGCTACTGCCTGACCGAGCCGGGCGCGGGCTCGGATGCGG
CCTCGCTCAAGACGCGCGCCGAGCTCGTCGGAAACGAATACGTCATCAACGGCGCCAAGGCCTTCATCAGCGGCGCCGGC
AGCACCGATGTGCTGGTGCTCATGGCCCGCACGGGGTCGCCCGATTCCGGCGCGGGAGGCATCAGCGCCTTCGCCGTGCC
GGCGGATGCGGCAGGCATCCAGTACGGCAAGAAGGAAGAGAAGATGGGCTGGAACAGCCAGCCCACGCGCACCATCAGTT
TCGACAGCGTGCGCATCCCGGCCGACCATCTGCTGGGGGCCGGGGGCGAAGGCTTCAAGATCGCGATGAAGGGCCTGGAC
GGGGGCCGCATCAACATTGCCACCTGCTCGGTGGGCGCGGCCCAGGGGGCGCTGAACGCCGCACAGCAATACATGCAGGA
CCGCAAGCAGTTCGGCAAGGCCATCGCCAGTTTCCAGGCACTGCAATTCAAGCTGGCCGACATGGCGACGGAGCTGGTCG
CCGCGCGGCAGATGGTGCGGCTGGCCGCCAGCAAACTCGATGCCGGTGCGCGCGATGCCTCCACCTACTGCGCCATGGCC
AAGCGCTTCGCCACCGATGCGGGATTCGACGTGGTGAACGAGGCGCTGCAGTTGCATGGCGGCTACGGCTACATCCGCGA
ATACCCGCTGGAGCGCCTGCTGCGCGATGCGCGCGTGCACCAGATCCTGGAAGGCACGAACGAGATCATGCGCGTCATCA
TCGCCCGGCGCATGCTCGACGGCGGCGCGCCGGACGCGATCCGCTGA

Upstream 100 bases:

>100_bases
TGGAGCATCCATCCGCGAAACCCTAGCGGGCACCACGCATCCACACGCCCCACCAGCACGGCGACAAAGACAAGACAACG
AGCAGGACGAGACAAGCACC

Downstream 100 bases:

>100_bases
GCCCTGCCGTACCACCGGCTGAAGTGCCTCCAGATGCCTGCCCGCCCCATCTCCGACGAGACACTGCACCTCATCGATGC
CGTGCGCCATGCACTGGCGC

Product: acyl-CoA dehydrogenase domain-containing protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MDFELTEEQRAFADTAREFARAELAPHAAQWDAEGIFPREAIAKAGALGFCGLYAPENAGGLALPRLDATLVFEEMAAID
PSTTAFITIHNMATWMLGTWATDAVRNHWGPLLTSGQKLASYCLTEPGAGSDAASLKTRAELVGNEYVINGAKAFISGAG
STDVLVLMARTGSPDSGAGGISAFAVPADAAGIQYGKKEEKMGWNSQPTRTISFDSVRIPADHLLGAGGEGFKIAMKGLD
GGRINIATCSVGAAQGALNAAQQYMQDRKQFGKAIASFQALQFKLADMATELVAARQMVRLAASKLDAGARDASTYCAMA
KRFATDAGFDVVNEALQLHGGYGYIREYPLERLLRDARVHQILEGTNEIMRVIIARRMLDGGAPDAIR

Sequences:

>Translated_388_residues
MDFELTEEQRAFADTAREFARAELAPHAAQWDAEGIFPREAIAKAGALGFCGLYAPENAGGLALPRLDATLVFEEMAAID
PSTTAFITIHNMATWMLGTWATDAVRNHWGPLLTSGQKLASYCLTEPGAGSDAASLKTRAELVGNEYVINGAKAFISGAG
STDVLVLMARTGSPDSGAGGISAFAVPADAAGIQYGKKEEKMGWNSQPTRTISFDSVRIPADHLLGAGGEGFKIAMKGLD
GGRINIATCSVGAAQGALNAAQQYMQDRKQFGKAIASFQALQFKLADMATELVAARQMVRLAASKLDAGARDASTYCAMA
KRFATDAGFDVVNEALQLHGGYGYIREYPLERLLRDARVHQILEGTNEIMRVIIARRMLDGGAPDAIR
>Mature_388_residues
MDFELTEEQRAFADTAREFARAELAPHAAQWDAEGIFPREAIAKAGALGFCGLYAPENAGGLALPRLDATLVFEEMAAID
PSTTAFITIHNMATWMLGTWATDAVRNHWGPLLTSGQKLASYCLTEPGAGSDAASLKTRAELVGNEYVINGAKAFISGAG
STDVLVLMARTGSPDSGAGGISAFAVPADAAGIQYGKKEEKMGWNSQPTRTISFDSVRIPADHLLGAGGEGFKIAMKGLD
GGRINIATCSVGAAQGALNAAQQYMQDRKQFGKAIASFQALQFKLADMATELVAARQMVRLAASKLDAGARDASTYCAMA
KRFATDAGFDVVNEALQLHGGYGYIREYPLERLLRDARVHQILEGTNEIMRVIIARRMLDGGAPDAIR

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7656849, Length=375, Percent_Identity=51.2, Blast_Score=406, Evalue=1e-113,
Organism=Homo sapiens, GI4557231, Length=383, Percent_Identity=40.2088772845953, Blast_Score=278, Evalue=5e-75,
Organism=Homo sapiens, GI187960098, Length=383, Percent_Identity=40.2088772845953, Blast_Score=278, Evalue=8e-75,
Organism=Homo sapiens, GI4557233, Length=379, Percent_Identity=39.5778364116095, Blast_Score=248, Evalue=5e-66,
Organism=Homo sapiens, GI4501857, Length=378, Percent_Identity=35.1851851851852, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI21361497, Length=354, Percent_Identity=37.2881355932203, Blast_Score=228, Evalue=9e-60,
Organism=Homo sapiens, GI4501859, Length=378, Percent_Identity=34.3915343915344, Blast_Score=224, Evalue=9e-59,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=34.5744680851064, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI76496475, Length=335, Percent_Identity=34.9253731343284, Blast_Score=204, Evalue=8e-53,
Organism=Homo sapiens, GI4557235, Length=335, Percent_Identity=34.9253731343284, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI226958414, Length=340, Percent_Identity=34.1176470588235, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI4503943, Length=379, Percent_Identity=26.3852242744063, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI7669494, Length=355, Percent_Identity=26.4788732394366, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI48976061, Length=391, Percent_Identity=26.8542199488491, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI211971008, Length=391, Percent_Identity=26.8542199488491, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI38505218, Length=339, Percent_Identity=27.4336283185841, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1786223, Length=384, Percent_Identity=30.46875, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI87081958, Length=385, Percent_Identity=30.1298701298701, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI87082384, Length=292, Percent_Identity=29.1095890410959, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI87081702, Length=393, Percent_Identity=22.9007633587786, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17533517, Length=366, Percent_Identity=48.9071038251366, Blast_Score=376, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=39.3700787401575, Blast_Score=265, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=38.0577427821522, Blast_Score=262, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI17534899, Length=388, Percent_Identity=38.4020618556701, Blast_Score=259, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI17506239, Length=378, Percent_Identity=35.7142857142857, Blast_Score=222, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17508101, Length=377, Percent_Identity=32.8912466843501, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI71985184, Length=352, Percent_Identity=35.2272727272727, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17538396, Length=379, Percent_Identity=33.509234828496, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI71990804, Length=281, Percent_Identity=36.2989323843416, Blast_Score=167, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=36.7965367965368, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71985192, Length=298, Percent_Identity=33.5570469798658, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17505929, Length=367, Percent_Identity=30.2452316076294, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17551932, Length=373, Percent_Identity=26.8096514745308, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17534353, Length=377, Percent_Identity=27.5862068965517, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI71982178, Length=276, Percent_Identity=26.4492753623188, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17562446, Length=288, Percent_Identity=28.8194444444444, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17531909, Length=244, Percent_Identity=28.2786885245902, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI86563383, Length=333, Percent_Identity=26.7267267267267, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI86563381, Length=333, Percent_Identity=26.7267267267267, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24660351, Length=385, Percent_Identity=39.7402597402597, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24646207, Length=375, Percent_Identity=37.8666666666667, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI21356377, Length=378, Percent_Identity=35.4497354497354, Blast_Score=221, Evalue=7e-58,
Organism=Drosophila melanogaster, GI24666513, Length=373, Percent_Identity=34.3163538873995, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI21355753, Length=382, Percent_Identity=35.6020942408377, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI281363737, Length=335, Percent_Identity=32.2388059701493, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI19920834, Length=381, Percent_Identity=27.5590551181102, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI45550141, Length=303, Percent_Identity=24.0924092409241, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221473076, Length=303, Percent_Identity=24.4224422442244, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI281365206, Length=302, Percent_Identity=25.8278145695364, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24585193, Length=302, Percent_Identity=25.8278145695364, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24585195, Length=302, Percent_Identity=25.8278145695364, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24585191, Length=302, Percent_Identity=25.8278145695364, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 41271; Mature: 41271

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFELTEEQRAFADTAREFARAELAPHAAQWDAEGIFPREAIAKAGALGFCGLYAPENAG
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCEEEECCCCCCC
GLALPRLDATLVFEEMAAIDPSTTAFITIHNMATWMLGTWATDAVRNHWGPLLTSGQKLA
CCEECCCHHHHHHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHHHCCHHHCCHHHHH
SYCLTEPGAGSDAASLKTRAELVGNEYVINGAKAFISGAGSTDVLVLMARTGSPDSGAGG
HHHCCCCCCCCCHHHHHHHHHHCCCCEEEECHHHHHCCCCCCCEEEEEEECCCCCCCCCC
ISAFAVPADAAGIQYGKKEEKMGWNSQPTRTISFDSVRIPADHLLGAGGEGFKIAMKGLD
CEEEECCCCHHCCCCCCHHHHCCCCCCCCEEEECCCEECCHHHHHCCCCCCEEEEEECCC
GGRINIATCSVGAAQGALNAAQQYMQDRKQFGKAIASFQALQFKLADMATELVAARQMVR
CCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAASKLDAGARDASTYCAMAKRFATDAGFDVVNEALQLHGGYGYIREYPLERLLRDARVH
HHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
QILEGTNEIMRVIIARRMLDGGAPDAIR
HHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MDFELTEEQRAFADTAREFARAELAPHAAQWDAEGIFPREAIAKAGALGFCGLYAPENAG
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCEEEECCCCCCC
GLALPRLDATLVFEEMAAIDPSTTAFITIHNMATWMLGTWATDAVRNHWGPLLTSGQKLA
CCEECCCHHHHHHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHHHCCHHHCCHHHHH
SYCLTEPGAGSDAASLKTRAELVGNEYVINGAKAFISGAGSTDVLVLMARTGSPDSGAGG
HHHCCCCCCCCCHHHHHHHHHHCCCCEEEECHHHHHCCCCCCCEEEEEEECCCCCCCCCC
ISAFAVPADAAGIQYGKKEEKMGWNSQPTRTISFDSVRIPADHLLGAGGEGFKIAMKGLD
CEEEECCCCHHCCCCCCHHHHCCCCCCCCEEEECCCEECCHHHHHCCCCCCEEEEEECCC
GGRINIATCSVGAAQGALNAAQQYMQDRKQFGKAIASFQALQFKLADMATELVAARQMVR
CCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAASKLDAGARDASTYCAMAKRFATDAGFDVVNEALQLHGGYGYIREYPLERLLRDARVH
HHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
QILEGTNEIMRVIIARRMLDGGAPDAIR
HHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]