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The map label for this gene is lig [H]

Identifier: 120609078

GI number: 120609078

Start: 400893

End: 402593

Strand: Direct

Name: lig [H]

Synonym: Aave_0375

Alternate gene names: 120609078

Gene position: 400893-402593 (Clockwise)

Preceding gene: 120609077

Following gene: 120609079

Centisome position: 7.49

GC content: 71.02

Gene sequence:

>1701_bases
ATGAAGGACTTTGCCGCTCTCTACCGCGCGCTGGACGCGAGCACCTCCAGCCTCGCCAAGCAGGCGGCGCTGCAGGCTTA
CCTGCGCGCGGCGGCACCTGCGGATGCGGCCTGGGCGGTGTACTTCCTGGCAGGCGGCAAGCCGCGCCAGCTGGTCCCGA
CCAAGCTGCTGCGGCAGTTCGCGCGCGAGGCGGCGGGCCTGCCGGAATGGCTGTTCGACGAAAGCTATGAAGCGGTCGGA
GACCTCGCGGAAACCATCGCACTGCTGCTGCCGGCGCCCGCCGAGGCCCATGCGCTGGGCCTGGCCGAATGGGTGGAGCA
GCACCTGCTGCCGCTGCGCGGCATGGCGCCCGAAGCGCTGGAGCCGATGTTGCGGGCGCAGTGGAACCGGCTGGCGCCCG
AGGAGCGGCTCGTCTATTTCAAGCTCATCACGGGGGCCTTCCGCGTCGGTGTGTCGAAGCTGCAGGTCACGCAGGCCCTG
GCGGCCGTGAGCGGCGTGGATCCCAAGCGCGTGGCCCAGCGGCTCATGGGCTACACGCACATCGGCGCACGGCCCGGGCC
GGCGGATTACGAACGCCTCGTGGCGCCGCTCGCCGAGACCGGCCAGGGCGCGGCGGACGACGCGGCGCAGTCCGGCGAAA
CCAGCGGCCATCCCTATCCCTTCTTCCTGGCGCACCCGCTGTCGCTGCCCGTGGACCAGTTCGCGGCCACGCTCGGGCCG
CCCGGCGGCTGGATCGTGGAGTGGAAGTGGGACGGCATCCGCGCCCAACTGGTGCGGCGTGCGGGTGCCACCTGGGTCTG
GTCGCGCGGCGAGGAGCTGGTCAGCGACCGCTTTCCCGAACTGCAGCGCCTGGGCCAGGAGGCCCTGCCGGACGGTACCG
TGCTCGATGGCGAGATCGTCGTCTGGCAGCATGCGGAGGGCGATGCGCCGGCACGGGTGCGTCCGTTCGCGGACCTGCAG
AAACGCATCGGCCGCAAGACGCTCGGCCCCAAGCTGCTGCGCGAGCTGCCCGTGGTGCTGCTGGCCTACGACCTGCTGGA
AGAGGACGGGAAGGATCTGCGGGCGCTGCCGCAGCATGAACGCCGGGCGCGCCTCGATGCCCTGCTCGCCCGGGTGTCGC
ATCCGGCGCTGGTCGCCAGCCCCCTGCTGCACGGCCATGACTGGGACGAGCTGGCCGCCCGGCGGGCCCATGCCCGATCC
CTGGGCGTCGAAGGCATGATGCTCAAGGCCCGCGACGCGCAGTACGGCGTGGGCCGCACCAAGGATGTGGGAACGTGGTG
GAAATGGAAGATCGACCCTCTGAGCGTGGATGCGGTGCTCATCTATGCGCAGCGCGGCCACGGGCGTCGCGCCAGCCTGT
ACAGCGACTACACCTTCGCCGTCTGGGACGGGCCGCCCGGCGCGGAAGGCCGCTCTCTCGTGCCGTTCGCGAAAGCGTAT
TCGGGCCTGACCGACGCCGAGATGGCGCGCGTGGACGCGGTCATCCGCCGCACCACGGTGGAAACCTTCGGGCCGGTACG
CAGCGTGAAGCCCACGCTGGTATTCGAGCTCGGCTTCGAGGGCATCGCCCGCAGTGCGCGGCACAAGAGCGGCATCGCGG
TGCGGTTTCCGCGGATGCTGCGCTGGCGGGAGGACAAGCCGGTGGAGGAGGCGGATTCGCTGGAGACGCTGGAGGCGCTG
TTGCCGAGGTCGGATCCTTGA

Upstream 100 bases:

>100_bases
CGCCGGATGCCTCCACGGCTACACCGCCGGTCGCCGCGCCGGGCGGTGATGCTTCGCCTGTCGAAGACGATGGCCCGCCA
GAGGGCGGGGAAGCGGCGCC

Downstream 100 bases:

>100_bases
TTTCCAATGCATGGCCCGCAGCGCTGCCCGTTCCACCATGAAGACGGCGCCAGCGGCCCGGTCACCGCGGTGACGCCGCC
CACCATCCTCCACCTCCATG

Product: ATP-dependent DNA ligase

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP] [H]

Number of amino acids: Translated: 566; Mature: 566

Protein sequence:

>566_residues
MKDFAALYRALDASTSSLAKQAALQAYLRAAAPADAAWAVYFLAGGKPRQLVPTKLLRQFAREAAGLPEWLFDESYEAVG
DLAETIALLLPAPAEAHALGLAEWVEQHLLPLRGMAPEALEPMLRAQWNRLAPEERLVYFKLITGAFRVGVSKLQVTQAL
AAVSGVDPKRVAQRLMGYTHIGARPGPADYERLVAPLAETGQGAADDAAQSGETSGHPYPFFLAHPLSLPVDQFAATLGP
PGGWIVEWKWDGIRAQLVRRAGATWVWSRGEELVSDRFPELQRLGQEALPDGTVLDGEIVVWQHAEGDAPARVRPFADLQ
KRIGRKTLGPKLLRELPVVLLAYDLLEEDGKDLRALPQHERRARLDALLARVSHPALVASPLLHGHDWDELAARRAHARS
LGVEGMMLKARDAQYGVGRTKDVGTWWKWKIDPLSVDAVLIYAQRGHGRRASLYSDYTFAVWDGPPGAEGRSLVPFAKAY
SGLTDAEMARVDAVIRRTTVETFGPVRSVKPTLVFELGFEGIARSARHKSGIAVRFPRMLRWREDKPVEEADSLETLEAL
LPRSDP

Sequences:

>Translated_566_residues
MKDFAALYRALDASTSSLAKQAALQAYLRAAAPADAAWAVYFLAGGKPRQLVPTKLLRQFAREAAGLPEWLFDESYEAVG
DLAETIALLLPAPAEAHALGLAEWVEQHLLPLRGMAPEALEPMLRAQWNRLAPEERLVYFKLITGAFRVGVSKLQVTQAL
AAVSGVDPKRVAQRLMGYTHIGARPGPADYERLVAPLAETGQGAADDAAQSGETSGHPYPFFLAHPLSLPVDQFAATLGP
PGGWIVEWKWDGIRAQLVRRAGATWVWSRGEELVSDRFPELQRLGQEALPDGTVLDGEIVVWQHAEGDAPARVRPFADLQ
KRIGRKTLGPKLLRELPVVLLAYDLLEEDGKDLRALPQHERRARLDALLARVSHPALVASPLLHGHDWDELAARRAHARS
LGVEGMMLKARDAQYGVGRTKDVGTWWKWKIDPLSVDAVLIYAQRGHGRRASLYSDYTFAVWDGPPGAEGRSLVPFAKAY
SGLTDAEMARVDAVIRRTTVETFGPVRSVKPTLVFELGFEGIARSARHKSGIAVRFPRMLRWREDKPVEEADSLETLEAL
LPRSDP
>Mature_566_residues
MKDFAALYRALDASTSSLAKQAALQAYLRAAAPADAAWAVYFLAGGKPRQLVPTKLLRQFAREAAGLPEWLFDESYEAVG
DLAETIALLLPAPAEAHALGLAEWVEQHLLPLRGMAPEALEPMLRAQWNRLAPEERLVYFKLITGAFRVGVSKLQVTQAL
AAVSGVDPKRVAQRLMGYTHIGARPGPADYERLVAPLAETGQGAADDAAQSGETSGHPYPFFLAHPLSLPVDQFAATLGP
PGGWIVEWKWDGIRAQLVRRAGATWVWSRGEELVSDRFPELQRLGQEALPDGTVLDGEIVVWQHAEGDAPARVRPFADLQ
KRIGRKTLGPKLLRELPVVLLAYDLLEEDGKDLRALPQHERRARLDALLARVSHPALVASPLLHGHDWDELAARRAHARS
LGVEGMMLKARDAQYGVGRTKDVGTWWKWKIDPLSVDAVLIYAQRGHGRRASLYSDYTFAVWDGPPGAEGRSLVPFAKAY
SGLTDAEMARVDAVIRRTTVETFGPVRSVKPTLVFELGFEGIARSARHKSGIAVRFPRMLRWREDKPVEEADSLETLEAL
LPRSDP

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair [H]

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

Organism=Homo sapiens, GI4557719, Length=369, Percent_Identity=26.8292682926829, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71985269, Length=370, Percent_Identity=26.2162162162162, Blast_Score=114, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320038, Length=346, Percent_Identity=26.3005780346821, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI85815841, Length=376, Percent_Identity=29.2553191489362, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24762424, Length=334, Percent_Identity=26.3473053892216, Blast_Score=90, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022865
- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N [H]

EC number: =6.5.1.1 [H]

Molecular weight: Translated: 62309; Mature: 62309

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS00024 HEMOPEXIN ; PS00697 DNA_LIGASE_A1 ; PS50160 DNA_LIGASE_A3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDFAALYRALDASTSSLAKQAALQAYLRAAAPADAAWAVYFLAGGKPRQLVPTKLLRQF
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHH
AREAAGLPEWLFDESYEAVGDLAETIALLLPAPAEAHALGLAEWVEQHLLPLRGMAPEAL
HHHHCCCCHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHH
EPMLRAQWNRLAPEERLVYFKLITGAFRVGVSKLQVTQALAAVSGVDPKRVAQRLMGYTH
HHHHHHHHHHCCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHH
IGARPGPADYERLVAPLAETGQGAADDAAQSGETSGHPYPFFLAHPLSLPVDQFAATLGP
CCCCCCCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHCCC
PGGWIVEWKWDGIRAQLVRRAGATWVWSRGEELVSDRFPELQRLGQEALPDGTVLDGEIV
CCCEEEEEEECCHHHHHHHHCCCCEEECCCHHHHHHCCHHHHHHHHHHCCCCCEECCEEE
VWQHAEGDAPARVRPFADLQKRIGRKTLGPKLLRELPVVLLAYDLLEEDGKDLRALPQHE
EEEECCCCCCCCCCCHHHHHHHHCHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHH
RRARLDALLARVSHPALVASPLLHGHDWDELAARRAHARSLGVEGMMLKARDAQYGVGRT
HHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCC
KDVGTWWKWKIDPLSVDAVLIYAQRGHGRRASLYSDYTFAVWDGPPGAEGRSLVPFAKAY
CCCCCEEEEEECCCCCCEEEEEEECCCCCCCEEECCEEEEEECCCCCCCCCCCCCHHHHH
SGLTDAEMARVDAVIRRTTVETFGPVRSVKPTLVFELGFEGIARSARHKSGIAVRFPRML
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHCCCCEEECHHHH
RWREDKPVEEADSLETLEALLPRSDP
HCCCCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKDFAALYRALDASTSSLAKQAALQAYLRAAAPADAAWAVYFLAGGKPRQLVPTKLLRQF
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHH
AREAAGLPEWLFDESYEAVGDLAETIALLLPAPAEAHALGLAEWVEQHLLPLRGMAPEAL
HHHHCCCCHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHH
EPMLRAQWNRLAPEERLVYFKLITGAFRVGVSKLQVTQALAAVSGVDPKRVAQRLMGYTH
HHHHHHHHHHCCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHH
IGARPGPADYERLVAPLAETGQGAADDAAQSGETSGHPYPFFLAHPLSLPVDQFAATLGP
CCCCCCCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHCCC
PGGWIVEWKWDGIRAQLVRRAGATWVWSRGEELVSDRFPELQRLGQEALPDGTVLDGEIV
CCCEEEEEEECCHHHHHHHHCCCCEEECCCHHHHHHCCHHHHHHHHHHCCCCCEECCEEE
VWQHAEGDAPARVRPFADLQKRIGRKTLGPKLLRELPVVLLAYDLLEEDGKDLRALPQHE
EEEECCCCCCCCCCCHHHHHHHHCHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHH
RRARLDALLARVSHPALVASPLLHGHDWDELAARRAHARSLGVEGMMLKARDAQYGVGRT
HHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCC
KDVGTWWKWKIDPLSVDAVLIYAQRGHGRRASLYSDYTFAVWDGPPGAEGRSLVPFAKAY
CCCCCEEEEEECCCCCCEEEEEEECCCCCCCEEECCEEEEEECCCCCCCCCCCCCHHHHH
SGLTDAEMARVDAVIRRTTVETFGPVRSVKPTLVFELGFEGIARSARHKSGIAVRFPRML
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHCCCCEEECHHHH
RWREDKPVEEADSLETLEALLPRSDP
HCCCCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA