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The map label for this gene is mdtA [H]

Identifier: 120610717

GI number: 120610717

Start: 2218872

End: 2220320

Strand: Direct

Name: mdtA [H]

Synonym: Aave_2038

Alternate gene names: 120610717

Gene position: 2218872-2220320 (Clockwise)

Preceding gene: 120610716

Following gene: 120610718

Centisome position: 41.45

GC content: 76.4

Gene sequence:

>1449_bases
ATGCGCTCCACCGATCCCCACGCCGCTCCTTCCGCTGACTCCGCGCCCGGCCCCGGCGCAGCGGGCCGGCCGCCGGGGCG
GCGCGCGCGCTGGCTGGGCACCGGGGTGGCACTGCTGGCCGTGGCGCTGCTGTGCGGCGGCGCATGGTGGCTGGTGCAGC
GCTCCAAGGCGCCGGTCGCCGGCCCGGGTTTTCCCGCCGCGGGCGGGCCGGGAGGGCCCGCCCGGCCGGCCGGCGCCGGG
CCCGCCGGTGGCCGCGCGCTGGTCACCGTGGGCGAGGCGACGGCCCGCCGGCTGCGCATGCCGGTGGCCATCGAGGCCCT
GGGCACCGTGATACCGGTCACCACCGTCACGCTCCGGCCCCAGGTGGCGGGCGTGCTCACCGAGGTGCTGTTCACCGAAG
GGCAGATGGTGCGCAAGGGCCAGGTGCTCGCGCAGATCGACCCGCGGCCCTACGAGCAGGCGCTGATGCAGGCCGAGGGC
ACGCTGCGGCGCGACGAGGCGCAGCTGGAGAACGCGCGCATCACCCTCGAGCGCTACCGCACCCTGCTGTCGCAGGACTC
CATCGCCCGGCAGGACGTGGATACGCAGGCCGCGCTGGTCAAGCAGCTGGAAGGCACCGTGATGACGGACCGGGCGCAGG
AGCGCAGCGCCCGGCTCAACCTCGGCTACACGCGCGTGACGGCGCCGGCCGCGGGCCGCATCGGCCTGCGTTCCGTGGAT
GCGGGCAATTACGTGACCACCGGAGATACCTCGGGCCTGGCCACCATCACCCAGACCACGCCGATCGACGTGCAGTTCTC
CATCCCGCAGGACCGCCTGGCCGACGTGCAGGCCGCCGCCGCCGAGGCCGGCGCCGCCGGGCTGCCGGTGGTGGCCAAGG
ACCGCACCCGCACCACGGACCTCGCCCAGGGGCGGTTCTCCACCCTGGACAACCTGGTGGACACCGCCACCGGCACGGTC
CGGGCCAAGGCGCGCTTCGCCAATGCCGACGGCCGGCTCTTCCCCAACCAGTTCGTGAACGTGCGTCTGGAGCTGCGCGA
GGTGGAGGCCCTGGTGGTGCCCGTGACCGCGGTGCGGACCGGGGCGAACGGCGACTTCGTGTACGTGATCAACGACGACC
GCACGGTGACGCTGCGCAGGGTGCGGCGCGGCCAGTCCACGGTGGAGTGGGTGGCGATCGCGGAAGGGCTGAAGCCCGGC
GAGCGCGTGGTGACCGAAGGCGGCGACCGCCTGCGCGACGGCGCGCGCGTGCAGTTGCCGGAACCCGGCGGGCCGGGAGC
GGCGCAGGGCGCGCCCGGGCGGCGCGGGCGGGCTTCCGGGGCTTCCTGGCCGGCGGGCGCGGAGCACGGCGGCTCCGACG
GCGCACCGCACCGCCAACGGCACCGGCCGGATGCCGGGGAGGCGGCGCCGGCCGCGCCGGCGGCGTCGGTGCCGGCCAGC
CGTTCCTGA

Upstream 100 bases:

>100_bases
TACGATCGGGGACGCCGGTCATCCCGCCCGTCGGGCCGGCCGGCCGTGACGCGCGGCCGCCTGCCCAACGGTTTTTCCCG
CCACCGCTTCCCTCAAGAAC

Downstream 100 bases:

>100_bases
TCCCCGCGTGCGCTTCCGCCCATGAGTCCGTCGCGTCCCTTTATCGAGCGGCCCGTCGCCACAGCGCTCCTCATGCTGGC
CATCGTGCTGGCGGGGCTGG

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MRSTDPHAAPSADSAPGPGAAGRPPGRRARWLGTGVALLAVALLCGGAWWLVQRSKAPVAGPGFPAAGGPGGPARPAGAG
PAGGRALVTVGEATARRLRMPVAIEALGTVIPVTTVTLRPQVAGVLTEVLFTEGQMVRKGQVLAQIDPRPYEQALMQAEG
TLRRDEAQLENARITLERYRTLLSQDSIARQDVDTQAALVKQLEGTVMTDRAQERSARLNLGYTRVTAPAAGRIGLRSVD
AGNYVTTGDTSGLATITQTTPIDVQFSIPQDRLADVQAAAAEAGAAGLPVVAKDRTRTTDLAQGRFSTLDNLVDTATGTV
RAKARFANADGRLFPNQFVNVRLELREVEALVVPVTAVRTGANGDFVYVINDDRTVTLRRVRRGQSTVEWVAIAEGLKPG
ERVVTEGGDRLRDGARVQLPEPGGPGAAQGAPGRRGRASGASWPAGAEHGGSDGAPHRQRHRPDAGEAAPAAPAASVPAS
RS

Sequences:

>Translated_482_residues
MRSTDPHAAPSADSAPGPGAAGRPPGRRARWLGTGVALLAVALLCGGAWWLVQRSKAPVAGPGFPAAGGPGGPARPAGAG
PAGGRALVTVGEATARRLRMPVAIEALGTVIPVTTVTLRPQVAGVLTEVLFTEGQMVRKGQVLAQIDPRPYEQALMQAEG
TLRRDEAQLENARITLERYRTLLSQDSIARQDVDTQAALVKQLEGTVMTDRAQERSARLNLGYTRVTAPAAGRIGLRSVD
AGNYVTTGDTSGLATITQTTPIDVQFSIPQDRLADVQAAAAEAGAAGLPVVAKDRTRTTDLAQGRFSTLDNLVDTATGTV
RAKARFANADGRLFPNQFVNVRLELREVEALVVPVTAVRTGANGDFVYVINDDRTVTLRRVRRGQSTVEWVAIAEGLKPG
ERVVTEGGDRLRDGARVQLPEPGGPGAAQGAPGRRGRASGASWPAGAEHGGSDGAPHRQRHRPDAGEAAPAAPAASVPAS
RS
>Mature_482_residues
MRSTDPHAAPSADSAPGPGAAGRPPGRRARWLGTGVALLAVALLCGGAWWLVQRSKAPVAGPGFPAAGGPGGPARPAGAG
PAGGRALVTVGEATARRLRMPVAIEALGTVIPVTTVTLRPQVAGVLTEVLFTEGQMVRKGQVLAQIDPRPYEQALMQAEG
TLRRDEAQLENARITLERYRTLLSQDSIARQDVDTQAALVKQLEGTVMTDRAQERSARLNLGYTRVTAPAAGRIGLRSVD
AGNYVTTGDTSGLATITQTTPIDVQFSIPQDRLADVQAAAAEAGAAGLPVVAKDRTRTTDLAQGRFSTLDNLVDTATGTV
RAKARFANADGRLFPNQFVNVRLELREVEALVVPVTAVRTGANGDFVYVINDDRTVTLRRVRRGQSTVEWVAIAEGLKPG
ERVVTEGGDRLRDGARVQLPEPGGPGAAQGAPGRRGRASGASWPAGAEHGGSDGAPHRQRHRPDAGEAAPAAPAASVPAS
RS

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=359, Percent_Identity=43.4540389972145, Blast_Score=277, Evalue=9e-76,
Organism=Escherichia coli, GI1786668, Length=359, Percent_Identity=31.7548746518106, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1789665, Length=309, Percent_Identity=33.9805825242718, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI1789929, Length=317, Percent_Identity=31.5457413249211, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI87081951, Length=133, Percent_Identity=30.0751879699248, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87081796, Length=168, Percent_Identity=30.3571428571429, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 50216; Mature: 50216

Theoretical pI: Translated: 10.91; Mature: 10.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSTDPHAAPSADSAPGPGAAGRPPGRRARWLGTGVALLAVALLCGGAWWLVQRSKAPVA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHCCEEEEEECCCCCCC
GPGFPAAGGPGGPARPAGAGPAGGRALVTVGEATARRLRMPVAIEALGTVIPVTTVTLRP
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHCCCCHHHHHCCEEEEEEEEECH
QVAGVLTEVLFTEGQMVRKGQVLAQIDPRPYEQALMQAEGTLRRDEAQLENARITLERYR
HHHHHHHHHHHHCCCCEECCCEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHEEEHHHHH
TLLSQDSIARQDVDTQAALVKQLEGTVMTDRAQERSARLNLGYTRVTAPAAGRIGLRSVD
HHHHCCHHHHHCCHHHHHHHHHHCCCEECCCHHHHHCEEECCEEEEECCCCCCCCEEEEC
AGNYVTTGDTSGLATITQTTPIDVQFSIPQDRLADVQAAAAEAGAAGLPVVAKDRTRTTD
CCCEEECCCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHHHCCCCCCCEEECCCCCCHH
LAQGRFSTLDNLVDTATGTVRAKARFANADGRLFPNQFVNVRLELREVEALVVPVTAVRT
HHCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCEEEEEEEEEEEEEEEEEEHEEE
GANGDFVYVINDDRTVTLRRVRRGQSTVEWVAIAEGLKPGERVVTEGGDRLRDGARVQLP
CCCCCEEEEECCCCEEEHHHHHCCCCHHHHHHHHCCCCCCHHHHHCCCHHHCCCCEEECC
EPGGPGAAQGAPGRRGRASGASWPAGAEHGGSDGAPHRQRHRPDAGEAAPAAPAASVPAS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCC
RS
CC
>Mature Secondary Structure
MRSTDPHAAPSADSAPGPGAAGRPPGRRARWLGTGVALLAVALLCGGAWWLVQRSKAPVA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHCCEEEEEECCCCCCC
GPGFPAAGGPGGPARPAGAGPAGGRALVTVGEATARRLRMPVAIEALGTVIPVTTVTLRP
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHCCCCHHHHHCCEEEEEEEEECH
QVAGVLTEVLFTEGQMVRKGQVLAQIDPRPYEQALMQAEGTLRRDEAQLENARITLERYR
HHHHHHHHHHHHCCCCEECCCEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHEEEHHHHH
TLLSQDSIARQDVDTQAALVKQLEGTVMTDRAQERSARLNLGYTRVTAPAAGRIGLRSVD
HHHHCCHHHHHCCHHHHHHHHHHCCCEECCCHHHHHCEEECCEEEEECCCCCCCCEEEEC
AGNYVTTGDTSGLATITQTTPIDVQFSIPQDRLADVQAAAAEAGAAGLPVVAKDRTRTTD
CCCEEECCCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHHHCCCCCCCEEECCCCCCHH
LAQGRFSTLDNLVDTATGTVRAKARFANADGRLFPNQFVNVRLELREVEALVVPVTAVRT
HHCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCEEEEEEEEEEEEEEEEEEHEEE
GANGDFVYVINDDRTVTLRRVRRGQSTVEWVAIAEGLKPGERVVTEGGDRLRDGARVQLP
CCCCCEEEEECCCCEEEHHHHHCCCCHHHHHHHHCCCCCCHHHHHCCCHHHCCCCEEECC
EPGGPGAAQGAPGRRGRASGASWPAGAEHGGSDGAPHRQRHRPDAGEAAPAAPAASVPAS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCC
RS
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA