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The map label for this gene is ywrD [H]

Identifier: 120609289

GI number: 120609289

Start: 643070

End: 644686

Strand: Direct

Name: ywrD [H]

Synonym: Aave_0589

Alternate gene names: 120609289

Gene position: 643070-644686 (Clockwise)

Preceding gene: 120609288

Following gene: 120609293

Centisome position: 12.01

GC content: 73.65

Gene sequence:

>1617_bases
ATGACTGCACCCCACGGCGACCGCGCCATCGATTGGACCCTGCCCTATGCCTCGCACCGCAGCGCGGTCATGGGCCGCAA
TGTCGTTTCCACCTCGCAGCCCCTGGCCGCCCAGGCCGGGCTGCGGATGCTGCAGGCGGGCGGCAATGCGGTCGATGCGG
CCCTGGCCGCGGCGATGGTGCTCACCGTGGTCGAGCCCACGGGCTGCGGCATCGGCAGCGATGCATTCGCCATCGTATGG
GACGGCCAGGAACTGCACGGCCTGAACGCCTCGGGGCGGGCCCCCGCCGCCTGGACACCCGGCTACTTCGCCGAGCGCGG
CGGCATCCCGGAGACGGGCTGGAACGCCGTGACGGTGCCGGGCGCCGTCTCGGGCTGGGTGGCGCTCTCGCGGCGCTTCG
GCCGCCTGCCTTTCGCGCAGCTCGCGCAGCCGGCCATCGATTACGCGCGCGGCGGTTTCGCCGTCTCGCCCACCATCGCC
CGGCAATGGGCGCTGGGGGCCGCCAGGCTGGGGAGCCAGCCGGGGTTCGCCGAATGCTTCCTGCCCGGCGGCCGCGCGCC
GCGCGCGGGCGAGATCTTCCGCAGCGAAGCCCATGCCCGCACGCTGGAGCGCATCGCCGTCACCGGGGGCGAGGACTTCT
ACCGGGGCGAACTGGCCCGGCAGATGGCCGCGCACGCCCGCGCGAACGGCGGCGCGATGACCGAGGACGATCTCGCGGCC
CACCAGGCCGACTGGGTGGGTACCGTGAGCCGGCGCTTCGGTGACTCCGTGATCCACGAGATTCCGCCCAACGGTCAGGG
CATCGCGGCGCTGATGGCGCTGGGCATGCTGGATGTGGCCGGCATCGGCGCGCAGCCGGTGGACCATGTGGACACCGTGC
ACGCGAGCATCGAGGCGATGAAGCTCGCGCTGGCCGACCTGTACCGCCACAACGCCGATGCCGATGCCATGCGGGTGGCC
GCGCGCGACCTGCTGTCGGATGCCTACGTGCGCGAGCGCGCCGCGCTCATCGACCCGGCCCGCGCGGGCGATCCCGGCCA
CGGCATGCCGCGCCCGGGCGGCACCGTGTACCTCGCCGCGGCCGACGAGAGCGGCATGATGGTCTCCTTCATCCAGTCCA
ACTACATGGGCTTCGGCTCCGGAGTGGTGGTGCCGGGTACGGGCATCAGCCTGCAGAACCGTGGTCACTGCTTCACCGCC
GAGGCAGGGCACGCGAACGAGGTGGCGCCGCGCAAGCGCCCCTCGCACACCATCATCCCGGCCTTCGCCACGGATGCCGA
CGGCGCGCCGCGCATGGCCTTCGGCGTCATGGGCGGGCCGATGCAGTCGCAGGGCCACGTGCAGATGGCGCTGCGCGTGC
TGCGCTACGGCCAGAACCCCCAGGCCGCTGCCGATGCACCGCGCTGGCGCGTGACGGGCGGCCGCGGCGTGGCCGTGGAG
CCGGCATTCGATCCCGCCGTGGTCGGGGCGCTGCGCGCGCGCGGCCACGACGTGGCGGTGGAGGCGGGTGATGGCGTCTT
CGCGTTCGGCGGCGCCCAGTTGGTGCTGCGGCTGGACAGCGGCGCCTACGCCGCGGGTTCGGACCCGCGCAAGGACGGGC
ACGCCGTCGCGTACTGA

Upstream 100 bases:

>100_bases
TGGCCCGGGACTGATGCCGCCACGGCGGGCGCCGCGCGGGCCGCGCACCTGCAAGAATGCCGTCTCCATCCGAACGCATT
CCTGAAGGAGACAACGCACC

Downstream 100 bases:

>100_bases
GCGTTGCCCACAAGCCCCGTCCCCGCCCGCGGCCCCCGTGGGGGCGGTGCCGCGTCAGCGCCGCGCCAGCAGCATCGCGT
CGCCGTAGCTGAAGAACCGG

Product: gamma-glutamyltransferase 2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 538; Mature: 537

Protein sequence:

>538_residues
MTAPHGDRAIDWTLPYASHRSAVMGRNVVSTSQPLAAQAGLRMLQAGGNAVDAALAAAMVLTVVEPTGCGIGSDAFAIVW
DGQELHGLNASGRAPAAWTPGYFAERGGIPETGWNAVTVPGAVSGWVALSRRFGRLPFAQLAQPAIDYARGGFAVSPTIA
RQWALGAARLGSQPGFAECFLPGGRAPRAGEIFRSEAHARTLERIAVTGGEDFYRGELARQMAAHARANGGAMTEDDLAA
HQADWVGTVSRRFGDSVIHEIPPNGQGIAALMALGMLDVAGIGAQPVDHVDTVHASIEAMKLALADLYRHNADADAMRVA
ARDLLSDAYVRERAALIDPARAGDPGHGMPRPGGTVYLAAADESGMMVSFIQSNYMGFGSGVVVPGTGISLQNRGHCFTA
EAGHANEVAPRKRPSHTIIPAFATDADGAPRMAFGVMGGPMQSQGHVQMALRVLRYGQNPQAAADAPRWRVTGGRGVAVE
PAFDPAVVGALRARGHDVAVEAGDGVFAFGGAQLVLRLDSGAYAAGSDPRKDGHAVAY

Sequences:

>Translated_538_residues
MTAPHGDRAIDWTLPYASHRSAVMGRNVVSTSQPLAAQAGLRMLQAGGNAVDAALAAAMVLTVVEPTGCGIGSDAFAIVW
DGQELHGLNASGRAPAAWTPGYFAERGGIPETGWNAVTVPGAVSGWVALSRRFGRLPFAQLAQPAIDYARGGFAVSPTIA
RQWALGAARLGSQPGFAECFLPGGRAPRAGEIFRSEAHARTLERIAVTGGEDFYRGELARQMAAHARANGGAMTEDDLAA
HQADWVGTVSRRFGDSVIHEIPPNGQGIAALMALGMLDVAGIGAQPVDHVDTVHASIEAMKLALADLYRHNADADAMRVA
ARDLLSDAYVRERAALIDPARAGDPGHGMPRPGGTVYLAAADESGMMVSFIQSNYMGFGSGVVVPGTGISLQNRGHCFTA
EAGHANEVAPRKRPSHTIIPAFATDADGAPRMAFGVMGGPMQSQGHVQMALRVLRYGQNPQAAADAPRWRVTGGRGVAVE
PAFDPAVVGALRARGHDVAVEAGDGVFAFGGAQLVLRLDSGAYAAGSDPRKDGHAVAY
>Mature_537_residues
TAPHGDRAIDWTLPYASHRSAVMGRNVVSTSQPLAAQAGLRMLQAGGNAVDAALAAAMVLTVVEPTGCGIGSDAFAIVWD
GQELHGLNASGRAPAAWTPGYFAERGGIPETGWNAVTVPGAVSGWVALSRRFGRLPFAQLAQPAIDYARGGFAVSPTIAR
QWALGAARLGSQPGFAECFLPGGRAPRAGEIFRSEAHARTLERIAVTGGEDFYRGELARQMAAHARANGGAMTEDDLAAH
QADWVGTVSRRFGDSVIHEIPPNGQGIAALMALGMLDVAGIGAQPVDHVDTVHASIEAMKLALADLYRHNADADAMRVAA
RDLLSDAYVRERAALIDPARAGDPGHGMPRPGGTVYLAAADESGMMVSFIQSNYMGFGSGVVVPGTGISLQNRGHCFTAE
AGHANEVAPRKRPSHTIIPAFATDADGAPRMAFGVMGGPMQSQGHVQMALRVLRYGQNPQAAADAPRWRVTGGRGVAVEP
AFDPAVVGALRARGHDVAVEAGDGVFAFGGAQLVLRLDSGAYAAGSDPRKDGHAVAY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=556, Percent_Identity=28.2374100719424, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI73915090, Length=556, Percent_Identity=28.2374100719424, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI73915096, Length=556, Percent_Identity=28.2374100719424, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI73915094, Length=556, Percent_Identity=28.2374100719424, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI113429324, Length=556, Percent_Identity=27.5179856115108, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI113429326, Length=561, Percent_Identity=27.6292335115865, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI153266885, Length=544, Percent_Identity=26.8382352941176, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI153266901, Length=545, Percent_Identity=26.7889908256881, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI153266907, Length=540, Percent_Identity=25.9259259259259, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI109148539, Length=489, Percent_Identity=28.0163599182004, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI30581157, Length=210, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI30581155, Length=210, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1789856, Length=531, Percent_Identity=28.6252354048964, Blast_Score=182, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17506189, Length=539, Percent_Identity=26.1595547309833, Blast_Score=131, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI212646519, Length=465, Percent_Identity=26.0215053763441, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI72000294, Length=465, Percent_Identity=26.0215053763441, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI193208247, Length=508, Percent_Identity=25.7874015748031, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI193208245, Length=508, Percent_Identity=25.7874015748031, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI161077878, Length=534, Percent_Identity=26.2172284644195, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24642670, Length=534, Percent_Identity=26.2172284644195, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24642666, Length=534, Percent_Identity=26.2172284644195, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI161077880, Length=534, Percent_Identity=26.2172284644195, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI45551474, Length=534, Percent_Identity=26.2172284644195, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI18859893, Length=498, Percent_Identity=26.7068273092369, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI161077496, Length=505, Percent_Identity=25.1485148514851, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI18859741, Length=525, Percent_Identity=24.952380952381, Blast_Score=109, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 55908; Mature: 55776

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPHGDRAIDWTLPYASHRSAVMGRNVVSTSQPLAAQAGLRMLQAGGNAVDAALAAAMV
CCCCCCCCEEEEECCCCCCCHHHHCCCHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
LTVVEPTGCGIGSDAFAIVWDGQELHGLNASGRAPAAWTPGYFAERGGIPETGWNAVTVP
HHEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCEEECC
GAVSGWVALSRRFGRLPFAQLAQPAIDYARGGFAVSPTIARQWALGAARLGSQPGFAECF
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHCCCCCCEEEE
LPGGRAPRAGEIFRSEAHARTLERIAVTGGEDFYRGELARQMAAHARANGGAMTEDDLAA
CCCCCCCCHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
HQADWVGTVSRRFGDSVIHEIPPNGQGIAALMALGMLDVAGIGAQPVDHVDTVHASIEAM
HHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
KLALADLYRHNADADAMRVAARDLLSDAYVRERAALIDPARAGDPGHGMPRPGGTVYLAA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEE
ADESGMMVSFIQSNYMGFGSGVVVPGTGISLQNRGHCFTAEAGHANEVAPRKRPSHTIIP
ECCCCCEEEEEHHCCCCCCCCEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCEEEE
AFATDADGAPRMAFGVMGGPMQSQGHVQMALRVLRYGQNPQAAADAPRWRVTGGRGVAVE
EEECCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCEEEC
PAFDPAVVGALRARGHDVAVEAGDGVFAFGGAQLVLRLDSGAYAAGSDPRKDGHAVAY
CCCCHHHHHHHHHCCCEEEEECCCCEEEECCEEEEEEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TAPHGDRAIDWTLPYASHRSAVMGRNVVSTSQPLAAQAGLRMLQAGGNAVDAALAAAMV
CCCCCCCEEEEECCCCCCCHHHHCCCHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
LTVVEPTGCGIGSDAFAIVWDGQELHGLNASGRAPAAWTPGYFAERGGIPETGWNAVTVP
HHEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCEEECC
GAVSGWVALSRRFGRLPFAQLAQPAIDYARGGFAVSPTIARQWALGAARLGSQPGFAECF
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHCCCCCCEEEE
LPGGRAPRAGEIFRSEAHARTLERIAVTGGEDFYRGELARQMAAHARANGGAMTEDDLAA
CCCCCCCCHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
HQADWVGTVSRRFGDSVIHEIPPNGQGIAALMALGMLDVAGIGAQPVDHVDTVHASIEAM
HHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
KLALADLYRHNADADAMRVAARDLLSDAYVRERAALIDPARAGDPGHGMPRPGGTVYLAA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEE
ADESGMMVSFIQSNYMGFGSGVVVPGTGISLQNRGHCFTAEAGHANEVAPRKRPSHTIIP
ECCCCCEEEEEHHCCCCCCCCEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCEEEE
AFATDADGAPRMAFGVMGGPMQSQGHVQMALRVLRYGQNPQAAADAPRWRVTGGRGVAVE
EEECCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCEEEC
PAFDPAVVGALRARGHDVAVEAGDGVFAFGGAQLVLRLDSGAYAAGSDPRKDGHAVAY
CCCCHHHHHHHHHCCCEEEEECCCCEEEECCEEEEEEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]