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The map label for this gene is ribH

Identifier: 120610905

GI number: 120610905

Start: 2451343

End: 2451807

Strand: Reverse

Name: ribH

Synonym: Aave_2231

Alternate gene names: 120610905

Gene position: 2451807-2451343 (Counterclockwise)

Preceding gene: 120610906

Following gene: 120610904

Centisome position: 45.8

GC content: 68.17

Gene sequence:

>465_bases
ATGTTTGGCGCAGACAAAGGAACCGCGGACAGGCTCGACGGCAGGAAGCTGCACATCGGCATCGTGCAGGCCCGCTTCAA
CGAAGGCATCACCGAGGCCCTGGCGGCCGCGTGCCGCGAAGAGCTGCTCGCCCTGGGCGTGCAGGAAAAGAACATCCGCC
ACGTGCGCGTGCCCGGCGCCCTCGAAGTACCCCTGGCGCTGCAGGCCCTGGCCGAGCAGGACGAATACGACGCGCTCATC
GCGCTGGGCTGCATCATCCGCGGCGAAACCTACCACTTCGAGCTGGTGGCCAACGAGTCCGGTGCCGGCGTGACGCGCGT
CTCGCTCGATACCCAGACGCCGATCGCCAACGCCATCCTGACCACCGAGAACCTGGAGCAGGCCGTCGCCCGCCAGACCG
AGAAGGGCCGCGACGCGGCGCGCGTGGCCGTGGAGATGGCGAACCTGCTGGAGGAGCTGTCTTGA

Upstream 100 bases:

>100_bases
GTCACGCGCATGCAGCTCATGGGCCAGCAGCGGCGCCTGCCCAGCATGACCGGCTACGGCCTCGAGATCACCGGATACAT
CCCCAAGGAATAAGCAACAC

Downstream 100 bases:

>100_bases
GCGACGATTCCGCTTCCACCCCGGCGCCCGGCGGCGCCAAGCGCCCGCCGCGGCAGGCGCGCACGGGCACCACGTCCACG
GGCGCGCGCAAGGCCGCGTC

Product: 6,7-dimethyl-8-ribityllumazine synthase

Products: NA

Alternate protein names: DMRL synthase; Lumazine synthase; Riboflavin synthase beta chain

Number of amino acids: Translated: 154; Mature: 154

Protein sequence:

>154_residues
MFGADKGTADRLDGRKLHIGIVQARFNEGITEALAAACREELLALGVQEKNIRHVRVPGALEVPLALQALAEQDEYDALI
ALGCIIRGETYHFELVANESGAGVTRVSLDTQTPIANAILTTENLEQAVARQTEKGRDAARVAVEMANLLEELS

Sequences:

>Translated_154_residues
MFGADKGTADRLDGRKLHIGIVQARFNEGITEALAAACREELLALGVQEKNIRHVRVPGALEVPLALQALAEQDEYDALI
ALGCIIRGETYHFELVANESGAGVTRVSLDTQTPIANAILTTENLEQAVARQTEKGRDAARVAVEMANLLEELS
>Mature_154_residues
MFGADKGTADRLDGRKLHIGIVQARFNEGITEALAAACREELLALGVQEKNIRHVRVPGALEVPLALQALAEQDEYDALI
ALGCIIRGETYHFELVANESGAGVTRVSLDTQTPIANAILTTENLEQAVARQTEKGRDAARVAVEMANLLEELS

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes

COG id: COG0054

COG function: function code H; Riboflavin synthase beta-chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DMRL synthase family

Homologues:

Organism=Escherichia coli, GI1786617, Length=140, Percent_Identity=44.2857142857143, Blast_Score=108, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324429, Length=155, Percent_Identity=31.6129032258064, Blast_Score=82, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RISB_ACIAC (A1TPC1)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_970583.1
- ProteinModelPortal:   A1TPC1
- SMR:   A1TPC1
- STRING:   A1TPC1
- GeneID:   4666599
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_2231
- NMPDR:   fig|397945.5.peg.1926
- eggNOG:   COG0054
- HOGENOM:   HBG311126
- OMA:   KAGNKGW
- PhylomeDB:   A1TPC1
- ProtClustDB:   PRK00061
- BioCyc:   AAVE397945:AAVE_2231-MONOMER
- HAMAP:   MF_00178
- InterPro:   IPR002180
- Gene3D:   G3DSA:3.40.50.960
- PANTHER:   PTHR21058
- TIGRFAMs:   TIGR00114

Pfam domain/function: PF00885 DMRL_synthase; SSF52121 DMRL_synthase

EC number: =2.5.1.9

Molecular weight: Translated: 16591; Mature: 16591

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGADKGTADRLDGRKLHIGIVQARFNEGITEALAAACREELLALGVQEKNIRHVRVPGA
CCCCCCCCCCCCCCCEEEEEEEEEHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCC
LEVPLALQALAEQDEYDALIALGCIIRGETYHFELVANESGAGVTRVSLDTQTPIANAIL
CCHHHHHHHHHCCCCHHHHHHHHHEEECCEEEEEEEECCCCCCEEEEEECCCCCHHHHHC
TTENLEQAVARQTEKGRDAARVAVEMANLLEELS
CHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFGADKGTADRLDGRKLHIGIVQARFNEGITEALAAACREELLALGVQEKNIRHVRVPGA
CCCCCCCCCCCCCCCEEEEEEEEEHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCC
LEVPLALQALAEQDEYDALIALGCIIRGETYHFELVANESGAGVTRVSLDTQTPIANAIL
CCHHHHHHHHHCCCCHHHHHHHHHEEECCEEEEEEEECCCCCCEEEEEECCCCCHHHHHC
TTENLEQAVARQTEKGRDAARVAVEMANLLEELS
CHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA