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The map label for this gene is livH [H]

Identifier: 120609971

GI number: 120609971

Start: 1409951

End: 1410835

Strand: Direct

Name: livH [H]

Synonym: Aave_1284

Alternate gene names: 120609971

Gene position: 1409951-1410835 (Clockwise)

Preceding gene: 120609970

Following gene: 120609972

Centisome position: 26.34

GC content: 65.42

Gene sequence:

>885_bases
ATGGAAATCTTCGGTGTCTCCCTGCCGGCCCTGCTGAGCCAGCTCCTGCTGGGGCTGGTCAACGGCTCGTTCTACGCCAT
CCTCAGCCTGGGGCTGGCGGTGATCTTCGGCCTGCTGAACGTCATCAACTTCGCGCATGGCGCGCTGTTCATGCTGGGGG
CGCTGCTCACCTGGATGGCGGGGTCGTATTTCGGCATCAACTACTGGGTGATGCTCGTCGCGGCGCCGCTCGTCGTCGGC
CTTTTCGGCGTGGTGATCGAGCGGCTGCTGCTGCGCTGGATCTACAAGCTCGACCACCTCTACGGCCTGCTGCTCACGCT
CGGGCTCACGCTGCTCATCGAGGGCGTGTTCCGCTCCATCTACGGTGTCTCGGGCCTGGGGTACGACACGCCCGAACTGC
TGGAAGGCGCCACCAACCTCGGCTTCATGATCCTGCCCAACTACCGCGCCTGGGTGGTGGCGGCGTCCATCGTGGTCTGC
ATCGGCACCTGGTACGTCATCGAGAAGACCAAGCTCGGCGCCTACCTGCGCGCCGGCACCGAGAACCCGCGCCTGGTGGA
GGCCTTCGGCATCAACGTGCCGGTGATGATCACGCTCACCTACGCCTTCGGCGCGGCACTGGCCGCGTTCGCGGGCGTGC
TGGCCGCCCCCGTGTACCAGGTCACGCCCCTCATGGGGCAGAACCTCATCATCGTGGTGTTCGCGGTGGTGGTGATCGGC
GGCATGGGCTCCATCATGGGCTCCATCCTCACGGGCCTGGGCCTGGGCGTCGTCGAGGGTTTCACCAAGGTGTTCTATCC
CGAGGCATCGTCCACCGTGGTGTTCGTCATCATGGTGGTGGTGCTGCTCATCCGCCCCGCCGGCCTGTTCGGCAAGGAAA
AGTGA

Upstream 100 bases:

>100_bases
CGACCAGGTGTTCGCCACCAAGGCCGAGAGCAAGTGCGCGCTCTGGAAATGATCCGCACCGCCTGAGCGCCATCCACCCG
CATCCCCTAGCCGACTCCCC

Downstream 100 bases:

>100_bases
CCAGGACGGGGCCGCGCACATGCACCACAAGAATCTCGCCACCTTCGGCTACGGCCTGCTGCTGCTGGGCCTGATCGCCG
CGCCGTTCCTCGGCGCCTAT

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MEIFGVSLPALLSQLLLGLVNGSFYAILSLGLAVIFGLLNVINFAHGALFMLGALLTWMAGSYFGINYWVMLVAAPLVVG
LFGVVIERLLLRWIYKLDHLYGLLLTLGLTLLIEGVFRSIYGVSGLGYDTPELLEGATNLGFMILPNYRAWVVAASIVVC
IGTWYVIEKTKLGAYLRAGTENPRLVEAFGINVPVMITLTYAFGAALAAFAGVLAAPVYQVTPLMGQNLIIVVFAVVVIG
GMGSIMGSILTGLGLGVVEGFTKVFYPEASSTVVFVIMVVVLLIRPAGLFGKEK

Sequences:

>Translated_294_residues
MEIFGVSLPALLSQLLLGLVNGSFYAILSLGLAVIFGLLNVINFAHGALFMLGALLTWMAGSYFGINYWVMLVAAPLVVG
LFGVVIERLLLRWIYKLDHLYGLLLTLGLTLLIEGVFRSIYGVSGLGYDTPELLEGATNLGFMILPNYRAWVVAASIVVC
IGTWYVIEKTKLGAYLRAGTENPRLVEAFGINVPVMITLTYAFGAALAAFAGVLAAPVYQVTPLMGQNLIIVVFAVVVIG
GMGSIMGSILTGLGLGVVEGFTKVFYPEASSTVVFVIMVVVLLIRPAGLFGKEK
>Mature_294_residues
MEIFGVSLPALLSQLLLGLVNGSFYAILSLGLAVIFGLLNVINFAHGALFMLGALLTWMAGSYFGINYWVMLVAAPLVVG
LFGVVIERLLLRWIYKLDHLYGLLLTLGLTLLIEGVFRSIYGVSGLGYDTPELLEGATNLGFMILPNYRAWVVAASIVVC
IGTWYVIEKTKLGAYLRAGTENPRLVEAFGINVPVMITLTYAFGAALAAFAGVLAAPVYQVTPLMGQNLIIVVFAVVVIG
GMGSIMGSILTGLGLGVVEGFTKVFYPEASSTVVFVIMVVVLLIRPAGLFGKEK

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=300, Percent_Identity=30, Blast_Score=99, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 31406; Mature: 31406

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIFGVSLPALLSQLLLGLVNGSFYAILSLGLAVIFGLLNVINFAHGALFMLGALLTWMA
CCEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GSYFGINYWVMLVAAPLVVGLFGVVIERLLLRWIYKLDHLYGLLLTLGLTLLIEGVFRSI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGVSGLGYDTPELLEGATNLGFMILPNYRAWVVAASIVVCIGTWYVIEKTKLGAYLRAGT
HCCCCCCCCCHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHEEHHHHHHHHHCCC
ENPRLVEAFGINVPVMITLTYAFGAALAAFAGVLAAPVYQVTPLMGQNLIIVVFAVVVIG
CCCCEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
GMGSIMGSILTGLGLGVVEGFTKVFYPEASSTVVFVIMVVVLLIRPAGLFGKEK
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MEIFGVSLPALLSQLLLGLVNGSFYAILSLGLAVIFGLLNVINFAHGALFMLGALLTWMA
CCEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GSYFGINYWVMLVAAPLVVGLFGVVIERLLLRWIYKLDHLYGLLLTLGLTLLIEGVFRSI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGVSGLGYDTPELLEGATNLGFMILPNYRAWVVAASIVVCIGTWYVIEKTKLGAYLRAGT
HCCCCCCCCCHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHEEHHHHHHHHHCCC
ENPRLVEAFGINVPVMITLTYAFGAALAAFAGVLAAPVYQVTPLMGQNLIIVVFAVVVIG
CCCCEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
GMGSIMGSILTGLGLGVVEGFTKVFYPEASSTVVFVIMVVVLLIRPAGLFGKEK
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]