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The map label for this gene is moeA [H]

Identifier: 120609928

GI number: 120609928

Start: 1365924

End: 1367183

Strand: Direct

Name: moeA [H]

Synonym: Aave_1241

Alternate gene names: 120609928

Gene position: 1365924-1367183 (Clockwise)

Preceding gene: 120609927

Following gene: 120609929

Centisome position: 25.52

GC content: 73.65

Gene sequence:

>1260_bases
ATGAGCGCGGCTGCTGCGGCTGCCCGGCCGCCGCTCAGGTCCCTGGACGATGCGCTGGCGGAGCTGCTCGCGCAGGCCGG
CCCGCTGGACGGCGCGGAGGAAGTGGACACCTTCGAGGCCGACGGCCGCGTGCTGGCGGCCGATGCCGTATCGCCGCTGC
GGGTGCCGCCGCACGACAACAGCGCCATGGACGGCTATGCCGTCCGCCGGGCGGACGTTGCTGCGGCGGGTGCTTCCCTC
TCCATCGAACTGCCGGTGTCCCAACGCATCGCGGCGGGCTCCGCGCCCCGGCCGCTGGAGCCGGGCACGGCCGCGCGCAT
CTTCACGGGCGCACCCCTGCCGCCCGGCGCGGATGCCGTATGCATGCAGGAGGACTGCGAGGCGCTCGATGGCGGCGCAC
GCGTGCGCATCCAGGCCGTGCCGCAGCCGGGCCAGTGGGTGCGCCGTGCGGGCGAGGACATCGAAACCGGCGCGACGGTG
CTCGCGGCCGGCACGCGGCTGACGCCGGCCGCGCTGGGGCTGGCGGCCAGCATCGGCCTGGCCCGGCTGCGCGTGGCGCG
GCGGCCCCGCGTCGCGCTGTTTTCCACCGGCGACGAACTGGTCATGCCTGGCGAGGTGCCCCCGGAGCGCATGCCGCCGG
GTGCCATCTACAACAGCAACCGCTTCTTCCTGCGCGCGATGCTGCTGCGGCTGGGCTGCGAGGTGTCGGATTTCGGCATC
GTGCCCGACCGGCGCGATGCCACGCAGCAGGCGCTGGCCGACGCCGCGGCGGCGCACGACCTGGTACTCACCAGCGGGGG
CGTGTCGGTGGGCGAGGAAGACCACGTGAAGCCCGCCGTGGCCGCGCTCGGGCGCATCGACCTCTGGCAGGTGGCGCTCA
AGCCGGGCAAGCCCTTCGCCTATGGCCGCATCGGCGAGCGCGTGCATTTCATGGGGCTGCCGGGCAATCCGGCGTCCAGC
CTCGTCACCTTCGCGATCCTGGTGCGGCCGTTCCTGCTGTGTCTGCAGGGCGTGCAGGATGTCGTTCCGCGCGCCGTGGA
GGCGAGGGCGAATTTCCACTGGCCGCGGGCCGACAAGCGGCGCGAGTTCCTGCGCGTGCGCCGCGATGCCGACGGCGGGT
TGGAACTGTTCCCGAACCAGGGTTCGGGGGTGCTGACCTCCGCGGCCTGGTGCGATGGGCTGGTGGACAACCCGCCGGGC
CGCACCATCGCCCGTGGCGACACGGTGCGCTTCATCCCCCTGTCCGATCTGCTCGCATGA

Upstream 100 bases:

>100_bases
GCGCGTTGCCGGTCTTCGACGTGAATGCGCCGGCCGTGCTGGCCGACTGGCTGCGTGCCAGCGGCGAACGCTGGGCGTAC
CGCGCCGCGGAGGCCCGGGC

Downstream 100 bases:

>100_bases
CCTCCGGTACGACCCCTTCATCCTCTCCCGCCGTGACGGTCACCGTGCGGTATTTCGCGTCCATCCGCGAGGCGGTGGGG
CAGGGCAGCGAGACCCTGTC

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MSAAAAAARPPLRSLDDALAELLAQAGPLDGAEEVDTFEADGRVLAADAVSPLRVPPHDNSAMDGYAVRRADVAAAGASL
SIELPVSQRIAAGSAPRPLEPGTAARIFTGAPLPPGADAVCMQEDCEALDGGARVRIQAVPQPGQWVRRAGEDIETGATV
LAAGTRLTPAALGLAASIGLARLRVARRPRVALFSTGDELVMPGEVPPERMPPGAIYNSNRFFLRAMLLRLGCEVSDFGI
VPDRRDATQQALADAAAAHDLVLTSGGVSVGEEDHVKPAVAALGRIDLWQVALKPGKPFAYGRIGERVHFMGLPGNPASS
LVTFAILVRPFLLCLQGVQDVVPRAVEARANFHWPRADKRREFLRVRRDADGGLELFPNQGSGVLTSAAWCDGLVDNPPG
RTIARGDTVRFIPLSDLLA

Sequences:

>Translated_419_residues
MSAAAAAARPPLRSLDDALAELLAQAGPLDGAEEVDTFEADGRVLAADAVSPLRVPPHDNSAMDGYAVRRADVAAAGASL
SIELPVSQRIAAGSAPRPLEPGTAARIFTGAPLPPGADAVCMQEDCEALDGGARVRIQAVPQPGQWVRRAGEDIETGATV
LAAGTRLTPAALGLAASIGLARLRVARRPRVALFSTGDELVMPGEVPPERMPPGAIYNSNRFFLRAMLLRLGCEVSDFGI
VPDRRDATQQALADAAAAHDLVLTSGGVSVGEEDHVKPAVAALGRIDLWQVALKPGKPFAYGRIGERVHFMGLPGNPASS
LVTFAILVRPFLLCLQGVQDVVPRAVEARANFHWPRADKRREFLRVRRDADGGLELFPNQGSGVLTSAAWCDGLVDNPPG
RTIARGDTVRFIPLSDLLA
>Mature_418_residues
SAAAAAARPPLRSLDDALAELLAQAGPLDGAEEVDTFEADGRVLAADAVSPLRVPPHDNSAMDGYAVRRADVAAAGASLS
IELPVSQRIAAGSAPRPLEPGTAARIFTGAPLPPGADAVCMQEDCEALDGGARVRIQAVPQPGQWVRRAGEDIETGATVL
AAGTRLTPAALGLAASIGLARLRVARRPRVALFSTGDELVMPGEVPPERMPPGAIYNSNRFFLRAMLLRLGCEVSDFGIV
PDRRDATQQALADAAAAHDLVLTSGGVSVGEEDHVKPAVAALGRIDLWQVALKPGKPFAYGRIGERVHFMGLPGNPASSL
VTFAILVRPFLLCLQGVQDVVPRAVEARANFHWPRADKRREFLRVRRDADGGLELFPNQGSGVLTSAAWCDGLVDNPPGR
TIARGDTVRFIPLSDLLA

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=410, Percent_Identity=36.0975609756098, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI10880983, Length=410, Percent_Identity=36.0975609756098, Blast_Score=190, Evalue=2e-48,
Organism=Escherichia coli, GI1787049, Length=382, Percent_Identity=45.8115183246073, Blast_Score=283, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI25147659, Length=346, Percent_Identity=30.3468208092486, Blast_Score=130, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17562606, Length=341, Percent_Identity=24.3401759530792, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17136978, Length=371, Percent_Identity=32.8840970350404, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24638841, Length=371, Percent_Identity=32.8840970350404, Blast_Score=139, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44081; Mature: 43950

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAAAAAARPPLRSLDDALAELLAQAGPLDGAEEVDTFEADGRVLAADAVSPLRVPPHDN
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCEEEECCCCCCCCCCCCC
SAMDGYAVRRADVAAAGASLSIELPVSQRIAAGSAPRPLEPGTAARIFTGAPLPPGADAV
CCCCCHHHHHHHHHHCCCEEEEECCHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCEE
CMQEDCEALDGGARVRIQAVPQPGQWVRRAGEDIETGATVLAAGTRLTPAALGLAASIGL
HHHHHHHHCCCCCEEEEEECCCCHHHHHHCCCCHHCCCEEEECCCCCCHHHHHHHHHHHH
ARLRVARRPRVALFSTGDELVMPGEVPPERMPPGAIYNSNRFFLRAMLLRLGCEVSDFGI
HHHHHHCCCCEEEEECCCCEEECCCCCCCCCCCCCEECCCHHHHHHHHHHHCCCCHHCCC
VPDRRDATQQALADAAAAHDLVLTSGGVSVGEEDHVKPAVAALGRIDLWQVALKPGKPFA
CCCCCHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCCHHHHHHCCCEEEEEEECCCCCEE
YGRIGERVHFMGLPGNPASSLVTFAILVRPFLLCLQGVQDVVPRAVEARANFHWPRADKR
ECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
REFLRVRRDADGGLELFPNQGSGVLTSAAWCDGLVDNPPGRTIARGDTVRFIPLSDLLA
HHHHHHHCCCCCCEEECCCCCCCEEEHHHHHCCCCCCCCCCEEECCCEEEEEEHHHHCC
>Mature Secondary Structure 
SAAAAAARPPLRSLDDALAELLAQAGPLDGAEEVDTFEADGRVLAADAVSPLRVPPHDN
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCEEEECCCCCCCCCCCCC
SAMDGYAVRRADVAAAGASLSIELPVSQRIAAGSAPRPLEPGTAARIFTGAPLPPGADAV
CCCCCHHHHHHHHHHCCCEEEEECCHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCEE
CMQEDCEALDGGARVRIQAVPQPGQWVRRAGEDIETGATVLAAGTRLTPAALGLAASIGL
HHHHHHHHCCCCCEEEEEECCCCHHHHHHCCCCHHCCCEEEECCCCCCHHHHHHHHHHHH
ARLRVARRPRVALFSTGDELVMPGEVPPERMPPGAIYNSNRFFLRAMLLRLGCEVSDFGI
HHHHHHCCCCEEEEECCCCEEECCCCCCCCCCCCCEECCCHHHHHHHHHHHCCCCHHCCC
VPDRRDATQQALADAAAAHDLVLTSGGVSVGEEDHVKPAVAALGRIDLWQVALKPGKPFA
CCCCCHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCCHHHHHHCCCEEEEEEECCCCCEE
YGRIGERVHFMGLPGNPASSLVTFAILVRPFLLCLQGVQDVVPRAVEARANFHWPRADKR
ECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
REFLRVRRDADGGLELFPNQGSGVLTSAAWCDGLVDNPPGRTIARGDTVRFIPLSDLLA
HHHHHHHCCCCCCEEECCCCCCCEEEHHHHHCCCCCCCCCCEEECCCEEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]