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The map label for this gene is envZ [H]

Identifier: 120610268

GI number: 120610268

Start: 1748558

End: 1750075

Strand: Reverse

Name: envZ [H]

Synonym: Aave_1583

Alternate gene names: 120610268

Gene position: 1750075-1748558 (Counterclockwise)

Preceding gene: 120610269

Following gene: 120610265

Centisome position: 32.69

GC content: 70.09

Gene sequence:

>1518_bases
ATGAGCGCCTCCCACGACGCGTCCGCAGACGCCACCAGCCCCGCGCCACTGGAGACGACGCCGAACCGGCGTGCGTCCCA
GCGCACGCGCGTCGGCCTGAACCTCTTCTGGCGCACTTTTTTCCTGCTCGCCCTGCTGCTGGTGGGCAGCATCCTGGCCT
GGCTGCAGACGCTGCGCGCGCTCGAATTCGAGCCCCGCACCCTGCAGACCGCGCAGCAGATCGCCTCCCTCGTGAACCTG
AGCCGTGCCGCGCTGGTGCATGCGGACGCCATCGCCCGCGTCTCGCTCATCAAGACCATGGCGGACCAGGAGGGCGTGCG
CATCCTGCCCCGCGAGCCCAGCGACCGCTTCGACCTCGTGGACGACACCGCGCTGGGCGTGCGCCTCACCGAGGAACTGA
CCGAGCGGCTCGGCCCGGGCACCATCGTGGCCGGCAACGTGAACGGCGAGAGCGGGCTGTGGGTGGGCTTCACCATCAAC
GGCGATCCCAACTGGCTGCTGATGGACCGCTCGCGCCTGAGCACGGCGGGCGGCAAGACCTGGCTGATCTGGCTCATCAC
CGCGGGTGCCCTGTCGCTGGCGGGCGCGGCGGCGATCGCGCGGCTCATCAACCGGCCGCTCAAGCAGCTCTCCTACGCCG
CCAACCGCGTGCGCGACGGCGATTTCGCGGCCAGCCAGCTCGACGAGGAAGTGGTGACCAGCGAGATCCGCGAGGTGAAC
ATCGGCTTCAACCGCATGGCGCAGAAGCTCGCGAAGCTCGAACAGGACCGGGCGGTGATGCTGGCCGGCATCTCCCACGA
CCTGCGCACGCCGCTGGCGCGCCTGCGGCTGGAAACCGAGATGAGCGTGATCGACGACGTGGCCCGCGAGCACATGGTGG
CCGACATCGTGCAGCTCGACGCCACCATCGACAAGTTCCTGGACTACGCGCGGCCGGACCACGTCACGCTCACGCCGGTG
AACCTGCACGGCGTGGTGTCTTCCTGCGTGTATGCGGTGCAGGACCACCGCGAACTGCAGATCTCCATGAACGTGCCGGA
AGACCTGATCGTGCTGGCCGACGAGGTGGAGCTGGCGCGCGTGATCTCCAACCTGCTGGAGAACGCCCGCCGCTACGGCA
AGACGCCCGAGAGCGGCACGGCCTCCGTGGAAATCGCCGCCAAGGGGCGCGAGAAATGGGTGCTGGTGAAGGTGCGCGAC
CACGGCCCGGGCGTGCCGCCCGACCAGTTGAGCAACCTGACCAAGCCCTTCTTCCGCGGCAACTCCGCGCGCACGGCGGC
CGCGGGCGCGGGCCTGGGCCTGGCCATCGTGGACAAGACCGTGCAGCGCATGGGCGGCATCTTCGCGCTGGCCAATTCCG
GCTCCGGTGGCCTGGTGGCGCACATCCAGCTGCAGCGCGCCTCGCAGCTGCCGGCCGGCAAGGACCCCAAGCAGCGGCTG
CAGCGCCCGCAGATCAAGCGCCAGCTGCCGCCCGACGCGGCCAAGGGCGGCAAGCCCGTCAAGCCGGCGAAGGCCTGA

Upstream 100 bases:

>100_bases
GACAACCCCGCGCGCGGGCACCGGGGCGGCACCCTGTGCAGCCCCGGTGCCCGCAGCCCTTCCACGGCCTGCAGCGGCCC
GGCTCTTCTCCTGACCTGAC

Downstream 100 bases:

>100_bases
ACAGCAGCACGGCCGCGCGCGCCTCCATGGCCAGGCCCTGCCCCACGGGGCCCATGCGCTCGGCCGTCTTGGCCTTCACG
TTCACCTGATCGGGCTGCAG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MSASHDASADATSPAPLETTPNRRASQRTRVGLNLFWRTFFLLALLLVGSILAWLQTLRALEFEPRTLQTAQQIASLVNL
SRAALVHADAIARVSLIKTMADQEGVRILPREPSDRFDLVDDTALGVRLTEELTERLGPGTIVAGNVNGESGLWVGFTIN
GDPNWLLMDRSRLSTAGGKTWLIWLITAGALSLAGAAAIARLINRPLKQLSYAANRVRDGDFAASQLDEEVVTSEIREVN
IGFNRMAQKLAKLEQDRAVMLAGISHDLRTPLARLRLETEMSVIDDVAREHMVADIVQLDATIDKFLDYARPDHVTLTPV
NLHGVVSSCVYAVQDHRELQISMNVPEDLIVLADEVELARVISNLLENARRYGKTPESGTASVEIAAKGREKWVLVKVRD
HGPGVPPDQLSNLTKPFFRGNSARTAAAGAGLGLAIVDKTVQRMGGIFALANSGSGGLVAHIQLQRASQLPAGKDPKQRL
QRPQIKRQLPPDAAKGGKPVKPAKA

Sequences:

>Translated_505_residues
MSASHDASADATSPAPLETTPNRRASQRTRVGLNLFWRTFFLLALLLVGSILAWLQTLRALEFEPRTLQTAQQIASLVNL
SRAALVHADAIARVSLIKTMADQEGVRILPREPSDRFDLVDDTALGVRLTEELTERLGPGTIVAGNVNGESGLWVGFTIN
GDPNWLLMDRSRLSTAGGKTWLIWLITAGALSLAGAAAIARLINRPLKQLSYAANRVRDGDFAASQLDEEVVTSEIREVN
IGFNRMAQKLAKLEQDRAVMLAGISHDLRTPLARLRLETEMSVIDDVAREHMVADIVQLDATIDKFLDYARPDHVTLTPV
NLHGVVSSCVYAVQDHRELQISMNVPEDLIVLADEVELARVISNLLENARRYGKTPESGTASVEIAAKGREKWVLVKVRD
HGPGVPPDQLSNLTKPFFRGNSARTAAAGAGLGLAIVDKTVQRMGGIFALANSGSGGLVAHIQLQRASQLPAGKDPKQRL
QRPQIKRQLPPDAAKGGKPVKPAKA
>Mature_504_residues
SASHDASADATSPAPLETTPNRRASQRTRVGLNLFWRTFFLLALLLVGSILAWLQTLRALEFEPRTLQTAQQIASLVNLS
RAALVHADAIARVSLIKTMADQEGVRILPREPSDRFDLVDDTALGVRLTEELTERLGPGTIVAGNVNGESGLWVGFTING
DPNWLLMDRSRLSTAGGKTWLIWLITAGALSLAGAAAIARLINRPLKQLSYAANRVRDGDFAASQLDEEVVTSEIREVNI
GFNRMAQKLAKLEQDRAVMLAGISHDLRTPLARLRLETEMSVIDDVAREHMVADIVQLDATIDKFLDYARPDHVTLTPVN
LHGVVSSCVYAVQDHRELQISMNVPEDLIVLADEVELARVISNLLENARRYGKTPESGTASVEIAAKGREKWVLVKVRDH
GPGVPPDQLSNLTKPFFRGNSARTAAAGAGLGLAIVDKTVQRMGGIFALANSGSGGLVAHIQLQRASQLPAGKDPKQRLQ
RPQIKRQLPPDAAKGGKPVKPAKA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=335, Percent_Identity=33.4328358208955, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1788393, Length=274, Percent_Identity=31.3868613138686, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI1787894, Length=290, Percent_Identity=32.0689655172414, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI87082128, Length=304, Percent_Identity=28.6184210526316, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790346, Length=272, Percent_Identity=26.4705882352941, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1786912, Length=232, Percent_Identity=32.3275862068966, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1787374, Length=309, Percent_Identity=26.2135922330097, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1786783, Length=324, Percent_Identity=25.3086419753086, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1790861, Length=297, Percent_Identity=27.6094276094276, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1790551, Length=284, Percent_Identity=27.8169014084507, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1789149, Length=260, Percent_Identity=28.4615384615385, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1790436, Length=207, Percent_Identity=28.0193236714976, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786600, Length=213, Percent_Identity=27.6995305164319, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081816, Length=317, Percent_Identity=24.6056782334385, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54808; Mature: 54676

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASHDASADATSPAPLETTPNRRASQRTRVGLNLFWRTFFLLALLLVGSILAWLQTLRA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEFEPRTLQTAQQIASLVNLSRAALVHADAIARVSLIKTMADQEGVRILPREPSDRFDLV
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCC
DDTALGVRLTEELTERLGPGTIVAGNVNGESGLWVGFTINGDPNWLLMDRSRLSTAGGKT
CCCHHCEEHHHHHHHHCCCCEEEEECCCCCCCEEEEEEECCCCCEEEEECHHHCCCCCCE
WLIWLITAGALSLAGAAAIARLINRPLKQLSYAANRVRDGDFAASQLDEEVVTSEIREVN
EEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHC
IGFNRMAQKLAKLEQDRAVMLAGISHDLRTPLARLRLETEMSVIDDVAREHMVADIVQLD
CCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATIDKFLDYARPDHVTLTPVNLHGVVSSCVYAVQDHRELQISMNVPEDLIVLADEVELAR
HHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEECHHHHHH
VISNLLENARRYGKTPESGTASVEIAAKGREKWVLVKVRDHGPGVPPDQLSNLTKPFFRG
HHHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCC
NSARTAAAGAGLGLAIVDKTVQRMGGIFALANSGSGGLVAHIQLQRASQLPAGKDPKQRL
CCCCCHHCCCCCHHHHHHHHHHHHCCEEEEECCCCCCEEEEEEEEHHHCCCCCCCHHHHH
QRPQIKRQLPPDAAKGGKPVKPAKA
CCCHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SASHDASADATSPAPLETTPNRRASQRTRVGLNLFWRTFFLLALLLVGSILAWLQTLRA
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEFEPRTLQTAQQIASLVNLSRAALVHADAIARVSLIKTMADQEGVRILPREPSDRFDLV
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCC
DDTALGVRLTEELTERLGPGTIVAGNVNGESGLWVGFTINGDPNWLLMDRSRLSTAGGKT
CCCHHCEEHHHHHHHHCCCCEEEEECCCCCCCEEEEEEECCCCCEEEEECHHHCCCCCCE
WLIWLITAGALSLAGAAAIARLINRPLKQLSYAANRVRDGDFAASQLDEEVVTSEIREVN
EEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHC
IGFNRMAQKLAKLEQDRAVMLAGISHDLRTPLARLRLETEMSVIDDVAREHMVADIVQLD
CCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATIDKFLDYARPDHVTLTPVNLHGVVSSCVYAVQDHRELQISMNVPEDLIVLADEVELAR
HHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEECHHHHHH
VISNLLENARRYGKTPESGTASVEIAAKGREKWVLVKVRDHGPGVPPDQLSNLTKPFFRG
HHHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCC
NSARTAAAGAGLGLAIVDKTVQRMGGIFALANSGSGGLVAHIQLQRASQLPAGKDPKQRL
CCCCCHHCCCCCHHHHHHHHHHHHCCEEEEECCCCCCEEEEEEEEHHHCCCCCCCHHHHH
QRPQIKRQLPPDAAKGGKPVKPAKA
CCCHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]