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The map label for this gene is panE [C]

Identifier: 120610087

GI number: 120610087

Start: 1535499

End: 1536536

Strand: Reverse

Name: panE [C]

Synonym: Aave_1400

Alternate gene names: 120610087

Gene position: 1536536-1535499 (Counterclockwise)

Preceding gene: 120610092

Following gene: 120610086

Centisome position: 28.71

GC content: 71.19

Gene sequence:

>1038_bases
ATGACTGCATCCCCATCGGCTGCTCCCGCCGGAGGCCTGCCTCCGTCGCCGTCCGATCCGGCAACCCCGCCCCTGCGCAT
CGCCGTGATGGGTGCCGGCGCCGTGGGCTGCTACTTCGGCGCCCTGCTCGCGCGCGCCGGCCATGCGGTCACGCTGATCG
GCCGGCCCGCGCACGTCGAGGCCATCCGCGCGAACGGCCTGCGCCTGCAGACCGCCACGCTCGACGAAAACGTGCCCATG
GCGGCCGACACCGATCCCGCCGCGGTACGCGGCGCGGACGTGGTGATGTTCTGCGTGAAATCCACCGACACCGAGGACGC
GGCACGCCAGATCCAGCCACACCTCGCGCCCGGCGCGCTCGTGCTCACGCTGCAGAACGGCGTGGACAACGACGAGCGCG
TGCGCGGCGTGCTGGGCGATGCCCACCCCGTCGCCGCCGCCGTGGTCTATGTGGCCACCGAAATGGCCGGCCCCGGCCAC
GTGCGCCACCACGGGCGCGGCGAACTGGTGATCGCACCCTCGCCCCGCAGCGCCGCGGTGGCCCAGCAGTTCAGCGCGGC
CGGCATCGCCACGGAGATTTCAGGCAACGTGCGCGGCGCGCTCTGGGCCAAGCTGGTGCTCAACTGTGCATACAACGCGA
TCTCTGCGCTCGCGCAGCAGCCTTACGGCCGGCTGGTGCAGACGCCCGGCGTGGCAGACGTGATTGCCGACGTGGTGGCC
GAATGCCTGGCCGTGGCCGAAGCGGACGGCATCCAGATTCCGGGCGATGTGGGCGCGGCGGTGAACCGCATTGCGGCCAC
CATGCCTGGGCAGATGTCGTCTACCGCGCAGGACCTGGCGCGGGGCAAGCCGAGCGAGATCGATCACCTCAATGGGTATG
TGGTGGCGCGGGGGAAGGCGGTGGGGGTGGGGACGCCGGTGAATCGGGTGTTGTGGGTGTTGGTGAAGGTGGTGGAGGCG
GGCAACCGGTCGTTCGACACGGGCGTACTATCGGCCGGCTTAGCCGGCCTACCCTCCGCCGGTCAGCTCCGACGTTAG

Upstream 100 bases:

>100_bases
AACGACACATCCGCCATCCCTATCGTGCAAACCCCTGGAGGCAGCAGCCCCAGCCGGGCGTACCATGCTCGACAGAGAAG
AGAGAGAGAGAGATAAACGC

Downstream 100 bases:

>100_bases
GCCTTGCAACTATCGCCGGCCCCGCTCAGCAAGAACATGGACTGGCTCACATTCATCAGCAAGCTGATCGATTCAATTGC
GTGGCCTGTCGCCGCCGTGC

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MTASPSAAPAGGLPPSPSDPATPPLRIAVMGAGAVGCYFGALLARAGHAVTLIGRPAHVEAIRANGLRLQTATLDENVPM
AADTDPAAVRGADVVMFCVKSTDTEDAARQIQPHLAPGALVLTLQNGVDNDERVRGVLGDAHPVAAAVVYVATEMAGPGH
VRHHGRGELVIAPSPRSAAVAQQFSAAGIATEISGNVRGALWAKLVLNCAYNAISALAQQPYGRLVQTPGVADVIADVVA
ECLAVAEADGIQIPGDVGAAVNRIAATMPGQMSSTAQDLARGKPSEIDHLNGYVVARGKAVGVGTPVNRVLWVLVKVVEA
GNRSFDTGVLSAGLAGLPSAGQLRR

Sequences:

>Translated_345_residues
MTASPSAAPAGGLPPSPSDPATPPLRIAVMGAGAVGCYFGALLARAGHAVTLIGRPAHVEAIRANGLRLQTATLDENVPM
AADTDPAAVRGADVVMFCVKSTDTEDAARQIQPHLAPGALVLTLQNGVDNDERVRGVLGDAHPVAAAVVYVATEMAGPGH
VRHHGRGELVIAPSPRSAAVAQQFSAAGIATEISGNVRGALWAKLVLNCAYNAISALAQQPYGRLVQTPGVADVIADVVA
ECLAVAEADGIQIPGDVGAAVNRIAATMPGQMSSTAQDLARGKPSEIDHLNGYVVARGKAVGVGTPVNRVLWVLVKVVEA
GNRSFDTGVLSAGLAGLPSAGQLRR
>Mature_344_residues
TASPSAAPAGGLPPSPSDPATPPLRIAVMGAGAVGCYFGALLARAGHAVTLIGRPAHVEAIRANGLRLQTATLDENVPMA
ADTDPAAVRGADVVMFCVKSTDTEDAARQIQPHLAPGALVLTLQNGVDNDERVRGVLGDAHPVAAAVVYVATEMAGPGHV
RHHGRGELVIAPSPRSAAVAQQFSAAGIATEISGNVRGALWAKLVLNCAYNAISALAQQPYGRLVQTPGVADVIADVVAE
CLAVAEADGIQIPGDVGAAVNRIAATMPGQMSSTAQDLARGKPSEIDHLNGYVVARGKAVGVGTPVNRVLWVLVKVVEAG
NRSFDTGVLSAGLAGLPSAGQLRR

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=315, Percent_Identity=24.4444444444444, Blast_Score=83, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 35005; Mature: 34874

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASPSAAPAGGLPPSPSDPATPPLRIAVMGAGAVGCYFGALLARAGHAVTLIGRPAHVE
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCHHH
AIRANGLRLQTATLDENVPMAADTDPAAVRGADVVMFCVKSTDTEDAARQIQPHLAPGAL
HEECCCEEEEEEECCCCCCCCCCCCCCHHCCCEEEEEEECCCCHHHHHHHHCCCCCCCEE
VLTLQNGVDNDERVRGVLGDAHPVAAAVVYVATEMAGPGHVRHHGRGELVIAPSPRSAAV
EEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCHHHH
AQQFSAAGIATEISGNVRGALWAKLVLNCAYNAISALAQQPYGRLVQTPGVADVIADVVA
HHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHH
ECLAVAEADGIQIPGDVGAAVNRIAATMPGQMSSTAQDLARGKPSEIDHLNGYVVARGKA
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHCCCCEEEECCEE
VGVGTPVNRVLWVLVKVVEAGNRSFDTGVLSAGLAGLPSAGQLRR
EECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TASPSAAPAGGLPPSPSDPATPPLRIAVMGAGAVGCYFGALLARAGHAVTLIGRPAHVE
CCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCHHH
AIRANGLRLQTATLDENVPMAADTDPAAVRGADVVMFCVKSTDTEDAARQIQPHLAPGAL
HEECCCEEEEEEECCCCCCCCCCCCCCHHCCCEEEEEEECCCCHHHHHHHHCCCCCCCEE
VLTLQNGVDNDERVRGVLGDAHPVAAAVVYVATEMAGPGHVRHHGRGELVIAPSPRSAAV
EEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCHHHH
AQQFSAAGIATEISGNVRGALWAKLVLNCAYNAISALAQQPYGRLVQTPGVADVIADVVA
HHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHH
ECLAVAEADGIQIPGDVGAAVNRIAATMPGQMSSTAQDLARGKPSEIDHLNGYVVARGKA
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHCCCCEEEECCEE
VGVGTPVNRVLWVLVKVVEAGNRSFDTGVLSAGLAGLPSAGQLRR
EECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]