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The map label for this gene is yfhK [H]

Identifier: 120609568

GI number: 120609568

Start: 949854

End: 951314

Strand: Reverse

Name: yfhK [H]

Synonym: Aave_0874

Alternate gene names: 120609568

Gene position: 951314-949854 (Counterclockwise)

Preceding gene: 120609569

Following gene: 120609567

Centisome position: 17.77

GC content: 69.88

Gene sequence:

>1461_bases
ATGGGCTTCGCCGCGCGCCTCTTCCGCCGCCAGCAGGGCGTCGCCGCCCTCGGGGGGCTGTCGTTCCAGCAGATGCTGCT
GCTGGCCTTCCTGCTCATCGCCGGGCTGCAGGGCGCCAGTTCGCTGCGCGCCATCTTCACGCTGGAGCAGCTCATGGTCC
AGAGCCGCAATGGCGCGGCCGAGGCCATCCAGCTCAACGCCGCGGCCCAGAGCCTGAACGCCCGCGGCCAGACGCTGGAG
CGCGCCGCCCGGCAATCGCTGGTGCTGGCCGACCGCTCGCTGCGCCGCCGCTTCGACGACATCTCGCGCGAGGCGCACGA
GATCCTGCAGCGCCTGGAAACCAAGGGCCTGCCACCCGAACTCGCCGCGCAATGGCGCGCCCACCTCGCCCAGGTCACCG
CGCTGCTGGACGGTCCTCCGGCCCTCTCGCTGGACAACGAGCGCGCCGTGGCCGGGCTCTTCCTGGAACTCGACGGCGTG
AACGGTGCCATTGCCCAGTCGGTACAGGACATCAACACCCGCCGCAGCGCCGAACTGCAGGAAAAGATCGAAGCCAGCCG
CCGCGAGGTGACCCACCAGGTGGTCGGGGTGATCGTGCTGGCCCTCGTGCTCGCGCTGGCCCTGGGCATCTGGCTCGCCC
GGCCCTTCAAGCGCCTGGAACACGCCATCCGCCTGCTGGGGGAGAACGAACTGGCCCAGTCCGTGGAGATCCCCGGTCCG
GTGGACATCCGCCGCGTGGGCCAGCAGCTCGAATGGCTGCGCGTGCGGCTGCTGGAGCTGGACGCCGACAAGGCCCGGTT
CCTGCGGCACATCTCGCACGAACTCAAGACCCCCCTGGCCTCCATGCGCGAGGGCGTCGCCCTGCTGCAGGACGGCGTGA
CCGGCGAACTGGGCGCGGGCCAGCGCGAGGTGGTGGACATCCTGCACCAGAACACCCTGGTGCTGCAGGGCGAGATCGAG
GCCCTGCTGCGTTTCAACGCCGCGGCCTTCGAGGCCCGCCAGCTGCACCGCGCCCCCACCGACCTGCTGGCGCTGATCGA
GGCCCAGGTCGAGACCCAGCGCCTGCAGTGGCAGGCCCGCAAGCTCGACGTGGTGGTCGAAGGCAGGCCCGTCACGCTGC
CGGTGGACGCCGAGAAGATCGCCTCGGCCGTGGGCAACCTGCTCTCCAACGCGATCCGTTTCTCGCCCCAGGGCGGCAGG
ATTCTGATTCAACTCATACGTTTCGAAGACCGCATCCGCATCGATGTGACCGACGAAGGCCCCGGCGTGCATGAAAATGA
CCGTGCCCGCATCTTCGAGCCTTTCTACCGGGGGGTGCGGCAGCCGGAAGACGCCGCGCGCGGCACCGGCATCGGCCTGT
CCATCGTCCAGGAGTACGTCGCCGCCCATGGCGGACGCGTGAGCCTCGTCGAAGCCGGCGAACGTACACCCTTCCGCATC
GAACTGCCCCATGCCTCCTGA

Upstream 100 bases:

>100_bases
GTCGATGTCACCATCACCGAAGCCAAGGCCTACACGCTGCGCGGCGAGGTGGTCACGGCGGACCACGGCGCGCTGGCCGC
GCACTGAGGCAGAGGGCCGC

Downstream 100 bases:

>100_bases
TCATCCGCTGCCGCGCCATGGCGCACGCCCCCGCGCCGGTGCCGCGCGCCCCGCAGGGGCGCACCTGGCGCACCTGACGC
ATCTGGCAATAGCGACCGCA

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MGFAARLFRRQQGVAALGGLSFQQMLLLAFLLIAGLQGASSLRAIFTLEQLMVQSRNGAAEAIQLNAAAQSLNARGQTLE
RAARQSLVLADRSLRRRFDDISREAHEILQRLETKGLPPELAAQWRAHLAQVTALLDGPPALSLDNERAVAGLFLELDGV
NGAIAQSVQDINTRRSAELQEKIEASRREVTHQVVGVIVLALVLALALGIWLARPFKRLEHAIRLLGENELAQSVEIPGP
VDIRRVGQQLEWLRVRLLELDADKARFLRHISHELKTPLASMREGVALLQDGVTGELGAGQREVVDILHQNTLVLQGEIE
ALLRFNAAAFEARQLHRAPTDLLALIEAQVETQRLQWQARKLDVVVEGRPVTLPVDAEKIASAVGNLLSNAIRFSPQGGR
ILIQLIRFEDRIRIDVTDEGPGVHENDRARIFEPFYRGVRQPEDAARGTGIGLSIVQEYVAAHGGRVSLVEAGERTPFRI
ELPHAS

Sequences:

>Translated_486_residues
MGFAARLFRRQQGVAALGGLSFQQMLLLAFLLIAGLQGASSLRAIFTLEQLMVQSRNGAAEAIQLNAAAQSLNARGQTLE
RAARQSLVLADRSLRRRFDDISREAHEILQRLETKGLPPELAAQWRAHLAQVTALLDGPPALSLDNERAVAGLFLELDGV
NGAIAQSVQDINTRRSAELQEKIEASRREVTHQVVGVIVLALVLALALGIWLARPFKRLEHAIRLLGENELAQSVEIPGP
VDIRRVGQQLEWLRVRLLELDADKARFLRHISHELKTPLASMREGVALLQDGVTGELGAGQREVVDILHQNTLVLQGEIE
ALLRFNAAAFEARQLHRAPTDLLALIEAQVETQRLQWQARKLDVVVEGRPVTLPVDAEKIASAVGNLLSNAIRFSPQGGR
ILIQLIRFEDRIRIDVTDEGPGVHENDRARIFEPFYRGVRQPEDAARGTGIGLSIVQEYVAAHGGRVSLVEAGERTPFRI
ELPHAS
>Mature_485_residues
GFAARLFRRQQGVAALGGLSFQQMLLLAFLLIAGLQGASSLRAIFTLEQLMVQSRNGAAEAIQLNAAAQSLNARGQTLER
AARQSLVLADRSLRRRFDDISREAHEILQRLETKGLPPELAAQWRAHLAQVTALLDGPPALSLDNERAVAGLFLELDGVN
GAIAQSVQDINTRRSAELQEKIEASRREVTHQVVGVIVLALVLALALGIWLARPFKRLEHAIRLLGENELAQSVEIPGPV
DIRRVGQQLEWLRVRLLELDADKARFLRHISHELKTPLASMREGVALLQDGVTGELGAGQREVVDILHQNTLVLQGEIEA
LLRFNAAAFEARQLHRAPTDLLALIEAQVETQRLQWQARKLDVVVEGRPVTLPVDAEKIASAVGNLLSNAIRFSPQGGRI
LIQLIRFEDRIRIDVTDEGPGVHENDRARIFEPFYRGVRQPEDAARGTGIGLSIVQEYVAAHGGRVSLVEAGERTPFRIE
LPHAS

Specific function: Probable member of a two-component regulatory system yfhA/yfhK. May activate yfhA by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082128, Length=418, Percent_Identity=33.2535885167464, Blast_Score=189, Evalue=5e-49,
Organism=Escherichia coli, GI1790861, Length=299, Percent_Identity=29.4314381270903, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1788393, Length=285, Percent_Identity=29.1228070175439, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1790346, Length=259, Percent_Identity=29.3436293436293, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI145693157, Length=226, Percent_Identity=29.646017699115, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1787894, Length=302, Percent_Identity=26.4900662251656, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1789808, Length=281, Percent_Identity=25.9786476868327, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI48994928, Length=237, Percent_Identity=27.4261603375527, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788279, Length=360, Percent_Identity=25, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786600, Length=237, Percent_Identity=24.4725738396624, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786783, Length=376, Percent_Identity=22.8723404255319, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1789149, Length=239, Percent_Identity=25.5230125523013, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87081816, Length=226, Percent_Identity=28.3185840707965, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53533; Mature: 53402

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFAARLFRRQQGVAALGGLSFQQMLLLAFLLIAGLQGASSLRAIFTLEQLMVQSRNGAA
CCHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCH
EAIQLNAAAQSLNARGQTLERAARQSLVLADRSLRRRFDDISREAHEILQRLETKGLPPE
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LAAQWRAHLAQVTALLDGPPALSLDNERAVAGLFLELDGVNGAIAQSVQDINTRRSAELQ
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
EKIEASRREVTHQVVGVIVLALVLALALGIWLARPFKRLEHAIRLLGENELAQSVEIPGP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCC
VDIRRVGQQLEWLRVRLLELDADKARFLRHISHELKTPLASMREGVALLQDGVTGELGAG
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCC
QREVVDILHQNTLVLQGEIEALLRFNAAAFEARQLHRAPTDLLALIEAQVETQRLQWQAR
HHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
KLDVVVEGRPVTLPVDAEKIASAVGNLLSNAIRFSPQGGRILIQLIRFEDRIRIDVTDEG
HEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEECCC
PGVHENDRARIFEPFYRGVRQPEDAARGTGIGLSIVQEYVAAHGGRVSLVEAGERTPFRI
CCCCCCCCHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCEEE
ELPHAS
ECCCCC
>Mature Secondary Structure 
GFAARLFRRQQGVAALGGLSFQQMLLLAFLLIAGLQGASSLRAIFTLEQLMVQSRNGAA
CHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCH
EAIQLNAAAQSLNARGQTLERAARQSLVLADRSLRRRFDDISREAHEILQRLETKGLPPE
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LAAQWRAHLAQVTALLDGPPALSLDNERAVAGLFLELDGVNGAIAQSVQDINTRRSAELQ
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
EKIEASRREVTHQVVGVIVLALVLALALGIWLARPFKRLEHAIRLLGENELAQSVEIPGP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCC
VDIRRVGQQLEWLRVRLLELDADKARFLRHISHELKTPLASMREGVALLQDGVTGELGAG
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCC
QREVVDILHQNTLVLQGEIEALLRFNAAAFEARQLHRAPTDLLALIEAQVETQRLQWQAR
HHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
KLDVVVEGRPVTLPVDAEKIASAVGNLLSNAIRFSPQGGRILIQLIRFEDRIRIDVTDEG
HEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEECCC
PGVHENDRARIFEPFYRGVRQPEDAARGTGIGLSIVQEYVAAHGGRVSLVEAGERTPFRI
CCCCCCCCHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCEEE
ELPHAS
ECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]