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The map label for this gene is fbp [H]

Identifier: 120610074

GI number: 120610074

Start: 1521512

End: 1521871

Strand: Reverse

Name: fbp [H]

Synonym: Aave_1387

Alternate gene names: 120610074

Gene position: 1521871-1521512 (Counterclockwise)

Preceding gene: 120610075

Following gene: 120610073

Centisome position: 28.43

GC content: 69.72

Gene sequence:

>360_bases
ATGGCATTCACCACCACCCCGTCCGGACTGCAGTACGAAGACACCACCGTCGGCGAAGGCGCCGAGGCCACCAGCGGCCA
GCCGGTGCGCGTGCACTACACCGGCTGGCTCTACAACGACGGCCAGCAGGGCGCGAAGTTCGATTCCAGCCGCGACCGCA
ATGCCCCGTTCGAGTTCCACCTCGGCGCCGGCATGGTGATCAAGGGCTGGGACGAAGGCGTGCAGGGCATGAAGATCGGC
GGCCAGCGCACGCTCATCATCCCCGCCGCCCTGGGCTACGGCGCGCGCGGCGCGGGGGGCGTGATCCCGCCGAACGCCAC
GCTGAAGTTCGACGTGGAACTGCTCGGCGTCGGCCGCTGA

Upstream 100 bases:

>100_bases
GCCCGCGCCGCCAGGGCCGCCGGCACGCCCCCCGCTCCCCGGAGCTGAACGGCGGCCCGAGGCTCTTTCCCTTTACCCAC
CACCCAGGAGTTTTTCACCC

Downstream 100 bases:

>100_bases
GCACCTTTTCCCGGGCCGGCTTCGCGCCGGCCCCCGGCCGCCATGCCGTGCATTCCGCAGCACGGCAACCTTTGCGCCGG
CCACGGGCACCCACCACGCG

Product: peptidylprolyl isomerase

Products: NA

Alternate protein names: Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase [H]

Number of amino acids: Translated: 119; Mature: 118

Protein sequence:

>119_residues
MAFTTTPSGLQYEDTTVGEGAEATSGQPVRVHYTGWLYNDGQQGAKFDSSRDRNAPFEFHLGAGMVIKGWDEGVQGMKIG
GQRTLIIPAALGYGARGAGGVIPPNATLKFDVELLGVGR

Sequences:

>Translated_119_residues
MAFTTTPSGLQYEDTTVGEGAEATSGQPVRVHYTGWLYNDGQQGAKFDSSRDRNAPFEFHLGAGMVIKGWDEGVQGMKIG
GQRTLIIPAALGYGARGAGGVIPPNATLKFDVELLGVGR
>Mature_118_residues
AFTTTPSGLQYEDTTVGEGAEATSGQPVRVHYTGWLYNDGQQGAKFDSSRDRNAPFEFHLGAGMVIKGWDEGVQGMKIGG
QRTLIIPAALGYGARGAGGVIPPNATLKFDVELLGVGR

Specific function: PPIases accelerate the folding of proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm And Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=110, Percent_Identity=50.9090909090909, Blast_Score=101, Evalue=1e-22,
Organism=Homo sapiens, GI4503725, Length=110, Percent_Identity=50.9090909090909, Blast_Score=101, Evalue=1e-22,
Organism=Homo sapiens, GI4758380, Length=110, Percent_Identity=50, Blast_Score=100, Evalue=3e-22,
Organism=Homo sapiens, GI206725530, Length=98, Percent_Identity=51.0204081632653, Blast_Score=94, Evalue=2e-20,
Organism=Homo sapiens, GI17149844, Length=98, Percent_Identity=51.0204081632653, Blast_Score=94, Evalue=2e-20,
Organism=Homo sapiens, GI17149842, Length=98, Percent_Identity=51.0204081632653, Blast_Score=94, Evalue=2e-20,
Organism=Homo sapiens, GI192448443, Length=96, Percent_Identity=47.9166666666667, Blast_Score=85, Evalue=1e-17,
Organism=Homo sapiens, GI224809331, Length=100, Percent_Identity=51, Blast_Score=85, Evalue=1e-17,
Organism=Homo sapiens, GI224809329, Length=100, Percent_Identity=51, Blast_Score=82, Evalue=6e-17,
Organism=Homo sapiens, GI224809327, Length=100, Percent_Identity=51, Blast_Score=82, Evalue=6e-17,
Organism=Homo sapiens, GI4758384, Length=100, Percent_Identity=51, Blast_Score=82, Evalue=6e-17,
Organism=Homo sapiens, GI4503729, Length=99, Percent_Identity=47.4747474747475, Blast_Score=82, Evalue=7e-17,
Organism=Homo sapiens, GI33469985, Length=110, Percent_Identity=43.6363636363636, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI150010552, Length=112, Percent_Identity=36.6071428571429, Blast_Score=81, Evalue=2e-16,
Organism=Homo sapiens, GI8923659, Length=94, Percent_Identity=45.7446808510638, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI206725547, Length=105, Percent_Identity=41.9047619047619, Blast_Score=73, Evalue=4e-14,
Organism=Homo sapiens, GI31317231, Length=106, Percent_Identity=42.4528301886792, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082390, Length=114, Percent_Identity=46.4912280701754, Blast_Score=87, Evalue=3e-19,
Organism=Escherichia coli, GI1789745, Length=113, Percent_Identity=43.3628318584071, Blast_Score=73, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17540882, Length=98, Percent_Identity=51.0204081632653, Blast_Score=99, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71993519, Length=93, Percent_Identity=55.9139784946236, Blast_Score=97, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17561782, Length=99, Percent_Identity=49.4949494949495, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17561778, Length=116, Percent_Identity=37.9310344827586, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71993555, Length=73, Percent_Identity=43.8356164383562, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17506167, Length=113, Percent_Identity=37.1681415929204, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17506169, Length=113, Percent_Identity=37.1681415929204, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320727, Length=96, Percent_Identity=55.2083333333333, Blast_Score=104, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6324194, Length=109, Percent_Identity=47.7064220183486, Blast_Score=98, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6323566, Length=109, Percent_Identity=45.8715596330275, Blast_Score=86, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323482, Length=109, Percent_Identity=44.0366972477064, Blast_Score=84, Evalue=7e-18,
Organism=Drosophila melanogaster, GI281363946, Length=112, Percent_Identity=53.5714285714286, Blast_Score=115, Evalue=5e-27,
Organism=Drosophila melanogaster, GI17352457, Length=112, Percent_Identity=53.5714285714286, Blast_Score=115, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24655568, Length=110, Percent_Identity=52.7272727272727, Blast_Score=107, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24647110, Length=113, Percent_Identity=47.787610619469, Blast_Score=96, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24583150, Length=100, Percent_Identity=49, Blast_Score=86, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21356629, Length=97, Percent_Identity=56.701030927835, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 12558; Mature: 12427

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFTTTPSGLQYEDTTVGEGAEATSGQPVRVHYTGWLYNDGQQGAKFDSSRDRNAPFEFH
CCCCCCCCCCEECCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCEEEE
LGAGMVIKGWDEGVQGMKIGGQRTLIIPAALGYGARGAGGVIPPNATLKFDVELLGVGR
CCCCEEEECCCCCCCEEEECCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEEEECC
>Mature Secondary Structure 
AFTTTPSGLQYEDTTVGEGAEATSGQPVRVHYTGWLYNDGQQGAKFDSSRDRNAPFEFH
CCCCCCCCCEECCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCEEEE
LGAGMVIKGWDEGVQGMKIGGQRTLIIPAALGYGARGAGGVIPPNATLKFDVELLGVGR
CCCCEEEECCCCCCCEEEECCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]