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The map label for this gene is rnc [H]

Identifier: 120609884

GI number: 120609884

Start: 1316723

End: 1317409

Strand: Direct

Name: rnc [H]

Synonym: Aave_1196

Alternate gene names: 120609884

Gene position: 1316723-1317409 (Clockwise)

Preceding gene: 120609883

Following gene: 120609885

Centisome position: 24.6

GC content: 67.69

Gene sequence:

>687_bases
TTGGTTTCACCCAGCCTTTCCGCGCTGCAGGACCGCCTGCAGCATGTTTTCTCCGATCCATCCCTGCTGCAGCGGGCCAC
CACGCACCGCAGCTTCTCGGCCGACCATAACGAACGCCTGGAGTTTCTCGGCGACTCGGTGCTGAACCTGGCCGTATCGA
GCCTGCTCTACCAGCGCCTGCGCGACCTGCCGGAAGGCGATCTCTCCCGGGTGCGCGCCAACTTGGTGCGCCAGGAGGCG
CTGCACAGCCTGGCCCTGGGCCTGCAGTTGCCGCAGGTGCTGCGCCTGGGCGAGGGGGAGACGAAATCCGGTGGCAAGCA
GCGCCCGTCCATCCTGGCCGATGCCCTGGAAGCCCTGATCGGGGCCGTCTACCTGGATGCCGGCTACCAGTGCGCCGAGG
CGCTGGTGCACCGGCTCTACCAGGACGTGGAGATCAATCCTCGCATGCCGGCGGCCGAGAAGGATGCCAAGACCGCATTG
CAGGAGTGGCTGCAGGGCCGCAAAATGAAGCTGCCGCAGTACCGCGTGGTCGCCACGGTGGGGGCTGCCCACCGGCAGAC
CTTCGACGTGGAATGCGACATCCCGGAACTGGGCCTGACCGAGCGCGGCATCGGCGGATCGCGGAGGGCGGGCGAACAGG
CTGCCGCCGCCGCCATGCTGGCCACCCTGAAAGCGAAACACCCATGA

Upstream 100 bases:

>100_bases
GTCCTTCAGTTATTCGCGCGAGATCGCGCTCGTCGGCCCCGCCTACCTGGTGTACCGCTTCCGCGACCAGACCAACTGAC
CCTTTCTTCCTTCTTCCGTT

Downstream 100 bases:

>100_bases
ACTCCTCTCCTCCCTCCGTTCCCGGCGCACTCCAGGACGACCTGGAGGCCATGCTGGCGGCGGCACGCCCCGGCGCGGCC
GTGCCCGCCGCAGCCGGGAC

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MVSPSLSALQDRLQHVFSDPSLLQRATTHRSFSADHNERLEFLGDSVLNLAVSSLLYQRLRDLPEGDLSRVRANLVRQEA
LHSLALGLQLPQVLRLGEGETKSGGKQRPSILADALEALIGAVYLDAGYQCAEALVHRLYQDVEINPRMPAAEKDAKTAL
QEWLQGRKMKLPQYRVVATVGAAHRQTFDVECDIPELGLTERGIGGSRRAGEQAAAAAMLATLKAKHP

Sequences:

>Translated_228_residues
MVSPSLSALQDRLQHVFSDPSLLQRATTHRSFSADHNERLEFLGDSVLNLAVSSLLYQRLRDLPEGDLSRVRANLVRQEA
LHSLALGLQLPQVLRLGEGETKSGGKQRPSILADALEALIGAVYLDAGYQCAEALVHRLYQDVEINPRMPAAEKDAKTAL
QEWLQGRKMKLPQYRVVATVGAAHRQTFDVECDIPELGLTERGIGGSRRAGEQAAAAAMLATLKAKHP
>Mature_228_residues
MVSPSLSALQDRLQHVFSDPSLLQRATTHRSFSADHNERLEFLGDSVLNLAVSSLLYQRLRDLPEGDLSRVRANLVRQEA
LHSLALGLQLPQVLRLGEGETKSGGKQRPSILADALEALIGAVYLDAGYQCAEALVHRLYQDVEINPRMPAAEKDAKTAL
QEWLQGRKMKLPQYRVVATVGAAHRQTFDVECDIPELGLTERGIGGSRRAGEQAAAAAMLATLKAKHP

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=200, Percent_Identity=29.5, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI155030236, Length=200, Percent_Identity=29.5, Blast_Score=78, Evalue=7e-15,
Organism=Escherichia coli, GI1788920, Length=221, Percent_Identity=49.3212669683258, Blast_Score=182, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17506883, Length=208, Percent_Identity=31.25, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI193202651, Length=208, Percent_Identity=31.25, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17137682, Length=201, Percent_Identity=31.3432835820896, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 24964; Mature: 24964

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSPSLSALQDRLQHVFSDPSLLQRATTHRSFSADHNERLEFLGDSVLNLAVSSLLYQRL
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RDLPEGDLSRVRANLVRQEALHSLALGLQLPQVLRLGEGETKSGGKQRPSILADALEALI
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
GAVYLDAGYQCAEALVHRLYQDVEINPRMPAAEKDAKTALQEWLQGRKMKLPQYRVVATV
HHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHH
GAAHRQTFDVECDIPELGLTERGIGGSRRAGEQAAAAAMLATLKAKHP
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVSPSLSALQDRLQHVFSDPSLLQRATTHRSFSADHNERLEFLGDSVLNLAVSSLLYQRL
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RDLPEGDLSRVRANLVRQEALHSLALGLQLPQVLRLGEGETKSGGKQRPSILADALEALI
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
GAVYLDAGYQCAEALVHRLYQDVEINPRMPAAEKDAKTALQEWLQGRKMKLPQYRVVATV
HHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHH
GAAHRQTFDVECDIPELGLTERGIGGSRRAGEQAAAAAMLATLKAKHP
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA