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The map label for this gene is fabF [H]

Identifier: 120609875

GI number: 120609875

Start: 1307106

End: 1308350

Strand: Direct

Name: fabF [H]

Synonym: Aave_1187

Alternate gene names: 120609875

Gene position: 1307106-1308350 (Clockwise)

Preceding gene: 120609874

Following gene: 120609876

Centisome position: 24.42

GC content: 66.91

Gene sequence:

>1245_bases
ATGAGCCGTCGTCGCGTCGTCGTGACCGGCCTGGGTTGCATCACCCCCGTCGGTAACACGGTGGCGGAAGCCTGGGCCCG
AATCTTGGCCGGCCAGTCCGGCATTGGCCTCATCACCAAGTTCGATGCTTCGAACTTCGCCTGCAAGATCGCTGGCGAGG
TCAAGGATTTCGACCTGAACGCCTACATCAGCGCCAAGGATGCGCGCACGATGGACAGCTTCATCCATTACGGCATCGCC
GCGGCCGACCAGGCCGTGCGCGACGCGGGCCTGCCCGTGGGCGAGGCGCTGGATGAGGACCTGGCGAACCGCATCGGCTG
CATCATCGGCTCGGGCATCGGCGGCCTGCCGCTGATCGAGAACACGCACGCGGAGCTCGAGAATCGCGGCCCCCGGCGCA
TCACCCCCTTCTTCGTCCCGGCCTCCATCATCAACATGGTGGTGGGGCACGTGTCGATGCGCTTCGGCTTCAAGGGGCCG
AACCTGTCGGTCGTCACGGCGTGCACCACCGGCCTGCACTGCATCGGCGAGGCCGCGCGCAAGATCGAGTACGGCGATGC
CGACGTGATCGTCGCGGGCGGCACGGAATCCACCGTCTCGCCCCTGGGCGTGGGCGGCTTCGCGGCGATGCGGGCACTGT
CCACGCGCAACGACGATCCGGCCACCGCGTCCCGTCCCTGGGACAAGGACCGGGACGGCTTCGTGCTGGGCGAGGGCGCG
GGCGTGCTGGTCCTCGAGGAGTACGAGCATGCGAAGGCCCGTGGCGCGAAGATCTACGCCGAGCTCTCGGGCTACGGCAT
GAGCGCGGACGCCGGCCACATGACCGCTCCCAACATGGACGGGCCCCGGCGCGCCATGCTGGCGGCGCTGCGCAATGCGG
GCATCAACGCCGACGAAGTCGATTACCTGAACGCCCACGGCACCTCCACGCCGCTGGGTGACTTGAACGAGACGAACGCC
ATCAAGGCGGCCCTCGGGGACCATGCCAGGAACATGGTGGTCAGCTCGACCAAGTCGATGACGGGCCACCTGCTGGGCGG
CGCCGGCGGCATCGAGAGCGTTTTCACCGTGCTGGCGCTGCACGACCAGAAAGTGCCCCCGACCATCAATATCTTCGAGC
AGGATCCGGAGTGCGATCTGGATTACTGCGCCAATACGGCCCGCGACATGAAGATGGACGTCGCCGTGAAGAACAATTTC
GGGTTCGGCGGCACGAACGGCACGCTGGTTTTCCGGCGCATCTGA

Upstream 100 bases:

>100_bases
ACTACGCGAACACCCACCAGAAGGCCTGACCGTCCGGTCTCCGCCTCCCCCCGCGGATCGCCCTTAGCGGTCCCGCATCA
GCACGAAAGAGTCTTAGCGC

Downstream 100 bases:

>100_bases
CGGCCGCACCGCCGTCGCGGCTCCGGATCCATGGCCGATCTCGCGCGGGAAGAGTTCCACGCTCCGGTGTTGCGCCACCC
CGCAGGCGCGGAACATCGGC

Product: 3-oxoacyl-[acyl-carrier-protein] synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MSRRRVVVTGLGCITPVGNTVAEAWARILAGQSGIGLITKFDASNFACKIAGEVKDFDLNAYISAKDARTMDSFIHYGIA
AADQAVRDAGLPVGEALDEDLANRIGCIIGSGIGGLPLIENTHAELENRGPRRITPFFVPASIINMVVGHVSMRFGFKGP
NLSVVTACTTGLHCIGEAARKIEYGDADVIVAGGTESTVSPLGVGGFAAMRALSTRNDDPATASRPWDKDRDGFVLGEGA
GVLVLEEYEHAKARGAKIYAELSGYGMSADAGHMTAPNMDGPRRAMLAALRNAGINADEVDYLNAHGTSTPLGDLNETNA
IKAALGDHARNMVVSSTKSMTGHLLGGAGGIESVFTVLALHDQKVPPTINIFEQDPECDLDYCANTARDMKMDVAVKNNF
GFGGTNGTLVFRRI

Sequences:

>Translated_414_residues
MSRRRVVVTGLGCITPVGNTVAEAWARILAGQSGIGLITKFDASNFACKIAGEVKDFDLNAYISAKDARTMDSFIHYGIA
AADQAVRDAGLPVGEALDEDLANRIGCIIGSGIGGLPLIENTHAELENRGPRRITPFFVPASIINMVVGHVSMRFGFKGP
NLSVVTACTTGLHCIGEAARKIEYGDADVIVAGGTESTVSPLGVGGFAAMRALSTRNDDPATASRPWDKDRDGFVLGEGA
GVLVLEEYEHAKARGAKIYAELSGYGMSADAGHMTAPNMDGPRRAMLAALRNAGINADEVDYLNAHGTSTPLGDLNETNA
IKAALGDHARNMVVSSTKSMTGHLLGGAGGIESVFTVLALHDQKVPPTINIFEQDPECDLDYCANTARDMKMDVAVKNNF
GFGGTNGTLVFRRI
>Mature_413_residues
SRRRVVVTGLGCITPVGNTVAEAWARILAGQSGIGLITKFDASNFACKIAGEVKDFDLNAYISAKDARTMDSFIHYGIAA
ADQAVRDAGLPVGEALDEDLANRIGCIIGSGIGGLPLIENTHAELENRGPRRITPFFVPASIINMVVGHVSMRFGFKGPN
LSVVTACTTGLHCIGEAARKIEYGDADVIVAGGTESTVSPLGVGGFAAMRALSTRNDDPATASRPWDKDRDGFVLGEGAG
VLVLEEYEHAKARGAKIYAELSGYGMSADAGHMTAPNMDGPRRAMLAALRNAGINADEVDYLNAHGTSTPLGDLNETNAI
KAALGDHARNMVVSSTKSMTGHLLGGAGGIESVFTVLALHDQKVPPTINIFEQDPECDLDYCANTARDMKMDVAVKNNFG
FGGTNGTLVFRRI

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=419, Percent_Identity=47.255369928401, Blast_Score=374, Evalue=1e-104,
Organism=Homo sapiens, GI223972627, Length=145, Percent_Identity=51.7241379310345, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI41872631, Length=428, Percent_Identity=23.1308411214953, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1787337, Length=417, Percent_Identity=60.9112709832134, Blast_Score=478, Evalue=1e-136,
Organism=Escherichia coli, GI1788663, Length=415, Percent_Identity=39.7590361445783, Blast_Score=264, Evalue=7e-72,
Organism=Caenorhabditis elegans, GI71983541, Length=421, Percent_Identity=36.3420427553444, Blast_Score=242, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI71983535, Length=259, Percent_Identity=40.9266409266409, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI212642053, Length=396, Percent_Identity=24.2424242424242, Blast_Score=101, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17550940, Length=278, Percent_Identity=25.1798561151079, Blast_Score=88, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=446, Percent_Identity=37.6681614349776, Blast_Score=285, Evalue=1e-77,
Organism=Drosophila melanogaster, GI24644341, Length=415, Percent_Identity=45.3012048192771, Blast_Score=349, Evalue=2e-96,
Organism=Drosophila melanogaster, GI24581345, Length=429, Percent_Identity=23.0769230769231, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI19920632, Length=381, Percent_Identity=25.9842519685039, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI221330659, Length=381, Percent_Identity=25.9842519685039, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43585; Mature: 43454

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRRVVVTGLGCITPVGNTVAEAWARILAGQSGIGLITKFDASNFACKIAGEVKDFDLN
CCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCCEEECEE
AYISAKDARTMDSFIHYGIAAADQAVRDAGLPVGEALDEDLANRIGCIIGSGIGGLPLIE
EEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCEEEECCCCCCCEEC
NTHAELENRGPRRITPFFVPASIINMVVGHVSMRFGFKGPNLSVVTACTTGLHCIGEAAR
CCHHHHHCCCCCEECCEECHHHHHHHHHHHHHEEECCCCCCEEEEEEHHHHHHHHHHHHH
KIEYGDADVIVAGGTESTVSPLGVGGFAAMRALSTRNDDPATASRPWDKDRDGFVLGEGA
HEECCCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCC
GVLVLEEYEHAKARGAKIYAELSGYGMSADAGHMTAPNMDGPRRAMLAALRNAGINADEV
CEEEEECCHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
DYLNAHGTSTPLGDLNETNAIKAALGDHARNMVVSSTKSMTGHLLGGAGGIESVFTVLAL
CEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCEEECCCCCHHHHHHHHHH
HDQKVPPTINIFEQDPECDLDYCANTARDMKMDVAVKNNFGFGGTNGTLVFRRI
CCCCCCCEEEEECCCCCCCHHHHCCCHHCCEEEEEEECCCCCCCCCCEEEEEEC
>Mature Secondary Structure 
SRRRVVVTGLGCITPVGNTVAEAWARILAGQSGIGLITKFDASNFACKIAGEVKDFDLN
CCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCCEEECEE
AYISAKDARTMDSFIHYGIAAADQAVRDAGLPVGEALDEDLANRIGCIIGSGIGGLPLIE
EEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCEEEECCCCCCCEEC
NTHAELENRGPRRITPFFVPASIINMVVGHVSMRFGFKGPNLSVVTACTTGLHCIGEAAR
CCHHHHHCCCCCEECCEECHHHHHHHHHHHHHEEECCCCCCEEEEEEHHHHHHHHHHHHH
KIEYGDADVIVAGGTESTVSPLGVGGFAAMRALSTRNDDPATASRPWDKDRDGFVLGEGA
HEECCCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCC
GVLVLEEYEHAKARGAKIYAELSGYGMSADAGHMTAPNMDGPRRAMLAALRNAGINADEV
CEEEEECCHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
DYLNAHGTSTPLGDLNETNAIKAALGDHARNMVVSSTKSMTGHLLGGAGGIESVFTVLAL
CEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCEEECCCCCHHHHHHHHHH
HDQKVPPTINIFEQDPECDLDYCANTARDMKMDVAVKNNFGFGGTNGTLVFRRI
CCCCCCCEEEEECCCCCCCHHHHCCCHHCCEEEEEEECCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]