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The map label for this gene is lepB [H]

Identifier: 120609882

GI number: 120609882

Start: 1315266

End: 1316240

Strand: Direct

Name: lepB [H]

Synonym: Aave_1194

Alternate gene names: 120609882

Gene position: 1315266-1316240 (Clockwise)

Preceding gene: 120609881

Following gene: 120609883

Centisome position: 24.57

GC content: 64.72

Gene sequence:

>975_bases
ATGCAAGCCATGCAATATGTGACCGCCGCGATCCTGGCGGCTTTCGTCGGCTACGTGGGCGCCTGGTACGTGGGCGCCAT
CGAAGGCAATTTCGCGCTGCTGCTGCTGCTGGCGACGGTGGTGACCGGCGCCTACTGGCTGGCCGAGCGCCTCGTCTTCC
TGCCGCGGCGCCGCCGCGCGGCCCAGGCCATCGAGGAGGCGGCCGTGCAGCGGCGCGCCGAGCTGGACCGCATGGGCATC
GCCAAGGTGGACGGCGACGTGCAGGAGGCGAAGGACCGCATCCTGATGCAGCCGTGGTGGCTGGACTGGACGGCGGGACT
CTTCCCGGTGATCGCCATCGTCTTCGTGCTGCGCTCGTTCCTCTTCGAGCCGTTCAAGATCCCCTCCGGATCGATGATCC
CGACCTTGCTGGTGGGCGACCTGATCCTCGTGAACAAGTTCACCTACGGCATCCGGCTGCCGGTGATCAACAAGAAGATC
ACGCAGGGCACGCCGCCCCAGCGCGGCGACGTGATGGTGTTCCGCTATCCGCCGCAGCCCAGCATGGACTACATCAAGCG
CGTGGTCGGCGTGCCGGGCGACGAGATCGCCTACCTGAACAAGCGGCTCACGGTGAACGGCAAGCCGGTCGAGACCACGG
CGCTGCCCGATTTCCTCGACGAGGACACGATGCGCTACTTCAAGCAGTACGACGAGCATCTGGGCGCCAGGCCGCACCGC
ATGATCAACAACCCCGACGTGCCGGCGTTCATCCAGGGAGCCAGCGACTACGCCTTCCGCGAGAATTGCCGCTACAGCGT
GGAAGGCGTGGTGTGCAAGGTGCCCGAGGGCCACTATTTCATGATGGGCGACAACCGCGATAATTCGTTCGATTCCCGCT
ATTGGGGCTTCGTGCCCGACGCGAACATCGTCGGCAAGGCCTTTTTCGTGTGGATGAATTTCGGCAACCTGAAGCGCATC
GGCGGCTTCCAGTAA

Upstream 100 bases:

>100_bases
GAGAAGCAGAAAGCGGGCAAGAAGCGCATGAAGCAGATCGGTTCCGTCGAAGTGCCGCAGGAAGCCTTCCTGGCCATCCT
GCAAGTGGAGGAGTGATCCG

Downstream 100 bases:

>100_bases
CGGCTTGCCGCAGACCGCGGCGCTTCCTTCAAGACATACCAAAGAAGAGGGTCCGGACCATGGGTCTGCATCAGCACCAC
CTGCCTCGCTGCGCATCGAA

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MQAMQYVTAAILAAFVGYVGAWYVGAIEGNFALLLLLATVVTGAYWLAERLVFLPRRRRAAQAIEEAAVQRRAELDRMGI
AKVDGDVQEAKDRILMQPWWLDWTAGLFPVIAIVFVLRSFLFEPFKIPSGSMIPTLLVGDLILVNKFTYGIRLPVINKKI
TQGTPPQRGDVMVFRYPPQPSMDYIKRVVGVPGDEIAYLNKRLTVNGKPVETTALPDFLDEDTMRYFKQYDEHLGARPHR
MINNPDVPAFIQGASDYAFRENCRYSVEGVVCKVPEGHYFMMGDNRDNSFDSRYWGFVPDANIVGKAFFVWMNFGNLKRI
GGFQ

Sequences:

>Translated_324_residues
MQAMQYVTAAILAAFVGYVGAWYVGAIEGNFALLLLLATVVTGAYWLAERLVFLPRRRRAAQAIEEAAVQRRAELDRMGI
AKVDGDVQEAKDRILMQPWWLDWTAGLFPVIAIVFVLRSFLFEPFKIPSGSMIPTLLVGDLILVNKFTYGIRLPVINKKI
TQGTPPQRGDVMVFRYPPQPSMDYIKRVVGVPGDEIAYLNKRLTVNGKPVETTALPDFLDEDTMRYFKQYDEHLGARPHR
MINNPDVPAFIQGASDYAFRENCRYSVEGVVCKVPEGHYFMMGDNRDNSFDSRYWGFVPDANIVGKAFFVWMNFGNLKRI
GGFQ
>Mature_324_residues
MQAMQYVTAAILAAFVGYVGAWYVGAIEGNFALLLLLATVVTGAYWLAERLVFLPRRRRAAQAIEEAAVQRRAELDRMGI
AKVDGDVQEAKDRILMQPWWLDWTAGLFPVIAIVFVLRSFLFEPFKIPSGSMIPTLLVGDLILVNKFTYGIRLPVINKKI
TQGTPPQRGDVMVFRYPPQPSMDYIKRVVGVPGDEIAYLNKRLTVNGKPVETTALPDFLDEDTMRYFKQYDEHLGARPHR
MINNPDVPAFIQGASDYAFRENCRYSVEGVVCKVPEGHYFMMGDNRDNSFDSRYWGFVPDANIVGKAFFVWMNFGNLKRI
GGFQ

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=342, Percent_Identity=39.1812865497076, Blast_Score=214, Evalue=4e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 36725; Mature: 36725

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAMQYVTAAILAAFVGYVGAWYVGAIEGNFALLLLLATVVTGAYWLAERLVFLPRRRRA
CCHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQAIEEAAVQRRAELDRMGIAKVDGDVQEAKDRILMQPWWLDWTAGLFPVIAIVFVLRSF
HHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHH
LFEPFKIPSGSMIPTLLVGDLILVNKFTYGIRLPVINKKITQGTPPQRGDVMVFRYPPQP
HCCCCCCCCCCCHHHHHHHHHHHHHHHHCEEECCCCCCHHCCCCCCCCCCEEEEECCCCC
SMDYIKRVVGVPGDEIAYLNKRLTVNGKPVETTALPDFLDEDTMRYFKQYDEHLGARPHR
CHHHHHHHHCCCCCHHHHHCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHH
MINNPDVPAFIQGASDYAFRENCRYSVEGVVCKVPEGHYFMMGDNRDNSFDSRYWGFVPD
HCCCCCCCCEEECCCCHHHHHCCCEEECEEEEECCCCCEEEEECCCCCCCCCCCCCCCCC
ANIVGKAFFVWMNFGNLKRIGGFQ
CHHHHHEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MQAMQYVTAAILAAFVGYVGAWYVGAIEGNFALLLLLATVVTGAYWLAERLVFLPRRRRA
CCHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQAIEEAAVQRRAELDRMGIAKVDGDVQEAKDRILMQPWWLDWTAGLFPVIAIVFVLRSF
HHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHH
LFEPFKIPSGSMIPTLLVGDLILVNKFTYGIRLPVINKKITQGTPPQRGDVMVFRYPPQP
HCCCCCCCCCCCHHHHHHHHHHHHHHHHCEEECCCCCCHHCCCCCCCCCCEEEEECCCCC
SMDYIKRVVGVPGDEIAYLNKRLTVNGKPVETTALPDFLDEDTMRYFKQYDEHLGARPHR
CHHHHHHHHCCCCCHHHHHCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHH
MINNPDVPAFIQGASDYAFRENCRYSVEGVVCKVPEGHYFMMGDNRDNSFDSRYWGFVPD
HCCCCCCCCEEECCCCHHHHHCCCEEECEEEEECCCCCEEEEECCCCCCCCCCCCCCCCC
ANIVGKAFFVWMNFGNLKRIGGFQ
CHHHHHEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1546969 [H]