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The map label for this gene is aceE [H]

Identifier: 120611133

GI number: 120611133

Start: 2686571

End: 2689294

Strand: Direct

Name: aceE [H]

Synonym: Aave_2462

Alternate gene names: 120611133

Gene position: 2686571-2689294 (Clockwise)

Preceding gene: 120611127

Following gene: 120611134

Centisome position: 50.19

GC content: 65.64

Gene sequence:

>2724_bases
ATGACTGCTCAGACCGACCCTCAGGCCGGAAAAACCGCGACGTCCGCCCCCGATACCGACCAACAGGAGACCCGCGAGTG
GATGGACGCACTGTCTGCCGTGATCGACCGCGAAGGCGCTGAACGGGCCCACTTCCTGCTCGAGCAATTGCTCGAACACG
CGCGCCAGAGCAGCATCGACATGCCGTTCTCCGCCAACACGGGCTACGTGAACACGATCGAGCCCAGCCAGGAGGCACGC
TGCCCCGGCAATCTGGAAATCGAAGCGCGCCTGCGCGCCTACATGCGCTGGAACGCCATGGCGATGGTGGTCAAAGCCAA
CCGCCACCATCCTCCCGAAGGCGGCGACCTGGGCGGCCACATCGGCTCCTTCGCCTCCCTGGCCAACATGTTCGGCGCAG
GTTTCAACCACTTCTGGCACGCAGAGAGCGAGAACCACGGCGGCGACCTGCTGTACATCCAGGGCCATGTGTCCCCCGGC
ATCTATGCGCGCGCCTACCTGGAAGGCCGCCTGACCGAGGAACAACTGCTGAACTTCCGCCAGGAAGTGGACGGCAAGGG
TCTCTCCAGCTACCCGCATCCCAAGCTGATGCCCGAGTTCTGGCAGTTCCCGACGGTCTCGATGGGCCTGGGCCCGCTGA
TGGCCATCTACCAGGCCCGTTTCCTCAAATATCTGCAGGCCCGCGGCATCGCCAACACCGAGAACCGCAAGGTCTGGGTG
TTCTGCGGCGACGGCGAGATGGACGAGGTGGAATCCCTGGGCGCGATCGGCCTGGCCGCGCGCGAGAACCTCGACAACCT
GATCTTCGTCATCAACTGCAACCTGCAGCGCCTGGACGGCCCGGTGCGCGGCAACGGCAAGATCATCCAGGAGCTGGAAG
GCGAATTCCGCGGCTCCGGCTGGAACGTGATCAAGCTGCTGTGGGGCAAGGGCTGGGACGACCTGCTGGCCCGCGACAAG
GACGGCGCGCTGCGCAAGATCATGATGGACTGCAACGACGGGGACTACCAGTCGTTCAAGGCCAATGACGGCGCCTACGT
GCGCAAGAACTTCTTCGGCCGCGATCCGCGCACGCTGAAGATGGTCGAGCACATGAGCGACGACGAGATCTGGAACCTGC
GCCGCGGCGGCCACGACGCGCAGAAGGTCTATGCGGCGTTCAAGGCGGCCAACGAGCACAAGGGCCAGCCCACGGTGCTG
CTGGTGAAGACCGTCAAGGGCTTCGGCATGGGCAAGATCGGCGAGGGCAAGAACACCGTCCACCAGACCAAGAAGCTCGG
CGACGAGGACATCAAGGCCTTCCGCGACCGCTTCAACATTCCGATTCCCGACAGCCAGATCGCCGACCTGCCGTTCTACA
AGCCGGCCGACGACACCCCGGAAATGAAGTACCTGCACGAGCGCCGCAAGGCCCTCGGCGGCTACCTGCCGCACCGCCGC
ACGAAGGCCGACGAGAGCTTCACCGTGCCGTCGCTGGAAACCTTCAAGGCCGTGCTCGATCCCACGCCCGAAGGCCGCGA
GATCTCGACCACGCAGGCCTACGTGCGCTTCCTCACGCAGCTGCTGCGCGACCAGGCCATCGGCCCGCGCGTGGTGCCCA
TCCTGGTGGACGAGGCCCGCACCTTCGGCATGGAAGGCCTGTTCCGCCAGATCGGCATCTACAACCCGCACGGCCAGCAG
TACACCCCGGTGGACAAGGACCAGGTGATGTACTACCGCGAGGACAAGGCCGGCCAGATCCTGCAGGAAGGCATCAACGA
GGCCGGCGGCATGTCCAGCTGGATCGCCGCGGCCACGTCGTACAGCACGAACAACCGGATCATGATCCCGTTCTACGTGT
ACTACTCGATGTTCGGCTTCCAGCGCGTCGGCGACCTGGCCTGGGCGGCCGGCGACATGCAGGCGCGGGGCTTCCTGCTG
GGCGGCACGTCGGGCCGCACCACGCTGAACGGCGAAGGCCTGCAGCACGAGGACGGCCACAGCCACATCCTGGCCAACAC
GATTCCGAACTGCATCAGCTACGACCCGACCTTCGCGCACGAAGTCGCCGTCATCATGCACGACGGCCTGAAGCGCATGG
TCGAGCGCCAGGAGAATGTCTTTTACTACCTGACGCTGCTCAACGAGAACTACGCCATGCCCGGCCTGCAGCCCGGCACG
GAAGAGCAGATCATCAAGGGCATGTACCTCTGCAAACAGGCGCCGGCCCTCAAGAAGGGCGCGCCCGCCGTGCAGCTGCT
GGGCAGCGGCACGATCCTGCGCGAGTCGTTCGTCGCCCAGGAACTGCTGGAGAAGGACTGGGGCGTGGCCGCGTCCGTGT
GGAGCTGCCCGAGCTTCAACGAGCTGACGCGCGACGGCCAGGAGGCGGAGCGCTGGAACCTGCTGCACCCCACGGAAACG
CCGCGCACGTCGTTCGTGGAGGAGCAGCTCGGCAAGACCGAGGGCCCGGTGATCGCTTCCACCGACTACATGAAGGCGTA
CGCCGAGCAGATCCGTCCGTTCGTGCCCAAGGGCCGGACGTACAAGGTGCTGGGCACCGACGGCTTCGGCCGCAGCGACT
TCCGCCGCAAGCTGCGCGAGCATTTCGAGGTGGACCGCCACTACATCGTCGTGGCCGCGCTCAAGGCCCTGGCCGAGGAT
GGCAAGCTGCCCGCTGCCAAGGTGGCCGAGGCCATCCAGAAGTACGGCATCCAGGCCGACAAGGTGAACCCGCTGCACGC
CTGA

Upstream 100 bases:

>100_bases
ATATTGTGGTGTTGGAGCGCGCCATTCGAAATGTCGCGAAAGTGTGCGAAACTTCGCCGGATTTACCCCCCAACGCCAGC
GACTTATCAAGGAGACAGGC

Downstream 100 bases:

>100_bases
CCCCACCGGAGACAACAACATGGCACTGATTGACATCAAGGTCCCGGACATCGGGGATTTCGACGCCGTCGGCGTGATCG
AACTGCTGGTGAAGCCCGGC

Product: pyruvate dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 907; Mature: 906

Protein sequence:

>907_residues
MTAQTDPQAGKTATSAPDTDQQETREWMDALSAVIDREGAERAHFLLEQLLEHARQSSIDMPFSANTGYVNTIEPSQEAR
CPGNLEIEARLRAYMRWNAMAMVVKANRHHPPEGGDLGGHIGSFASLANMFGAGFNHFWHAESENHGGDLLYIQGHVSPG
IYARAYLEGRLTEEQLLNFRQEVDGKGLSSYPHPKLMPEFWQFPTVSMGLGPLMAIYQARFLKYLQARGIANTENRKVWV
FCGDGEMDEVESLGAIGLAARENLDNLIFVINCNLQRLDGPVRGNGKIIQELEGEFRGSGWNVIKLLWGKGWDDLLARDK
DGALRKIMMDCNDGDYQSFKANDGAYVRKNFFGRDPRTLKMVEHMSDDEIWNLRRGGHDAQKVYAAFKAANEHKGQPTVL
LVKTVKGFGMGKIGEGKNTVHQTKKLGDEDIKAFRDRFNIPIPDSQIADLPFYKPADDTPEMKYLHERRKALGGYLPHRR
TKADESFTVPSLETFKAVLDPTPEGREISTTQAYVRFLTQLLRDQAIGPRVVPILVDEARTFGMEGLFRQIGIYNPHGQQ
YTPVDKDQVMYYREDKAGQILQEGINEAGGMSSWIAAATSYSTNNRIMIPFYVYYSMFGFQRVGDLAWAAGDMQARGFLL
GGTSGRTTLNGEGLQHEDGHSHILANTIPNCISYDPTFAHEVAVIMHDGLKRMVERQENVFYYLTLLNENYAMPGLQPGT
EEQIIKGMYLCKQAPALKKGAPAVQLLGSGTILRESFVAQELLEKDWGVAASVWSCPSFNELTRDGQEAERWNLLHPTET
PRTSFVEEQLGKTEGPVIASTDYMKAYAEQIRPFVPKGRTYKVLGTDGFGRSDFRRKLREHFEVDRHYIVVAALKALAED
GKLPAAKVAEAIQKYGIQADKVNPLHA

Sequences:

>Translated_907_residues
MTAQTDPQAGKTATSAPDTDQQETREWMDALSAVIDREGAERAHFLLEQLLEHARQSSIDMPFSANTGYVNTIEPSQEAR
CPGNLEIEARLRAYMRWNAMAMVVKANRHHPPEGGDLGGHIGSFASLANMFGAGFNHFWHAESENHGGDLLYIQGHVSPG
IYARAYLEGRLTEEQLLNFRQEVDGKGLSSYPHPKLMPEFWQFPTVSMGLGPLMAIYQARFLKYLQARGIANTENRKVWV
FCGDGEMDEVESLGAIGLAARENLDNLIFVINCNLQRLDGPVRGNGKIIQELEGEFRGSGWNVIKLLWGKGWDDLLARDK
DGALRKIMMDCNDGDYQSFKANDGAYVRKNFFGRDPRTLKMVEHMSDDEIWNLRRGGHDAQKVYAAFKAANEHKGQPTVL
LVKTVKGFGMGKIGEGKNTVHQTKKLGDEDIKAFRDRFNIPIPDSQIADLPFYKPADDTPEMKYLHERRKALGGYLPHRR
TKADESFTVPSLETFKAVLDPTPEGREISTTQAYVRFLTQLLRDQAIGPRVVPILVDEARTFGMEGLFRQIGIYNPHGQQ
YTPVDKDQVMYYREDKAGQILQEGINEAGGMSSWIAAATSYSTNNRIMIPFYVYYSMFGFQRVGDLAWAAGDMQARGFLL
GGTSGRTTLNGEGLQHEDGHSHILANTIPNCISYDPTFAHEVAVIMHDGLKRMVERQENVFYYLTLLNENYAMPGLQPGT
EEQIIKGMYLCKQAPALKKGAPAVQLLGSGTILRESFVAQELLEKDWGVAASVWSCPSFNELTRDGQEAERWNLLHPTET
PRTSFVEEQLGKTEGPVIASTDYMKAYAEQIRPFVPKGRTYKVLGTDGFGRSDFRRKLREHFEVDRHYIVVAALKALAED
GKLPAAKVAEAIQKYGIQADKVNPLHA
>Mature_906_residues
TAQTDPQAGKTATSAPDTDQQETREWMDALSAVIDREGAERAHFLLEQLLEHARQSSIDMPFSANTGYVNTIEPSQEARC
PGNLEIEARLRAYMRWNAMAMVVKANRHHPPEGGDLGGHIGSFASLANMFGAGFNHFWHAESENHGGDLLYIQGHVSPGI
YARAYLEGRLTEEQLLNFRQEVDGKGLSSYPHPKLMPEFWQFPTVSMGLGPLMAIYQARFLKYLQARGIANTENRKVWVF
CGDGEMDEVESLGAIGLAARENLDNLIFVINCNLQRLDGPVRGNGKIIQELEGEFRGSGWNVIKLLWGKGWDDLLARDKD
GALRKIMMDCNDGDYQSFKANDGAYVRKNFFGRDPRTLKMVEHMSDDEIWNLRRGGHDAQKVYAAFKAANEHKGQPTVLL
VKTVKGFGMGKIGEGKNTVHQTKKLGDEDIKAFRDRFNIPIPDSQIADLPFYKPADDTPEMKYLHERRKALGGYLPHRRT
KADESFTVPSLETFKAVLDPTPEGREISTTQAYVRFLTQLLRDQAIGPRVVPILVDEARTFGMEGLFRQIGIYNPHGQQY
TPVDKDQVMYYREDKAGQILQEGINEAGGMSSWIAAATSYSTNNRIMIPFYVYYSMFGFQRVGDLAWAAGDMQARGFLLG
GTSGRTTLNGEGLQHEDGHSHILANTIPNCISYDPTFAHEVAVIMHDGLKRMVERQENVFYYLTLLNENYAMPGLQPGTE
EQIIKGMYLCKQAPALKKGAPAVQLLGSGTILRESFVAQELLEKDWGVAASVWSCPSFNELTRDGQEAERWNLLHPTETP
RTSFVEEQLGKTEGPVIASTDYMKAYAEQIRPFVPKGRTYKVLGTDGFGRSDFRRKLREHFEVDRHYIVVAALKALAEDG
KLPAAKVAEAIQKYGIQADKVNPLHA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=891, Percent_Identity=59.4837261503928, Blast_Score=1098, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 101606; Mature: 101475

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAQTDPQAGKTATSAPDTDQQETREWMDALSAVIDREGAERAHFLLEQLLEHARQSSID
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC
MPFSANTGYVNTIEPSQEARCPGNLEIEARLRAYMRWNAMAMVVKANRHHPPEGGDLGGH
CCCCCCCCEEEECCCCHHCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCH
IGSFASLANMFGAGFNHFWHAESENHGGDLLYIQGHVSPGIYARAYLEGRLTEEQLLNFR
HHHHHHHHHHHCCCCCCEECCCCCCCCCCEEEEEECCCCCCEEEHHHHCCCCHHHHHHHH
QEVDGKGLSSYPHPKLMPEFWQFPTVSMGLGPLMAIYQARFLKYLQARGIANTENRKVWV
HHHCCCCCCCCCCCCCCHHHHCCCCCHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
FCGDGEMDEVESLGAIGLAARENLDNLIFVINCNLQRLDGPVRGNGKIIQELEGEFRGSG
EECCCCHHHHHHCCHHHHHHHCCCCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCC
WNVIKLLWGKGWDDLLARDKDGALRKIMMDCNDGDYQSFKANDGAYVRKNFFGRDPRTLK
CEEEEEECCCCHHHHHHCCCCCHHHHHHCCCCCCCCCCEECCCCCEEHHHHCCCCCHHHH
MVEHMSDDEIWNLRRGGHDAQKVYAAFKAANEHKGQPTVLLVKTVKGFGMGKIGEGKNTV
HHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCHHH
HQTKKLGDEDIKAFRDRFNIPIPDSQIADLPFYKPADDTPEMKYLHERRKALGGYLPHRR
HHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
TKADESFTVPSLETFKAVLDPTPEGREISTTQAYVRFLTQLLRDQAIGPRVVPILVDEAR
CCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECHHH
TFGMEGLFRQIGIYNPHGQQYTPVDKDQVMYYREDKAGQILQEGINEAGGMSSWIAAATS
HHCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHC
YSTNNRIMIPFYVYYSMFGFQRVGDLAWAAGDMQARGFLLGGTSGRTTLNGEGLQHEDGH
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEECCCCCCCCCCC
SHILANTIPNCISYDPTFAHEVAVIMHDGLKRMVERQENVFYYLTLLNENYAMPGLQPGT
CEEHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCC
EEQIIKGMYLCKQAPALKKGAPAVQLLGSGTILRESFVAQELLEKDWGVAASVWSCPSFN
HHHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCEEHHCCCCCHH
ELTRDGQEAERWNLLHPTETPRTSFVEEQLGKTEGPVIASTDYMKAYAEQIRPFVPKGRT
HHHCCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCEEECHHHHHHHHHHHCCCCCCCCE
YKVLGTDGFGRSDFRRKLREHFEVDRHYIVVAALKALAEDGKLPAAKVAEAIQKYGIQAD
EEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCC
KVNPLHA
CCCCCCC
>Mature Secondary Structure 
TAQTDPQAGKTATSAPDTDQQETREWMDALSAVIDREGAERAHFLLEQLLEHARQSSID
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC
MPFSANTGYVNTIEPSQEARCPGNLEIEARLRAYMRWNAMAMVVKANRHHPPEGGDLGGH
CCCCCCCCEEEECCCCHHCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCH
IGSFASLANMFGAGFNHFWHAESENHGGDLLYIQGHVSPGIYARAYLEGRLTEEQLLNFR
HHHHHHHHHHHCCCCCCEECCCCCCCCCCEEEEEECCCCCCEEEHHHHCCCCHHHHHHHH
QEVDGKGLSSYPHPKLMPEFWQFPTVSMGLGPLMAIYQARFLKYLQARGIANTENRKVWV
HHHCCCCCCCCCCCCCCHHHHCCCCCHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
FCGDGEMDEVESLGAIGLAARENLDNLIFVINCNLQRLDGPVRGNGKIIQELEGEFRGSG
EECCCCHHHHHHCCHHHHHHHCCCCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCC
WNVIKLLWGKGWDDLLARDKDGALRKIMMDCNDGDYQSFKANDGAYVRKNFFGRDPRTLK
CEEEEEECCCCHHHHHHCCCCCHHHHHHCCCCCCCCCCEECCCCCEEHHHHCCCCCHHHH
MVEHMSDDEIWNLRRGGHDAQKVYAAFKAANEHKGQPTVLLVKTVKGFGMGKIGEGKNTV
HHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCHHH
HQTKKLGDEDIKAFRDRFNIPIPDSQIADLPFYKPADDTPEMKYLHERRKALGGYLPHRR
HHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
TKADESFTVPSLETFKAVLDPTPEGREISTTQAYVRFLTQLLRDQAIGPRVVPILVDEAR
CCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECHHH
TFGMEGLFRQIGIYNPHGQQYTPVDKDQVMYYREDKAGQILQEGINEAGGMSSWIAAATS
HHCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHC
YSTNNRIMIPFYVYYSMFGFQRVGDLAWAAGDMQARGFLLGGTSGRTTLNGEGLQHEDGH
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEECCCCCCCCCCC
SHILANTIPNCISYDPTFAHEVAVIMHDGLKRMVERQENVFYYLTLLNENYAMPGLQPGT
CEEHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCC
EEQIIKGMYLCKQAPALKKGAPAVQLLGSGTILRESFVAQELLEKDWGVAASVWSCPSFN
HHHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCEEHHCCCCCHH
ELTRDGQEAERWNLLHPTETPRTSFVEEQLGKTEGPVIASTDYMKAYAEQIRPFVPKGRT
HHHCCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCEEECHHHHHHHHHHHCCCCCCCCE
YKVLGTDGFGRSDFRRKLREHFEVDRHYIVVAALKALAEDGKLPAAKVAEAIQKYGIQAD
EEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCC
KVNPLHA
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8021225 [H]