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The map label for this gene is etfA [H]

Identifier: 120610843

GI number: 120610843

Start: 2384236

End: 2385168

Strand: Direct

Name: etfA [H]

Synonym: Aave_2169

Alternate gene names: 120610843

Gene position: 2384236-2385168 (Clockwise)

Preceding gene: 120610842

Following gene: 120610844

Centisome position: 44.54

GC content: 69.45

Gene sequence:

>933_bases
ATGACCTCTCTCGTTATTGCAGAACACGACAACGCTTCGATCAAGCCCGCCACGCTCCACACCGTCACGGCGGCTGCCGC
CTGCGGCGGTGACGTGCACGTGCTGGTGGCCGGCCAGGGCGCCGAAGCCGCCGCCCAGGCCGCCGCGCAGATCGCGGGCG
TTACCAAGGTCATCCTGGCCGACGGCGCAAGCCTCAAGGACGGCCTGGCCGAGAACGTGGCCGCCCAGGTGCTGGCCATC
GCTTCCAACTACAGCCACATCCTGTTCCCGGCCACGGCCGGCGGCAAGAACGTGGCGCCGCGGGTGGCGGCGAAGCTCGA
TGTCGCGCAGATCAGCGACATCACCAGGGTCGAAGGCCCGGACACGTTCGAGCGCCCGATCTACGCGGGCAACGCGATCG
CCACGGTGCAAAGCAGCGACAGCGTGAAGGTGATCACGGTGCGCACCACGGGCTTCGACGCCGCGGTGGCGACGGGCGGC
TCGGCGGCGGTGGAGAAGGCCGATGCGGCCGCGGACAGCGGCAAGAGCCAGTTCGTGGGCCGCGAGGTCACCAAGAGCGA
CCGGCCCGAGCTCACGGCGGCCAAGATCATCGTCTCGGGCGGCCGGGCGCTGGGCAGCGCGGAGAAGTTCAACGAAGTGA
TGACGCCGCTGGCGGACAAGCTGGGCGCGGCGATCGGCGCGAGCCGCGCGGCGGTGGATGCGGGCTATGCCCCGAACGAC
CTGCAGGTGGGGCAGACGGGCAAGATCGTGGCGCCGCAGCTCTACATCGCGGCGGGCATCTCGGGCGCGATCCAGCATCT
GGCGGGCATGAAGGATTCCAAGGTGATCGTGGCGATCAACAAGGACGCCGAGGCGCCGATCTTCAGCGTGGCCGACTACG
GGCTGGAGGCGGACCTGTTCACCGCCGTGCCCGAACTCGTGAAGTCCCTCTGA

Upstream 100 bases:

>100_bases
CGGGGCGGCCCTTCCTCGGTGTCCCTCGCATCGGCCGCGCCGGAACTGAAAGCCGCGGGCGATACAGGTATCCCTGACAT
TCAAGAGAAAGACGACTGAA

Downstream 100 bases:

>100_bases
CCCTGGCGGCCCCGACGGAGCCGCAGGCTGCAGGCAGGGCCTCCACGAGGGCATCGCATGCGGTGCCCTTTTTTTTGCCC
GGCCCGTCCGGTCCGCGGCC

Product: electron transfer flavoprotein subunit alpha

Products: NA

Alternate protein names: Alpha-ETF; Electron transfer flavoprotein large subunit; ETFLS [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MTSLVIAEHDNASIKPATLHTVTAAAACGGDVHVLVAGQGAEAAAQAAAQIAGVTKVILADGASLKDGLAENVAAQVLAI
ASNYSHILFPATAGGKNVAPRVAAKLDVAQISDITRVEGPDTFERPIYAGNAIATVQSSDSVKVITVRTTGFDAAVATGG
SAAVEKADAAADSGKSQFVGREVTKSDRPELTAAKIIVSGGRALGSAEKFNEVMTPLADKLGAAIGASRAAVDAGYAPND
LQVGQTGKIVAPQLYIAAGISGAIQHLAGMKDSKVIVAINKDAEAPIFSVADYGLEADLFTAVPELVKSL

Sequences:

>Translated_310_residues
MTSLVIAEHDNASIKPATLHTVTAAAACGGDVHVLVAGQGAEAAAQAAAQIAGVTKVILADGASLKDGLAENVAAQVLAI
ASNYSHILFPATAGGKNVAPRVAAKLDVAQISDITRVEGPDTFERPIYAGNAIATVQSSDSVKVITVRTTGFDAAVATGG
SAAVEKADAAADSGKSQFVGREVTKSDRPELTAAKIIVSGGRALGSAEKFNEVMTPLADKLGAAIGASRAAVDAGYAPND
LQVGQTGKIVAPQLYIAAGISGAIQHLAGMKDSKVIVAINKDAEAPIFSVADYGLEADLFTAVPELVKSL
>Mature_309_residues
TSLVIAEHDNASIKPATLHTVTAAAACGGDVHVLVAGQGAEAAAQAAAQIAGVTKVILADGASLKDGLAENVAAQVLAIA
SNYSHILFPATAGGKNVAPRVAAKLDVAQISDITRVEGPDTFERPIYAGNAIATVQSSDSVKVITVRTTGFDAAVATGGS
AAVEKADAAADSGKSQFVGREVTKSDRPELTAAKIIVSGGRALGSAEKFNEVMTPLADKLGAAIGASRAAVDAGYAPNDL
QVGQTGKIVAPQLYIAAGISGAIQHLAGMKDSKVIVAINKDAEAPIFSVADYGLEADLFTAVPELVKSL

Specific function: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) [H]

COG id: COG2025

COG function: function code C; Electron transfer flavoprotein, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF alpha-subunit/fixB family [H]

Homologues:

Organism=Homo sapiens, GI4503607, Length=311, Percent_Identity=58.5209003215434, Blast_Score=348, Evalue=3e-96,
Organism=Homo sapiens, GI189181759, Length=275, Percent_Identity=59.2727272727273, Blast_Score=311, Evalue=5e-85,
Organism=Escherichia coli, GI1786226, Length=236, Percent_Identity=33.8983050847458, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1787990, Length=274, Percent_Identity=30.6569343065693, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87082157, Length=246, Percent_Identity=31.3008130081301, Blast_Score=88, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17506929, Length=312, Percent_Identity=55.7692307692308, Blast_Score=326, Evalue=1e-89,
Organism=Saccharomyces cerevisiae, GI6325261, Length=284, Percent_Identity=45.7746478873239, Blast_Score=247, Evalue=2e-66,
Organism=Drosophila melanogaster, GI17136898, Length=312, Percent_Identity=61.2179487179487, Blast_Score=352, Evalue=1e-97,
Organism=Drosophila melanogaster, GI24652801, Length=312, Percent_Identity=61.2179487179487, Blast_Score=352, Evalue=1e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001308
- InterPro:   IPR014730
- InterPro:   IPR014731
- InterPro:   IPR018206
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01012 ETF; PF00766 ETF_alpha [H]

EC number: NA

Molecular weight: Translated: 31152; Mature: 31020

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00696 ETF_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLVIAEHDNASIKPATLHTVTAAAACGGDVHVLVAGQGAEAAAQAAAQIAGVTKVILA
CCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHEEEEEE
DGASLKDGLAENVAAQVLAIASNYSHILFPATAGGKNVAPRVAAKLDVAQISDITRVEGP
CCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHCCHHHHCCHHCCCCC
DTFERPIYAGNAIATVQSSDSVKVITVRTTGFDAAVATGGSAAVEKADAAADSGKSQFVG
CCCCCCEECCCEEEEEECCCCEEEEEEEECCCCCEEECCCHHHHHHHHHHHCCCCHHHCC
REVTKSDRPELTAAKIIVSGGRALGSAEKFNEVMTPLADKLGAAIGASRAAVDAGYAPND
CHHCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCC
LQVGQTGKIVAPQLYIAAGISGAIQHLAGMKDSKVIVAINKDAEAPIFSVADYGLEADLF
CEECCCCCEECCCEEEECCHHHHHHHHHCCCCCEEEEEECCCCCCCEEEHHHCCCCHHHH
TAVPELVKSL
HHHHHHHHCC
>Mature Secondary Structure 
TSLVIAEHDNASIKPATLHTVTAAAACGGDVHVLVAGQGAEAAAQAAAQIAGVTKVILA
CEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHEEEEEE
DGASLKDGLAENVAAQVLAIASNYSHILFPATAGGKNVAPRVAAKLDVAQISDITRVEGP
CCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHCCHHHHCCHHCCCCC
DTFERPIYAGNAIATVQSSDSVKVITVRTTGFDAAVATGGSAAVEKADAAADSGKSQFVG
CCCCCCEECCCEEEEEECCCCEEEEEEEECCCCCEEECCCHHHHHHHHHHHCCCCHHHCC
REVTKSDRPELTAAKIIVSGGRALGSAEKFNEVMTPLADKLGAAIGASRAAVDAGYAPND
CHHCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCC
LQVGQTGKIVAPQLYIAAGISGAIQHLAGMKDSKVIVAINKDAEAPIFSVADYGLEADLF
CEECCCCCEECCCEEEECCHHHHHHHHHCCCCCEEEEEECCCCCCCEEEHHHCCCCHHHH
TAVPELVKSL
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]