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The map label for this gene is iscS [H]

Identifier: 120611114

GI number: 120611114

Start: 2667954

End: 2669174

Strand: Direct

Name: iscS [H]

Synonym: Aave_2443

Alternate gene names: 120611114

Gene position: 2667954-2669174 (Clockwise)

Preceding gene: 120611113

Following gene: 120611115

Centisome position: 49.84

GC content: 65.03

Gene sequence:

>1221_bases
ATGGACATGACACCGCATTTCCCCATCTACCTGGACTATGGAGCCACGACGCCGGTCGATCCGCGCGTGGTGGACGCCAT
GATCCCCTGGTTGCGCGAGCACTTCGGCAACCCGGCGTCGCGCAGCCATGCGTGGGGCTGGGAAGCCGAGGAGGCCGTGG
AAAAGGCGCGTGCCGACGTCGCGGCGCTCATCCAAGCGGATCCCCGCGAGATCGTCTGGACCAGCGGTGCCACCGAGTCC
AACAACCTCGCCATCAAGGGCGCAGGCCATTTCTACAAGGGCAAGGGCAAGCACCTCATCACCGTCAAGACGGAGCACAA
GGCCGTTCTCGACACGATGCGCGAGATGGAGCGCCAGGGCTTCGAGGTCACCTACCTGGACGTGCAGGAAAACGGCCTGC
TCGATTTCGAAGTGCTGAAGGCGGCCATCCGCCCCGACACGATCCTGCTGAGCGTGATGTTCGTGAATAACGAGATCGGC
GTCATTCAGGACATTCCCGCGATCGGCGCGCTGTGCCGCGAAAAGGGCGTCATCTTCCACGTCGATGCGGCCCAGGCCAC
CGGCAAGGTGGAGATCGACCTGCAGACCCTGCCGGTGGACCTCATGAGCCTGGCTTCGCACAAGACCTACGGCCCCAAGG
GCATCGGTGCGCTCTATGTGCGCCGCAAGCCCCGGGTGCGCCTGGAGGCGCAGATGCACGGTGGAGGGCACGAGCGCGGC
ATGCGCTCCGGCACCCTGCCGACGCACCAGATCGTCGGCATGGGCGAGGCCTTCCGCATCGCCCGCGAAGAAATGGCGCA
GGACCTTGCCAAGGTCCGCGTGCTGCAGAAGCGCCTGCTCGACGGGCTGACCGACATCGAACAGGTGTTCGTGAACGGCG
ACCTCGAGCGCCGCGTGCCGCACAACCTCAACATCAGCTTCAACTTCGTCGAAGGCGAATCGCTGATCATGGGTATCAAG
GGCCTGGCGGTGTCGTCGGGCTCCGCGTGCACCTCCGCGAGCCTGGAGCCCAGCTACGTGCTGCGCGCGCTGGGCCGCAG
CGACGAACTGGCGCACAGCAGCCTGCGCATGACGATCGGCCGGTTCACCACCGAGGAAGAGATCGATGTCGCGGTGTCCT
CCATCCGCCACAACGTCGCCAAGCTGCGCGAACTGAGCCCCCTGTGGGAAATGTACAAGGATGGCGTGGACATCAGCTCC
ATCCAATGGGCTGCCCACTGA

Upstream 100 bases:

>100_bases
CTGAACCCGACGGCCCGGGCGACCCCGGGGTTCGGGGTCGGCTCGGTCAGGGCCGCTCCCGTCGCCACGATTCGCCAGCC
AGACATTTACTGAGCCAGCC

Downstream 100 bases:

>100_bases
TCCCGGCAGCCACGAAGAAGTGAAAGGCAGGTAGAAATCATGGCTTACTCCGACAAGGTCATCGACCATTACGAAAACCC
CCGCAACGTGGGTTCGTTCG

Product: cysteine desulfurase IscS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MDMTPHFPIYLDYGATTPVDPRVVDAMIPWLREHFGNPASRSHAWGWEAEEAVEKARADVAALIQADPREIVWTSGATES
NNLAIKGAGHFYKGKGKHLITVKTEHKAVLDTMREMERQGFEVTYLDVQENGLLDFEVLKAAIRPDTILLSVMFVNNEIG
VIQDIPAIGALCREKGVIFHVDAAQATGKVEIDLQTLPVDLMSLASHKTYGPKGIGALYVRRKPRVRLEAQMHGGGHERG
MRSGTLPTHQIVGMGEAFRIAREEMAQDLAKVRVLQKRLLDGLTDIEQVFVNGDLERRVPHNLNISFNFVEGESLIMGIK
GLAVSSGSACTSASLEPSYVLRALGRSDELAHSSLRMTIGRFTTEEEIDVAVSSIRHNVAKLRELSPLWEMYKDGVDISS
IQWAAH

Sequences:

>Translated_406_residues
MDMTPHFPIYLDYGATTPVDPRVVDAMIPWLREHFGNPASRSHAWGWEAEEAVEKARADVAALIQADPREIVWTSGATES
NNLAIKGAGHFYKGKGKHLITVKTEHKAVLDTMREMERQGFEVTYLDVQENGLLDFEVLKAAIRPDTILLSVMFVNNEIG
VIQDIPAIGALCREKGVIFHVDAAQATGKVEIDLQTLPVDLMSLASHKTYGPKGIGALYVRRKPRVRLEAQMHGGGHERG
MRSGTLPTHQIVGMGEAFRIAREEMAQDLAKVRVLQKRLLDGLTDIEQVFVNGDLERRVPHNLNISFNFVEGESLIMGIK
GLAVSSGSACTSASLEPSYVLRALGRSDELAHSSLRMTIGRFTTEEEIDVAVSSIRHNVAKLRELSPLWEMYKDGVDISS
IQWAAH
>Mature_406_residues
MDMTPHFPIYLDYGATTPVDPRVVDAMIPWLREHFGNPASRSHAWGWEAEEAVEKARADVAALIQADPREIVWTSGATES
NNLAIKGAGHFYKGKGKHLITVKTEHKAVLDTMREMERQGFEVTYLDVQENGLLDFEVLKAAIRPDTILLSVMFVNNEIG
VIQDIPAIGALCREKGVIFHVDAAQATGKVEIDLQTLPVDLMSLASHKTYGPKGIGALYVRRKPRVRLEAQMHGGGHERG
MRSGTLPTHQIVGMGEAFRIAREEMAQDLAKVRVLQKRLLDGLTDIEQVFVNGDLERRVPHNLNISFNFVEGESLIMGIK
GLAVSSGSACTSASLEPSYVLRALGRSDELAHSSLRMTIGRFTTEEEIDVAVSSIRHNVAKLRELSPLWEMYKDGVDISS
IQWAAH

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=400, Percent_Identity=57.75, Blast_Score=504, Evalue=1e-143,
Organism=Homo sapiens, GI156713448, Length=419, Percent_Identity=32.6968973747017, Blast_Score=204, Evalue=2e-52,
Organism=Escherichia coli, GI48994898, Length=402, Percent_Identity=69.1542288557214, Blast_Score=592, Evalue=1e-170,
Organism=Escherichia coli, GI1787970, Length=390, Percent_Identity=25.6410256410256, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1789175, Length=388, Percent_Identity=25, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI25143064, Length=401, Percent_Identity=58.8528678304239, Blast_Score=498, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17533177, Length=324, Percent_Identity=31.7901234567901, Blast_Score=141, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6319831, Length=399, Percent_Identity=56.8922305764411, Blast_Score=489, Evalue=1e-139,
Organism=Drosophila melanogaster, GI20129463, Length=400, Percent_Identity=57, Blast_Score=478, Evalue=1e-135,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 44938; Mature: 44938

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMTPHFPIYLDYGATTPVDPRVVDAMIPWLREHFGNPASRSHAWGWEAEEAVEKARADV
CCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
AALIQADPREIVWTSGATESNNLAIKGAGHFYKGKGKHLITVKTEHKAVLDTMREMERQG
HHHHCCCCCEEEEECCCCCCCCEEEEECCCEECCCCCEEEEEECCHHHHHHHHHHHHHCC
FEVTYLDVQENGLLDFEVLKAAIRPDTILLSVMFVNNEIGVIQDIPAIGALCREKGVIFH
CEEEEEEECCCCCCCHHHHHHHHCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHCCCEEE
VDAAQATGKVEIDLQTLPVDLMSLASHKTYGPKGIGALYVRRKPRVRLEAQMHGGGHERG
EECCCCCCEEEEEEEECCHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEEECCCCHHCC
MRSGTLPTHQIVGMGEAFRIAREEMAQDLAKVRVLQKRLLDGLTDIEQVFVNGDLERRVP
CCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCC
HNLNISFNFVEGESLIMGIKGLAVSSGSACTSASLEPSYVLRALGRSDELAHSSLRMTIG
CCCCEEEEEECCCEEEEEEECEEECCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
RFTTEEEIDVAVSSIRHNVAKLRELSPLWEMYKDGVDISSIQWAAH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECC
>Mature Secondary Structure
MDMTPHFPIYLDYGATTPVDPRVVDAMIPWLREHFGNPASRSHAWGWEAEEAVEKARADV
CCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
AALIQADPREIVWTSGATESNNLAIKGAGHFYKGKGKHLITVKTEHKAVLDTMREMERQG
HHHHCCCCCEEEEECCCCCCCCEEEEECCCEECCCCCEEEEEECCHHHHHHHHHHHHHCC
FEVTYLDVQENGLLDFEVLKAAIRPDTILLSVMFVNNEIGVIQDIPAIGALCREKGVIFH
CEEEEEEECCCCCCCHHHHHHHHCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHCCCEEE
VDAAQATGKVEIDLQTLPVDLMSLASHKTYGPKGIGALYVRRKPRVRLEAQMHGGGHERG
EECCCCCCEEEEEEEECCHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEEECCCCHHCC
MRSGTLPTHQIVGMGEAFRIAREEMAQDLAKVRVLQKRLLDGLTDIEQVFVNGDLERRVP
CCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCC
HNLNISFNFVEGESLIMGIKGLAVSSGSACTSASLEPSYVLRALGRSDELAHSSLRMTIG
CCCCEEEEEECCCEEEEEEECEEECCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
RFTTEEEIDVAVSSIRHNVAKLRELSPLWEMYKDGVDISSIQWAAH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA