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The map label for this gene is gbpR [H]

Identifier: 120610931

GI number: 120610931

Start: 2483711

End: 2484673

Strand: Direct

Name: gbpR [H]

Synonym: Aave_2257

Alternate gene names: 120610931

Gene position: 2483711-2484673 (Clockwise)

Preceding gene: 120610917

Following gene: 120610933

Centisome position: 46.4

GC content: 69.37

Gene sequence:

>963_bases
ATGAGCACCTACAACCACTGGTTCATCCGCGCGCGCCTCAAGACGCGGCAGCTGCTGCTGCTGGTGGCCCTGGCCGAGGA
GGGCAACATCCACCGCGCGGCCCAGGTGCTCAGCATGACGCAGCCGGCCGCCTCCAAGCTGCTCAAGGACCTGGAAGACG
TGCTGGAGGTGCCGCTGTTCGAGCGCCTGCCCCGCGGCATGCGGCCCACCTGGTATGGCGAAACCATGATCCGCCATGCG
CGCATGGCGCTGGCGAGCCTCAACCAGGCCCATGACGAGATCGGCGCGCTGAAGACGGGGCACTACGGCCAGGTGGGCAT
CGGCGCCATCACCTCGCCGGGCCTGAGCCTGCTGCCGGCGGCGGTGGCGCTGGTGAAGCAGCAGCACCCGAGCCTGCGCA
TCTCGCTGGAGATCGAGACCAGCCCGGTGCTGCTGGAGCGCCTGGAGCAGGGCCGGATCGACATCATGGTGGGGCGTGTG
CTCGCCGGGCCGGAAACCGGCCACCTGCGCTACGAGACGCTGACGGACGAGCCGGTCTGCGCCGTCACCCGTCCCGGCCA
TCCGCTGTCGGGCATGAGCGGCCTGACGCTGCGGGACGTGCTCTCGGCCAGCTGGATCGTGCCGCCCGCCGGCAGCGTGC
TGCGGCACCGCTTCGACCTGATGTTCCAGCAGGAAGGGCTGCCCCCGCCCACGGACATCGTGGAAACCTCCGCGCTGCTG
TTCACCACCCGCATGCTGCAGCAGAGCGAGATGATCGGCGTGGTCGGCGCGGACGTGGCCCACTATTACGCGGCCCACGG
CATCGTCACCGTGCTGCCCATCGCCATGCCCTGCCACATGGACGCCTTCGGCATCGTCACCCGCACCGACCGCCTGCTGT
CGCCCGCCGCCAAGGTGATGATGAAGGCGCTCAAGCAGACCAGCCTCGTGCAGTACGGCCGCAAGCTGGAGATGGACGAG
TAG

Upstream 100 bases:

>100_bases
TCTTTGCTACGGTTGCGCTGCAGTCTATGGAGGTTTTTTATATCAATCCAATAGTTTTTTGGACAAAATAGATATCAATC
CCGGCATTCAGGAAAACCCC

Downstream 100 bases:

>100_bases
GCCGCGGCCCCCGATGAAGGCCCACGCGGATGTGCGCTGTGCCACGGCCTCTGCACAGGCACGGCCCCGCCAGCAACCGC
CGCGCAAGGGCCGCCCCGCC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Galactose-binding protein regulator; GBP regulator [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MSTYNHWFIRARLKTRQLLLLVALAEEGNIHRAAQVLSMTQPAASKLLKDLEDVLEVPLFERLPRGMRPTWYGETMIRHA
RMALASLNQAHDEIGALKTGHYGQVGIGAITSPGLSLLPAAVALVKQQHPSLRISLEIETSPVLLERLEQGRIDIMVGRV
LAGPETGHLRYETLTDEPVCAVTRPGHPLSGMSGLTLRDVLSASWIVPPAGSVLRHRFDLMFQQEGLPPPTDIVETSALL
FTTRMLQQSEMIGVVGADVAHYYAAHGIVTVLPIAMPCHMDAFGIVTRTDRLLSPAAKVMMKALKQTSLVQYGRKLEMDE

Sequences:

>Translated_320_residues
MSTYNHWFIRARLKTRQLLLLVALAEEGNIHRAAQVLSMTQPAASKLLKDLEDVLEVPLFERLPRGMRPTWYGETMIRHA
RMALASLNQAHDEIGALKTGHYGQVGIGAITSPGLSLLPAAVALVKQQHPSLRISLEIETSPVLLERLEQGRIDIMVGRV
LAGPETGHLRYETLTDEPVCAVTRPGHPLSGMSGLTLRDVLSASWIVPPAGSVLRHRFDLMFQQEGLPPPTDIVETSALL
FTTRMLQQSEMIGVVGADVAHYYAAHGIVTVLPIAMPCHMDAFGIVTRTDRLLSPAAKVMMKALKQTSLVQYGRKLEMDE
>Mature_319_residues
STYNHWFIRARLKTRQLLLLVALAEEGNIHRAAQVLSMTQPAASKLLKDLEDVLEVPLFERLPRGMRPTWYGETMIRHAR
MALASLNQAHDEIGALKTGHYGQVGIGAITSPGLSLLPAAVALVKQQHPSLRISLEIETSPVLLERLEQGRIDIMVGRVL
AGPETGHLRYETLTDEPVCAVTRPGHPLSGMSGLTLRDVLSASWIVPPAGSVLRHRFDLMFQQEGLPPPTDIVETSALLF
TTRMLQQSEMIGVVGADVAHYYAAHGIVTVLPIAMPCHMDAFGIVTRTDRLLSPAAKVMMKALKQTSLVQYGRKLEMDE

Specific function: Does not seem to be required for sbpA expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87081904, Length=298, Percent_Identity=30.2013422818792, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1787601, Length=289, Percent_Identity=28.0276816608997, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI145693105, Length=286, Percent_Identity=23.7762237762238, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1789506, Length=307, Percent_Identity=20.5211726384365, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1789204, Length=268, Percent_Identity=27.2388059701493, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788887, Length=187, Percent_Identity=31.0160427807487, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1790399, Length=203, Percent_Identity=27.5862068965517, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI157672245, Length=297, Percent_Identity=23.2323232323232, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788481, Length=207, Percent_Identity=28.0193236714976, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1787879, Length=195, Percent_Identity=25.1282051282051, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35229; Mature: 35098

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTYNHWFIRARLKTRQLLLLVALAEEGNIHRAAQVLSMTQPAASKLLKDLEDVLEVPLF
CCCCCEEEEEEEHHHHHEEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHH
ERLPRGMRPTWYGETMIRHARMALASLNQAHDEIGALKTGHYGQVGIGAITSPGLSLLPA
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
AVALVKQQHPSLRISLEIETSPVLLERLEQGRIDIMVGRVLAGPETGHLRYETLTDEPVC
HHHHHHHCCCCEEEEEEECCCHHHHHHHHCCCEEEEEEHEECCCCCCCEEEEECCCCCEE
AVTRPGHPLSGMSGLTLRDVLSASWIVPPAGSVLRHRFDLMFQQEGLPPPTDIVETSALL
EEECCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
FTTRMLQQSEMIGVVGADVAHYYAAHGIVTVLPIAMPCHMDAFGIVTRTDRLLSPAAKVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
MKALKQTSLVQYGRKLEMDE
HHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
STYNHWFIRARLKTRQLLLLVALAEEGNIHRAAQVLSMTQPAASKLLKDLEDVLEVPLF
CCCCEEEEEEEHHHHHEEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHH
ERLPRGMRPTWYGETMIRHARMALASLNQAHDEIGALKTGHYGQVGIGAITSPGLSLLPA
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
AVALVKQQHPSLRISLEIETSPVLLERLEQGRIDIMVGRVLAGPETGHLRYETLTDEPVC
HHHHHHHCCCCEEEEEEECCCHHHHHHHHCCCEEEEEEHEECCCCCCCEEEEECCCCCEE
AVTRPGHPLSGMSGLTLRDVLSASWIVPPAGSVLRHRFDLMFQQEGLPPPTDIVETSALL
EEECCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
FTTRMLQQSEMIGVVGADVAHYYAAHGIVTVLPIAMPCHMDAFGIVTRTDRLLSPAAKVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
MKALKQTSLVQYGRKLEMDE
HHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10361275 [H]