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The map label for this gene is uvrB [H]

Identifier: 120611112

GI number: 120611112

Start: 2664974

End: 2667064

Strand: Direct

Name: uvrB [H]

Synonym: Aave_2441

Alternate gene names: 120611112

Gene position: 2664974-2667064 (Clockwise)

Preceding gene: 120611108

Following gene: 120611113

Centisome position: 49.79

GC content: 66.0

Gene sequence:

>2091_bases
ATGCCAAAACCCATCGAAACCATGCCGGAGGCGCGAGGCGAAGGCACCCTCGTGCGCTTTCCCGATTCGCCATTCGAGCT
CTACCAGCCCTATCCGCCGGCGGGCGACCAGCCCACCGCCATCGATCAGCTGGTCGAGGGCGTGCGCGACGGCGAAGTCT
TCCAGACCCTGCTGGGCGTGACCGGGTCCGGCAAGACGTTCACCATGGCCAACGTGATCGCCCGGCTCGGCCGGCCGGCG
ATCGTGTTCGCCCCCAACAAGACGCTCGCCGCCCAGCTCTACAGCGAGTTCCGGGAGTTCTTCCCGAACAATGCCGTCGA
GTACTTCGTCAGCTACTACGACTATTACCAGCCCGAGGCCTACGTCCCGCAGCGCGATCTTTTCATCGAAAAGGACTCGG
CCATCAACGAGCACATCGAGCAGATGCGGCTGTCGGCCACCAAGAGCGTGCTCGAGCGGCGCGACGTGGTCATCGTGGCC
ACGGTGAGCGCCATCTACGGTATCGGGGCGCCCGAGGACTACACCAAGATGCGCTTCATCATGCGCGTGGGCGACGAGAT
CAGCCAGCGCGACGTGATCTCGCGCCTGATCCGCATGCAGTACACGCGCAACGAGCAGGATTTCGCGCGCGGCACCTTCC
GTGTGCGCGGCGACACCATCGACGTGTTCCCCTCGGAGCACAGCGAACTGGCCATCCGCATCGAATTGTTCGACGACGAG
ATCGAAACCCTGTCGCTGTTCGACCCGCTCACCGGTCGCGTTCGCCAGAAGATCCCGCGCTTCACCATCTACCCCAGCAG
CCACTACGTCACCCCCCGCGACAAGGTGCTGGCCGCCGTCGAGACCATCAAGCTGGAGTTGAACGAGCGGCTGGCCCAGT
TCGTGGCCGAGGGCAAGCTCGTGGAGGCGCAGCGCCTGGAGCAGCGCACCCGGTTCGACCTGGAGATGCTCAGCGAGGTC
GGCCACTGCAAGGGCATCGAGAACTACACGCGCCACCTGTCCGGCGCCGCGCCGGGCGATCCGCCGCCCACGCTCACCGA
CTACCTGCCTCCCGACGCCCTCATGTTCCTGGACGAGAGCCACCAGATGATAGGCCAGCTCGCGGCGATGTTCAACGGTG
ACCGCGCGCGCAAGACCACCCTGGTCGAATATGGCTTCCGACTGCCTTCCGCGCTCGACAACCGGCCGCTCAAGTTCGAG
GAGTTCGAGCGGCGCATGCGCCAGGTCGTCTTCGTGTCGGCCACGCCGGCCGACTACGAGAAGACCCACTCGGGCCAGGT
GGTGGACCAGGTGGTGCGCCCGACGGGGCTGGTGGACCCCGTCGTGGAGGTGCGCCCCGCCACCCACCAGGTGGACGACG
TGCTGCAGGAGATCCGCGTGCGTGTCGAACGCAACGAGCGGGTGCTGATCACCACGCTCACCAAGCGCATGGCCGAGCAG
CTCACGGACTACCTGACCGACAACGGCGTGAAGGTGCGCTACCTCCACTCCGACATCGACACCGTCGAACGCGTGGAAAT
CATCCGCGACCTGCGGCTGGGGGCCTTCGACGTACTGGTGGGGATCAACCTGCTGCGCGAGGGGCTAGACATCCCCGAGG
TGTCTCTGGTGGCCATCCTCGATGCGGACAAGGAGGGCTTCCTGCGCGCCGAGCGCAGCCTGATCCAGACCATCGGGCGC
GCCGCGCGCAACCTGAACGGCCAGGCGATCCTCTATGCGGACCGCATCACCGAGTCCATGAAAAAAGCCATCGGCGAAAC
GGAACGGCGGCGCGCGAAACAGATCGCACACAACGAAGCCCAGGGGATCACGCCACGGAGCATCGTCAAGCAGGTCCGCG
ACCTGATCGACGGGGTCTATAGCGAGAAGACCGGCCGGGAGGCCGAGCGTCTCGAGCAGGAGGCCCTGCGCCGGGCCCAG
GTCGAGGACATGTCCGAAAAGGATGTCGCCCGCGAAATCAAGCGGCTGGAAAAGCAGATGCTGGACCATGCGCGCAACCT
GGAGTTCGAACAGGCCGCCCGGGTGCGGGACCAGCTGAACCGGCTGAAGGCGCAGGCCTTCGGAGCCAGCGGGGCCGACC
AGGCGGCCTGA

Upstream 100 bases:

>100_bases
TTTCCTTGGGGTATCGACGAAGGATGTCGGAACGGGAGACCCGGCCTGTTGTACTCTGCCAGGTCGCCCCGATTTTAAGG
GCTCCACCCTGAGCCAGCCC

Downstream 100 bases:

>100_bases
ACGTAAGAAGAGGGCGCCGCCTGGGCGAAAAGGTGACTGATGGGTTTTGTTACCCGACAAAAACAATAGGGTTTTGTGCT
ATACTTGGGCGCAACACTCA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 696; Mature: 695

Protein sequence:

>696_residues
MPKPIETMPEARGEGTLVRFPDSPFELYQPYPPAGDQPTAIDQLVEGVRDGEVFQTLLGVTGSGKTFTMANVIARLGRPA
IVFAPNKTLAAQLYSEFREFFPNNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSAINEHIEQMRLSATKSVLERRDVVIVA
TVSAIYGIGAPEDYTKMRFIMRVGDEISQRDVISRLIRMQYTRNEQDFARGTFRVRGDTIDVFPSEHSELAIRIELFDDE
IETLSLFDPLTGRVRQKIPRFTIYPSSHYVTPRDKVLAAVETIKLELNERLAQFVAEGKLVEAQRLEQRTRFDLEMLSEV
GHCKGIENYTRHLSGAAPGDPPPTLTDYLPPDALMFLDESHQMIGQLAAMFNGDRARKTTLVEYGFRLPSALDNRPLKFE
EFERRMRQVVFVSATPADYEKTHSGQVVDQVVRPTGLVDPVVEVRPATHQVDDVLQEIRVRVERNERVLITTLTKRMAEQ
LTDYLTDNGVKVRYLHSDIDTVERVEIIRDLRLGAFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQTIGR
AARNLNGQAILYADRITESMKKAIGETERRRAKQIAHNEAQGITPRSIVKQVRDLIDGVYSEKTGREAERLEQEALRRAQ
VEDMSEKDVAREIKRLEKQMLDHARNLEFEQAARVRDQLNRLKAQAFGASGADQAA

Sequences:

>Translated_696_residues
MPKPIETMPEARGEGTLVRFPDSPFELYQPYPPAGDQPTAIDQLVEGVRDGEVFQTLLGVTGSGKTFTMANVIARLGRPA
IVFAPNKTLAAQLYSEFREFFPNNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSAINEHIEQMRLSATKSVLERRDVVIVA
TVSAIYGIGAPEDYTKMRFIMRVGDEISQRDVISRLIRMQYTRNEQDFARGTFRVRGDTIDVFPSEHSELAIRIELFDDE
IETLSLFDPLTGRVRQKIPRFTIYPSSHYVTPRDKVLAAVETIKLELNERLAQFVAEGKLVEAQRLEQRTRFDLEMLSEV
GHCKGIENYTRHLSGAAPGDPPPTLTDYLPPDALMFLDESHQMIGQLAAMFNGDRARKTTLVEYGFRLPSALDNRPLKFE
EFERRMRQVVFVSATPADYEKTHSGQVVDQVVRPTGLVDPVVEVRPATHQVDDVLQEIRVRVERNERVLITTLTKRMAEQ
LTDYLTDNGVKVRYLHSDIDTVERVEIIRDLRLGAFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQTIGR
AARNLNGQAILYADRITESMKKAIGETERRRAKQIAHNEAQGITPRSIVKQVRDLIDGVYSEKTGREAERLEQEALRRAQ
VEDMSEKDVAREIKRLEKQMLDHARNLEFEQAARVRDQLNRLKAQAFGASGADQAA
>Mature_695_residues
PKPIETMPEARGEGTLVRFPDSPFELYQPYPPAGDQPTAIDQLVEGVRDGEVFQTLLGVTGSGKTFTMANVIARLGRPAI
VFAPNKTLAAQLYSEFREFFPNNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSAINEHIEQMRLSATKSVLERRDVVIVAT
VSAIYGIGAPEDYTKMRFIMRVGDEISQRDVISRLIRMQYTRNEQDFARGTFRVRGDTIDVFPSEHSELAIRIELFDDEI
ETLSLFDPLTGRVRQKIPRFTIYPSSHYVTPRDKVLAAVETIKLELNERLAQFVAEGKLVEAQRLEQRTRFDLEMLSEVG
HCKGIENYTRHLSGAAPGDPPPTLTDYLPPDALMFLDESHQMIGQLAAMFNGDRARKTTLVEYGFRLPSALDNRPLKFEE
FERRMRQVVFVSATPADYEKTHSGQVVDQVVRPTGLVDPVVEVRPATHQVDDVLQEIRVRVERNERVLITTLTKRMAEQL
TDYLTDNGVKVRYLHSDIDTVERVEIIRDLRLGAFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQTIGRA
ARNLNGQAILYADRITESMKKAIGETERRRAKQIAHNEAQGITPRSIVKQVRDLIDGVYSEKTGREAERLEQEALRRAQV
EDMSEKDVAREIKRLEKQMLDHARNLEFEQAARVRDQLNRLKAQAFGASGADQAA

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=670, Percent_Identity=65.2238805970149, Blast_Score=860, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=242, Percent_Identity=25.2066115702479, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 79162; Mature: 79031

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKPIETMPEARGEGTLVRFPDSPFELYQPYPPAGDQPTAIDQLVEGVRDGEVFQTLLGV
CCCCCCCCCCCCCCCCEEECCCCCHHHCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHCC
TGSGKTFTMANVIARLGRPAIVFAPNKTLAAQLYSEFREFFPNNAVEYFVSYYDYYQPEA
CCCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
YVPQRDLFIEKDSAINEHIEQMRLSATKSVLERRDVVIVATVSAIYGIGAPEDYTKMRFI
CCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCCCHHHHHHHH
MRVGDEISQRDVISRLIRMQYTRNEQDFARGTFRVRGDTIDVFPSEHSELAIRIELFDDE
HHHCCHHHHHHHHHHHHHHHHCCCHHHHHCCEEEEECCEEEECCCCCCCEEEEEEEECCC
IETLSLFDPLTGRVRQKIPRFTIYPSSHYVTPRDKVLAAVETIKLELNERLAQFVAEGKL
HHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VEAQRLEQRTRFDLEMLSEVGHCKGIENYTRHLSGAAPGDPPPTLTDYLPPDALMFLDES
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHH
HQMIGQLAAMFNGDRARKTTLVEYGFRLPSALDNRPLKFEEFERRMRQVVFVSATPADYE
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHEEEEECCCCCCH
KTHSGQVVDQVVRPTGLVDPVVEVRPATHQVDDVLQEIRVRVERNERVLITTLTKRMAEQ
HCCCCHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHH
LTDYLTDNGVKVRYLHSDIDTVERVEIIRDLRLGAFDVLVGINLLREGLDIPEVSLVAIL
HHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEEEE
DADKEGFLRAERSLIQTIGRAARNLNGQAILYADRITESMKKAIGETERRRAKQIAHNEA
ECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCHHHHHHHHHHHHHHC
QGITPRSIVKQVRDLIDGVYSEKTGREAERLEQEALRRAQVEDMSEKDVAREIKRLEKQM
CCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LDHARNLEFEQAARVRDQLNRLKAQAFGASGADQAA
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
PKPIETMPEARGEGTLVRFPDSPFELYQPYPPAGDQPTAIDQLVEGVRDGEVFQTLLGV
CCCCCCCCCCCCCCCEEECCCCCHHHCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHCC
TGSGKTFTMANVIARLGRPAIVFAPNKTLAAQLYSEFREFFPNNAVEYFVSYYDYYQPEA
CCCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
YVPQRDLFIEKDSAINEHIEQMRLSATKSVLERRDVVIVATVSAIYGIGAPEDYTKMRFI
CCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCCCHHHHHHHH
MRVGDEISQRDVISRLIRMQYTRNEQDFARGTFRVRGDTIDVFPSEHSELAIRIELFDDE
HHHCCHHHHHHHHHHHHHHHHCCCHHHHHCCEEEEECCEEEECCCCCCCEEEEEEEECCC
IETLSLFDPLTGRVRQKIPRFTIYPSSHYVTPRDKVLAAVETIKLELNERLAQFVAEGKL
HHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VEAQRLEQRTRFDLEMLSEVGHCKGIENYTRHLSGAAPGDPPPTLTDYLPPDALMFLDES
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHH
HQMIGQLAAMFNGDRARKTTLVEYGFRLPSALDNRPLKFEEFERRMRQVVFVSATPADYE
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHEEEEECCCCCCH
KTHSGQVVDQVVRPTGLVDPVVEVRPATHQVDDVLQEIRVRVERNERVLITTLTKRMAEQ
HCCCCHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHH
LTDYLTDNGVKVRYLHSDIDTVERVEIIRDLRLGAFDVLVGINLLREGLDIPEVSLVAIL
HHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEEEE
DADKEGFLRAERSLIQTIGRAARNLNGQAILYADRITESMKKAIGETERRRAKQIAHNEA
ECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCHHHHHHHHHHHHHHC
QGITPRSIVKQVRDLIDGVYSEKTGREAERLEQEALRRAQVEDMSEKDVAREIKRLEKQM
CCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LDHARNLEFEQAARVRDQLNRLKAQAFGASGADQAA
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA