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The map label for this gene is hscB [H]

Identifier: 120611117

GI number: 120611117

Start: 2669990

End: 2670553

Strand: Direct

Name: hscB [H]

Synonym: Aave_2446

Alternate gene names: 120611117

Gene position: 2669990-2670553 (Clockwise)

Preceding gene: 120611116

Following gene: 120611118

Centisome position: 49.88

GC content: 66.49

Gene sequence:

>564_bases
ATGACGAACCGCCATCGCAGGTGTGCTGGCGGTTTTTTTCTTGACATGAATCTGCAATCCGACGATTTCGAGCTTTTCGA
CCTGCCCAAGCGCTTCGCCCAGGAGCGCCCGGCGATCGATGCCCGCTGGAAAGCCCTGCAGCGGGAGGCCCATCCCGACC
GCTTCGCGGCGCAGGGCGCGGCGGCCCAGAGGGTGGCGATGCAATGGTCCGTGCGCATCAATGAGGCCTACCAGCGGCTG
AAGGATCCGATCCGCCGGGCGGCCTACCTGTGCGAACTCCACGGGGCCCCCATCCAGGCGGAGGACAACACGGCCATGCC
GGCGGCATTCCTGATGCAGCAGATGGAGTGGCGCGAAGCCCTCGACGATGCCGCCGACGGGGCCGCCATCGACCGGCTGG
AGGCGGAGGTGCGACAGGCCCGTGGCGACGCACTGGATCGCTGCGGCGAACTGATCGACGTGCGCCAGGACTATGCGGCC
GCGGCGGGGGCTGTCAGAGGCCTTATGTTCATTGAGCGCTTTGCGCTCGACATCGATCGCCGCCGGGAGCAACTGGAACA
ATAG

Upstream 100 bases:

>100_bases
ACAATCCCAACGAGCGCGACCGCTGCGGCTGCGGGGAAAGTTTCCGCGTCTGAGCCGTCCGGCCCTCCGGGCGTTTCTGC
CGGTGTCGCCGGCATGGACC

Downstream 100 bases:

>100_bases
CCCCTTGCTTCTTCCGCAGGCCCGCATGGCCTCGCGCGTTTTCCATTTTCCGGAGCAGGGCGCCTTCGCGACCCACTTTA
CCCTCCGGCTTGCACGTTAC

Product: co-chaperone Hsc20

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 187; Mature: 186

Protein sequence:

>187_residues
MTNRHRRCAGGFFLDMNLQSDDFELFDLPKRFAQERPAIDARWKALQREAHPDRFAAQGAAAQRVAMQWSVRINEAYQRL
KDPIRRAAYLCELHGAPIQAEDNTAMPAAFLMQQMEWREALDDAADGAAIDRLEAEVRQARGDALDRCGELIDVRQDYAA
AAGAVRGLMFIERFALDIDRRREQLEQ

Sequences:

>Translated_187_residues
MTNRHRRCAGGFFLDMNLQSDDFELFDLPKRFAQERPAIDARWKALQREAHPDRFAAQGAAAQRVAMQWSVRINEAYQRL
KDPIRRAAYLCELHGAPIQAEDNTAMPAAFLMQQMEWREALDDAADGAAIDRLEAEVRQARGDALDRCGELIDVRQDYAA
AAGAVRGLMFIERFALDIDRRREQLEQ
>Mature_186_residues
TNRHRRCAGGFFLDMNLQSDDFELFDLPKRFAQERPAIDARWKALQREAHPDRFAAQGAAAQRVAMQWSVRINEAYQRLK
DPIRRAAYLCELHGAPIQAEDNTAMPAAFLMQQMEWREALDDAADGAAIDRLEAEVRQARGDALDRCGELIDVRQDYAAA
AGAVRGLMFIERFALDIDRRREQLEQ

Specific function: Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward hscA [H]

COG id: COG1076

COG function: function code O; DnaJ-domain-containing proteins 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 J domain [H]

Homologues:

Organism=Homo sapiens, GI50301234, Length=126, Percent_Identity=30.952380952381, Blast_Score=68, Evalue=6e-12,
Organism=Escherichia coli, GI1788876, Length=168, Percent_Identity=36.9047619047619, Blast_Score=102, Evalue=1e-23,
Organism=Drosophila melanogaster, GI161084223, Length=175, Percent_Identity=26.2857142857143, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001623
- InterPro:   IPR009073
- InterPro:   IPR004640
- InterPro:   IPR015609 [H]

Pfam domain/function: PF00226 DnaJ; PF07743 HSCB_C [H]

EC number: NA

Molecular weight: Translated: 21393; Mature: 21262

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS50076 DNAJ_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNRHRRCAGGFFLDMNLQSDDFELFDLPKRFAQERPAIDARWKALQREAHPDRFAAQGA
CCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHH
AAQRVAMQWSVRINEAYQRLKDPIRRAAYLCELHGAPIQAEDNTAMPAAFLMQQMEWREA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
LDDAADGAAIDRLEAEVRQARGDALDRCGELIDVRQDYAAAAGAVRGLMFIERFALDIDR
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RREQLEQ
HHHHHCC
>Mature Secondary Structure 
TNRHRRCAGGFFLDMNLQSDDFELFDLPKRFAQERPAIDARWKALQREAHPDRFAAQGA
CCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHH
AAQRVAMQWSVRINEAYQRLKDPIRRAAYLCELHGAPIQAEDNTAMPAAFLMQQMEWREA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
LDDAADGAAIDRLEAEVRQARGDALDRCGELIDVRQDYAAAAGAVRGLMFIERFALDIDR
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RREQLEQ
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA